KEGG   ENZYME: 3.1.3.74Help
Entry
EC 3.1.3.74                 Enzyme                                 

Name
pyridoxal phosphatase;
vitamine B6 (pyridoxine) phosphatase;
PLP phosphatase;
vitamin B6-phosphate phosphatase;
PNP phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
pyridoxal-5'-phosphate phosphohydrolase
Reaction(IUBMB)
pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate [RN:R00173]
Reaction(KEGG)
R00173;
(other) R01911 R02494
Show
Substrate
pyridoxal 5'-phosphate [CPD:C00018];
H2O [CPD:C00001]
Product
pyridoxal [CPD:C00250];
phosphate [CPD:C00009]
Comment
Requires Mg2+. This enzyme is specific for phosphorylated vitamin B6 compounds: it acts not only on pyridoxal phosphate (PLP), but also on pyridoxine phosphate (PNP), pyridoxamine phosphate (PMP), 4-pyridoxic acid phosphate and 4-deoxypyridoxine phosphate. This reaction can also be carried out by EC 3.1.3.1 (alkaline phosphatase) and EC 3.1.3.2 (acid phosphatase), but these enzymes have very broad substrate specificities.
History
EC 3.1.3.74 created 2004
Pathway
ec00750  Vitamin B6 metabolism
ec01100  Metabolic pathways
Orthology
K07758  pyridoxal phosphatase
K13248  pyridoxal phosphate phosphatase PHOSPHO2
Genes
HSA: 493911(PHOSPHO2) 57026(PDXP)
PTR: 459719(PHOSPHO2)
PPS: 103786618(PDXP) 103787064(PHOSPHO2)
GGO: 101131418(PHOSPHO2)
PON: 103888967(PDXP) 103889977(PHOSPHO2)
NLE: 100582371(PDXP) 100582638(PHOSPHO2)
MCC: 100429653(PHOSPHO2) 107000658(PDXP)
MCF: 101865359(PDXP) 102140894(PHOSPHO2)
CSAB: 103217273(PHOSPHO2) 103223282(PDXP)
RRO: 104655044(PHOSPHO2) 104682575(PDXP)
RBB: 108516828(PHOSPHO2)
CJC: 100399798(PHOSPHO2) 100399981(PDXP)
SBQ: 101028765(PHOSPHO2) 101054290(PDXP)
MMU: 57028(Pdxp) 73373(Phospho2)
RNO: 295663(Phospho2) 727679(Pdxp)
CGE: 100755599(Pdxp) 100764721(Phospho2)
NGI: 103737980(Phospho2) 103741821 103748608(Pdxp)
HGL: 101719475(Pdxp) 101722484(Phospho2)
CCAN: 109685677(Pdxp) 109698018(Phospho2)
OCU: 108176292(PDXP)
TUP: 102469858(PDXP) 102479589(PHOSPHO2)
CFA: 100684043(PHOSPHO2) 100688635(PDXP)
AML: 100472338(PHOSPHO2) 105235510(PDXP)
UMR: 103659545(PHOSPHO2) 103676541(PDXP)
ORO: 101368120(PHOSPHO2) 101382844(PDXP)
FCA: 101087253(PHOSPHO2) 101093872(PDXP) 101093877
PTG: 102959923(PDXP) 102967832(PHOSPHO2)
AJU: 106981047(PDXP) 106987668(PHOSPHO2)
BTA: 506308(PDXP) 507308(PHOSPHO2)
BOM: 102272704(PHOSPHO2) 102286951(PDXP)
BIU: 109558621(PDXP) 109566749(PHOSPHO2)
PHD: 102315311 102321640(PDXP) 102330660(PHOSPHO2)
CHX: 102170186(PHOSPHO2) 102180199(PDXP)
OAS: 101119113(PHOSPHO2) 101123544(PDXP)
SSC: 100152929(PHOSPHO2) 100623846(PDXP)
CFR: 102504844(PHOSPHO2)
CDK: 105091073(PHOSPHO2)
BACU: 103003329(PDXP) 103007775(PHOSPHO2)
LVE: 103073497(PDXP) 103080288(PHOSPHO2)
OOR: 101272288(PDXP) 101285843(PHOSPHO2)
ECB: 100052701(PHOSPHO2) 100630816(PDXP)
EPZ: 103554217(PHOSPHO2)
EAI: 106843587(PHOSPHO2)
MYB: 102251338 102251449(PHOSPHO2) 102252377(PDXP)
MYD: 102752571(PHOSPHO2) 102773967(PDXP)
HAI: 109390417(PHOSPHO2) 109394527(PDXP)
RSS: 109445203(PHOSPHO2) 109458941(PDXP)
PALE: 102877859(PHOSPHO2) 102883992(PDXP)
LAV: 100668141(PHOSPHO2)
MDO: 100024396(PHOSPHO2) 100025700(PDXP)
SHR: 100922295(PHOSPHO2) 100924589(PDXP)
OAA: 100086567(PDXP) 100091800
GGA: 424160(PHOSPHO2) 771207(PDXP)
MGP: 100539695(PDXP) 100542382(PHOSPHO2)
CJO: 107313943(PDXP) 107316687(PHOSPHO2)
APLA: 101794607(PHOSPHO2) 101799043(PDXP)
ACYG: 106029977(PHOSPHO2) 106035787(PDXP)
TGU: 100219816(PHOSPHO2) 101234251(PDXP)
GFR: 102033327(PDXP) 102044333(PHOSPHO2)
FAB: 101809714(PDXP) 101815279(PHOSPHO2)
PHI: 102108764(PDXP) 102113616(PHOSPHO2)
PMAJ: 107204187(PDXP) 107207480(PHOSPHO2)
CCW: 104693891(PHOSPHO2) 104696513(PDXP)
FPG: 106112195(PDXP)
FCH: 106631635(PDXP)
CLV: 102095123(PHOSPHO2) 102098989(PDXP)
EGZ: 104128044(PHOSPHO2)
AAM: 106488247(PDXP) 106499198(PHOSPHO2)
ASN: 102376120(PDXP) 102382568(PHOSPHO2)
AMJ: 102566322(PDXP) 102570726(PHOSPHO2)
PSS: 102450474(PDXP) 102450695(PHOSPHO2)
CMY: 102933406(PHOSPHO2)
CPIC: 101950761(PHOSPHO2)
ACS: 100559885(phospho2) 100562224(pdxp)
PVT: 110075983(PDXP) 110076907(PHOSPHO2)
PBI: 103059635(PHOSPHO2)
GJA: 107105933(PDXP) 107119693(PHOSPHO2)
XLA: 779316(phospho2.L)
XTR: 493318(phospho2)
NPR: 108785496(PHOSPHO2)
DRE: 561030(pdxp) 799638(phospho2)
IPU: 108271665(phospho2) 108277379(pdxp)
AMEX: 103024835(phospho2) 103032875(pdxp)
TRU: 101069249(phospho2) 101079776(pdxp)
LCO: 104919874(phospho2) 104920831(pdxp)
NCC: 104961275(phospho2) 104964351(pdxp)
MZE: 101464860(pdxp) 101485115
OLA: 101158449(pdxp) 101174256
XMA: 102219566 102225249(pdxp)
PRET: 103462227 103470083(pdxp)
NFU: 107381999(phospho2) 107394160(pdxp)
CSEM: 103378978(phospho2) 103396959 103397631
LCF: 108882065(pdxp) 108897643(phospho2)
HCQ: 109513960(phospho2) 109526995(pdxp)
BPEC: 110155147(phospho2) 110172127(pdxp)
SFM: 108920705(phospho2) 108938493
LCM: 102350970(PHOSPHO2) 102351909(PDXP)
CMK: 103176439(phospho2)
APLC: 110983821
SKO: 100374642
DME: Dmel_CG12237(CG12237) Dmel_CG14212(CG14212)
DSI: Dsimw501_GD17453(Dsim_GD17453) Dsimw501_GD24455(Dsim_GD24455)
MDE: 101891971
AAG: 5575050
AME: 725365(GB15231)
BIM: 100740933
BTER: 105666736
SOC: 105192970
AEC: 105149951
ACEP: 105621298
PBAR: 105423117
HST: 105186458
CFO: 105248101
LHU: 105679863
PGC: 109853991
TCA: 100141932
DPA: 109534241
NVL: 108561852
BMOR: 101745817
PMAC: 106710189
PRAP: 110993710
DNX: 107163701
CRG: 105338198
MYI: 110442689
OBI: 106883989
EPA: 110254575
ADF: 107355999
AQU: 105312510
ATH: AT1G17710(PEPC1) AT1G73010(PS2) AT4G29530
LJA: Lj0g3v0125959.1(Lj0g3v0125959.1) Lj0g3v0193989.1(Lj0g3v0193989.1) Lj0g3v0319719.1(Lj0g3v0319719.1) Lj0g3v0319729.1(Lj0g3v0319729.1) Lj0g3v0319769.1(Lj0g3v0319769.1) Lj0g3v0319789.1(Lj0g3v0319789.1) Lj0g3v0319799.1(Lj0g3v0319799.1) Lj3g3v0301740.1(Lj3g3v0301740.1) Lj3g3v0302750.1(Lj3g3v0302750.1) Lj3g3v2693540.1(Lj3g3v2693540.1) Lj3g3v2693540.2(Lj3g3v2693540.2)
SLY: 101246036 101259946(psi14C) 543790(psi14B) 544179(psi14A)
DOSA: Os01t0600500-01(Os01g0600500) Os02t0226200-01(Os02g0226200)
OBR: 102701047
ATS: 109739137(LOC109739137) 109747901(LOC109747901)
ATR: 18443768
PPP: 112295379
CNE: CNI03770
CNB: CNBH3600
ABP: AGABI1DRAFT112429(AGABI1DRAFT_112429)
ABV: AGABI2DRAFT192397(AGABI2DRAFT_192397)
SMIN: v1.2.000195.t1(symbB.v1.2.000195.t1)
SPAR: SPRG_03461
 » show all
Taxonomy
Reference
1  [PMID:1322411]
  Authors
Fonda ML.
  Title
Purification and characterization of vitamin B6-phosphate phosphatase from human erythrocytes.
  Journal
J Biol Chem 267:15978-83 (1992)
Reference
2  [PMID:7625842]
  Authors
Fonda ML, Zhang YN.
  Title
Kinetic mechanism and divalent metal activation of human erythrocyte pyridoxal phosphatase.
  Journal
Arch Biochem Biophys 320:345-52 (1995)
DOI:10.1016/0003-9861(95)90018-7
Reference
3  [PMID:14522954]
  Authors
Jang YM, Kim DW, Kang TC, Won MH, Baek NI, Moon BJ, Choi SY, Kwon OS.
  Title
Human pyridoxal phosphatase. Molecular cloning, functional expression, and tissue distribution.
  Journal
J Biol Chem 278:50040-6 (2003)
DOI:10.1074/jbc.M309619200
  Sequence
[hsa:57026] [mmu:57028]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.74
IUBMB Enzyme Nomenclature: 3.1.3.74
ExPASy - ENZYME nomenclature database: 3.1.3.74
BRENDA, the Enzyme Database: 3.1.3.74
CAS: 9076-92-0

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