KEGG   ENZYME: 3.1.3.74
Entry
EC 3.1.3.74                 Enzyme                                 

Name
pyridoxal phosphatase;
vitamine B6 (pyridoxine) phosphatase;
PLP phosphatase;
vitamin B6-phosphate phosphatase;
PNP phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
pyridoxal-5'-phosphate phosphohydrolase
Reaction(IUBMB)
pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate [RN:R00173]
Reaction(KEGG)
R00173;
(other) R01911 R02494
Substrate
pyridoxal 5'-phosphate [CPD:C00018];
H2O [CPD:C00001]
Product
pyridoxal [CPD:C00250];
phosphate [CPD:C00009]
Comment
Requires Mg2+. This enzyme is specific for phosphorylated vitamin B6 compounds: it acts not only on pyridoxal phosphate (PLP), but also on pyridoxine phosphate (PNP), pyridoxamine phosphate (PMP), 4-pyridoxic acid phosphate and 4-deoxypyridoxine phosphate. This reaction can also be carried out by EC 3.1.3.1 (alkaline phosphatase) and EC 3.1.3.2 (acid phosphatase), but these enzymes have very broad substrate specificities.
History
EC 3.1.3.74 created 2004
Pathway
ec00750  Vitamin B6 metabolism
ec01100  Metabolic pathways
Orthology
K07758  pyridoxal phosphatase
K13248  pyridoxal phosphate phosphatase PHOSPHO2
Genes
HSA: 493911(PHOSPHO2) 57026(PDXP)
PTR: 459719(PHOSPHO2)
PPS: 103787064(PHOSPHO2)
GGO: 101131418(PHOSPHO2) 115931924(PDXP)
PON: 103888967(PDXP) 103889977(PHOSPHO2)
NLE: 100582638(PHOSPHO2)
MCC: 100429653(PHOSPHO2)
MCF: 101865359(PDXP) 102140894(PHOSPHO2)
CSAB: 103217273(PHOSPHO2) 103223282(PDXP)
CATY: 105575832(PDXP) 105579769(PHOSPHO2)
PANU: 101012533(PHOSPHO2) 116268555(PDXP)
RRO: 104655044(PHOSPHO2)
RBB: 108516828(PHOSPHO2)
TFN: 117070131(PDXP) 117094889(PHOSPHO2)
PTEH: 111524518(PHOSPHO2) 111549038(PDXP)
CJC: 100399798(PHOSPHO2) 100399981(PDXP)
SBQ: 101028765(PHOSPHO2) 101054290(PDXP)
MMUR: 105880697(PHOSPHO2) 105883760(PDXP)
MMU: 57028(Pdxp) 73373(Phospho2)
MCAL: 110286120(Phospho2) 110310563(Pdxp)
MPAH: 110318918(Phospho2) 110334906(Pdxp)
RNO: 295663(Phospho2) 727679(Pdxp)
MCOC: 116075679(Pdxp) 116090274(Phospho2)
MUN: 110547783(Phospho2) 110558854(Pdxp)
CGE: 100755599(Pdxp) 100764721(Phospho2)
PLEU: 114694241 114701801(Phospho2)
NGI: 103737980(Phospho2) 103741821 103748608(Pdxp)
HGL: 101719475(Pdxp) 101722484(Phospho2)
CPOC: 100721803(Pdxp) 100732519(Phospho2)
CCAN: 109685677(Pdxp) 109698018(Phospho2)
OCU: 108176292(PDXP)
OPI: 101529705 101536714(PHOSPHO2)
TUP: 102469858(PDXP) 102479589(PHOSPHO2)
CFA: 100684043(PHOSPHO2) 100688635(PDXP)
VVP: 112916429(PHOSPHO2) 112929147(PDXP)
VLG: 121491521 121501744(PHOSPHO2)
AML: 100472338(PHOSPHO2) 105235510(PDXP)
UMR: 103659545(PHOSPHO2) 103676541(PDXP)
UAH: 113241802(PDXP) 113250798(PHOSPHO2)
ORO: 101368120(PHOSPHO2) 101382844(PDXP)
MPUF: 101671978(PHOSPHO2) 101678418(PDXP)
EJU: 114218383(PDXP) 114224357(PHOSPHO2)
MLX: 117998704(PDXP) 118012349(PHOSPHO2)
FCA: 101087253(PHOSPHO2) 101093872(PDXP) 101093877
PYU: 121030672(PHOSPHO2)
PBG: 122472724 122481433(PHOSPHO2)
PTG: 102959923(PDXP) 102967832(PHOSPHO2)
PPAD: 109265541(PDXP)
AJU: 106981047(PDXP) 106987668(PHOSPHO2)
HHV: 120241133 120242852(PHOSPHO2)
BTA: 506308(PDXP) 507308(PHOSPHO2)
BOM: 102272704(PHOSPHO2) 102286951(PDXP)
BIU: 109558621(PDXP) 109566749(PHOSPHO2)
BBUB: 102389454(PHOSPHO2) 102391389(PDXP)
CHX: 102170186(PHOSPHO2) 102180199(PDXP)
OAS: 101119113(PHOSPHO2) 101123544(PDXP)
ODA: 120854902(PHOSPHO2) 120857669
CCAD: 122423382 122453885(PHOSPHO2)
SSC: 100152929(PHOSPHO2) 100623846(PDXP)
CFR: 102504844(PHOSPHO2)
CBAI: 105073144(PDXP) 105081990(PHOSPHO2)
CDK: 105091073(PHOSPHO2) 116156496(PDXP)
BACU: 103003329(PDXP) 103007775(PHOSPHO2)
LVE: 103073497(PDXP) 103080288(PHOSPHO2)
OOR: 101272288(PDXP) 101285843(PHOSPHO2)
DLE: 111172842(PHOSPHO2)
PCAD: 102985156(PHOSPHO2) 112065875 112065907
PSIU: 116756984(PHOSPHO2)
ECB: 100052701(PHOSPHO2) 100630816(PDXP)
EPZ: 103541255 103554217(PHOSPHO2)
EAI: 106843587(PHOSPHO2) 123289788
MYB: 102251338 102251449(PHOSPHO2) 102252377(PDXP)
MYD: 102752571(PHOSPHO2) 102773967(PDXP)
MMYO: 118650382 118661668(PHOSPHO2)
MLF: 102422828(PDXP) 102436199(PHOSPHO2)
MNA: 107528593(PHOSPHO2) 107545076(PDXP)
PKL: 118709997(PHOSPHO2) 118728741 118728786
HAI: 109390417(PHOSPHO2) 109394527(PDXP)
DRO: 112322013(PDXP) 112322248(PHOSPHO2)
SHON: 118985728(PHOSPHO2) 119002374
AJM: 119045837(PHOSPHO2) 119060532
PDIC: 114495420(PHOSPHO2) 114513310
MMF: 118624131 118625159(PHOSPHO2)
RFQ: 117026361(PHOSPHO2) 117029236(PDXP)
PALE: 102877859(PHOSPHO2) 102883992(PDXP)
PGIG: 120596926(PHOSPHO2)
RAY: 107519284(PDXP) 107521050(PHOSPHO2)
MJV: 108392676(PDXP) 108409447(PHOSPHO2)
TOD: 119247284 119255912(PHOSPHO2)
LAV: 100668141(PHOSPHO2)
MDO: 100024396(PHOSPHO2) 100025700(PDXP)
GAS: 123239264(PHOSPHO2) 123248994
SHR: 100924589(PDXP) 116419009(PHOSPHO2)
PCW: 110205758(PDXP) 110211551(PHOSPHO2)
OAA: 100091800
GGA: 424160(PHOSPHO2) 771207(PDXP)
PCOC: 116232881(PHOSPHO2) 116233319(PDXP)
MGP: 100539695(PDXP) 100542382(PHOSPHO2)
CJO: 107313943(PDXP) 107316687(PHOSPHO2)
NMEL: 110393065(PDXP) 110400143(PHOSPHO2)
APLA: 101794607(PHOSPHO2) 101799043 113843327
ACYG: 106029977(PHOSPHO2) 106035787(PDXP)
TGU: 100219816(PHOSPHO2) 101234251(PDXP)
LSR: 110472775(PHOSPHO2) 110483791(PDXP)
SCAN: 103813599(PDXP) 103814419(PHOSPHO2)
PMOA: 120500062(PHOSPHO2) 120509966
OTC: 121335535(PHOSPHO2) 121342432
PRUF: 121356428(PHOSPHO2) 121361203
GFR: 102033327(PDXP) 102044333(PHOSPHO2)
FAB: 101809714(PDXP) 101815279(PHOSPHO2)
PHI: 102108764(PDXP) 102113616(PHOSPHO2)
PMAJ: 107204187(PDXP) 107207480(PHOSPHO2)
CCAE: 111932106(PHOSPHO2) 111935173(PDXP)
CCW: 104693891(PHOSPHO2) 104696513
ETL: 114055402(PDXP) 114073767(PHOSPHO2)
FPG: 106112195(PDXP)
FCH: 106631635(PDXP) 114014216(PHOSPHO2)
CLV: 102095123(PHOSPHO2) 102098989(PDXP)
EGZ: 104128044(PHOSPHO2)
NNI: 104009988(PHOSPHO2)
ACUN: 113481988(PHOSPHO2) 113487950(PDXP)
PADL: 103918164(PHOSPHO2)
AAM: 106488247(PDXP) 106499198(PHOSPHO2)
AROW: 112963916(PHOSPHO2) 112969321(PDXP)
NPD: 112947779(PDXP) 112953892(PHOSPHO2)
DNE: 112979420(PHOSPHO2) 112990705(PDXP)
ASN: 102376120(PDXP) 102382568(PHOSPHO2)
AMJ: 102566322(PDXP) 102570726(PHOSPHO2)
CPOO: 109316647(PDXP) 109323043(PHOSPHO2)
GGN: 109296399(PDXP) 109301543(PHOSPHO2)
PSS: 102450474(PDXP) 102450695(PHOSPHO2)
CMY: 102933406(PHOSPHO2)
CPIC: 101950761(PHOSPHO2)
TST: 117885083(PHOSPHO2)
CABI: 116819387(PHOSPHO2)
MRV: 120374887(PHOSPHO2)
ACS: 100559885(phospho2) 100562224(pdxp)
PVT: 110075983(PDXP) 110076907(PHOSPHO2)
SUND: 121918890(PHOSPHO2)
PBI: 103059635(PHOSPHO2)
PMUR: 107290303(PHOSPHO2)
TSR: 106544265(PHOSPHO2)
PGUT: 117671225(PHOSPHO2)
VKO: 123016902(PHOSPHO2)
PMUA: 114607202(PHOSPHO2)
ZVI: 118094947(PHOSPHO2)
GJA: 107105933(PDXP) 107119693(PHOSPHO2)
XLA: 779316(phospho2.L)
XTR: 493318(phospho2)
NPR: 108785496(PHOSPHO2)
DRE: 561030(pdxp) 799638(phospho2)
IPU: 108271665(phospho2) 108277379(pdxp)
PHYP: 113544919(pdxp) 113545925(phospho2)
AMEX: 103024835(phospho2) 103032875(pdxp)
EEE: 113570300(phospho2) 113583766(pdxp)
LCO: 104919874(phospho2) 104920831(pdxp)
NCC: 104961275(phospho2) 104964351(pdxp)
CGOB: 115006336(phospho2) 115013332(pdxp)
ELY: 117252978(pdxp) 117269183(phospho2)
PLEP: 121941538(phospho2) 121944081 121964825
SLUC: 116043793(phospho2) 116054093
ECRA: 117943892(phospho2) 117945355(pdxp)
PFLV: 114555153(pdxp) 114556762
GAT: 120830962 120835589(phospho2)
PPUG: 119194631(phospho2) 119225407
MSAM: 119890215(phospho2) 119891643
CUD: 121510334 121514890(phospho2)
MZE: 101464860(pdxp) 101485115
ONL: 100704477 100705958(pdxp)
OAU: 116328392 116333269(phospho2)
OLA: 101158449(pdxp) 101174256
OML: 112148098 112161176(phospho2)
XMA: 102219566 102225249(pdxp)
XHE: 116719250 116730438(pdxp)
PRET: 103462227 103470083(pdxp)
GAF: 122827343 122844202(phospho2)
CVG: 107092655(pdxp) 107096031(phospho2)
CTUL: 119785621(phospho2) 119798584
NFU: 107381999(phospho2) 107394160(pdxp)
KMR: 108233719 108241596(phospho2)
ALIM: 106513663(pdxp) 106534911(phospho2)
AOCE: 111564709(pdxp) 111567203(phospho2)
CSEM: 103378978(phospho2) 103396959 103397631
POV: 109624747(phospho2) 109637080(pdxp)
SSEN: 122769304 122771915(phospho2)
HHIP: 117753660(phospho2) 117768522(pdxp)
LCF: 108882065(pdxp) 108897643(phospho2)
SDU: 111219985 111237762(pdxp)
SLAL: 111651685(pdxp) 111672261
XGL: 120796303(phospho2) 120805608
HCQ: 109513960(phospho2) 109526995(pdxp)
BPEC: 110155147(phospho2) 110172127(pdxp)
MALB: 109956628 109969926(phospho2)
OTW: 112219704(pdxp) 112242041(phospho2) 112262792
SALP: 111957714 111961217 112078560(phospho2)
SFM: 108920705(phospho2) 108938493
PKI: 111839313(pdxp) 111841018(phospho2)
AANG: 118206758 118212595(pdxp) 118222899(phospho2)
LOC: 102690458 102692700(phospho2)
LCM: 102350970(PHOSPHO2) 102351909(PDXP)
CMK: 103176439(phospho2)
RTP: 109917160(phospho2)
BBEL: 109474649
CIN: 113475804
SCLV: 120347486
APLC: 110983821
SKO: 100374642
DME: Dmel_CG12237(CG12237) Dmel_CG14212(CG14212)
DSI: Dsimw501_GD17453(Dsim_GD17453) Dsimw501_GD24455(Dsim_GD24455)
DAN: 6503123
DVI: 6634543
MDE: 101891971
SCAC: 106082087
LCQ: 111688580
ACOZ: 120952379
AARA: 120897625
AAG: 5575050
AME: 725365
ACER: 107999726
BIM: 100740933
BBIF: 117216196
BVK: 117241976
BVAN: 117163956
BTER: 105666736
BPYO: 122568501
CCAL: 108631509
OBB: 114878402
NMEA: 116430312
CGIG: 122399414
SOC: 105192970
MPHA: 105836592
AEC: 105149951
ACEP: 105621298
PBAR: 105423117
VEM: 105562624
HST: 105186458
DQU: 106745743
CFO: 105248101
FEX: 115245041
LHU: 105679863
PGC: 109853991
OBO: 105283699
PCF: 106787060
PFUC: 122523173
VPS: 122636262
MDL: 103569628
CGLO: 123260432
FAS: 105269716
DAM: 107035766
CCIN: 107266386
TCA: 100141932
DPA: 109534241
ATD: 109605635
AGB: 108913965
LDC: 111517741
NVL: 108561852
APLN: 108738121
OTU: 111428071
BMOR: 101745817
BMAN: 114244171
MSEX: 115450992
BANY: 112045680
PMAC: 106710189
PPOT: 106107670
PXU: 106115906
PRAP: 110993710
ZCE: 119839032
HAW: 110380867
TNL: 113505595
DNX: 107163701
AGS: 114125555
RMD: 113550143
BTAB: 109034019
CLEC: 106670835
NLU: 111063136
FOC: 113205522
CSEC: 111873564
DMK: 116931343
PVM: 113815557
PJA: 122243477
HAME: 121872867
EAF: 111706404
DSV: 119442323
RMP: 119159588
VDE: 111245942
VJA: 111260027
CSCU: 111613261
PTEP: 107448827
SDM: 118187260
PCAN: 112564507
BGT: 106060471
GAE: 121380536
MYI: 110442689
PMAX: 117344053
OBI: 106883989
OSN: 115215931
NVE: 5521298
EPA: 110254575
ATEN: 116288588
ADF: 107355999
AMIL: 114958750
PDAM: 113676502
SPIS: 111330826
DGT: 114524566
AQU: 105312510
ATH: AT1G17710(PEPC1) AT1G73010(PS2) AT4G29530
LJA: Lj0g3v0125959.1(Lj0g3v0125959.1) Lj0g3v0193989.1(Lj0g3v0193989.1) Lj0g3v0319789.1(Lj0g3v0319789.1) Lj3g3v0301740.1(Lj3g3v0301740.1) Lj3g3v0302750.1(Lj3g3v0302750.1) Lj3g3v2693540.1(Lj3g3v2693540.1) Lj3g3v2693540.2(Lj3g3v2693540.2)
SLY: 101246036 101259946(psi14C) 543790(psi14B) 544179(psi14A)
DOSA: Os01t0600500-01(Os01g0600500) Os02t0226200-01(Os02g0226200)
PPP: 112295379
CNE: CNI03770
CNB: CNBH3600
TASA: A1Q1_02576
ABP: AGABI1DRAFT112429(AGABI1DRAFT_112429)
ABV: AGABI2DRAFT192397(AGABI2DRAFT_192397)
MGL: MGL_1592
MRT: MRET_0683
SMIN: v1.2.000195.t1(symbB.v1.2.000195.t1)
SPAR: SPRG_03461
 » show all
Reference
1  [PMID:1322411]
  Authors
Fonda ML.
  Title
Purification and characterization of vitamin B6-phosphate phosphatase from human erythrocytes.
  Journal
J Biol Chem 267:15978-83 (1992)
Reference
2  [PMID:7625842]
  Authors
Fonda ML, Zhang YN.
  Title
Kinetic mechanism and divalent metal activation of human erythrocyte pyridoxal phosphatase.
  Journal
Arch Biochem Biophys 320:345-52 (1995)
DOI:10.1016/0003-9861(95)90018-7
Reference
3  [PMID:14522954]
  Authors
Jang YM, Kim DW, Kang TC, Won MH, Baek NI, Moon BJ, Choi SY, Kwon OS.
  Title
Human pyridoxal phosphatase. Molecular cloning, functional expression, and tissue distribution.
  Journal
J Biol Chem 278:50040-6 (2003)
DOI:10.1074/jbc.M309619200
  Sequence
[hsa:57026] [mmu:57028]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.74
IUBMB Enzyme Nomenclature: 3.1.3.74
ExPASy - ENZYME nomenclature database: 3.1.3.74
BRENDA, the Enzyme Database: 3.1.3.74
CAS: 9076-92-0

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