| Entry |
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| Name |
diacylglycerol diphosphate phosphatase;
DGPP phosphatase;
DGPP phosphohydrolase;
DPP1;
DPPL1;
DPPL2;
PAP2;
pyrophosphate phosphatase
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| Class |
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
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| Sysname |
1,2-diacyl-sn-glycerol 3-phosphate phosphohydrolase
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| Reaction(IUBMB) |
1,2-diacyl-sn-glycerol 3-diphosphate + H2O = 1,2-diacyl-sn-glycerol 3-phosphate + phosphate [RN: R09644]
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| Reaction(KEGG) |
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| Substrate |
1,2-diacyl-sn-glycerol 3-diphosphate [CPD: C19776];
H2O [CPD: C00001]
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| Product |
1,2-diacyl-sn-glycerol 3-phosphate [CPD: C00416];
phosphate [CPD: C00009]
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| Comment |
The bifunctional enzyme catalyses the dephosphorylation of diacylglycerol diphosphate to phosphatidate and the subsequent dephosphorylation of phosphatidate to diacylglycerol (cf. phosphatidate phosphatase (EC 3.1.3.4)). It regulates intracellular levels of diacylglycerol diphosphate and phosphatidate, phospholipid molecules believed to play a signalling role in stress response [6]. The phosphatase activity of the bifunctional enzyme is Mg2+-independent and N-ethylmaleimide-insensitive and is distinct from the Mg2+-dependent and N-ethylmaleimide-sensitive enzyme EC 3.1.3.4 (phosphatidate phosphatase) [5].The diacylglycerol pyrophosphate phosphatase activity in Saccharomyces cerevisiae is induced by zinc depletion, by inositol supplementation, and when cells enter the stationary phase [4].
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| History |
EC 3.1.3.81 created 2010
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| Pathway |
| ec00564 | Glycerophospholipid metabolism |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K01096 | phosphatidylglycerophosphatase B |
| K18693 | diacylglycerol diphosphate phosphatase / phosphatidate phosphatase |
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| Genes |
» show all
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| Reference |
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| Authors |
Dillon DA, Wu WI, Riedel B, Wissing JB, Dowhan W, Carman GM |
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| Title |
The Escherichia coli pgpB gene encodes for a diacylglycerol pyrophosphate phosphatase activity. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Dillon DA, Chen X, Zeimetz GM, Wu WI, Waggoner DW, Dewald J, Brindley DN, Carman GM |
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| Title |
Mammalian Mg2+-independent phosphatidate phosphatase (PAP2) displays diacylglycerol pyrophosphate phosphatase activity. |
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| Journal |
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| Reference |
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| Authors |
Wu WI, Liu Y, Riedel B, Wissing JB, Fischl AS, Carman GM |
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| Title |
Purification and characterization of diacylglycerol pyrophosphate phosphatase from Saccharomyces cerevisiae. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Oshiro J, Han GS, Carman GM |
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| Title |
Diacylglycerol pyrophosphate phosphatase in Saccharomyces cerevisiae. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Carman GM |
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| Title |
Phosphatidate phosphatases and diacylglycerol pyrophosphate phosphatases in Saccharomyces cerevisiae and Escherichia coli. |
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| Journal |
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| Reference |
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| Authors |
Han GS, Johnston CN, Chen X, Athenstaedt K, Daum G, Carman GM |
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| Title |
Regulation of the Saccharomyces cerevisiae DPP1-encoded diacylglycerol pyrophosphate phosphatase by zinc. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.1.3.81 |
| ExPASy - ENZYME nomenclature database: | 3.1.3.81 |
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