| Entry |
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| Name |
glucosyl-3-phosphoglycerate phosphatase;
GpgP protein
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| Class |
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
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| Sysname |
alpha-D-glucosyl-3-phospho-D-glycerate phosphohydrolase
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| Reaction(IUBMB) |
2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate + H2O = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + phosphate [RN: R09664]
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| Reaction(KEGG) |
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| Substrate |
2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate [CPD: C19791];
H2O [CPD: C00001]
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| Product |
2-O-(alpha-D-glucopyranosyl)-D-glycerate [CPD: C19792];
phosphate [CPD: C00009]
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| Comment |
The enzyme is involved in biosynthesis of 2-O-(alpha-D-glucopyranosyl)-D-glycerate via the two-step pathway in which EC 2.4.1.266 (glucosyl-3-phosphoglycerate synthase) catalyses the conversion of GDP-glucose and 3-phospho-D-glycerate into 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate, which is then converted to 2-O-(alpha-D-glucopyranosyl)-D-glycerate by glucosyl-3-phosphoglycerate phosphatase. In vivo the enzyme catalyses the dephosphorylation of 2-O-(alpha-D-mannopyranosyl)-3-phospho-D-glycerate with lower efficiency [1,2]. Divalent metal ions (Mg2+, Mn2+ or Co2+) stimulate activity [1,2].
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| History |
EC 3.1.3.85 created 2011
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| Orthology |
| K22306 | glucosyl-3-phosphoglycerate phosphatase |
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| Genes |
» show all
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| Reference |
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| Authors |
Costa J, Empadinhas N, da Costa MS |
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| Title |
Glucosylglycerate biosynthesis in the deepest lineage of the Bacteria: characterization of the thermophilic proteins GpgS and GpgP from Persephonella marina. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Costa J, Empadinhas N, Goncalves L, Lamosa P, Santos H, da Costa MS |
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| Title |
Characterization of the biosynthetic pathway of glucosylglycerate in the archaeon Methanococcoides burtonii. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Mendes V, Maranha A, Alarico S, da Costa MS, Empadinhas N |
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| Title |
Mycobacterium tuberculosis Rv2419c, the missing glucosyl-3-phosphoglycerate phosphatase for the second step in methylglucose lipopolysaccharide biosynthesis. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.1.3.85 |
| ExPASy - ENZYME nomenclature database: | 3.1.3.85 |
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