Entry
Name
glucosyl-3-phosphoglycerate phosphatase;
GpgP protein
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
alpha-D-glucosyl-3-phospho-D-glycerate phosphohydrolase
Reaction(IUBMB)
2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate + H2O = 2-O-(alpha-D-glucopyranosyl)-D-glycerate + phosphate [RN:
R09664 ]
Reaction(KEGG)
Substrate
2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate [CPD:
C19791 ];
H2O [CPD:
C00001 ]
Product
2-O-(alpha-D-glucopyranosyl)-D-glycerate [CPD:
C19792 ];
phosphate [CPD:
C00009 ]
Comment
The enzyme is involved in biosynthesis of 2-O-(alpha-D-glucopyranosyl)-D-glycerate via the two-step pathway in which EC
2.4.1.266 (glucosyl-3-phosphoglycerate synthase) catalyses the conversion of GDP-glucose and 3-phospho-D-glycerate into 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate, which is then converted to 2-O-(alpha-D-glucopyranosyl)-D-glycerate by glucosyl-3-phosphoglycerate phosphatase. In vivo the enzyme catalyses the dephosphorylation of 2-O-(alpha-D-mannopyranosyl)-3-phospho-D-glycerate with lower efficiency [1,2]. Divalent metal ions (Mg2+, Mn2+ or Co2+) stimulate activity [1,2].
History
EC 3.1.3.85 created 2011
Orthology
K22306 glucosyl-3-phosphoglycerate phosphatase
Genes
AMIH : CO731_01615(gpgP_1)
EAH : FA04_10365 FA04_25540
MAQU : Maq22A_1p33125(gpmB)
LCK : HN018_01050 HN018_12320
PCAT : Pcatena_08080(gpmA_2)
MBO : BQ2027_MB2442C(gpgp)
MAVM : MAA44156_02560(gpgP_1)
MMAL : CKJ54_07770 CKJ54_24410
MMAE : MMARE11_36540(gpm_1)
MGOR : H0P51_15825 H0P51_18950
MBAI : MB901379_03329(gpgP)
MHEK : JMUB5695_01942(gpgP)
MMAM : K3U93_00665 K3U93_16050
MKY : IWGMT90018_20570(gpgP)
MPHL : MPHLCCUG_03565(gpgP)
MCHT : MCHIJ_15520 MCHIJ_31230
MKR : MKOR_03440 MKOR_16880
MSAL : DSM43276_01485(gpgP)
MTER : 4434518_01385(gpm_1)
CDIP : ERS451417_01789(gpmB)
CUN : Cul210932_1752(gpmB2)
CUQ : Cul210931_1650(gpmB2)
CUZ : Cul05146_1736(gpmB2)
CUJ : CUL131002_1674c(gpmB2)
CUS : CulFRC11_1652(gpmB2)
NWL : NWFMUON74_53810(gpgP)
NSPU : IFM12276_48260(gpgP)
GOM : D7316_00080(gpgP) D7316_03695
SAMB : SAM23877_2626(gpgP)
SLE : sle_46590(sle_46590)
SALF : SMD44_02866(gpmB) SMD44_04715
SXT : KPP03845_102744(gpgP)
LXL : KDY119_02318(gpgP) KDY119_03730
BRZ : CFK38_05095 CFK38_09805
BRR : C1N80_05190 C1N80_09810
ALX : LVQ62_01975 LVQ62_14945
HALT : IM660_12160 IM660_12565
DEM : LGT36_002745 LGT36_002750
DCP : RN607_04610 RN607_04615
PRL : BCB70_00790 BCB70_04405
CGRN : 4412665_00751 4412665_01007
PFR : PFREUD_08550(gmpB) PFREUD_11950(pgm2) PFREUD_12180(pgm)
PFRE : RM25_0813 RM25_0972 RM25_0996
PACD : EGX94_00950 EGX94_11585 EGX94_12245
AJI : C0Z10_08195 C0Z10_10235
TLA : TLA_TLA_02754(gpgP_2)
PRV : G7070_00890 G7070_09715
BROO : brsh051_06060 brsh051_24770
AFUV : AADG42_06990 AADG42_13740
NSN : EXE58_14535 EXE58_16805
NAQU : ENKNEFLB_01923(gpgP_2)
NRO : K8W59_10860 K8W59_14060
AEZ : C3E78_05680 C3E78_16280
AEB : C6I20_00365 C6I20_04320
AWS : ACN3XK_17760 ACN3XK_18385
SPIQ : OHA34_12865 OHA34_13125
NOW : GBF35_16540 GBF35_24865 GBF35_38990
NFS : OIE67_05720 OIE67_50520
PSEQ : AD006_13590 AD006_21125
PECQ : AD017_00705 AD017_21425
PHH : AFB00_02835 AFB00_16690
LED : BBK82_04355 BBK82_30660
ATL : Athai_12770 Athai_59600
ASER : Asera_15430 Asera_60930
CATI : CS0771_00640(gpm_1)
BAQK : QN215_00150 QN215_06175
BFK : QN062_00610 QN062_05955
» show all
Taxonomy
Reference
Authors
Costa J, Empadinhas N, da Costa MS
Title
Glucosylglycerate biosynthesis in the deepest lineage of the Bacteria: characterization of the thermophilic proteins GpgS and GpgP from Persephonella marina.
Journal
Sequence
Reference
Authors
Costa J, Empadinhas N, Goncalves L, Lamosa P, Santos H, da Costa MS
Title
Characterization of the biosynthetic pathway of glucosylglycerate in the archaeon Methanococcoides burtonii.
Journal
Sequence
Reference
Authors
Mendes V, Maranha A, Alarico S, da Costa MS, Empadinhas N
Title
Mycobacterium tuberculosis Rv2419c, the missing glucosyl-3-phosphoglycerate phosphatase for the second step in methylglucose lipopolysaccharide biosynthesis.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.85
ExPASy - ENZYME nomenclature database: 3.1.3.85