Entry
Name
2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase;
HK-MTPenyl-1-P phosphatase;
MtnX;
YkrX;
2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate phosphohydrolase;
2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate phosphohydrolase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-en-1-yl phosphate phosphohydrolase
Reaction(IUBMB)
2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-en-1-yl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate [RN:
R07394 ]
Reaction(KEGG)
Substrate
2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-en-1-yl phosphate;
H2O [CPD:
C00001 ]
Product
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one [CPD:
C15606 ];
phosphate [CPD:
C00009 ]
Comment
The enzyme participates in the methionine salvage pathway in Bacillus subtilis [2]. In some species a single bifunctional enzyme, EC
3.1.3.77 , acireductone synthase, catalyses both this reaction and EC
5.3.2.5 , 2,3-diketo-5-methylthiopentyl-1-phosphate enolase [1].
History
EC 3.1.3.87 created 2012
Pathway
ec00270 Cysteine and methionine metabolism
Orthology
K08966 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase
Genes
LCJ : NCTC11976_02520(mtnX)
RAD : CO657_23490 CO657_30995
BLI : BL00251 BL03541(mtnB)
BLD : BLi01516(mtnB_mtnX) BLi04260
BLH : BaLi_c15950(mtnX) BaLi_c42510
BAZ : BAMTA208_10335(mtnX)
BAE : BATR1942_04555(mtnX)
BSON : S101395_03399 S101395_04974
BTHR : YBT1520_21495(mtnX)
BTHU : YBT1518_22365(mtnX)
BACQ : DOE78_07030 DOE78_12950
BMQ : BMQ_1251(mtnX) BMQ_2498
BMD : BMD_1235(mtnX) BMD_2485
BMH : BMWSH_2710(ykrX) BMWSH_3985(mtnX)
BMEG : BG04_3550(mtnX) BG04_4945
BFX : BC359_11525 BC359_14800
BON : A361_08450(mtnX) A361_12740
CFIR : NAF01_07955 NAF01_11405
PARG : PspKH34_28390(mtnX)
AGN : AFK25_04405(mtnX) AFK25_06620
NTM : BTDUT50_06100 BTDUT50_08255
BVQ : FHE72_08650 FHE72_12410
PCHI : PC41400_12050 PC41400_25915
COHN : KCTCHS21_26510(mtnX)
SURE : SporoP32a_07275(mtnX)
ETM : CE91St48_00450(mtnX)
NTH : Nther_2774 Nther_2826
HABY : HLVA_14910 HLVA_18480
» show all
Taxonomy
Reference
Authors
Myers RW, Wray JW, Fish S, Abeles RH.
Title
Purification and characterization of an enzyme involved in oxidative carbon-carbon bond cleavage reactions in the methionine salvage pathway of Klebsiella pneumoniae.
Journal
J Biol Chem 268:24785-91 (1993)
Reference
Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.87
ExPASy - ENZYME nomenclature database: 3.1.3.87