KEGG   ENZYME: 3.1.3.99Help
Entry
EC 3.1.3.99                 Enzyme                                 

Name
IMP-specific 5'-nucleotidase;
ISN1 (gene name)
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
inosine 5'-phosphate phosphohydrolase
Reaction(IUBMB)
IMP + H2O = inosine + phosphate [RN:R01126]
Reaction(KEGG)
Substrate
IMP [CPD:C00130];
H2O [CPD:C00001]
Product
inosine [CPD:C00294];
phosphate [CPD:C00009]
Comment
The enzyme, isolated from the yeast Saccharomyces cerevisiae, is highly specific for inosine 5'-phosphate, and has no detectable activity with other purine and pyrimidine nucleotides. Requires divalent metals, such as Mg2+, Co2+ or Mn2+.
History
EC 3.1.3.99 created 2016
Pathway
ec00230  Purine metabolism
ec01100  Metabolic pathways
Orthology
K18550  IMP and pyridine-specific 5'-nucleotidase
Genes
QSU: 111990697 112019689
SMO: SELMODRAFT_103387 SELMODRAFT_413967 SELMODRAFT_415743 SELMODRAFT_99737
PPP: 112282666 112283810 112286598 112287728 112291556 112292774
CRE: CHLREDRAFT_171044
VCN: VOLCADRAFT_105288 VOLCADRAFT_92492
MNG: MNEG_14919 MNEG_6875
OLU: OSTLU_4044
OTA: OT_ostta06g01180
BPG: Bathy05g01210
MIS: MICPUN_107875
APRO: F751_2896
SCE: YOR155C(ISN1)
ERC: Ecym_5451
KMX: KLMA_30643(ISN1)
NCS: NCAS_0H02430(NCAS0H02430)
NDI: NDAI_0C01230(NDAI0C01230)
TPF: TPHA_0J02930(TPHA0J02930)
TBL: TBLA_0D01760(TBLA0D01760)
TDL: TDEL_0A03650(TDEL0A03650)
KAF: KAFR_0C05230(KAFR0C05230)
PIC: PICST_38342(ISN1)
CAL: CAALFM_C101650WA(ISN1)
SLB: AWJ20_2890(ISN1)
NCR: NCU01945
NTE: NEUTE1DRAFT55104(NEUTE1DRAFT_55104)
MGR: MGG_02955
SSCK: SPSK_06243
MAW: MAC_05366
MAJ: MAA_03704
CMT: CCM_06504
MBE: MBM_07528
ANI: AN3222.2
ANG: ANI_1_1120164(An18g01690)
PBL: PAAG_11311(PAAG_01584)
ABE: ARB_05991
TVE: TRV_06351
 » show all
Taxonomy
Reference
1  [PMID:8141771]
  Authors
Itoh R
  Title
Purification and some properties of an IMP-specific 5'-nucleotidase from yeast.
  Journal
Biochem J 298 Pt 3:593-8 (1994)
Reference
2  [PMID:12735798]
  Authors
Itoh R, Saint-Marc C, Chaignepain S, Katahira R, Schmitter JM, Daignan-Fornier B
  Title
The yeast ISN1 (YOR155c) gene encodes a new type of IMP-specific 5'-nucleotidase.
  Journal
BMC Biochem 4:4 (2003)
DOI:10.1186/1471-2091-4-4
  Sequence
[sce:YOR155C]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.99
IUBMB Enzyme Nomenclature: 3.1.3.99
ExPASy - ENZYME nomenclature database: 3.1.3.99
BRENDA, the Enzyme Database: 3.1.3.99
CAS: 9027-73-0

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