KEGG   ENZYME: 3.1.31.1
Entry
EC 3.1.31.1                 Enzyme                                 

Name
micrococcal nuclease;
spleen endonuclease;
thermonuclease;
nuclease T;
micrococcal endonuclease;
nuclease T';
staphylococcal nuclease;
spleen phosphodiesterase;
Staphylococcus aureus nuclease;
Staphylococcus aureus nuclease B;
ribonucleate (deoxynucleate) 3'-nucleotidohydrolase
Class
Hydrolases;
Acting on ester bonds;
Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters
Reaction(IUBMB)
Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products
Comment
Hydrolyses double- or single-stranded substrate.
History
EC 3.1.31.1 created 1961 as EC 3.1.4.7, transferred 1978 to EC 3.1.31.1, modified 1981
Orthology
K01174  micrococcal nuclease
Genes
PIF: PITG_08009
PSOJ: PHYSODRAFT_529487 PHYSODRAFT_565379
SPAR: SPRG_03573 SPRG_04830
EHX: EMIHUDRAFT_230816 EMIHUDRAFT_251835
ECF: ECH74115_B0084
ETW: ECSP_6078
ELX: CDCO157_A0070 CDCO157_B0026(yeaA)
EOI: ECO111_p1-095 ECO111_p3-11
EOH: ECO103_p49
ECOH: ECRM13516_5554 ECRM13516_5589
EOC: CE10_A64
ECZ: ECS88_p0098(yigB)
ECOI: ECOPMV1_p00064(nuc)
ECOJ: P423_25795
SFE: SFxv_5105
SSN: SSON_P200
SBO: SBO_P130
SDY: SDY_P127
CTU: Ctu_2p00050(parB)
KPU: KP1_p054
KPX: PMK1_ndm00294(nucH)
KPNU: LI86_28145
KPE: KPK_A0183
REE: electrica_05643(exoI)
PSTS: E05_51280
YPM: YP_pCRY24
MTHI: C7M52_04149(nuc)
HIN: HI_1296
HIT: NTHI1828
HIP: CGSHiEE_04220(queF)
HIU: HIB_14510
HIA: H733_0922
HIW: NTHI477_00324(nuc)
HIC: NTHIC486_01369(nucH)
HIX: NTHI723_00241(nucH)
HPIT: NCTC13334_01569(yhcR)
HHZ: NCTC10839_01386(nucH)
HAEG: NCTC8502_01714(nucH)
HAP: HAPS_2190
HPAZ: K756_07760
HPAS: JL26_06670
HPAK: JT17_04205
HSO: HS_0966
HSM: HSM_1440
PMU: PM0881
PMP: Pmu_09690
PMUL: DR93_1722
PDAG: 4362423_00584(yncB)
MSU: MS1272
MHQ: D650_9320
MHAT: B824_17270
MHAE: F382_03440
MHAM: J450_02640
MHAO: J451_03745
MHAL: N220_09490
MHAQ: WC39_04675
MHAY: VK67_04675
MVE: X875_6260
APL: APL_1126
APJ: APJL_1145
APA: APP7_1184
ALIG: NCTC10568_01408(nucH)
AAT: D11S_1664
AACN: AANUM_1664
ASEG: NCTC10977_01592(yhcR)
BTO: WQG_8100
BTRE: F542_13950
BTRH: F543_15570
BTRA: F544_8430
AVT: NCTC3438_01390(yncB)
PAET: NCTC13378_00899(nucH)
ABX: ABK1_3793
ABAZ: AGW27727.1
SLO: Shew_0382
SSE: Ssed_0537
SPL: Spea_3775
SHL: Shal_3860
SPSW: Sps_05362
MICC: AUP74_00781(nucH)
MICT: FIU95_05910(nuc)
METL: U737_17690
MMAI: sS8_1485
TCX: Tcr_0124
MEJ: Q7A_3032
MEC: Q7C_1320
CYQ: Q91_1684
NOC: Noc_1218
NHL: Nhal_0762
NWA: Nwat_1102
TEE: Tel_14215
NTT: TAO_0599
TGR: Tgr7_2968
TKM: TK90_2786
HCH: HCH_01990
KKO: Kkor_2506
SLIM: SCL_2749
SVA: SVA_3849
TBN: TBH_C2685
VOK: COSY_0067
NZO: SAMEA4504057_1698(nucH)
ECOR: SAMEA4412678_1803(yncB)
AXX: ERS451415_04340(yhcR)
TEA: KUI_0739
TEG: KUK_0577
TAS: TASI_0946
TAT: KUM_0159
BPSI: IX83_05100
RFR: Rfer_1306
POL: Bpro_0873
HYB: Q5W_16510
HPSE: HPF_04950
HAR: HEAR0469
CFU: CFU_1834
RGE: RGE_37820
NEU: NE2385
NET: Neut_0850
TBD: Tbd_2029
HCP: HCN_1935
SULC: CVO_09055
CJE: Cj0979c
CJU: C8J_0918
CJI: CJSA_0922
CJS: CJS3_1029
CJEJ: N564_00946
CJEU: N565_00993
CJEN: N755_00985
CJEI: N135_01016
CJER: H730_05780
CJY: QZ67_01053(nucH)
CJQ: UC78_0937(nucH)
CJR: CJE1061
CLA: CLA_0563
CCQ: N149_0916
CCF: YSQ_04125
CCY: YSS_05310
CCOI: YSU_04160
CCOF: VC76_04750(nucH)
CCOO: ATE51_01664(nucH)
CIS: CINS_0485
CVO: CVOL_0500
CPEL: CPEL_0518
CCUN: CCUN_0740
CAVI: CAV_0451
COJ: CORN_0584
CBLA: CBLAS_0289
CARM: CARM_0568
SULJ: SJPD1_1195
GLO: Glov_0454
GEO: Geob_2760
GEB: GM18_2224
GBM: Gbem_1985
PCA: Pcar_2433
DEU: DBW_3159
DVU: DVU_1787
DVM: DvMF_0873
DTR: RSDT_0503
DAS: Daes_0648
PPRF: DPRO_2172
LIP: LI0038
LIR: LAW_00037
DPS: DP2647
DOL: Dole_2932
MXA: MXAN_0570
SCL: sce7025
SFU: Sfum_3457
AVI: Avi_8127(yci)
RHT: NT26_3810
KAI: K32_38970
OAH: DR92_3327
BRS: S23_02570
BRAD: BF49_0265
BARH: WN72_01390
NHA: Nham_3090
OCA: OCAR_4333
MPO: Mpop_3053
HDN: Hden_3157
MCG: GL4_3309
HDI: HDIA_0285
PSF: PSE_3066
LABT: FIU93_30750(yokF1) FIU93_31455(yokF2)
SIL: SPO3900
RUT: FIU92_04000(exoI1) FIU92_04015(exoI2)
RDE: RD1_4011
LAQU: R2C4_01485
CID: P73_4562
ROH: FIU89_02050(exoI)
RHC: RGUI_2908
GAK: X907_2832
HBA: Hbal_0769
SWI: Swit_4945
SSY: SLG_26560
BLAS: BSY18_1639
AAY: WYH_02023(yncB_1) WYH_02024(yncB_2)
PORL: BG023_119
RCE: RC1_2345
TXI: TH3_12535
MGM: Mmc1_3427
BBW: BDW_06945
BSU: BSU21610(yokF)
BSR: I33_1967
BSL: A7A1_3318
BSH: BSU6051_17620(yncB) BSU6051_21610(yokF)
BSUT: BSUB_01894(yncB) BSUB_02325(yokF)
BSUL: BSUA_01894(yncB) BSUA_02325(yokF)
BSUS: Q433_10390
BSO: BSNT_08334(yncB)
BSQ: B657_17620(yncB) B657_21610(yokF)
BSX: C663_1818(yncB)
BSS: BSUW23_09040(yncB)
BST: GYO_2117
BAQ: BACAU_1985(nucB3)
BYA: BANAU_1709(yokF)
BAMP: B938_10245
BAML: BAM5036_1910(yokF)
BAMA: RBAU_1946(yokF) RBAU_2164
BAMB: BAPNAU_1563(nuc) BAPNAU_1750(yokF)
BAMT: AJ82_11250
BAMY: V529_21730
BMP: NG74_02073(yokF)
BAO: BAMF_1818(nuc)
BQL: LL3_02390(nuc)
BQY: MUS_1922(yokF)
BMOJ: HC660_19320(nukF)
BAI: BAA_A0216
BANT: A16_60530
BANR: A16R_61550
BANV: DJ46_5623
BCA: BCE_A0141
BCQ: BCQ_PI098
BCX: BCA_A0204
BNC: BCN_P258
BCER: BCK_27193
BJS: MY9_1920
BACP: SB24_18790
BACO: OXB_3577
BACL: BS34A_19500(yncB) BS34A_23830(yokF)
BALM: BsLM_1865
BGY: BGLY_3147
BFD: NCTC4823_01479(yokF)
BMQ: BMQ_2840
BMD: BMD_2874
BMEG: BG04_5380(yncB)
BCK: BCO26_2125(yokF)
BAG: Bcoa_2359
BCOA: BF29_1224(yokF) BF29_2488(yokF) BF29_2564(yokF)
BKW: BkAM31D_16040(yncB)
GKA: GK2918
GTN: GTNG_2868
GEA: GARCT_02948(yokF)
PCAL: BV455_02395(yncB)
ANM: GFC28_493
AAMY: GFC30_1816(yokF)
PSYO: PB01_01345
BLEN: NCTC4824_02894(yokF)
SAU: SA0746 SA1160(nuc)
SAV: SAV0815(nuc) SAV1324(nuc)
SAW: SAHV_0811(nuc) SAHV_1313(nuc)
SAM: MW0769 MW1211(nuc)
SAR: SAR0847(nuc) SAR1334(nucI)
SAC: SACOL0860(nuc) SACOL1357
SAE: NWMN_0760 NWMN_1236(nuc)
SAD: SAAV_0761(nuc) SAAV_1303
SUE: SAOV_0832(nuc) SAOV_1337(nucI)
SUZ: MS7_0843(nuc) MS7_1283(nucH)
SAUS: SA40_0730(nuc) SA40_1203(nucI)
SAUU: SA957_0745(nuc) SA957_1218(nucI)
SAUG: SA268_0744(nuc) SA268_1223(nucI)
SAB: SAB0748(nuc) SAB1182(nucI)
SAUB: C248_0884(nuc) C248_1358(nucI)
SAUC: CA347_1263(nucH) CA347_810(nuc)
SAUI: AZ30_06440
SER: SERP0891
SEP: SE_1004
SEPP: SEB_01029
SEPS: DP17_2330(nucH)
SHA: SH1583(nuc) SH1688
SSP: SSP1444
SCA: SCA_0025(nuc) SCA_0963(nuc)
SLN: SLUG_15760(nucI)
SDT: SPSE_1449(nucA) SPSE_1452(nucB) SPSE_2407(nucC)
SPAS: STP1_2353
SXO: SXYL_01562(nuc)
SCAP: AYP1020_0535(nuc) AYP1020_0632(nucH)
SSCZ: RN70_07580
SARL: SAP2_15210
SSIM: SAMEA4384339_1221(nucH)
SSTE: SAMEA4384403_1447(nucC)
MCAK: MCCS_18890(nuc_1) MCCS_23490(nuc_2)
ESI: Exig_0209
EAN: Eab7_0198
GMO: NCTC11323_00754(yncB)
GHA: NCTC10459_00776(yncB)
PMW: B2K_27260
PSWU: SY83_15545
ASOC: CB4_02102(nucH_1) CB4_02227(nucH_2) CB4_03174(yokF_2)
AAC: Aaci_0018
BTS: Btus_1737
SIV: SSIL_3210
KZO: NCTC404_00263(yncB) NCTC404_01020(yokF)
EFA: EF0511(nuc-1) EF_B0045(nuc-2)
EFL: EF62_pB0046(pcfT) EF62_pC0033(pcfT)
EFQ: DR75_3002(yncB)
CRN: CAR_c07670(yokF)
CARC: NY10_59
CBL: CLK_A0066
CBB: CLD_A0131
CBI: CLJ_0002
CPAT: CLPA_c04520(nucH)
CPAE: CPAST_c04520(nucH)
CSQ: CSCA_0087
CTYK: CTK_C11500
ASF: SFBM_0242
BPB: bpr_II283
BFI: CIY_18770
EAC: EAL2_808p06360(nucH)
FAA: HMPREF0389_00861(nucH)
STH: STH2345
TMR: Tmar_1711
CTHM: CFE_1921
CBAR: PATL70BA_2967(nucH)
CHY: CHY_1644(nucH1) CHY_1698 CHY_1699(nucH2)
ADG: Adeg_1341
PED: ING2D1G_0444(nucH)
PIV: NCTC13079_01583(nucH)
ERH: ERH_1180
LPIL: LIP_2178
MMO: MMOB1270(nuc)
MHY: mhp109
MHJ: MHJ_0262
MHYO: MHL_2802
MHO: MHO_0660
MCD: MCRO_0604
MHR: MHR_0255
MHH: MYM_0330
MHM: SRH_00660
MHS: MOS_286
MHV: Q453_0360
MCAN: MCAN360_0524(snc)
MHYV: MHSN_00080
MNU: NCTC10166_00702(nucH)
MSAI: NCTC10113_01278(yncB)
MGLY: NCTC10194_00563(yhcR)
MCOU: NCTC10179_00681(yokF)
MPU: MYPU_1390(MYPU_1390)
MSY: MS53_0110
MAA: MAG0790
MAL: MAGa0850
MFR: MFE_01650
MFP: MBIO_0232
MBH: MMB_0081
MBI: Mbov_0087(nuc)
MCY: MCYN_0708(MCYN0708)
MFEL: JPM2_2710
MEDW: NCTC10132_00215(nucH)
MGAL: NCTC10186_00274(nucH)
MCIT: NCTC10181_00341(nucH)
MMAU: NCTC10168_00429(nucH)
MMEL: NCTC10153_00434(nucH)
MCOB: NCTC10184_00102(yncB)
ABRA: BN85316580
APAL: BN85414180
MBJ: KQ51_00354(nucH)
MHAS: MHAS_03984(nucH)
MALV: MALV_02030
ASD: AS9A_1464
CGL: Cgl1853(Cgl1853)
CGU: WA5_1779
CGV: CGLAU_07765(nucH)
CSUR: N24_1905
CUO: CUROG_07420(nucH)
RHU: A3Q40_03369(nucH)
GBR: Gbro_4927
GOR: KTR9_5325
MOO: BWL13_00380(nucH)
ARM: ART_3810
AAGI: NCTC2676_1_00186(nucH)
BCV: Bcav_3634
DCO: SAMEA4475696_0605(nucH)
NDK: I601_0037(nucH) I601_1605(nuc)
NAQU: ENKNEFLB_02118(nuc) ENKNEFLB_02994(nucH_1)
MMAR: MODMU_4087
SEN: SACE_3424
SACC: EYD13_17810(nucH)
AMYY: YIM_27085(yokF)
CWO: Cwoe_5232
GPA: GPA_22130
CYB: CYB_0109(nucH) CYB_2295
SYNR: KR49_00655
PMM: PMM1417
PMT: PMT_0297
AMR: AM1_1463
HHG: XM38_028130(nuc)
CYL: AA637_01785(nuc)
ANA: all2918
CALH: IJ00_00690
DOU: BMF77_00441(yncB) BMF77_04370(nucH)
CTHE: Chro_0331
RCA: Rcas_0199
CAU: Caur_0552
ATM: ANT_02750
TTR: Tter_2736
TRA: Trad_2390
PSL: Psta_2998
PIR: VN12_01935(yhcR)
ROL: CA51_49400(nucH)
AHEL: Q31a_17630(nucH)
LCRE: Pla8534_08200(nucH)
AAGG: ETAA8_00820 ETAA8_51460(nucH_3)
RLC: K227x_31210(nucH)
TTF: THTE_3660
AMUC: Pan181_19340(nucH)
PEH: Spb1_22530(nucH)
PLS: VT03_05060(nucH)
PLH: VT85_11270(nuc)
FMR: Fuma_01279(nucH)
MRI: Mal4_20880(nucH)
SDYN: Mal52_50690(nucH)
PLON: Pla110_44560(nucH)
GES: VT84_06390(nucH)
PBOR: BSF38_02094(nuc_1) BSF38_05072(nuc_2)
AGV: OJF2_23960(yokF) OJF2_55430(nucH)
KST: KSMBR1_0031(nucI)
PCOR: KS4_11860(nucH)
ALUS: STSP2_01832(nuc)
BRM: Bmur_1600
BIP: Bint_0324
ABAC: LuPra_01898(nucH)
THYD: TTHT_0615
EMI: Emin_0193
EPO: Epro_0711
LBA: Lebu_1478
TAI: Taci_1722
TLI: Tlie_1879
SBR: SY1_02080
DORI: FH5T_14940
CPI: Cpin_0658
STHA: NCTC11429_00551(nucH)
CHU: CHU_1190
DFE: Dfer_3244
LBY: Lbys_2496
GFO: GFO_2606
MESQ: C7H62_0422
CHZ: CHSO_1309
CGLE: NCTC11432_04551(nuc)
CANT: NCTC13489_01639(nuc_1) NCTC13489_02096(nuc_2)
BPI: BPLAN_500(lpxP)
BMM: MADAR_477(lpxP)
CLI: Clim_1380
PAA: Paes_1456
IAL: IALB_0418
CACI: CLOAM1654
AAE: aq_710(nucI)
HTH: HTH_0636(nuc)
TAL: Thal_1226
TLE: Tlet_1208
TME: Tmel_0612
TAF: THA_666
THER: Y592_03670
PMO: Pmob_1176
DTN: DTL3_0506
KOL: Kole_0136
NDE: NIDE4295
CTHI: THC_1519
ALAM: RT761_00303(yokF_1) RT761_02295(yokF_2)
SRG: XF24_00953(nucH)
MOX: DAMO_1702
MJA: MJ_1439
MMP: MMP1201
MMD: GYY_06835
MMAD: MMJJ_16440(nucH)
MAE: Maeo_0569
MVO: Mvol_0962
METC: MTCT_0425
METE: tca_00458(nuc)
MST: Msp_1089
MRU: mru_1383
MSI: Msm_1495
MMIL: sm9_0662
MEYE: TL18_06955
MOL: YLM1_0886
METH: MBMB1_0301
MFC: BRM9_1971
MCUB: MCBB_0554(nucI)
MKA: MK1164
GAH: GAH_01015
PFU: PF1298
PFI: PFC_05705
PHO: PH1212(PH1212)
PAB: PAB0704
PYN: PNA2_1734
PYS: Py04_0910
TON: TON_1652
TGA: TGAM_0136 TGAM_1824(nuc)
THM: CL1_1046
TEU: TEU_05670
MBU: Mbur_1900
MMET: MCMEM_0129
MPY: Mpsy_2270
MTP: Mthe_0608
HHB: Hhub_2325
HALH: HTSR_1259
HHSR: HSR6_1332
HMA: rrnAC3140(nuc)
HHI: HAH_0406(nuc)
HUT: Huta_1665
HTI: HTIA_1390
HMU: Hmuk_1261
HALL: LC1Hm_0475
HWA: HQ_3375A
HWC: Hqrw_3898
HME: HFX_1541(nuc)
IAG: Igag_0835
PIS: Pisl_1433
PCL: Pcal_2030
NMR: Nmar_1467
NEV: NTE_02636
TAA: NMY3_00683(nuc)
NBV: T478_0082
BARB: AOA66_0341
NEQ: NEQ097
NCON: LC1Nh_0767(nuc)
 » show all
Reference
1  [PMID:13860347]
  Authors
ALEXANDER M, HEPPEL LA, HURWITZ J.
  Title
The purification and properties of micrococcal nuclease.
  Journal
J Biol Chem 236:3014-9 (1961)
Reference
2
  Authors
Anfinsen, C.B., Cuatrecasas, P. and Taniuchi, H.
  Title
Staphylococcal nuclease, chemical properties and catalysis.
  Journal
In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 4, Academic Press, New York, 1971, p. 177-204.
Reference
3
  Authors
Reddi, K.K.
  Title
Micrococcal nuclease.
  Journal
Methods Enzymol 12A:257-262 (1967)
Reference
4  [PMID:5922962]
  Authors
Sulkowski E, Laskowski M Sr.
  Title
Phosphatase-free crystalline micrococcal nuclease.
  Journal
J Biol Chem 241:4386-8 (1966)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.31.1
IUBMB Enzyme Nomenclature: 3.1.31.1
ExPASy - ENZYME nomenclature database: 3.1.31.1
BRENDA, the Enzyme Database: 3.1.31.1
CAS: 9013-53-0

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