KEGG   ENZYME: 3.1.4.12Help
Entry
EC 3.1.4.12                 Enzyme                                 

Name
sphingomyelin phosphodiesterase;
neutral sphingomyelinase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
BRITE hierarchy
Sysname
sphingomyelin cholinephosphohydrolase
Reaction(IUBMB)
a sphingomyelin + H2O = a ceramide + phosphocholine [RN:R02541]
Reaction(KEGG)
Substrate
sphingomyelin [CPD:C00550];
H2O [CPD:C00001]
Product
ceramide [CPD:C00195];
phosphocholine [CPD:C00588]
Comment
Has very little activity on phosphatidylcholine.
History
EC 3.1.4.12 created 1972
Pathway
ec00600  Sphingolipid metabolism
ec01100  Metabolic pathways
Orthology
K01117  sphingomyelin phosphodiesterase
K12350  sphingomyelin phosphodiesterase
K12351  sphingomyelin phosphodiesterase 2
K12352  sphingomyelin phosphodiesterase 3
K12353  sphingomyelin phosphodiesterase 4
K12354  ectonucleotide pyrophosphatase/phosphodiesterase family member 7
Genes
HSA: 339221(ENPP7) 55512(SMPD3) 55627(SMPD4) 6609(SMPD1) 6610(SMPD2)
PTR: 450990(SMPD1) 459619 462928(SMPD2) 468008(SMPD3) 742055(ENPP7)
PPS: 100970699(SMPD2) 100971770 100972160(ENPP7) 100983093 100985758(SMPD3) 100992548 100994517(SMPD1)
GGO: 101128835(SMPD2) 101134642(SMPD4) 101145060(ENPP7) 101145253(SMPD1) 101148384 109025114(SMPD3)
PON: 100172518(SMPD1) 100174043(SMPD4) 100435456(SMPD3) 100455395(SMPD2) 100455485(ENPP7)
NLE: 100592756(SMPD4) 100593753(SMPD3) 100596565(SMPD1) 100599106 100604067(ENPP7) 100604925(SMPD2)
MCC: 698865(SMPD2) 703384(SMPD3) 711248(SMPD1) 717416(ENPP7) 718018(SMPD4)
MCF: 102135618(ENPP7) 102136513(SMPD1) 102138241(SMPD3) 102138369(SMPD2)
CSAB: 103216845(SMPD4) 103223603 103233234(SMPD3) 103240596(SMPD2) 103241532(SMPD1) 103243678(ENPP7)
RRO: 104655593(SMPD3) 104666481 104668826(SMPD2) 104670501(ENPP7) 104676288 104678292(SMPD1)
CJC: 100393530(SMPD4) 100394711(SMPD2) 100396745(SMPD3) 100400920(SMPD1) 100407918(ENPP7) 100895523
SBQ: 101027471(SMPD1) 101027879(ENPP7) 101038473(SMPD3) 101043250(SMPD2)
MMU: 20597(Smpd1) 20598(Smpd2) 238011(Enpp7) 58994(Smpd3) 77626(Smpd4)
RNO: 303729(Enpp7) 303790(Smpd4) 308909(Smpd1) 83537(Smpd2) 94338(Smpd3)
CGE: 100753418(Smpd4) 100755276(Smpd3) 100755684(Enpp7) 100760557(Smpd1) 100761434 100771550(Smpd2)
NGI: 103734906(Smpd3) 103737560(Smpd1) 103741471(Smpd4) 103747306(Enpp7) 103749556(Smpd2)
HGL: 101699020(Smpd4) 101699079(Smpd1) 101702568(Smpd2) 101722154(Smpd3) 101723307(Enpp7)
CCAN: 109684364(Smpd4) 109684678(Enpp7) 109694753(Smpd2) 109695569(Smpd1) 109697461(Smpd3)
OCU: 100348153(SMPD2) 100349475(ENPP7) 100350219(SMPD4) 100353898(SMPD1) 100355781(SMPD3)
TUP: 102468976(SMPD1) 102477662(ENPP7) 102486081(SMPD3) 102486082(SMPD2) 102491151(SMPD4) 102498536
CFA: 100855615 100856377(SMPD2) 485334(SMPD1) 486434(SMPD4) 489743(SMPD3) 608627(ENPP7)
AML: 100465162(SMPD4) 100474730(EEF2KMT) 100475585(SMPD1) 100476323(SMPD3) 100479011(SMPD2) 105235295
UMR: 103665973(ENPP7) 103668821 103669298(SMPD4) 103673629(SMPD3) 103677025(SMPD2) 103681411(SMPD1)
ORO: 101365096(SMPD4) 101365413 101369230(ENPP7) 101376764(SMPD3) 101379830(SMPD2) 101383347(SMPD1)
FCA: 101082570(SMPD2) 101085334(ENPP7) 101091244 101094390(SMPD3) 101099497(SMPD1) 105260241(SMPD4)
PTG: 102954580(ENPP7) 102962512(SMPD2) 102964338(SMPD1) 102964655(SMPD4) 102969137 102972684(SMPD3)
AJU: 106968889(SMPD2) 106972377(SMPD3) 106978753 106981163(SMPD1) 106981884(ENPP7) 106983611(SMPD4)
BTA: 505097(SMPD1) 505388(ENPP7) 507207(SMPD4) 509018(SMPD2) 514201(SMPD3) 521021
BOM: 102272896(SMPD2) 102274618 102274996(ENPP7) 102279104(SMPD4) 102284273(SMPD1) 102285822(SMPD3)
BIU: 109563837(SMPD2) 109569729(SMPD1) 109571182(SMPD4) 109572088(SMPD3) 109573342(ENPP7) 109578085
PHD: 102324093(SMPD3) 102330317(SMPD4) 102333165(ENPP7) 102337691(SMPD1) 102339127 102342685(SMPD2)
CHX: 102169323(SMPD3) 102169580(SMPD4) 102170015 102179963(SMPD1) 102186017(SMPD2) 102186630(ENPP7)
OAS: 100307047(SMPD1) 101105047 101107873(SMPD2) 101111726(ENPP7) 101119496(SMPD3) 101119587(SMPD4)
SSC: 100152155(SMPD2) 100152725(SMPD4) 100514726(ENPP7) 100518128(SMPD3) 100518980(SMPD1)
CFR: 102504439 102509587(SMPD1) 102519299(SMPD3) 102519400(ENPP7) 102519891(SMPD2) 102520572(SMPD4)
CDK: 105088412(SMPD3) 105095230(SMPD4) 105097111(SMPD2) 105097918(SMPD1) 105098455 105106258(ENPP7)
BACU: 102997214(SMPD3) 102998207(SMPD1) 103000888(SMPD2) 103015051(ENPP7) 103016787(SMPD4)
LVE: 103074234(SMPD4) 103075134(SMPD3) 103079318(SMPD1) 103079614(ENPP7) 103087233(SMPD2)
OOR: 101271703(SMPD1) 101285754(SMPD2) 101287560(SMPD3) 101289574(ENPP7) 101289575(SMPD4)
ECB: 100052086(SMPD4) 100057000(ENPP7) 100066652(SMPD2) 100066707(SMPD3) 100069949(SMPD1)
EPZ: 103542177(SMPD4) 103549714(SMPD3) 103551349(SMPD2) 103553547(SMPD1) 103567436(ENPP7)
EAI: 106822111(SMPD4) 106822434(SMPD3) 106829757(SMPD2) 106838188(SMPD1) 106845445(ENPP7)
MYB: 102240352(SMPD3) 102245332 102250208(ENPP7) 102251335(SMPD4) 102252179(SMPD2) 102255688(SMPD1)
MYD: 102752816 102759036(SMPD4) 102759843(SMPD2) 102764850(SMPD3) 102768084(SMPD1) 102769553(ENPP7)
HAI: 109376231(SMPD4) 109376525(SMPD1) 109383646(ENPP7) 109389457(SMPD3) 109391424(SMPD2) 109392110
RSS: 109433694(SMPD4) 109449081(SMPD2) 109449344(ENPP7) 109460465(SMPD1) 109460730 109460791(SMPD3)
PALE: 102884990(SMPD3) 102889583(SMPD1) 102891823(SMPD2) 102895085(ENPP7) 102895575(SMPD4)
LAV: 100660329(SMPD4) 100660894(ENPP7) 100665649(SMPD2) 100666566(SMPD3) 100668454(SMPD1)
MDO: 100022732(SMPD3) 100025584(SMPD4) 100026609 100029088(SMPD2) 100030863(SMPD1) 100030901(ENPP7)
SHR: 100915511(ENPP7) 100916633(SMPD1) 100917993(SMPD3) 100923932 100934158(SMPD4)
GGA: 415619(SMPD3) 416942(SMPD4) 419077(SMPD1) 426249(ENPP7) 770663(SMPD2)
MGP: 100539218(SMPD4) 100544613(SMPD3) 100545403(SMPD2) 104913770(ENPP7) 104916845(SMPD1)
CJO: 107308580(SMPD1) 107319041(SMPD3) 107321304(SMPD4) 107322203(ENPP7) 107324599(SMPD2)
APLA: 101796515(SMPD3) 101797457(ENPP7) 101798690(SMPD4)
ACYG: 106031303(SMPD4) 106043092(SMPD3) 106046128(SMPD2) 106046744(ENPP7)
TGU: 100225712(SMPD4) 100226949(ENPP7) 100227648(SMPD3)
GFR: 102035994(ENPP7) 102039010(SMPD3) 102041659(SMPD2) 102045158(SMPD4)
FAB: 101806515(ENPP7) 101809366(SMPD1) 101812312(SMPD3) 101817484(SMPD4) 101819908(SMPD2)
PHI: 102101799(ENPP7) 102101835(SMPD4) 102104472(SMPD3) 102113323(SMPD1) 102114253(SMPD2) 106629034(SMPD5)
PMAJ: 107198374(SMPD1) 107209752(SMPD3) 107211627(SMPD4) 107212279(ENPP7) 107214800(SMPD2)
CCW: 104687486(SMPD3) 104688764(SMPD4) 104692393(SMPD2) 104698101(SMPD1) 104698211(ENPP7)
FPG: 101914970(SMPD4) 101918131(ENPP7) 101921655(SMPD1) 101923170(SMPD3) 101923831(SMPD2)
FCH: 102050875(SMPD4) 102051582(ENPP7) 102052173(SMPD1) 102054815(SMPD3) 102060051(SMPD2)
CLV: 102086716(SMPD4) 102088815(SMPD3) 102091270(ENPP7) 102096161(SMPD2)
EGZ: 104130031(ENPP7) 104130138(SMPD4) 104130217(SMPD3)
AAM: 106483184(SMPD3) 106486001(ENPP7) 106486249(SMPD4) 106487704(SMPD2)
ASN: 102368595(SMPD3) 102371744(SMPD2) 102375177 102379883(SMPD1) 102380963(ENPP7) 102381624(SMPD4)
AMJ: 102557795 102558342(SMPD4) 102558419(ENPP7) 102564237(SMPD2) 102571628(SMPD3) 106740329(SMPD1)
PSS: 102447344 102447556(SMPD2) 102453490(SMPD3) 102457945(SMPD4) 102462744(ENPP7)
CMY: 102935543(SMPD2) 102941840(SMPD3) 102943179(ENPP7) 102943505(SMPD4) 102944026
CPIC: 101931283 101931716(ENPP7) 101935986(SMPD2) 101939616(SMPD4) 101943849 101949784(SMPD3) 101951948(SMPD1)
ACS: 100552784(smpd2) 100555572(smpd4) 100560692(smpd1) 100561467 100562803(enpp7) 100564529(smpd3) 103281522
PVT: 110078105(SMPD1) 110079714(SMPD2) 110081958(SMPD4) 110085490(SMPD3) 110091264(ENPP7)
PBI: 103048042(SMPD4) 103048657 103050708(SMPD3) 103052650(SMPD1) 103054403(ENPP7) 103058368(SMPD2) 103065467
GJA: 107110969(SMPD2) 107114186 107115087(SMPD4) 107119858(ENPP7) 107121986(SMPD1) 107126185(SMPD3)
XLA: 100462924(enpp7.L) 108701880 108702714(enpp7.S) 108705117 108708792(smpd1.L) 108709450 108715362 495009(smpd4.L) 734723(smpd3.L)
XTR: 100127861(smpd4) 100145256(smpd2) 100422804(enpp7) 100487433(smpd1) 100495702(smpd3) 100498586(enpp7-l)
NPR: 108792311 108795172(SMPD3) 108796846(ENPP7) 108799754(SMPD1) 108800766(SMPD4)
DRE: 556700(smpd1) 557756(enpp7.1) 557817(enpp7.2) 567548(smpd2a) 567592(smpd5) 568381(smpd3) 569930(zgc:153896) 793294(smpd4) 797914(smpd2b)
PRET: 103464236(smpd4) 103464706(smpd2) 103466286(smpd3) 103469047(enpp7) 103475516(smpd1) 103477493 103478589
LCM: 102346578(SMPD4) 102347420 102349868(SMPD5) 102351710(SMPD3) 102352082(SMPD2) 102355803(ENPP7) 102358628(SMPD1) 106704261
DSI: Dsimw501_GD11848(Dsim_GD11848) Dsimw501_GD13741(Dsim_GD13741) Dsimw501_GD20627(Dsim_GD20627)
CEL: CELE_B0252.2(asm-1) CELE_R05D11.9(R05D11.9) CELE_T27F6.6(T27F6.6) CELE_W03G1.7(asm-3) CELE_ZK455.4(asm-2)
CBR: CBG01606(Cbr-asm-3) CBG11183(Cbr-asm-1) CBG12510 CBG17365(Cbr-asm-2) CBG23668
ATR: 18428202
PPP: 112272647
SCE: YER019W(ISC1)
ERC: Ecym_1075
KMX: KLMA_10092(ISC1)
NCS: NCAS_0B08720(NCAS0B08720)
NDI: NDAI_0A00540(NDAI0A00540)
TPF: TPHA_0B04600(TPHA0B04600)
TBL: TBLA_0A05330(TBLA0A05330)
TDL: TDEL_0C06320(TDEL0C06320)
KAF: KAFR_0D00630(KAFR0D00630)
PIC: PICST_33012(ISC1) PICST_51970(IFP3)
CAL: CAALFM_CR05830CA(ISC1)
CAUR: QG37_08331
SLB: AWJ20_2827(ISC1) AWJ20_490(PPN1)
NCR: NCU03243
NTE: NEUTE1DRAFT72320(NEUTE1DRAFT_72320)
BFU: BCIN_03g08610(Bcisc1)
MBE: MBM_01294
ANI: AN3927.2
ANG: ANI_1_1578094(An11g00670) ANI_1_1670094(An11g01640)
ABE: ARB_07941
TVE: TRV_04097
PTE: PTT_04319
SPO: SPBC32F12.01c(css1)
CNE: CNA05370
CNB: CNBA5190
ABP: AGABI1DRAFT104039(AGABI1DRAFT_104039) AGABI1DRAFT115230(AGABI1DRAFT_115230)
ABV: AGABI2DRAFT182157(AGABI2DRAFT_182157) AGABI2DRAFT194192(AGABI2DRAFT_194192)
MGL: MGL_3789
DDI: DDB_G0270834(sgmA) DDB_G0293210(sgmB)
DFA: DFA_05558(sgmA) DFA_09070(sgmB)
EHI: EHI_007460(427.t00005) EHI_040600(164.t00014) EHI_088080(539.t00001) EHI_118110(18.t00042) EHI_193190(43.t00036)
TAN: TA09680
TPV: TP01_1199
BBO: BBOV_IV006490(23.m06085)
BEX: A11Q_2426
BAN: BA_0678(spH)
BAR: GBAA_0678(sph)
BAT: BAS0644
BAH: BAMEG_3908(sph)
BAI: BAA_0761(sph)
BANT: A16_07410
BANR: A16R_07470
BANS: BAPAT_0655
BANV: DJ46_5136(sph)
BCE: BC0671
BCA: BCE_0745(spH)
BCZ: BCE33L0589(spH)
BCR: BCAH187_A0805(sph)
BCB: BCB4264_A0708(sph)
BCU: BCAH820_0733(sph)
BCG: BCG9842_B4628(sph)
BCQ: BCQ_0745(spH)
BCX: BCA_0714(sph)
BAL: BACI_c06860(spH)
BNC: BCN_0653
BCF: bcf_03470
BCER: BCK_04765
BTK: BT9727_0588(spH)
BTL: BALH_0618(spH)
BTB: BMB171_C0590(sph)
BTT: HD73_0752
BTHI: BTK_03840
BTC: CT43_CH0601(sph)
BTM: MC28_5402(sph)
BTG: BTB_c06920(sph)
BTI: BTG_17770
BTW: BF38_1923(sph)
BWW: bwei_4920(sph)
SGR: SGR_1091
SAQ: Sare_2087
SYP: SYNPCC7002_A2848(sph)
SNG: SNE_A21560(smcL)
LBJ: LBJ_0291
LBL: LBL_2785
 » show all
Taxonomy
Reference
1  [PMID:5916388]
  Authors
Barnholz Y, Roitman A, Gatt S.
  Title
Enzymatic hydrolysis of sphingolipids. II. Hydrolysis of sphingomyelin by an enzyme from rat brain.
  Journal
J Biol Chem 241:3731-7 (1966)
Reference
2  [PMID:2545711]
  Authors
Chatterjee S, Ghosh N.
  Title
Neutral sphingomyelinase from human urine. Purification and preparation of monospecific antibodies.
  Journal
J Biol Chem 264:12554-61 (1989)
Reference
3  [PMID:5911524]
  Authors
Heller M, Shapiro B.
  Title
Enzymic hydrolysis of sphingomyelin by rat liver.
  Journal
Biochem J 98:763-9 (1966)
Reference
4  [PMID:5933867]
  Authors
Kanfer JN, Young OM, Shapiro D, Brady RO.
  Title
The metabolism of sphingomyelin. I. Purification and properties of a sphingomyelin-cleaving enzyme from rat liver tissue.
  Journal
J Biol Chem 241:1081-4 (1966)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.4.12
IUBMB Enzyme Nomenclature: 3.1.4.12
ExPASy - ENZYME nomenclature database: 3.1.4.12
BRENDA, the Enzyme Database: 3.1.4.12
CAS: 9031-54-3

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