KEGG   ENZYME: 3.1.4.37
Entry
EC 3.1.4.37                 Enzyme                                 
Name
2',3'-cyclic-nucleotide 3'-phosphodiesterase;
cyclic-CMP phosphodiesterase;
2',3'-cyclic AMP phosphodiesterase;
cyclic 2',3'-nucleotide 3'-phosphodiesterase;
cyclic 2',3'-nucleotide phosphodiesterase;
2',3'-cyclic nucleoside monophosphate phosphodiesterase;
2',3'-cyclic nucleotide 3'-phosphohydrolase;
CNPase;
2',3'-cyclic nucleotide phosphohydrolase;
2':3'-cyclic nucleotide 3'-phosphodiesterase;
2':3'-CNMP-3'-ase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
Sysname
nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase
Reaction(IUBMB)
nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate [RN:R03422]
Reaction(KEGG)
R03422
Substrate
nucleoside 2',3'-cyclic phosphate [CPD:C01240];
H2O [CPD:C00001]
Product
nucleoside 2'-phosphate [CPD:C03418]
Comment
The brain enzyme acts on 2',3'-cyclic AMP more rapidly than on the UMP or CMP derivatives. An enzyme from liver acts on 2',3'-cyclic CMP more rapidly than on the purine derivatives; it also hydrolyses the corresponding 3',5'-cyclic phosphates, but more slowly. This latter enzyme has been called cyclic-CMP phosphodiesterase.
History
EC 3.1.4.37 created 1976
Orthology
K01121  2',3'-cyclic-nucleotide 3'-phosphodiesterase
K15435  2',3'-cyclic-nucleotide 3'-phosphodiesterase
Genes
HSA1267(CNP)
PTR454673(CNP)
PPS100983181(CNP)
GGO101154558(CNP)
PON100171506(CNP)
NLE100595130(CNP)
HMH116474849(CNP)
MCC641337(CNP)
MCF101866793
MTHB126938500
MNI105472136(CNP)
CSAB103243434(CNP)
CATY105579659(CNP)
PANU101024891(CNP)
TGE112609141(CNP)
MLEU105552968(CNP)
RRO104680442(CNP)
RBB108518345(CNP)
TFN117066981(CNP)
PTEH111537385(CNP)
CANG105503023(CNP)
CJC100409009(CNP)
SBQ101050949(CNP)
CIMI108289841
CSYR103274482(CNP)
MMUR105872016(CNP)
LCAT123620943
PCOQ105820240(CNP)
OGA100964028(CNP)
MMU12799(Cnp)
MCAL110305046(Cnp)
MPAH110332178(Cnp)
RNO25275(Cnp)
MCOC116079258(Cnp)
ANU117711466(Cnp)
MUN110540732(Cnp)
CGE100753220(Cnp)
MAUA101830936
PROB127216178(Cnp)
PLEU114682839
MORG121442498
MFOT126510310
AAMP119812538
NGI103735880(Cnp)
HGL101703085(Cnp)
CPOC100715967(Cnp)
CCAN109695787(Cnp)
DORD106003154(Cnp)
DSP122103490
PLOP125365773
NCAR124980972
MMMA107150579
OCU103351568
OPI101525323
TUP102488860(CNP)
GVR103583990 103589187(CNP)
CFA607694(CNP)
CLUD112655268
VVP112910800(CNP)
VLG121473301
NPO129504783(CNP)
AML100467749(CNP)
UMR103672615
UAH113265436(CNP)
UAR123781824
ELK111151693
LLV125087130
MPUF101686926(CNP)
MNP132004051(CNP)
MLK131815842(CNP)
NVS122906209
ORO101368654(CNP)
EJU114201337(CNP)
ZCA113939250
MLX118024898(CNP)
NSU110573238
LWW102743527(CNP)
FCA101093220(CNP)
PYU121045009
PCOO112854149(CNP)
PBG122485589
LRUF124522212
PTG102971900(CNP)
PPAD109258574(CNP)
PUC125926554
AJU106972562
HHV120248439
BTA280752(CNP)
BOM102286486(CNP)
BIU109573868(CNP)
BBUB102392413
BBIS104990792(CNP)
CHX102182826(CNP)
OAS101120423(CNP)
BTAX128065057(CNP)
ODA120867110
CCAD122441757
MBEZ129544411(CNP)
SSC100511587(CNP)
CFR102508768(CNP)
CBAI105080128(CNP)
CDK105090447(CNP)
VPC102545095(CNP)
LVE103078417(CNP)
OOR101277548(CNP)
DLE111166446(CNP)
PCAD102986171(CNP)
NASI112400001(CNP)
ECB100066401(CNP)
EPZ103550374(CNP)
EAI106826330
MYB102246257(CNP)
MYD102757958(CNP)
MMYO118671523
MLF102431066(CNP)
MNA107544199(CNP)
PKL118726612
EFUS103293239(CNP)
HAI109395745(CNP)
DRO112298555(CNP)
SHON118978179
AJM119037549
PDIC114503573
PHAS123817605
MMF118634649
RFQ117013700(CNP)
PPAM129086911(CNP)
PALE102887386(CNP)
PGIG120611119
PVP105306307(CNP)
RAY107513810(CNP)
MJV108388336
TOD119232110(CNP)
SARA101557614(CNP)
LAV100670728(CNP)
TMU101346552
ETF101653360
DNM101434978(CNP)
MDO100012666(CNP)
GAS123243922
SHR105748993(CNP)
AFZ127560137
PCW110198448(CNP)
OAA114815024
GGA395921(CNP)
PCOC116233623(CNP)
MGP104914621(CNP)
CJO107325125(CNP)
TPAI128089171(CNP)
LMUT125684581
NMEL110388457(CNP)
APLA101794702
ACYG106048016
CATA118259124(CNP)
AFUL116498388(CNP)
TGU100223675(CNP)
LSR110471853(CNP)
SCAN103821597(CNP)
PMOA120496579
OTC121347531
PRUF121351093
GFR102036395(CNP)
FAB101806325(CNP)
OMA130263991(CNP)
PHI102099592(CNP)
PMAJ107215150(CNP)
CCAE111939964(CNP)
CCW104697757
CBRC103619705(CNP)
ETL114063640(CNP)
ZAB102067391(CNP)
ACHL103799853(CNP)
SVG106858678(CNP)
MMEA130585424(CNP)
HRT120763913(CNP)
FPG101923806(CNP)
FCH102051933(CNP)
CLV102094445(CNP)
EGZ104131388(CNP)
NNI104009869(CNP)
PCRI104029526(CNP)
PLET104614897(CNP)
EHS104513822
PCAO104042936(CNP)
ACUN113489131(CNP)
TALA104365619
PADL103919492(CNP)
AFOR103901747(CNP)
ACHC115344432
HALD104312407(CNP)
HLE104842932(CNP)
AGEN126038164
GCL127026615
CCRI104155843(CNP)
CSTI104549593(CNP)
CMAC104482477(CNP)
MUI104548203(CNP)
BREG104637264(CNP)
FGA104077628(CNP)
GSTE104263521(CNP)
LDI104353466(CNP)
MNB103770339(CNP)
OHA104330595(CNP)
NNT104411884(CNP)
SHAB115617598(CNP)
DPUB104309565(CNP)
PGUU104461535(CNP)
ACAR104517964
CPEA104385663(CNP)
AVIT104272585(CNP)
CVF104294777(CNP)
RTD128919170(CNP)
CUCA104054412(CNP)
TEO104377962(CNP)
BRHI104492654(CNP)
AAM106487631(CNP)
AROW112968736(CNP)
NPD112951793(CNP)
TGT104572239(CNP)
DNE112992597(CNP)
SCAM104152417(CNP)
ASN102370911(CNP)
AMJ102573017(CNP)
CPOO109320351(CNP)
GGN109289946(CNP)
PSS102444316(CNP)
CMY102931370
CCAY125626696
DCC119848909
CPIC101941109
TST117869293(CNP)
CABI116829914(CNP)
MRV120392092
ACS100562366(cnp)
ASAO132778312(CNP)
PVT110088998(CNP)
SUND121917743 121932990 121935086
PBI103058614(CNP)
PMUR107303041(CNP)
CTIG120315178
TSR106538255(CNP)
PGUT117664717(CNP)
APRI131198364(CNP)
PTEX113447853(CNP)
NSS113422066(CNP)
VKO123031726
PMUA114581999(CNP)
PRAF128400209(CNP)
ZVI118094457(CNP)
HCG128331503(CNP)
GJA107116247(CNP)
STOW125444688
XLA108702467(cnp.S) 444056(cnp.L)
XTR100492391(cnp)
NPR108792991(CNP)
RTEM120918723
BBUF121003504
BGAR122940201 122941235
MUO115481890(CNP)
GSH117347352(CNP)
DRE325896(cnp)
SRX107729184 107755574
SANH107687004 107690289
SGH107567700 107590558
CCAR109108741
CAUA113046939 113047371
CGIB127948393 127952881
PTET122341692
LROH127162913(cnp)
OMC131537828(cnp)
PPRM120489630
RKG130090646(cnp)
MAMB125279643
CIDE127508040
MASI127450501 127451135
MANU129436233(cnp)
IPU108256586(cnp)
IFU128601969(cnp)
PHYP113528287(cnp)
SMEO124397326
TFD113652151
TVC132860814(cnp)
AMEX103043047(cnp)
CMAO118821365
EEE113592330(cnp)
TRU101073131(cnp)
TFS130514604(cnp)
TNGGSTEN00021423G001
LCO104926069(cnp)
NCC104949163(cnp)
TBEN117492458(cnp)
CGOB115012153(cnp)
PGEO117450918(cnp)
GACU117548710(cnp)
ELY117268847(cnp)
EFO125879459
PLEP121956989
SLUC116059487
ECRA117958418(cnp)
ESP116702483(cnp)
PFLV114570104(cnp)
GAT120828430
PPUG119220185
AFB129098489(cnp)
CLUM117735032(cnp)
MSAM119892447
SCHU122869482
CUD121529595
ALAT119013391
MZE101484788(cnp)
ONL100702081(cnp)
OAU116312463
OLA101161559(cnp)
XMA102221544(cnp)
XCO114159621(cnp)
XHE116735629(cnp)
PRET103469413(cnp)
PFOR103142185(cnp)
PLAI106950772(cnp)
PMEI106921564(cnp)
GAF122822638
PPRL129374018(cnp)
CVG107099620(cnp)
CTUL119778893
GMU124862418 124863688
NFU107395299(cnp)
KMR108243754
ALIM106527949(cnp)
NWH119421382
AOCE111584365(cnp)
MCEP124998452
CSEM103393138(cnp)
POV109634035(cnp)
SSEN122785682
HHIP117765772(cnp)
HSP124854970
LCF108901289
SDU111217693(cnp)
SLAL111652815(cnp)
XGL120788285
HCQ109532536(cnp)
SSCV125983301
SBIA133514250(cnp)
PEE133415372(cnp)
PTAO133466359(cnp)
BPEC110161626(cnp)
MALB109964255(cnp)
BSPL114860754(cnp)
SJO128379139(cnp)
SASA100306871(cn37) 106601016
STRU115171102 115197748
OTW112225979 112258647
OMY110486251 110538182
OGO123999955 124015688
ONE115110871 115123342(cnp)
OKI109893308 109898418
OKE118365261 118370456
SALP111976172 112068733
SNH120033958 120035753
CCLU121569590 123482614
ELS105013339(cnp)
SFM108918982(cnp)
PKI111842498 111855988(cnp)
AANG118216801 118221444(cnp)
LOC102685682(cnp)
PSPA121301796 121324917
ARUT117433278 117434464
PSEX120517483
LCM102366632(CNP)
CMK103183808
RTP109913243(cnp)
CPLA122539841
HOC132830790(cnp)
LERI129710194(cnp)
PMRN116940939(CNP)
LRJ133344832(CNP)
BFO118405679
BBEL109465322
SPU115917953 582388
LPIC129254813
APLC110985385
SKO100373038
FOC113207652
TPAL117651277
CSEC111872167
DPXDAPPUDRAFT_109194
DMK116931132
PJA122251457
PCHN125045145
HAME121855476
PCLA123745548 123766250
CQD128684162 128697567
PTRU123513153 123514060
ESN127007269 127010329
HAZT108681948
LSM121127590
TCF131880903 131885664
PPOI119103100
DSV119445058 119446166 119446167
RSAN119389990
RMP119174425
CSCU111615988
PTEP107441103 107441104 107446139 107446140 107446143
UDV129230727
SDM118198139
LPOL106475258 106477729
PMEO129601042 129601050
HROHELRODRAFT_170216
LGILOTGIDRAFT_167168
PCAN112569653
BGT106066505
GAE121386688
HRF124113743
HRJ124253315 124264566
CRG105320298
CVN111125538
CANU128192188
OED125680717
MYI110442976
PMAX117317612
MMER123538711
RPHI132745465
OBI106867694
OSN115223283
LAK106159031
SMMSmp_147600
OVIT265_04033
EGLEGR_08413
ADF107343453
AMIL114959905
PDAM113670801
SPIS111324359
DGT114517431
HSY130641066
SCEYGR247W(CPD1)
SEUBDI49_2210
SPAOSPAR_G04560
AGOAGOS_AEL214C
ERCEcym_5571
KLAKLLA0_A05412g
KMXKLMA_10332(CPD1)
LTHKLTH0H00946g
VPOKpol_1050p76
ZROZYRO0C11462g
CGRCAGL0F08173g
NCSNCAS_0E03850(NCAS0E03850)
NDINDAI_0B00960(NDAI0B00960)
TPFTPHA_0A05230(TPHA0A05230)
TBLTBLA_0B08020(TBLA0B08020)
TGBHG536_0A01010
TDLTDEL_0G01030(TDEL0G01030)
KAFKAFR_0B04390(KAFR0B04390)
KNGKNAG_0K00500(KNAG0K00500)
ZMKHG535_0E00980
DHADEHA2G23430g
PICPICST_54649
PGUPGUG_04071
SPAASPAPADRAFT_134037
CALCAALFM_CR06690CA(CaO19.703)
CTPCTRG_00666
COTCORT_0D04920
CDUCD36_32230
CTENCANTEDRAFT_99353
YLIYALI0A20295g
CLUCLUG_02481
CLUSA9F13_28g00209
CAURCJI96_0003924
SLBAWJ20_4080(CPD1)
NCRNCU05539
NTENEUTE1DRAFT124587(NEUTE1DRAFT_124587)
SMPSMAC_03260
PANPODANSg2780
TTTTHITE_2126759
MTMMYCTH_2307154
CTHRCTHT_0044820
ELAUCREL1_742
PFYPFICI_08582
PNOSNOG_07066
PTEPTT_19261
BZECOCCADRAFT_39693
BSCCOCSADRAFT_173787
BORCOCMIDRAFT_1102
AALTCC77DRAFT_1093588
ARABEKO05_0001678
ZTRMYCGRDRAFT_107673
PFJMYCFIDRAFT_26614
FFUCLAFUR5_02370
CBETCB0940_04581
BCOMBAUCODRAFT_43864
NPAUCRNP2_1162
CNECND00730
CNGCNAG_00933
CCACCcaHIS019_0111810(CcaverHIS019_0111810)
TVSTRAVEDRAFT_136556
PCOPHACADRAFT_255378
SHSSTEHIDRAFT_39301
ADLAURDEDRAFT_180777
FMEFOMMEDRAFT_103881
GTRGLOTRDRAFT_109971
RSXRhiXN_02041
CCICC1G_01080
ABPAGABI1DRAFT68346(AGABI1DRAFT_68346)
MRRMoror_8394
 » show all
Reference
1
  Authors
Drummond, G.I., Iyer, N.T. and Keith, J.
  Title
Hydrolysis of ribonucleoside 2',3'-cyclic phosphates by a diesterase from brain.
  Journal
J Biol Chem 237:3535-3539 (1962)
Reference
2  [PMID:6274851]
  Authors
Helfman DM, Kuo JF.
  Title
A homogeneous cyclic CMP phosphodiesterase hydrolyzes both pyrimidine and purine cyclic 2':3'- and 3':5'-nucleotides.
  Journal
J Biol Chem 257:1044-7 (1982)
Reference
3  [PMID:6263914]
  Authors
Helfman DM, Shoji M, Kuo JF.
  Title
Purification to homogeneity and general properties of a novel phosphodiesterase hydrolyzing cyclic CMP and cyclic AMP.
  Journal
J Biol Chem 256:6327-34 (1981)
Reference
4  [PMID:6272743]
  Authors
Kurihara T, Nishizawa Y, Takahashi Y, Odani S.
  Title
Chemical, immunological and catalytic properties of 2':3'-cyclic nucleotide 3'-phosphodiesterase purified from brain white matter.
  Journal
Biochem J 195:153-7 (1981)
DOI:10.1042/bj1950153
Reference
5  [PMID:6258586]
  Authors
Nishizawa Y, Kurihara T, Takahashi Y.
  Title
Spectrophotometric assay, solubilization and purification of brain 2':3'-cyclic nucleotide 3'-phosphodiesterase.
  Journal
Biochem J 191:71-82 (1980)
DOI:10.1042/bj1910071
Other DBs
ExplorEnz - The Enzyme Database: 3.1.4.37
IUBMB Enzyme Nomenclature: 3.1.4.37
ExPASy - ENZYME nomenclature database: 3.1.4.37
BRENDA, the Enzyme Database: 3.1.4.37
CAS: 60098-35-3

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