KEGG   ENZYME: 3.1.4.37
Entry
EC 3.1.4.37                 Enzyme                                 
Name
2',3'-cyclic-nucleotide 3'-phosphodiesterase;
cyclic-CMP phosphodiesterase;
2',3'-cyclic AMP phosphodiesterase;
cyclic 2',3'-nucleotide 3'-phosphodiesterase;
cyclic 2',3'-nucleotide phosphodiesterase;
2',3'-cyclic nucleoside monophosphate phosphodiesterase;
2',3'-cyclic nucleotide 3'-phosphohydrolase;
CNPase;
2',3'-cyclic nucleotide phosphohydrolase;
2':3'-cyclic nucleotide 3'-phosphodiesterase;
2':3'-CNMP-3'-ase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
Sysname
nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase
Reaction(IUBMB)
nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate [RN:R03422]
Reaction(KEGG)
R03422
Substrate
nucleoside 2',3'-cyclic phosphate [CPD:C01240];
H2O [CPD:C00001]
Product
nucleoside 2'-phosphate [CPD:C03418]
Comment
The brain enzyme acts on 2',3'-cyclic AMP more rapidly than on the UMP or CMP derivatives. An enzyme from liver acts on 2',3'-cyclic CMP more rapidly than on the purine derivatives; it also hydrolyses the corresponding 3',5'-cyclic phosphates, but more slowly. This latter enzyme has been called cyclic-CMP phosphodiesterase.
History
EC 3.1.4.37 created 1976
Orthology
K01121  2',3'-cyclic-nucleotide 3'-phosphodiesterase
K15435  2',3'-cyclic-nucleotide 3'-phosphodiesterase
Genes
HSA1267(CNP)
PTR454673(CNP)
PPS100983181(CNP)
GGO101154558(CNP)
PON100171506(CNP)
NLE100595130(CNP)
MCC641337(CNP)
MCF101866793
MTHB126938500
CSAB103243434(CNP)
CATY105579659(CNP)
PANU101024891(CNP)
TGE112609141(CNP)
RRO104680442(CNP)
RBB108518345(CNP)
TFN117066981(CNP)
PTEH111537385(CNP)
CJC100409009(CNP)
SBQ101050949(CNP)
CSYR103274482(CNP)
MMUR105872016(CNP)
LCAT123620943
OGA100964028(CNP)
MMU12799(Cnp)
MCAL110305046(Cnp)
MPAH110332178(Cnp)
RNO25275(Cnp)
MCOC116079258(Cnp)
MUN110540732(Cnp)
CGE100753220(Cnp)
MAUA101830936
PLEU114682839
MORG121442498
MFOT126510310
AAMP119812538
NGI103735880(Cnp)
HGL101703085(Cnp)
CPOC100715967(Cnp)
CCAN109695787(Cnp)
DORD106003154(Cnp)
DSP122103490
NCAR124980972
OCU103351568(CNP)
OPI101525323
TUP102488860(CNP)
CFA607694(CNP)
CLUD112655268
VVP112910800(CNP)
VLG121473301
AML100467749(CNP)
UMR103672615(CNP)
UAH113265436(CNP)
UAR123781824
ELK111151693
LLV125087130
MPUF101686926(CNP)
ORO101368654(CNP)
EJU114201337(CNP)
ZCA113939250
MLX118024898(CNP)
NSU110573238
FCA101093220(CNP)
PYU121045009
PBG122485589
LRUF124522212
PTG102971900(CNP)
PPAD109258574(CNP)
AJU106972562(CNP)
HHV120248439
BTA280752(CNP)
BOM102286486(CNP)
BIU109573868(CNP)
BBUB102392413
CHX102182826(CNP)
OAS101120423(CNP)
ODA120867110
CCAD122441757
SSC100511587(CNP)
CFR102508768(CNP)
CBAI105080128(CNP)
CDK105090447(CNP)
VPC102545095(CNP)
LVE103078417(CNP)
OOR101277548(CNP)
DLE111166446(CNP)
PCAD102986171(CNP)
ECB100066401(CNP)
EPZ103550374(CNP)
EAI106826330
MYB102246257(CNP)
MYD102757958(CNP)
MMYO118671523
MLF102431066(CNP)
MNA107544199(CNP)
PKL118726612
HAI109395745(CNP)
DRO112298555(CNP)
SHON118978179
AJM119037549
PDIC114503573
PHAS123817605
MMF118634649
RFQ117013700(CNP)
PALE102887386(CNP)
PGIG120611119
PVP105306307(CNP)
RAY107513810(CNP)
MJV108388336(CNP)
TOD119232110
SARA101557614(CNP)
LAV100670728(CNP)
TMU101346552
DNM101434978(CNP)
MDO100012666(CNP)
GAS123243922
SHR105748993(CNP)
PCW110198448(CNP)
OAA114815024
GGA395921(CNP)
PCOC116233623(CNP)
MGP104914621(CNP)
CJO107325125(CNP)
NMEL110388457(CNP)
APLA101794702(CNP)
ACYG106048016
AFUL116498388(CNP)
TGU100223675(CNP)
LSR110471853(CNP)
SCAN103821597(CNP)
PMOA120496579
OTC121347531
PRUF121351093
GFR102036395(CNP)
FAB101806325(CNP)
PHI102099592(CNP)
PMAJ107215150(CNP)
CCAE111939964(CNP)
CCW104697757
CBRC103619705(CNP)
ETL114063640(CNP)
ZAB102067391(CNP)
ACHL103799853(CNP)
FPG101923806(CNP)
FCH102051933(CNP)
CLV102094445(CNP)
EGZ104131388(CNP)
NNI104009869(CNP)
PLET104614897(CNP)
PCRI104029526(CNP)
ACUN113489131(CNP)
TALA104365619
PADL103919492(CNP)
AFOR103901747(CNP)
ACHC115344432
HALD104312407(CNP)
CCRI104155843(CNP)
CSTI104549593(CNP)
EHS104513822
CMAC104482477(CNP)
MUI104548203(CNP)
FGA104077628(CNP)
GSTE104263521(CNP)
LDI104353466(CNP)
MNB103770339(CNP)
OHA104330595(CNP)
NNT104411884(CNP)
DPUB104309565(CNP)
PGUU104461535(CNP)
ACAR104517964
AVIT104272585(CNP)
CVF104294777(CNP)
AAM106487631(CNP)
AROW112968736(CNP)
NPD112951793(CNP)
TGT104572239(CNP)
DNE112992597(CNP)
SCAM104152417(CNP)
ASN102370911(CNP)
AMJ102573017(CNP)
CPOO109320351(CNP)
GGN109289946(CNP)
PSS102444316(CNP)
CMY102931370
CPIC101941109
TST117869293(CNP)
CABI116829914(CNP)
MRV120392092
ACS100562366(cnp)
PVT110088998(CNP)
SUND121917743 121932990 121935086
PBI103058614(CNP)
PMUR107303041(CNP)
CTIG120315178
TSR106538255(CNP)
PGUT117664717(CNP)
VKO123031726
PMUA114581999(CNP)
ZVI118094457(CNP)
GJA107116247(CNP)
STOW125444688
XLA108702467(cnp.S) 444056(cnp.L)
XTR100492391(cnp)
NPR108792991(CNP)
RTEM120918723
BBUF121003504
BGAR122940201 122941235
DRE325896(cnp)
SRX107729184 107755574
SANH107687004 107690289
SGH107567700 107590558
CCAR109108741
CAUA113046939 113047371
PPRM120489630
MAMB125279643
IPU108256586
PHYP113528287(cnp)
SMEO124397326
TFD113652151
AMEX103043047(cnp)
EEE113592330(cnp)
TRU101073131(cnp)
TNGGSTEN00021423G001
LCO104926069(cnp)
NCC104949163(cnp)
CGOB115012153(cnp)
ELY117268847(cnp)
EFO125879459
PLEP121956989
SLUC116059487
ECRA117958418(cnp)
ESP116702483(cnp)
PFLV114570104(cnp)
GAT120828430
PPUG119220185
MSAM119892447
CUD121529595
ALAT119013391
MZE101484788(cnp)
ONL100702081(cnp)
OAU116312463
OLA101161559(cnp)
XMA102221544(cnp)
XCO114159621(cnp)
XHE116735629(cnp)
PRET103469413(cnp)
PFOR103142185(cnp)
PLAI106950772(cnp)
PMEI106921564(cnp)
GAF122822638
CVG107099620(cnp)
CTUL119778893
GMU124862418 124863688
NFU107395299(cnp)
KMR108243754
ALIM106527949(cnp)
NWH119421382
AOCE111584365(cnp)
MCEP124998452
CSEM103393138(cnp)
POV109634035(cnp)
SSEN122785682
HHIP117765772(cnp)
HSP124854970
LCF108901289
SDU111217693(cnp)
SLAL111652815(cnp)
XGL120788285
HCQ109532536(cnp)
BPEC110161626(cnp)
MALB109964255(cnp)
BSPL114860754
SASA100306871(cn37) 106601016
STRU115171102 115197748
OTW112225979 112258647
OMY110486251 110538182
OGO123999955 124015688
ONE115110871 115123342(cnp)
SALP111976172 112068733
SNH120033958 120035753
CCLU121569590 123482614
ELS105013339(cnp)
SFM108918982(cnp)
PKI111842498 111855988(cnp)
AANG118216801 118221444(cnp)
LOC102685682(cnp)
PSPA121301796 121324917
ARUT117433278 117434464
LCM102366632(CNP)
CMK103183808
RTP109913243(cnp)
BFO118405679
BBEL109465322
SPU115917953 582388
APLC110985385
SKO100373038
BCOO119071662
FOC113207652
TPAL117651277
CSEC111872167
DPXDAPPUDRAFT_109194
DMK116931132
PJA122251457
PCHN125045145
HAME121855476
PCLA123745548 123766250
PTRU123513153 123514060
HAZT108681948
LSM121127590
PPOI119103100
ISCIscW_ISCW021782
DSV119445058 119446166 119446167
RSAN119389990
RMP119174425
CSCU111615988 111616207
PTEP107441103 107441104 107446139 107446140 107446143 107446144
SDM118198139
HROHELRODRAFT_170216
LGILOTGIDRAFT_167168
PCAN112569653
BGT106066505
GAE121386688
HRF124113743
HRJ124253315 124264566
CRG105320298
MYI110442976
PMAX117317612
MMER123538711
OBI106867694
OSN115223283
LAK106159031
SMMSmp_147600
OVIT265_04033
EGLEGR_08413
ADF107343453
AMIL114959905
PDAM113670801
SPIS111324359
DGT114517431
SCEYGR247W(CPD1)
SEUBDI49_2210
SPAOSPAR_G04560
AGOAGOS_AEL214C
ERCEcym_5571
KLAKLLA0_A05412g
KMXKLMA_10332(CPD1)
LTHKLTH0H00946g
VPOKpol_1050p76
ZROZYRO0C11462g
CGRCAGL0F08173g
NCSNCAS_0E03850(NCAS0E03850)
NDINDAI_0B00960(NDAI0B00960)
TPFTPHA_0A05230(TPHA0A05230)
TBLTBLA_0B08020(TBLA0B08020)
TDLTDEL_0G01030(TDEL0G01030)
TGBHG536_0A01010
KAFKAFR_0B04390(KAFR0B04390)
KNGKNAG_0K00500(KNAG0K00500)
ZMKHG535_0E00980
DHADEHA2G23430g
PICPICST_54649
PGUPGUG_04071
SPAASPAPADRAFT_134037
CALCAALFM_CR06690CA(CaO19.703)
CTPCTRG_00666
COTCORT_0D04920
CDUCD36_32230
CTENCANTEDRAFT_99353
YLIYALI0A20295g
CLUCLUG_02481
CLUSA9F13_28g00209
CAURCJI97_005219
SLBAWJ20_4080(CPD1)
NCRNCU05539
NTENEUTE1DRAFT124587(NEUTE1DRAFT_124587)
SMPSMAC_03260
PANPODANSg2780
TTTTHITE_2126759
MTMMYCTH_2307154
CTHRCTHT_0044820
ELAUCREL1_742
PFYPFICI_08582
PNOSNOG_07066
PTEPTT_19261
BZECOCCADRAFT_39693
BSCCOCSADRAFT_173787
BORCOCMIDRAFT_1102
AALTCC77DRAFT_1093588
ZTRMYCGRDRAFT_107673
PFJMYCFIDRAFT_26614
FFUCLAFUR5_02370
BCOMBAUCODRAFT_43864
NPAUCRNP2_1162
CNECND00730
CNGCNAG_00933
TVSTRAVEDRAFT_136556
PCOPHACADRAFT_255378
SHSSTEHIDRAFT_39301
ADLAURDEDRAFT_180777
FMEFOMMEDRAFT_103881
GTRGLOTRDRAFT_109971
CCICC1G_01080
ABPAGABI1DRAFT68346(AGABI1DRAFT_68346)
MRRMoror_8394
PGRPGTG_10569
 » show all
Reference
1
  Authors
Drummond, G.I., Iyer, N.T. and Keith, J.
  Title
Hydrolysis of ribonucleoside 2',3'-cyclic phosphates by a diesterase from brain.
  Journal
J Biol Chem 237:3535-3539 (1962)
Reference
2  [PMID:6274851]
  Authors
Helfman DM, Kuo JF.
  Title
A homogeneous cyclic CMP phosphodiesterase hydrolyzes both pyrimidine and purine cyclic 2':3'- and 3':5'-nucleotides.
  Journal
J Biol Chem 257:1044-7 (1982)
Reference
3  [PMID:6263914]
  Authors
Helfman DM, Shoji M, Kuo JF.
  Title
Purification to homogeneity and general properties of a novel phosphodiesterase hydrolyzing cyclic CMP and cyclic AMP.
  Journal
J Biol Chem 256:6327-34 (1981)
Reference
4  [PMID:6272743]
  Authors
Kurihara T, Nishizawa Y, Takahashi Y, Odani S.
  Title
Chemical, immunological and catalytic properties of 2':3'-cyclic nucleotide 3'-phosphodiesterase purified from brain white matter.
  Journal
Biochem J 195:153-7 (1981)
DOI:10.1042/bj1950153
Reference
5  [PMID:6258586]
  Authors
Nishizawa Y, Kurihara T, Takahashi Y.
  Title
Spectrophotometric assay, solubilization and purification of brain 2':3'-cyclic nucleotide 3'-phosphodiesterase.
  Journal
Biochem J 191:71-82 (1980)
DOI:10.1042/bj1910071
Other DBs
ExplorEnz - The Enzyme Database: 3.1.4.37
IUBMB Enzyme Nomenclature: 3.1.4.37
ExPASy - ENZYME nomenclature database: 3.1.4.37
BRENDA, the Enzyme Database: 3.1.4.37
CAS: 60098-35-3

DBGET integrated database retrieval system