KEGG   ENZYME: 3.1.4.45
Entry
EC 3.1.4.45                 Enzyme                                 
Name
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase;
alpha-N-acetylglucosaminyl phosphodiesterase;
lysosomal alpha-N-acetylglucosaminidase;
phosphodiester glycosidase;
alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase;
2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
Sysname
glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase
Reaction(IUBMB)
glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose [RN:R04373]
Reaction(KEGG)
R04373
Substrate
glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose [CPD:C04755];
H2O [CPD:C00001]
Product
N-acetyl-D-glucosamine [CPD:C00140];
glycoprotein phospho-D-mannose [CPD:C04010]
Comment
Acts on a variety of compounds in which N-acetyl-D-glucosamine is alpha-linked to a phosphate group, including the biosynthetic intermediates of the high mannose oligosaccharide components of some lysosomal enzymes and the products of EC 2.7.8.17 UDP-N-acetylglucosamine---lysosomal-enzyme N-acetylglucosaminephosphotransferase.
History
EC 3.1.4.45 created 1984
Orthology
K01125  N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
Genes
HSA51172(NAGPA)
PTR453894(NAGPA)
PPS100989924(NAGPA)
GGO101130231(NAGPA)
PON100458605(NAGPA)
NLE100605673(NAGPA)
MCC707352(NAGPA)
MCF102127868(NAGPA)
MTHB126944643
CSAB103227805(NAGPA)
CATY105572135(NAGPA)
PANU101019515(NAGPA)
TGE112614520(NAGPA)
RRO104654668(NAGPA)
RBB108538332(NAGPA)
TFN117097690(NAGPA)
PTEH111551708(NAGPA)
CJC100399724(NAGPA)
SBQ101046520(NAGPA)
CSYR103255711(NAGPA)
MMUR105859710(NAGPA)
LCAT123632350(NAGPA)
OGA100949244(NAGPA)
MMU27426(Nagpa)
MCAL110311436(Nagpa)
MPAH110329742(Nagpa)
RNO360476(Nagpa)
MCOC116084542(Nagpa)
MUN110545922(Nagpa)
CGE100774024(Nagpa)
MAUA101826915(Nagpa)
PLEU114682439(Nagpa)
MORG121463759(Nagpa)
MFOT126498201
AAMP119813034(Nagpa)
NGI103744761(Nagpa)
HGL101704527(Nagpa)
CPOC100723215(Nagpa)
CCAN109684800(Nagpa)
DORD105981869(Nagpa)
DSP122123874(Nagpa)
NCAR124970782
OCU100352892(NAGPA)
OPI101523438(NAGPA)
TUP102497727(NAGPA)
CFA490019(NAGPA)
CLUD112640409(NAGPA)
VVP112923293(NAGPA)
VLG121488322(NAGPA)
AML100470535(NAGPA)
UMR103668820(NAGPA)
UAH113270828(NAGPA)
UAR123783261(NAGPA)
ELK111156230
LLV125091019
MPUF101681994(NAGPA)
ORO101373357(NAGPA)
EJU114219947(NAGPA)
ZCA113932519(NAGPA)
MLX118021805(NAGPA)
NSU110587951(NAGPA)
FCA101091582(NAGPA)
PYU121019560(NAGPA)
PBG122471702(NAGPA)
LRUF124517937
PTG102971048(NAGPA)
PPAD109278286(NAGPA)
AJU106978751(NAGPA)
HHV120236508(NAGPA)
BTA515935(NAGPA)
BOM102275466(NAGPA)
BIU109578760(NAGPA)
BBUB102389631(NAGPA)
CHX102169152(NAGPA)
OAS101104545(NAGPA)
ODA120874707(NAGPA)
CCAD122433409(NAGPA)
SSC100512596(NAGPA)
CFR102503696(NAGPA)
CBAI105065824(NAGPA)
CDK105098404(NAGPA) 105098405
VPC102525682(NAGPA)
BACU103007873(NAGPA)
LVE103086351(NAGPA)
OOR101275254(NAGPA)
DLE111185276(NAGPA)
PCAD102973529(NAGPA)
PSIU116740853(NAGPA)
ECB100069983(NAGPA)
EPZ103563128(NAGPA)
EAI106825972(NAGPA)
MYB102248654(NAGPA)
MYD102752240(NAGPA)
MMYO118656470(NAGPA)
MLF102437799(NAGPA)
MNA107538264(NAGPA)
PKL118703585(NAGPA)
HAI109392143(NAGPA)
DRO112298486(NAGPA)
SHON118975773(NAGPA)
AJM119047992(NAGPA)
PDIC114502746(NAGPA)
PHAS123807251(NAGPA)
MMF118641863(NAGPA)
RFQ117019813(NAGPA)
PALE102891536(NAGPA)
PGIG120620359(NAGPA)
PVP105303076(NAGPA)
RAY107518987(NAGPA)
MJV108393855 108406667(NAGPA)
TOD119241959(NAGPA)
SARA101548023(NAGPA)
LAV100659563(NAGPA)
TMU101350545
DNM101417001(NAGPA)
MDO100026673(NAGPA)
GAS123231084(NAGPA)
SHR100916276(NAGPA)
PCW110203200(NAGPA)
OAA100089312(NAGPA)
GGA416395(NAGPA)
PCOC116230207(NAGPA)
MGP100548255(NAGPA)
CJO107320943(NAGPA)
NMEL110405754(NAGPA)
APLA101800969(NAGPA)
ACYG106046317(NAGPA)
AFUL116495367(NAGPA)
TGU100217812(NAGPA)
LSR110470214(NAGPA)
SCAN103817954(NAGPA)
PMOA120512987(NAGPA)
OTC121335561(NAGPA)
PRUF121350698(NAGPA)
GFR102038412(NAGPA)
FAB101813573(NAGPA)
PHI102111151(NAGPA)
PMAJ107210961(NAGPA)
CCAE111936235(NAGPA)
CCW104684926(NAGPA)
CBRC103620518(NAGPA)
ETL114060262(NAGPA)
ACHL103801209(NAGPA)
FPG101919735(NAGPA)
FCH102052824(NAGPA)
CLV102097700(NAGPA)
EGZ104127416(NAGPA)
NNI104023534(NAGPA)
PLET104615698(NAGPA)
PCRI104027352
ACUN113485818(NAGPA)
TALA116963007(NAGPA)
PADL103917205(NAGPA)
AFOR103898086(NAGPA)
ACHC115335991(NAGPA)
HALD104315105(NAGPA)
CCRI104163655
CSTI104554561(NAGPA)
EHS104511100(NAGPA)
CMAC104478190(NAGPA)
MUI104535126(NAGPA)
FGA104078000
GSTE104256521(NAGPA)
LDI104354828(NAGPA)
MNB103781015(NAGPA)
OHA104336115(NAGPA)
NNT104412164(NAGPA)
PGUU104463358(NAGPA)
ACAR104528724(NAGPA)
AVIT104273217(NAGPA)
CVF104292215(NAGPA)
AAM106499990(NAGPA)
AROW112965122(NAGPA)
NPD112955656(NAGPA)
TGT104570253(NAGPA)
DNE112981033(NAGPA)
SCAM104147569(NAGPA)
ASN102386970(NAGPA)
AMJ102559983(NAGPA)
CPOO109313532(NAGPA)
GGN109290697(NAGPA)
PSS102457278(NAGPA)
CMY102944702(NAGPA)
CPIC101944116(NAGPA)
TST117883768(NAGPA)
CABI116819176(NAGPA)
MRV120373050(NAGPA)
ACS100565001(nagpa)
PVT110087126(NAGPA)
SUND121937446(NAGPA)
PBI103066432(NAGPA)
PMUR107295339(NAGPA)
CTIG120310891(NAGPA)
TSR106549565
PGUT117667379(NAGPA)
VKO123031137(NAGPA)
PMUA114584488(NAGPA)
ZVI118092524(NAGPA)
GJA107114194(NAGPA)
STOW125431377(NAGPA)
XLA108708030(nagpa.L)
XTR100380073(nagpa)
NPR108801783(NAGPA)
RTEM120927614(NAGPA)
BBUF120994745(NAGPA)
BGAR122922788(NAGPA)
DRE569719(nagpa)
SRX107713811 107717356
SANH107666791 107668288
SGH107591935 107600512
CCAR109077407 109105040
CAUA113059303 113115929
PPRM120462261(nagpa)
MAMB125243757(nagpa)
IPU108270758(nagpa)
PHYP113526824(nagpa)
SMEO124384956(nagpa)
TFD113644738(nagpa)
AMEX103029606(nagpa)
EEE113573175(nagpa)
TRU101070394(nagpa)
TNGGSTEN00024302G001
LCO104939057(nagpa)
NCC104961681
CGOB115020960 115021408
ELY117265383(nagpa)
EFO125893900(nagpa)
SLUC116064086(nagpa)
PFLV114557234(nagpa)
GAT120810943(nagpa)
PPUG119197602(nagpa)
MSAM119896938(nagpa)
CUD121514144 121514193
ALAT119006021 119006022
MZE101480679(nagpa)
ONL100693112(nagpa)
OAU116325099(nagpa)
OLA101159945(nagpa)
OML112143971(nagpa)
XMA102219487(nagpa)
XCO114142028(nagpa)
XHE116717527(nagpa)
PRET103477595(nagpa)
PFOR103152433(nagpa)
PLAI106955109(nagpa)
PMEI106931299(nagpa)
GAF122831716(nagpa)
CVG107101004
CTUL119774775(nagpa)
GMU124865925(nagpa)
NFU107379282(nagpa)
KMR108240306(nagpa)
ALIM106524898(nagpa)
NWH119409881(nagpa)
AOCE111582435(nagpa)
MCEP125017051(nagpa)
CSEM103388064(nagpa)
POV109646856
HHIP117776373(nagpa)
HSP118114168(nagpa)
LCF108884642 108884663
SDU111234134(nagpa)
SLAL111644714
XGL120784790(nagpa)
HCQ109521111(nagpa)
BPEC110168494(nagpa)
MALB109970085(nagpa)
BSPL114843218(nagpa)
SASA106605373
STRU115179583
OTW112222878(nagpa)
OMY110486709(nagpa)
OGO123997793(nagpa)
ONE115141012(nagpa)
SALP111965050
SNH120048429(nagpa)
CCLU121570023(nagpa)
ELS105019241(nagpa)
SFM108940728(nagpa)
PKI111835813(nagpa)
AANG118234576(nagpa)
LOC102688461(nagpa)
PSPA121314966(nagpa)
ARUT117394761(nagpa)
LCM102354196(NAGPA)
CMK103175131(nagpa)
RTP109924281(nagpa)
BFO118418463 118418493 118429300
BBEL109473510 109473524
CIN100184943
SCLV120335200
SPU105440095 115920328 586707 752960
APLC110980138
SKO100374624 100375501
CSCU111631319
PTEP107453846
SDM118179666
LGILOTGIDRAFT_188920
PCAN112576498
BGT106050303
GAE121389573
HRF124110850 124134411 124137939 124140047 124140048
HRJ124255277 124292369
CRG105325388 105333741 105334859 105344273 117686614 117692361
MYI110446255 110458691
PMAX117335977 117337734 117338013
MMER123548672
OBI106871408
OSN115217778
LAK106160514 106175252
NVE5508554 5508574
EPA110253013
ATEN116300591
ADF107358275
AMIL114955467
PDAM113675618
SPIS111321003
DGT114516917
XEN124436643
HMG100202760
TADTRIADDRAFT_13000 TRIADDRAFT_13425
AQU100641351 100641951 109580194
MBRMONBRDRAFT_29045 MONBRDRAFT_37217
SREPTSG_04212 PTSG_12365
NGRNAEGRDRAFT_56913
 » show all
Reference
1
  Authors
Van den Tweel, W.J.J., Smits, J.P., Ogg, R.L.H.P. and de Bont, J.A.M.
  Title
The involvement of an enantioselective transaminase in the metabolism of D-3- and D-4-hydroxyphenylglycine in Pseudomonas putida.
  Journal
Appl Microbiol Biotechnol 29:224-230 (1988)
Reference
2  [PMID:4399430]
  Authors
van der Drift C, van Helvoort PE, Vogels GD.
  Title
S-ureidoglycolate dehydrogenase: purification and properties.
  Journal
Arch Biochem Biophys 145:465-9 (1971)
DOI:10.1016/S0003-9861(71)80006-1
Reference
3  [PMID:237557]
  Authors
Van der Drift L, Vogels GD, Van der Drift C.
  Title
Allantoin racemase: a new enzyme from Pseudomonas species.
  Journal
Biochim Biophys Acta 391:240-8 (1975)
DOI:10.1016/0005-2744(75)90170-9
Reference
4  [PMID:6263889]
  Authors
Waheed A, Hasilik A, von Figura K.
  Title
Processing of the phosphorylated recognition marker in lysosomal enzymes. Characterization and partial purification of a microsomal alpha-N-acetylglucosaminyl phosphodiesterase.
  Journal
J Biol Chem 256:5717-21 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.4.45
IUBMB Enzyme Nomenclature: 3.1.4.45
ExPASy - ENZYME nomenclature database: 3.1.4.45
BRENDA, the Enzyme Database: 3.1.4.45
CAS: 75788-84-0

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