KEGG   ENZYME: 3.1.4.52
Entry
EC 3.1.4.52                 Enzyme                                 

Name
cyclic-guanylate-specific phosphodiesterase;
cyclic bis(3'->5')diguanylate phosphodiesterase;
c-di-GMP-specific phosphodiesterase;
c-di-GMP phosphodiesterase;
phosphodiesterase (misleading);
phosphodiesterase A1;
PDEA1;
VieA
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
Sysname
cyclic bis(3'->5')diguanylate 3'-guanylylhydrolase
Reaction(IUBMB)
cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine [RN:R08991]
Reaction(KEGG)
R08991
Substrate
cyclic di-3',5'-guanylate [CPD:C16463];
H2O [CPD:C00001]
Product
5'-phosphoguanylyl(3'->5')guanosine [CPD:C18076]
Comment
Requires Mg2+ or Mn2+ for activity and is inhibited by Ca2+ and Zn2+. Contains a heme unit. This enzyme linearizes cyclic di-3',5'-guanylate, the product of EC 2.7.7.65, diguanylate cyclase and an allosteric activator of EC 2.4.1.12, cellulose synthase (UDP-forming), rendering it inactive [1]. It is the balance between these two enzymes that determines the cellular level of c-di-GMP [1].
History
EC 3.1.4.52 created 2008
Orthology
K07181  c-di-GMP phosphodiesterase
K13243  c-di-GMP-specific phosphodiesterase
K13244  c-di-GMP-specific phosphodiesterase
K13245  c-di-GMP-specific phosphodiesterase
K13246  c-di-GMP phosphodiesterase
K14051  c-di-GMP phosphodiesterase Gmr
K20962  c-di-GMP phosphodiesterase
K20963  c-di-GMP phosphodiesterase
K20964  c-di-GMP phosphodiesterase
K20965  c-di-GMP phosphodiesterase
K20966  c-di-GMP phosphodiesterase
K21024  c-di-GMP phosphodiesterase
K21086  c-di-GMP phosphodiesterase
K21090  c-di-GMP phosphodiesterase
Genes
API: 107885300
PXB: 108866923
ECO: b0315(pdeL) b1285(pdeR) b1489(dosP) b1815(pdeD) b3525(pdeH)
ECJ: JW0307(yahA) JW1278(gmr) JW1484(dos) JW1804(yoaD) JW3493(yhjH)
ECD: ECDH10B_0302(yahA) ECDH10B_1402(gmr) ECDH10B_1620(dos) ECDH10B_1953(yoaD) ECDH10B_3702(yhjH)
EBW: BWG_1117(gmr) BWG_1310(dos) BWG_1628(yoaD) BWG_3214(yhjH)
ECOK: ECMDS42_0238(yahA) ECMDS42_1083(gmr) ECMDS42_1201(dos) ECMDS42_1489(yoaD) ECMDS42_2960(yhjH)
ECE: Z0403(yahA) Z2220 Z2516(yciR) Z2858 Z4939(yhjH)
ECS: ECs0363 ECs1858 ECs2524 ECs4405
ECF: ECH74115_0378 ECH74115_2544 ECH74115_4888
ETW: ECSP_0371(yahA) ECSP_1806(gmr) ECSP_2388(yoaD) ECSP_4515(yhjH)
EOI: ECO111_0350(yahA) ECO111_1879(dos) ECO111_2321(yoaD) ECO111_4339(yhjH)
EOJ: ECO26_0350(yahA) ECO26_1852(gmr) ECO26_2087(dos) ECO26_2584(yoaD) ECO26_4615(yhjH)
EOH: ECO103_0293(yahA) ECO103_1449(gmr) ECO103_2004(yoaD) ECO103_4253(yhjH)
ECG: E2348C_0277(yahA) E2348C_1478(gmr) E2348C_1617(dos) E2348C_1938(yoaD) E2348C_3767(yhjH)
EOK: G2583_0420(yahA) G2583_1627(gmr) G2583_1852(dos) G2583_2263(yoaD) G2583_4261(yhjH)
ECR: ECIAI1_0313(yahA) ECIAI1_1310(gmr) ECIAI1_1499(dos) ECIAI1_1884(adrB) ECIAI1_3675(yhjH)
ECQ: ECED1_1496(gmr) ECED1_1635(dos) ECED1_2018(adrB) ECED1_4203(yhjH)
EUM: ECUMN_0354(yahA) ECUMN_1589(gmr) ECUMN_1743(dos) ECUMN_2107(adrB) ECUMN_4026(yhjH)
EOC: CE10_0280(yahA) CE10_1529(gmr) CE10_2098(adrB) CE10_4070(yhjH) CE10_4853
EBR: ECB_00271(yahA) ECB_01262(yciR) ECB_01447(dos) ECB_01785(yoaD) ECB_03373(yhjH)
EBL: ECD_00271(yahA) ECD_01262(gmr) ECD_01447(dosP) ECD_01785(yoaD) ECD_03373(yhjH)
EBE: B21_00274(yahA) B21_01273(gmr) B21_01459(dos) B21_01773(yoaD) B21_03326(yhjH)
ECC: c0435 c1246 c1756(yciR) c1918 c2221(yoaD) c4336(yhjH)
EKF: KO11_05140(yhjH) KO11_13640(adrB) KO11_16390(gmr) KO11_22020(yahA)
ELW: ECW_m0390(yahA) ECW_m1380(gmr) ECW_m1617(dos) ECW_m1985(yoaD) ECW_m3788(yhjH)
ELL: WFL_01915(yahA) WFL_06725(gmr) WFL_07915(dosP) WFL_09750(adrB) WFL_18500(yhjH)
ELF: LF82_0512(dos) LF82_0904(gmr) LF82_2511(yahA) LF82_3324(yhjH) LF82_3594(yoad)
ECOI: ECOPMV1_00318(yahA) ECOPMV1_01076(cdgR_1) ECOPMV1_01484(gmr_1) ECOPMV1_01623(dosP) ECOPMV1_01907(ycgG_2) ECOPMV1_03857(yhjH)
EFE: EFER_1261(adrB) EFER_1580(dos) EFER_1668(gmr) EFER_2670(yahA) EFER_3508(yhjH)
STY: STY1349 STY1957 STY4192(yhjH)
STT: t1050 t1616 t3906(yhjH)
STM: STM1703(yciR) STM1827 STM3611(yhjH)
SEO: STM14_2058(yciR) STM14_2209 STM14_4346(yhjH)
SEJ: STMUK_1673(yciR) STMUK_1800 STMUK_3596(yhjH)
SPT: SPA1046 SPA1174(yciR) SPA3467(yhjH)
SEI: SPC_1902 SPC_2029(yciR) SPC_3685(yhjH)
SEC: SCH_1697(yciR) SCH_1821(yoaD) SCH_3545(yhjH)
SEG: SG1290 SG1410(yciR) SG3825(yhjH)
SEL: SPUL_1512
SET: SEN1210 SEN1329(yciR) SEN3434(yhjH)
SFL: SF1413 SF3558(yhjH)
SFX: S1528 S4210(yhjH)
SFE: SFxv_1600(yoaD) SFxv_3876(yhjH)
SFT: NCTC1_01514(yoaD) NCTC1_01884(dosP) NCTC1_03839(yhjH_2)
SDY: SDY_4545(yhjH)
EEC: EcWSU1_02494(gmr) EcWSU1_02739(adrB) EcWSU1_04315(yhjH)
EBG: FAI37_07970(pdeH) FAI37_16755(pdeR)
CTU: CTU_09190 CTU_23300(gmr) CTU_24980(yoaD) CTU_40260(yhjH)
KPN: KPN_02331(yoaD) KPN_03274
KPX: PMK1_00757(yhjH_1) PMK1_03499(yhjH_2) PMK1_04693(adrB_3) PMK1_c00063(yhjH)
REE: electrica_00839(yhjH_1) electrica_01913(adrB_2) electrica_02082(yhjH_2)
CLAP: NCTC11466_01885(gmr_1) NCTC11466_04725(yhjH)
YPE: YPO3988
YPK: y3841
YPH: YPC_4497(yhjH)
YPA: YPA_3816
YPN: YPN_3638
YPM: YP_3351(rtn3)
YPZ: YPZ3_2177
YPD: YPD4_3509
YPX: YPD8_3515
YPW: CH59_1936
YPJ: CH55_2668
YPV: BZ15_3717
YPL: CH46_1069
YPS: YPTB3828
YPO: BZ17_2757
YPY: YPK_0103
YPB: YPTS_4043
YPQ: DJ40_2566(yhjH)
YPU: BZ21_3181
YPR: BZ20_2263
YPC: BZ23_3456
YPF: BZ19_3316
YEW: CH47_1008 CH47_3455(gmr) CH47_3670(yhjH)
YFR: AW19_1672 AW19_3200(gmr) AW19_3393(yhjH)
SRL: SOD_c13970(yhjH1) SOD_c26540(adrB) SOD_c45460(gmr) SOD_c45520(yhjH)
SPLY: Q5A_007585(yhjH) Q5A_014725(adrB_1) Q5A_024600(gmr_3)
ECA: ECA3271
PATR: EV46_16220
PATO: GZ59_32880
PCT: PC1_3065
PEC: W5S_1120
PPUJ: E2566_15795(pdeH)
SOD: Sant_3586
DDD: Dda3937_03856(yhjH)
DDQ: DDI_3038
DAQ: DAQ1742_01058(ecpC)
DIC: Dpoa569_000889(pdeH)
EAM: EAMY_3596(yhjH)
EAY: EAM_3378
ETA: ETA_33310 ETA_33830(yhjH)
EPY: EpC_35920
EPR: EPYR_03863(yhjH)
ERJ: EJP617_10700(yhjH)
EGE: EM595_1936(gmr) EM595_2047(adrB) EM595_3344(yhjH)
PAM: PANA_0139(yhjH) PANA_2043(yciR) PANA_2143(yoaD)
PLF: PANA5342_2028(yoaD) PANA5342_2130(yciR3) PANA5342_4286(yhjH)
PAJ: PAJ_1367(yciR) PAJ_1462(yoaD) PAJ_3299(yhjH)
PVA: Pvag_1481(yciR) Pvag_1588(yoaD) Pvag_3374(yhjH)
MINT: C7M51_01409(gmr) C7M51_01516(adrB_1) C7M51_03681(yhjH)
MTHI: C7M52_01233(adrB_2) C7M52_01339(gmr) C7M52_03344(yhjH)
TPTY: NCTC11468_03320(yhjH)
ETD: ETAF_2069 ETAF_3059(yhjH)
PPR: PBPRA0139(VP1147) PBPRA0620(VV2690) PBPRA1523
PAE: PA4367(bifA)
PMK: MDS_3651
PRE: PCA10_46820(bifA)
PPSE: BN5_1136
PCQ: PcP3B5_50120(adrB) PcP3B5_52380(cph2_12)
PPU: PP_0914
PPX: T1E_0120(ycgG) T1E_1924
PPUN: PP4_08860(bifA) PP4_28480
PSB: Psyr_4060
PSYR: N018_04895
PSES: PSCI_2910
PSET: THL1_4712
ACC: BDGL_000569(dos)
SDN: Sden_1018
SPL: Spea_3056
SHL: Shal_3143
SWD: Swoo_3557
SWP: swp_1222
SVO: SVI_3285
SPSW: Sps_04242
MAQ: Maqu_2024
MHC: MARHY1278
MARJ: MARI_16890
AAUS: EP12_07865
GNI: GNIT_3295
GPS: C427_3207
FBL: Fbal_1243
MVS: MVIS_2781
LPH: LPV_1322
LPO: LPO_1183
LPC: LPC_0633
LPA: lpa_01821
LHA: LHA_2945
LLG: 44548918_01418(ycgG)
METL: U737_16815
MMAI: sS8_2618
TCX: Tcr_0860
MEC: Q7C_1588
AEH: Mlg_2066
HHK: HH1059_13260(yuxH)
GAI: IMCC3135_28215(gmr_4)
HCO: LOKO_01370(cph2_7) LOKO_02376(cph2_15)
HBE: BEI_3628
AXE: P40_16165
TAU: Tola_0006
SALN: SALB1_1849
LHK: LHK_01115
PSE: NH8B_2649
BCN: Bcen_5008
BCEN: DM39_4582(gmr) DM39_6865
BCEW: DM40_3500 DM40_3641(gmr)
BCEO: I35_4139 I35_4474(rpfR)
BMK: DM80_4300(gmr) DM80_4469
BCED: DM42_4511(gmr) DM42_5021
BDL: AK34_4835
BUB: BW23_4297
BSTG: WT74_21925
BXE: Bxe_B1152
BXB: DR64_6470(gmr)
PPNO: DA70_15880
PPNM: LV28_14790
PSPU: NA29_04750
PAPI: SG18_09505
PLG: NCTC10937_01216(cph2_4)
BPT: Bpet1368
BHO: D560_1507
BHM: D558_1499
BHZ: ACR54_04554(adrB_2)
AXY: AXYL_02488(gmr)
AXX: ERS451415_02266(gmr_2)
AAV: Aave_4432
AAA: Acav_4326
HYB: Q5W_01870
HPSE: HPF_20155
OFO: BRW83_0024(pdeB)
AZO: azo1430
AOA: dqs_1554
SULC: CVO_04240
CFZ: CSG_6530
CHYO: CHH_1143
CSPF: CSF_1020
ATP: ATR_0259
APOC: APORC_1940
DAS: Daes_2729
DALK: DSCA_24260
SCL: sce1189
RAK: A1C_01795
RMS: RMA_0338
RJA: RJP_0261
RRE: MCC_02440
RAS: RAS_03970
SME: SMc00992
SMER: DU99_04430
SMD: Smed_0472
SFD: USDA257_c05720(mbaA)
SAME: SAMCFNEI73_Ch0900(mbaA)
EAD: OV14_1792
SHZ: shn_05985
BRA: BRADO0501
BBT: BBta_7681
BRS: S23_69150
AOL: S58_71590
BRAD: BF49_7293
RPC: RPC_4696
RPT: Rpal_0851
NHA: Nham_3276
OCA: OCAR_7505
BBAR: RHAL1_03548(gmr)
CCR: CC_3396
CCS: CCNA_03507(pdeA)
CAK: Caul_4493
CSE: Cseg_0294
PZU: PHZ_c0552
SAL: Sala_1771
SMAZ: LH19_00920
SPHU: SPPYR_3079
SPHT: K426_09585
AAY: WYH_03126(dosP)
GDI: GDI2590
GDJ: Gdia_0821
KSC: CD178_01268(dosP_2) CD178_01337(dosP_3) CD178_02739(dosP_6)
ACU: Atc_1558
HTL: HPTL_0653
BPUS: UP12_14985
PSYO: PB01_14845
BSE: Bsel_2406
JEO: JMA_36580
LAC: LBA1415
LAD: LA14_1413
LAF: SD55_1399
CBE: Cbei_2527
CBZ: Cbs_2527
CBEI: LF65_02999
CKL: CKL_0409
CKR: CKR_0358
CBV: U729_130
RUM: CK1_07140
BFI: CIY_18220
BHU: bhn_I1005
CCT: CC1_14850
BPRL: CL2_21500
HSD: SD1D_1329
CPRO: CPRO_17010
EHL: EHLA_0466
PFT: JBW_00932
STED: SPTER_43070(pdeB)
ACL: ACL_1183
NAZ: Aazo_4226
BLQ: L21SP5_00638(pdhS_1)
LOKI: Lokiarch_29610(kdpD) Lokiarch_43950(sasA_3)
 » show all
Reference
1  [PMID:11297407]
  Authors
Chang AL, Tuckerman JR, Gonzalez G, Mayer R, Weinhouse H, Volman G, Amikam D, Benziman M, Gilles-Gonzalez MA.
  Title
Phosphodiesterase A1, a regulator of cellulose synthesis in Acetobacter xylinum, is a heme-based sensor.
  Journal
Biochemistry 40:3420-6 (2001)
DOI:10.1021/bi0100236
Reference
2  [PMID:15994307]
  Authors
Christen M, Christen B, Folcher M, Schauerte A, Jenal U.
  Title
Identification and characterization of a cyclic di-GMP-specific phosphodiesterase and its allosteric control by GTP.
  Journal
J Biol Chem 280:30829-37 (2005)
DOI:10.1074/jbc.M504429200
  Sequence
[ccr:CC_3396]
Reference
3  [PMID:15995192]
  Authors
Schmidt AJ, Ryjenkov DA, Gomelsky M.
  Title
The ubiquitous protein domain EAL is a cyclic diguanylate-specific phosphodiesterase: enzymatically active and inactive EAL domains.
  Journal
J Bacteriol 187:4774-81 (2005)
DOI:10.1128/JB.187.14.4774-4781.2005
  Sequence
[eco:b1489 b0315]
Reference
4  [PMID:16081414]
  Authors
Tamayo R, Tischler AD, Camilli A.
  Title
The EAL domain protein VieA is a cyclic diguanylate phosphodiesterase.
  Journal
J Biol Chem 280:33324-30 (2005)
DOI:10.1074/jbc.M506500200
Other DBs
ExplorEnz - The Enzyme Database: 3.1.4.52
IUBMB Enzyme Nomenclature: 3.1.4.52
ExPASy - ENZYME nomenclature database: 3.1.4.52
BRENDA, the Enzyme Database: 3.1.4.52
CAS: 338732-46-0

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