KEGG   ENZYME: 3.1.4.57Help
Entry
EC 3.1.4.57                 Enzyme                                 

Name
phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase;
cyclic phosphate dihydrolase;
phnPP (gene name)
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
BRITE hierarchy
Sysname
5-phospho-alpha-D-ribose 1,2-cyclic phosphate 1,2-diphosphophosphohydrolase
Reaction(IUBMB)
(1) 5-phospho-alpha-D-ribose 1,2-cyclic phosphate + H2O = D-ribofuranose 2,5-bisphosphate [RN:R10972];
(2) D-ribofuranose 2,5-bisphosphate + H2O = D-ribofuranose 5-phosphate + phosphate [RN:R10973]
Reaction(KEGG)
Substrate
5-phospho-alpha-D-ribose 1,2-cyclic phosphate [CPD:C20440];
H2O [CPD:C00001];
D-ribofuranose 2,5-bisphosphate
Product
D-ribofuranose 2,5-bisphosphate;
D-ribofuranose 5-phosphate;
phosphate [CPD:C00009]
Comment
The enzyme, characterized from the bacterium Eggerthella lenta, is involed in degradation of methylphosphonate.
History
EC 3.1.4.57 created 2014
Pathway
ec00440  Phosphonate and phosphinate metabolism
Orthology
K20859  phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase
Genes
BON: A361_16710
OIH: OB0975
LGY: T479_13155
VHL: BME96_18175
LAO: AOX59_16425
SHV: AAT16_04630
PTA: HPL003_21630
BTS: Btus_3094
PKU: AUO94_01265
PANA: BBH88_04250
CPAS: Clopa_3535
PDC: CDIF630_03845(phnPP)
ELE: Elen_0235
AEQ: AEQU_1669
 » show all
Taxonomy
Reference
1  [PMID:24147537]
  Authors
Ghodge SV, Cummings JA, Williams HJ, Raushel FM
  Title
Discovery of a cyclic phosphodiesterase that catalyzes the sequential hydrolysis  of both ester bonds to phosphorus.
  Journal
J Am Chem Soc 135:16360-3 (2013)
DOI:10.1021/ja409376k
  Sequence
[ele:Elen_0235]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.4.57
IUBMB Enzyme Nomenclature: 3.1.4.57
ExPASy - ENZYME nomenclature database: 3.1.4.57
BRENDA, the Enzyme Database: 3.1.4.57

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