KEGG   ENZYME: 3.1.4.57
Entry
EC 3.1.4.57                 Enzyme                                 
Name
phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase;
cyclic phosphate dihydrolase;
phnPP (gene name)
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
Sysname
5-phospho-alpha-D-ribose 1,2-cyclic phosphate 1,2-diphosphophosphohydrolase
Reaction(IUBMB)
(1) 5-phospho-alpha-D-ribose 1,2-cyclic phosphate + H2O = D-ribofuranose 2,5-bisphosphate [RN:R10972];
(2) D-ribofuranose 2,5-bisphosphate + H2O = D-ribofuranose 5-phosphate + phosphate [RN:R10973]
Reaction(KEGG)
R10972 R10973
Substrate
5-phospho-alpha-D-ribose 1,2-cyclic phosphate [CPD:C20440];
H2O [CPD:C00001];
D-ribofuranose 2,5-bisphosphate
Product
D-ribofuranose 2,5-bisphosphate;
D-ribofuranose 5-phosphate;
phosphate [CPD:C00009]
Comment
The enzyme, characterized from the bacterium Eggerthella lenta, is involed in degradation of methylphosphonate.
History
EC 3.1.4.57 created 2014
Pathway
ec00440  Phosphonate and phosphinate metabolism
Orthology
K20859  phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase
Genes
PMRPMI2225
PMIBBB2000_2358
PVLAOB99_13045
ORBIPMB12_08225
BONA361_16710
BKOCKF48_11535
CPSSM5V91_04365
OIHOB0975
OCNCUC15_18900
OCBCV093_20380
LGYT479_13155
LCAPICJ70_14495
HNZP9989_08555
HSHIMUO14_07010
VHLBME96_18175
VIGBKP57_09550
VNECFK40_19470
VPNA21D_01679
VPTKBP50_21000
VIKKFZ58_16355
LAOAOX59_16425
PFRIL8956_19315
RAXKO561_19445
GRCGI584_22750
MEKUHUW50_12535
MSEMGMB29_03820
MDGK8L98_07815
ALKLMM271_07270
STEAC0679_00925
SHVAAT16_04630
JEAJEM45_10180
BCHSJNE38_07990
PTAHPL003_21630
PVOPVOR_21494
PPSCEHS13_07605
PLYCGXP70_25175
COHNKCTCHS21_53240
BTSBtus_3094
KYRCVV65_15305
EFFskT53_05480
PKUAUO94_01265
PANABBH88_04250
PFAEAJGP001_16440
NTRB0W44_15275
EFTM395_05000
EMUEMQU_2192
VPIBW732_08205
CRNCAR_c04960
CBACLB_0694
CBHCLC_0709
CBYCLM_0769
CBLCLK_0057
CBBCLD_0101
CBICLJ_B0727
CBFCLI_0732
CBMCBF_0700
CBJH04402_00728
CPASClopa_3535 Clopa_4267
CPATCLPA_c34290
CPAECPAST_c34290
CLDCLSPO_c06830
FSAC5Q98_00455
RBPB6259_05855
ESRES1_20910
ESUEUS_09310
CCELCCDG5_0088
EHAEthha_2741
RALRumal_0453
RCHRUM_21690
RUSRBI_I01096
FPRFP2_18910
FPRACG447_02550
FDUGXM22_06330
CAPREQM14_08565
CAMLH6X83_07695
CLFGJQ69_04680
SMANC12CBH8_01850
CFEMHCR03_01790
ACOLK5I23_14945
TMELNOG13_04145
PALMRBG61_01655
CHYLCE91St63_31710
ARFAR1Y2_3080
ACACEYQ97_02465
CDFCD630_35310
PDCCDIF630_03845(phnPP)
CDCCD196_3320
CDLCDR20291_3366
PDFCD630DERM_35310
FAAHMPREF0389_01627
DAIDesaci_1741
TFRBR63_00785
FWADCMF_19485
APRApre_0404
PFACPFJ30894_00322
AARGAargi30884_26100
ABSIA9CBEGH2_23420
ERBA4V01_17290
TURAT726_10395
TSGHLK68_10410
TBBJ0J69_00205
CIUG4D55_14195
ERMEYR00_04625
TSFNQ543_05765
ELEElen_0235
EGDGS424_001325
AEQAEQU_1669
RTSCE91St31_31500
CSOMMKD34_04725
 » show all
Reference
1  [PMID:24147537]
  Authors
Ghodge SV, Cummings JA, Williams HJ, Raushel FM
  Title
Discovery of a cyclic phosphodiesterase that catalyzes the sequential hydrolysis of both ester bonds to phosphorus.
  Journal
J Am Chem Soc 135:16360-3 (2013)
DOI:10.1021/ja409376k
  Sequence
[ele:Elen_0235]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.4.57
IUBMB Enzyme Nomenclature: 3.1.4.57
ExPASy - ENZYME nomenclature database: 3.1.4.57
BRENDA, the Enzyme Database: 3.1.4.57

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