KEGG   ENZYME: 3.1.6.12
Entry
EC 3.1.6.12                 Enzyme                                 
Name
N-acetylgalactosamine-4-sulfatase;
chondroitinsulfatase;
chondroitinase;
arylsulfatase B;
acetylgalactosamine 4-sulfatase;
N-acetylgalactosamine 4-sulfate sulfohydrolase
Class
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
Sysname
N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase
Reaction(IUBMB)
Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate [RN:R07823]
Reaction(KEGG)
R07823(G)
Comment
Acts also on N-acetylglucosamine 4-sulfate.
History
EC 3.1.6.12 created 1984
Pathway
ec00531  Glycosaminoglycan degradation
ec01100  Metabolic pathways
Orthology
K01135  arylsulfatase B
Genes
HSA411(ARSB)
PTR737316(ARSB)
PPS100987929(ARSB)
GGO101138081(ARSB)
PON100457196(ARSB)
NLE100587589(ARSB)
MCC709136(ARSB)
MCF102116401(ARSB)
CSAB103223561(ARSB)
CATY105599169(ARSB)
PANU101021373(ARSB)
TGE112626855(ARSB)
RRO104662974(ARSB)
RBB108528898(ARSB)
TFN117065308(ARSB)
PTEH111544427(ARSB)
CJC100394090(ARSB)
SBQ101045515(ARSB)
CSYR103256040(ARSB)
MMUR105872644(ARSB)
OGA100944911(ARSB)
MMU11881(Arsb)
MCAL110308214(Arsb)
MPAH110328948(Arsb)
RNO25227(Arsb)
MCOC116083781(Arsb)
MUN110558794
CGE100759794(Arsb)
PLEU114694634(Arsb)
NGI103750289(Arsb)
HGL101719731(Arsb)
CPOC100724077(Arsb)
CCAN109675293(Arsb)
DORD105985324(Arsb)
DSP122117171(Arsb)
NCAR124987087
OCU103346484(ARSB) 103346606
OPI101525191(ARSB)
TUP102469500(ARSB)
CFA610364(ARSB)
VVP112919590(ARSB)
VLG121489777(ARSB)
AML100467836(ARSB)
UMR103681492(ARSB)
UAH113255173(ARSB)
UAR123791539(ARSB)
ELK111148285
LLV125101095
MPUF101683721(ARSB)
ORO101374250(ARSB)
EJU114217566(ARSB)
ZCA113929257(ARSB)
MLX118016931(ARSB)
FCA100216331(ARSB)
PYU121014037(ARSB)
PBG122490184(ARSB)
PTG102963642(ARSB)
PPAD109274943
AJU106974796(ARSB)
HHV120242010(ARSB)
BTA538401(ARSB)
BOM102279001(ARSB)
BIU109564662(ARSB)
BBUB102401475(ARSB)
CHX102189402(ARSB)
OAS101108314(ARSB)
ODA120852580(ARSB)
CCAD122443004(ARSB)
SSC102158016(ARSB)
CFR102507706(ARSB)
CBAI105064445(ARSB)
CDK105084869(ARSB)
VPC102542651(ARSB)
BACU103001911(ARSB)
LVE103080763(ARSB)
OOR101281243(ARSB)
DLE111184985(ARSB)
PCAD102973706(ARSB)
PSIU116750874(ARSB)
ECB100073268(ARSB)
EPZ103548666(ARSB)
EAI106841176(ARSB)
MYB102252145(ARSB)
MYD102758054(ARSB)
MMYO118656318(ARSB)
MLF102418809(ARSB)
PKL118703141(ARSB)
HAI109381893(ARSB)
DRO112307472(ARSB)
SHON118977498(ARSB)
AJM119048141(ARSB)
PDIC114509932(ARSB)
PHAS123824714(ARSB)
MMF118641716(ARSB)
RFQ117025064(ARSB)
PALE102887255(ARSB)
PGIG120612465(ARSB)
PVP105303556(ARSB)
RAY107497236(ARSB)
MJV108398416(ARSB)
TOD119261443(ARSB)
SARA101544267(ARSB)
LAV100665589(ARSB)
TMU101359357
DNM101439191(ARSB)
MDO100032622(ARSB)
GAS123251609(ARSB)
SHR100931900(ARSB)
PCW110216573(ARSB)
OAA100088121(ARSB)
GGA771459(ARSB)
PCOC116239909(ARSB)
MGP104914958
CJO107305934(ARSB)
NMEL110389380(ARSB)
APLA101802978(ARSB)
ACYG106042122(ARSB)
TGU100228383(ARSB)
LSR110479755(ARSB)
SCAN103819543(ARSB)
PMOA120502485(ARSB)
OTC121341252(ARSB)
PRUF121355467(ARSB)
GFR102044758(ARSB)
FAB101813661(ARSB)
PHI102102961(ARSB)
PMAJ107216097(ARSB)
CCAE111941403(ARSB)
CCW104695689(ARSB)
ETL114057492(ARSB)
ZAB102071314(ARSB)
FPG101910790(ARSB)
FCH102049359(ARSB)
CLV102091560(ARSB)
EGZ104124897(ARSB)
NNI104017612(ARSB)
ACUN113489665(ARSB)
TALA104364260(ARSB)
PADL103919762(ARSB)
ACHC115337076(ARSB)
AAM106487821
AROW112967353(ARSB)
NPD112944074(ARSB)
DNE112987068(ARSB)
ASN102377963(ARSB)
AMJ106737251(ARSB)
CPOO109307999(ARSB)
GGN109297736(ARSB)
PSS102445150(ARSB)
CMY102947173(ARSB)
CPIC101938081(ARSB)
TST117879473(ARSB)
CABI116821374(ARSB)
MRV120408208(ARSB)
ACS100564703(arsb)
PVT110084605(ARSB)
SUND121923514(ARSB)
PBI103060554(ARSB)
PMUR107287875(ARSB)
TSR106544488(ARSB)
PGUT117679273(ARSB)
VKO123031421(ARSB)
PMUA114606559(ARSB)
ZVI118076774(ARSB)
GJA107117399(ARSB)
XLA108717994(arsb.L)
XTR100493013(arsb)
NPR108799973(ARSB)
RTEM120929350 120934180
BBUF120992416(ARSB)
BGAR122924736 122929500
DRE100538007(arsb)
SRX107724712(arsb)
SANH107694537(arsb)
SGH107574102(arsb)
CCAR109046309
CAUA113080754 113090446
IPU108279373
PHYP113543096(arsb)
SMEO124397530
TFD113638612
AMEX103041418(arsb)
EEE113590451(arsb)
TRU101061832(arsb)
LCO104926623(arsb)
NCC104966860(arsb)
CGOB115016356(arsb)
ELY117269428(arsb)
PLEP121959498 121960059 121960060
SLUC116062810(arsb)
ECRA117959335(arsb)
PFLV114571405(arsb)
GAT120831501(arsb)
PPUG119226902(arsb)
MSAM119914678(arsb)
CUD121524630(arsb)
MZE101485324(arsb)
ONL100697368(arsb)
OAU116315912(arsb)
OLA101169377(arsb)
OML112162825(arsb)
XMA102227522(arsb)
XCO114149560(arsb)
XHE116724800(arsb)
PRET103473308(arsb)
PFOR103135837(arsb)
PLAI106952255(arsb)
PMEI106916211(arsb)
GAF122819373(arsb)
CVG107093772(arsb)
CTUL119788261(arsb)
GMU124872022(arsb)
NFU107374848(arsb)
KMR108251298(arsb)
ALIM106515071(arsb)
NWH119424603
AOCE111570347(arsb)
CSEM103390009 103390010 103390011 103390012 103390027
POV109626042(arsb)
SSEN122758285 122787021
HHIP117771690(arsb)
LCF108895444(arsb)
SDU111239020(arsb)
SLAL111666800(arsb)
XGL120806123(arsb)
HCQ109517689(arsb)
BPEC110157319(arsb)
MALB109953005(arsb)
SASA100380367(arsb)
OTW112230814(arsb)
OMY110509666(arsb)
OGO124007397(arsb)
ONE115101010(arsb)
SALP111963905(arsb)
SNH120021268(arsb)
ELS105015172(arsb)
SFM108925070(arsb)
PKI111849813(arsb)
AANG118213303(arsb)
LOC102689449(arsb)
PSPA121313665
ARUT117403499 117403810
LCM102353782(ARSB)
CMK103177857(arsb)
RTP109923016(arsb)
BFO118403590 118403591 118404651 118405951 118407366 118407458 118410571 118410754 118411641 118412106 118422400 118428666 118428667 118428764 118429766 118430529 118430580
BBEL109463755 109468779 109468929 109470497 109470804 109474268 109474711 109474717 109478262 109482381 109482383 109482418 109483559
CIN100185884 100187202 100187242
SCLV120328676 120334404 120334405 120345394
SPU100891337 105439655 115918901 115925932 583464 583878 584709 586205 587189 591704
APLC110978032 110982778 110982779 110984133 110984141 110984263 110986227
SKO100367265 100367284 100367451 100367841 100367915 100368065 100368130 100368255 100368279 100368400 100368517 100368670 100369267 100369301 100369410 100369474 100369888 100370868 100371460 100371615 100371768 100372000 100373029 100373229 100373276 100373562 100373775 100374292 100374639 100374997 100375292 100375535 100376019 100377092 100377632 100377677 100377827 100378421 100378661 100378747 100378957 102801346 102801374 102804222 102804409 102805297 102805475 102805529 102805609 102805724 102805842 102805902 102806010 102806349 102806641 102807117 102807169 102808053 102808173 102809375 102809734 102810355
DMEDmel_CG7402(CG7402) Dmel_CG8646(CG8646)
DER6546392
DSE6606148
DSIDsimw501_GD14734(Dsim_GD14734)
DYADyak_GE19935
DAN6507210
DSR110178876
DPODpse_GA21235 Dpse_GA23896
DPE6590802 6598916
DMN108160908 108165341
DWI6640948 6645691
DGR6568659
DMODmoj_GI18487
DNV108653866
DHE111593491 111593520
CCAT101455257 101460904
BOD106616381 106617878
MDE101894738
SCAC106088675 106094181
LCQ111681211
AGAAgaP_AGAP011347 AgaP_AGAP011348 AgaP_AGAP012047
ACOZ120957632 120958921 120960151
AARA120899659 120902632 120903652
AAG110680266 23687612 23687723 5566067 5579667
AALB109422334
CQUCpipJ_CPIJ006774 CpipJ_CPIJ006775 CpipJ_CPIJ011047
CPII120425168 120425250 120425252
CNS116345933 116348944
AME411657 412829 551758 552073
ACER107995018 107997858 107997901 108002824
ALAB122714583 122714816 122714874 122718585
BIM100743595 100745153 100745993 100748801
BBIF117206761 117211943 117211944 117213786
BVK117234384 117236804 117239095 117239096
BVAN117155672 117166011 117166012 117166419
BTER100646129 100646246 100647958 100650037
BPYO122568369 122574873 122576984 122576985
CCAL108623175 108626707 108627331
OBB114880106 114880647 114881981
MGEN117225040
NMEA116427571 116427572 116430149 116434360
CGIG122396570 122396571 122397662 122404843
SOC105195249 105205601 105205602 113004483
MPHA105829515 105829516 105833694
AEC105146955 105153878 105153880
ACEP105618404 105618405 105627005
PBAR105422468 105432242 105433969 105434003
VEM105559557 105562117 105568724 105569613 105569617
HST105180566 105180571 105182628 105191573
DQU106742444 106742445 106742451 106742452 106745848 106749778
CFO105257710 105259242 105259243 105259244
FEX115234886 115234996 115242453
LHU105675071 105675079 105678114
PGC109852204 109856743 109857397
OBO105280178 105283953 105283954 105284162
PCF106787109 106787778 106789725 106791572
PFUC122515469 122517935
VPS122629233 122632238 122632452 122632468
NVI100120225 100120251 100121172 100122775 100123823
CSOL105364395 105364511 105366204 105368206
TPRE106649348 106649349 106649383 106653071 106654388 111694152
MDL103571122 103571123 103572887
CGLO123266786 123273144 123273145
FAS105267368 105267369 105268376 105270229 105274036
DAM107038985 107038987 107039149 107041831 107045965 107046882
AGIF122853211 122856674 122858330
CCIN107266741 107270268 107274117 107274127
TCA659525 659587(ARSB) 664109
DPA109535454 109539982 109541530
SOY115875853 115875967 115888131 115890991
ATD109595271 109595272 109597944 109601898 109605475
CSET123309253 123309294 123320330
AGB108904382 108904791 108911436 108914912 108915058
LDC111504774 111513541 111516033 111516535 111517583
NVL108556673 108557734 108557751 108558186 108561317 108561318
APLN108735083 108741086 108741449 108741453 108744206 112905632
PPYR116162249 116167607 116168515 116168731 116169294 116169302 116169756 116169991
OTU111417801 111423022 111424228 111427329 111427343 111428760
BMOR101737544 101737902
BMAN114239795 114243605 114243622 114243648
MSEX115444077 115444080 115444090 115452542
DPLKGM_211903
BANY112052759 112052761 112053488
PMAC106709565 106717721 106718139
PPOT106103469 106103803 106103804 106104953
PXU106115801 106115802 106123291
PRAP110996498 110996500 110998364 123689095 123689760
ZCE119833604 119838288
HAW110374404 110374783 110375086 110375159
TNL113500687 113501874
OFU114362497 114363964 114363965 114363971 114363974
PXY105382281 105385659 105385673 105385674 105390597(Gss)
API100163725 100167141 100169526
DNX107165744 107168015 107169055
AGS114123259 114126617 114127012 114132461 114132505
RMD113552555 113556052 113556643 113557146
BTAB109036051 109036852 109037766 109039068 109042265 109042336 109042337 109042345 109044026 109044747 109044749
DCI103505129 103507251 103513493 103517846
CLEC106661985 106666275 106666289 106670001 106670042
HHAL106681678 106681679 106681682 106681684 106683444 106690031 106690084 106692685
NLU111044180 111050017 111056249 111058429 111058431
PHUPhum_PHUM168260 Phum_PHUM570670 Phum_PHUM604070 Phum_PHUM616230 Phum_PHUM616890
FOC113203184 113206193 113206506 113209157 113213058
ZNE110827813 110827898 110829584 110830065 110830356 110833850 110834448 110835042 110835045
CSEC111861403 111861404 111861406 111868003 111871491 111874291
FCD110845904
DPXDAPPUDRAFT_303738
DMK116933255
PVM113818036 113818038 113824334 113824571 113824803
PJA122246221 122246236 122257104
PCHN125028157 125032754 125032884
HAME121857808 121870394 121870395
PCLA123745394 123746896 123762128 123762130 123766951 123773237
PTRU123511851 123517602
HAZT108667823 108674596 108680938
EAF111694782 111697676 111705836 111707351 111707359
ISCIscW_ISCW001140 IscW_ISCW003809 IscW_ISCW004669 IscW_ISCW005802 IscW_ISCW006047 IscW_ISCW006919 IscW_ISCW006920 IscW_ISCW006921 IscW_ISCW008712 IscW_ISCW010087 IscW_ISCW011661 IscW_ISCW012148 IscW_ISCW014096 IscW_ISCW014599 IscW_ISCW014600 IscW_ISCW016893 IscW_ISCW019335 IscW_ISCW020211 IscW_ISCW020731 IscW_ISCW022771
DSV119430911 119432438 119432440 119436140 119439986 119440047 119440396 119440530 119440644 119440648 119440649 119440650 119440651 119440652 119440750 119441369 119441569 119441601 119442426 119442428 119443130 119444434 119444954 119444955 119446051 119454087 119454189 119454191 119454192 119459170 119462009 119465002 119465357 119465833
RSAN119372065 119372325 119374230 119374233 119374235 119374237 119375162 119375524 119376481 119377175 119377428 119382172 119385761 119385978 119386005 119386296 119386342 119386347 119386348 119386349 119386350 119386356 119386357 119386365 119386799 119387892 119388139 119388257 119391531 119396287 119397627 119398877 119398878 119398881 119399096 119400816 119401905 119402608 119403670 119405631 119405633
RMP119159502 119159503 119159504 119160159 119160160 119161271 119163461 119164201 119164209 119164609 119165200 119165392 119166300 119166316 119167222 119167274 119167549 119167568 119168428 119169810 119173955 119177853 119177854 119178369 119179410 119185161
VDE111243161 111250929 111251462
VJA111263271 111263711 111272214
TUT107359178
DFR124499221
CSCU111618473 111624330 111624331 111624367 111626041 111627899 111631434 111634628 111634634
PTEP107436815 107436822 107437881 107442262 107455078 107455733 107457152 107457162 107457163 122270221
SDM118184453 118190561 118194754 118196697 118196698 118196699 118198317 118198770
LGILOTGIDRAFT_105309 LOTGIDRAFT_112980 LOTGIDRAFT_124040 LOTGIDRAFT_168762 LOTGIDRAFT_182669 LOTGIDRAFT_197818 LOTGIDRAFT_206748 LOTGIDRAFT_225566 LOTGIDRAFT_235167 LOTGIDRAFT_71987
PCAN112555109 112557037 112557446 112558224 112558739 112558827 112558828 112558937 112559749 112559784 112560458 112560459 112566597 112568594 112573812 112574237 112574451 112575575 112575688
BGT106060780 106067311 106071851 106072562
GAE121371995 121383318 121388441 121390427 121390548
HRF124112232 124112248 124112822 124113120 124113136 124113142 124113149 124113158 124113169 124113181 124113198 124113216 124115269 124115280 124117736 124117737 124117738 124117739 124117740 124118160 124118166 124118167 124118168 124118182 124121090 124121859 124121861 124121939 124121947 124121949 124121950 124122502 124124486 124125959 124125962 124125963 124126041 124126042 124126043 124126044 124126535 124126536 124127423 124128207 124128298 124129227 124129229 124129384 124134912 124134913 124134914 124137818 124142654 124142661 124142672 124142682 124142691 124142705 124142712 124143401 124143421 124143434 124143696 124143795 124143802 124143811 124143822 124143839 124143844 124143845 124143851 124143862 124143874 124145690 124145792 124145805 124145845 124145846 124147767 124147768 124151544 124151545 124151555 124151556 124151559
HRJ124255519 124255520 124255872 124255876 124255877 124255884 124256247 124257483 124257504 124257505 124257506 124264005 124264016 124264027 124264039 124264055 124265677 124265694 124266337 124266346 124266355 124269168 124270485 124270864 124270866 124270868 124270869 124270870 124270872 124270873 124271678 124275215 124275219 124275246 124275249 124275250 124275252 124275253 124275254 124275313 124275314 124275315 124275319 124275324 124275325 124275326 124275731 124277670 124282275 124283334 124283335 124283336 124283338 124283341 124283342 124285715 124286414 124287590 124287599 124287613 124287628 124287866 124287867 124287873 124287875 124287878 124291481
CRG105320184 105320186 105339974 105341749 105345766 105349071 105349072 105349073 117690967
MYI110441366 110446197 110446205 110447882 110447883 110447887 110453798 110453799 110459647 110464404 110464405 110464406 110464407 110464431
PMAX117314550 117321074 117321672 117321740 117322320 117322322 117342043 117342050 117342303
MMER123524425 123524426 123527601 123529033 123529223 123529331 123533174 123535271 123536045 123554240 123554874 123559437 123559558
OBI106871320 106872930 106883114
OSN115210801 115228404
LAK106152974 106160231 106160972 106169745 106174598 106175140 106176485 106181460 112041454
NVE116602018 5498671 5501660 5503369 5503856 5505596 5507089 5510518 5519814
EPA110240881 110244428 110244429 110244430 110251142 110251521 110253174
ATEN116287081 116291801 116295946 116297159 116303021 116305430 116305431 116308962
ADF107327108 107336127 107336130 107336131 107341039 107351713 107353264 107353266
AMIL114952768 114952775 114952793 114958897 114958932 114962210 114963012 114966486 114970384
PDAM113673636 113673638 113675104 113676218 113676334 113676488 113677649 113677788 113678231 113678237 113684900
SPIS111320759 111321416 111322000 111322101 111331497 111333830 111333997 111338690 111342241 111342786
DGT114515982 114528126
XEN124444659 124445399 124445940 124446838 124457929
HMG100212594
AQU100632436 100632563 100632818 100632939 100632944 100633070 100634880 100635593 100636537 100638166 100639099 100640253 100641487 105312142 109581016 109583239
MBRMONBRDRAFT_13917 MONBRDRAFT_16015 MONBRDRAFT_16099(ASB) MONBRDRAFT_2548 MONBRDRAFT_28433 MONBRDRAFT_32685 MONBRDRAFT_891
SREPTSG_00448 PTSG_04073 PTSG_05666 PTSG_08011 PTSG_08687 PTSG_09899
SMINv1.2.004770.t3(symbB.v1.2.004770.t3) v1.2.006990.t1(symbB.v1.2.006990.t1) v1.2.006992.t1(symbB.v1.2.006992.t1) v1.2.025906.t1(symbB.v1.2.025906.t1) v1.2.033030.t1(symbB.v1.2.033030.t1) v1.2.034521.t1(symbB.v1.2.034521.t1)
PTIPHATRDRAFT_42934
FCYFRACYDRAFT_182357(ARSB1)
NGDNGA_0431201(ARSB) NGA_0431202(ARSB)
AAFAURANDRAFT_13369 AURANDRAFT_22180(ARS) AURANDRAFT_23174(ARS13) AURANDRAFT_2359 AURANDRAFT_2707 AURANDRAFT_30634(ARS20) AURANDRAFT_32660(ARS12) AURANDRAFT_33025 AURANDRAFT_66030(ARS6) AURANDRAFT_67258 AURANDRAFT_72312(ARS3)
EHXEMIHUDRAFT_213721 EMIHUDRAFT_222125 EMIHUDRAFT_226193 EMIHUDRAFT_248910 EMIHUDRAFT_433677 EMIHUDRAFT_62301 EMIHUDRAFT_73553
SJASJ2017_1926
PATPatl_0889
OSGBST96_10725
MTHDA3224_10135
MAGAMag101_05810
HJABST95_16145
RBSRHODOSMS8_00747(atsA)
BSYMCIT39_22215
BOSBSY19_414(arsb)
RHZRHPLAN_52420
DPMFNV33_04605
CHREIE160_10675
BRXBH708_11250
BRVCFK39_06980
BGGCFK41_15095
BRZCFK38_04065
BSAUDWV08_16070
CYNCyan7425_1449
ROOG5S37_23450
LUOHHL09_15300
RBARB1475(arsB)
PSLPsta_1162
PIRVN12_02835(atsA_6)
BVOPan97_28610(atsA_35)
AMUCPan181_07500(atsA_6)
FMRFuma_03883(atsA_24)
GIMF1728_19930
FTJFTUN_6165
ULIETAA1_13480(atsA_4)
SACISinac_5718
PBUL21SP3_02067(atsA_28)
PBPSTSP1_01762(atsA_37)
HBSIPV69_11400
OCKEXM22_16245
ASHAL1_00180
MCOSGM418_00935
AGIFSB73_00300
OLIFKG96_22690
ECHIFKX85_19170
RUFTH63_11970
GFLGRFL_1426
FGLEM308_15790
DOKMED134_14677
LVNBWR22_11120
AHZAPS56_01130
MARFCJ739_1062
 » show all
Reference
1  [PMID:976430]
  Authors
Farooqui AA.
  Title
The desulphation of hexosamine sulphates by arylsulphatase B.
  Journal
Experientia 32:1242-4 (1976)
DOI:10.1007/BF01953071
Reference
2  [PMID:738706]
  Authors
Gorham SD, Cantz M.
  Title
Arylsulphatase B, an exo-sulphatase for chondroitin 4-sulphate tetrasaccharide.
  Journal
Hoppe Seylers Z Physiol Chem 359:1811-4 (1978)
Reference
3  [PMID:7370276]
  Authors
Tsuji M, Nakanishi Y, Habuchi H, Ishihara K, Suzuki S.
  Title
The common identity of UDP-N-acetylgalactosamine 4-sulfatase, nitrocatechol sulfatase (arylsulfatase), and chondroitin 4-sulfatase.
  Journal
Biochim Biophys Acta 612:373-83 (1980)
DOI:10.1016/0005-2744(80)90120-5
Other DBs
ExplorEnz - The Enzyme Database: 3.1.6.12
IUBMB Enzyme Nomenclature: 3.1.6.12
ExPASy - ENZYME nomenclature database: 3.1.6.12
BRENDA, the Enzyme Database: 3.1.6.12
CAS: 55354-43-3

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