KEGG   ENZYME: 3.1.6.20
Entry
EC 3.1.6.20                 Enzyme                                 
Name
S-sulfosulfanyl-L-cysteine sulfohydrolase;
SoxB
Class
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
Sysname
[SoxY protein]-S-sulfosulfanyl-L-cysteine sulfohydrolase
Reaction(IUBMB)
(1) [SoxY protein]-S-sulfosulfanyl-L-cysteine + H2O = [SoxY protein]-S-sulfanyl-L-cysteine + sulfate [RN:R12096];
(2) [SoxY protein]-S-(2-sulfodisulfanyl)-L-cysteine + H2O = [SoxY protein]-S-disulfanyl-L-cysteine + sulfate [RN:R12097]
Reaction(KEGG)
R12096 R12097
Substrate
[SoxY protein]-S-sulfosulfanyl-L-cysteine [CPD:C21815];
H2O [CPD:C00001];
[SoxY protein]-S-(2-sulfodisulfanyl)-L-cysteine [CPD:C21899]
Product
[SoxY protein]-S-sulfanyl-L-cysteine [CPD:C21898];
sulfate [CPD:C00059];
[SoxY protein]-S-disulfanyl-L-cysteine [CPD:C21814]
Comment
Contains Mn2+. The enzyme is part of the Sox enzyme system, which participates in a bacterial thiosulfate oxidation pathway that produces sulfate. It catalyses two reactions in the pathway. In both cases the enzyme hydrolyses a sulfonate moiety that is bound (either directly or via a sulfane) to a cysteine residue of a SoxY protein, releasing sulfate. The enzyme from Paracoccus pantotrophus contains a pyroglutamate (cycloglutamate) at its N-terminus.
History
EC 3.1.6.20 created 2018
Pathway
ec00920  Sulfur metabolism
Orthology
K17224  S-sulfosulfanyl-L-cysteine sulfohydrolase
Genes
PCIPCH70_42190
PFNHZ99_04805
PSESPSCI_2482
MSQBKP64_06035
AFUSEYZ66_09735(soxB)
MAHMEALZ_3396
MBUREQU24_17835(soxB)
MESLKKZ03_08270
TCXTcr_1549
HTREPV75_04415 EPV75_08360
HMARHVMH_0780(soxB_1) HVMH_1723(soxB_2)
TCYThicy_0833
TAOTHIAE_04785
THIOAYJ59_05560 AYJ59_09395
TMHJX580_04750
THIGFE785_07125
TXAHQN79_07555
TIBTHMIRHAM_14130(soxB)
TSETHMIRHAS_10590(soxB)
TZOTHMIRHAT_11840(soxB)
TIGTHII_1577
BLEPAL038_05225(soxB)
THISHZT40_21675(soxB)
TUNJ9260_16955(soxB)
TLOJ9253_18010(soxB)
TSBHMY34_10995(soxB)
TANIJ8380_05855(soxB)
TWNL2Y54_05615(soxB)
ALVAlvin_2167(soxB)
TVIThivi_2200
MPURMARPU_05475
CJAPGWK36_11230(soxB)
THIMKFB96_04485(soxB)
TBOGLT988_24235(soxB)
HHAHhal_1939
HHCM911_11275
EBSECTOBSL9_0294
TGRTgr7_2223
TKMTK90_0627 TK90_1150
TNITVNIR_3254(yfkN_[H])
TTITHITH_03570
TVRTVD_06210 TVD_10675
APRSBI364_03825
HNAHneap_1916
HAZA9404_05595
GAIIMCC3135_13775(mggB)
GHLGM160_02345(soxB)
TTCFOKN1_1148
THICTspCOW1_15140(soxB)
MSECLN244_09720(soxB)
MARLHH196_02280(soxB)
NCUF0U83_06380(soxB)
NJPNEJAP_2232(soxB1)
AJPAMJAP_1134(soxB1)
RFOREIFOR_02323(soxB)
LLPGH975_09700(soxB)
SLIMSCL_2233
SVASVA_3003
ACIIC4901_02710 C4901_13035(soxB)
ATYA9R16_002295 A9R16_003935(soxB)
TBNTBH_C2351(soxB)
SEDSAAY24_16210
THOSP60_05195
REVHUE57_04650(soxB)
RMARmag_0156
REOHUE58_06675
VOKCOSY_0161(soxB)
EPSL0Y14_12760(soxB)
EBHBSEPE_0262(soxB)
BTHGMS2017_1861
ENMEBS_0922(soxB)
IFOCVFO_0410(soxB)
APHFCVPH_1263(soxB)
VFFVITFI_CDS0979 VITFI_CDS2148
RSORSc3253
RSCRCFBP_10227
RSLRPSI07_0194
RSNRSPO_c00211
RSMCMR15_10214
RSEF504_3294(soxB)
RSYRSUY_02460
RPIRpic_3451
RPFRpic12D_3123
RPJN234_19915
RMNTK49_02080
RINACS15_3549
RPUCDC45_16635(soxB)
REHH16_A3563(h16_A3563)
CNCCNE_1c35130
CUHBJN34_19030
REUReut_A3249
RMERmet_3417(soxB)
CTIRALTA_A3016
CBWRR42_m3995
CGDCR3_2725(ushA)
CCUPBKK81_00845
CUPBKK80_00175
CUUBKK79_11975
CPAUEHF44_06320(soxB)
COXE0W60_26965(soxB)
CCAMM5D45_16525(soxB)
PNUPnuc_0807
PNEPnec_1032
PDQCL55_00010910
POHDPM16_03930(soxB)
PTRPDCO17_06000(soxB)
PANIDCO16_05345(soxB)
PPALAOC06_06900(soxB)
PCOSC2747_05650(soxB)
PPKU875_24495
PPNODA70_17220
PPNMLV28_13530
PRBX636_09655
PPULRO07_07470
PSPUNA29_03350
PAPISG18_07910
PVEUC34_23565
POXMB84_03580
PFGAB870_10480
PNRAT302_07090
PANDDRB87_22015(soxB)
PFIBPI93_023600(soxB)
PCOMNTU39_25740(soxB)
LIMNHKT17_06710(soxB)
AXYAXYL_05423
ADYHLG70_08860(soxB)
AKATKWG_08995 TKWG_14010
AMIMMIM_c17110
PARKLSG25_11085(soxB)
RACRA876_14670
RHFEUB48_02720(soxB)
POLBpro_2625
POSDT070_18140(soxB)
POOF7R28_12445(soxB)
AMONH9L24_00255(soxB)
VBOCKY39_30915(soxB)
CTTCtCNB1_2867
CTESO987_17340
COFFOZ74_01850(soxB)
CODOLAD35_04905(soxB)
RTARta_13840
OTDJ1M35_04755(soxB)
LIML103DPR2_01197(yfkN)
LIHL63ED372_00551(yfkN_1)
HYRBSY239_2850 BSY239_838(soxB)
HYBQ5W_03665
HYLLPB072_18245
HYCE5678_10615(soxB)
HPSEHPF_06300(yfkN)
HYNF9K07_22645(soxB)
HTNKI616_20150(soxB)
DIHG7047_06275(soxB)
DRGH9K76_15000(soxB)
MELAC6568_01375 C6568_08775(soxB)
MJELVC68_00185(soxB)
KIAG8A07_27210(soxB)
PBHAAW51_2272(soxB)
MPTMpe_A2432
METPC1M51_15780(soxB)
SNNEWH46_01845(soxB)
IDCLRM40_06620(soxB)
HARHEAR1195
MMSmma_0453(soxB)
MANCIV454_25860(soxB)
LCHLcho_3778
TINTint_2294
THITHI_2667
TTWLCC91_08225(soxB)
SHDSUTH_02730(soxB)
METRBSY238_1526(soxB)
TBDTbd_0563 Tbd_1286 Tbd_1292 Tbd_2012
SLTSlit_1696
SDRSCD_n02408(soxB)
SULFCAP31_05840 CAP31_10670 CAP31_12810
SPLBSFPGR_29780(soxB)
SNIVSFSGTM_02850(soxB) SFSGTM_09690 SFSGTM_09750
SLACSKTS_04550(soxB)
URUDSM104443_02063
UPLDSM104440_01898
OTROTERR_06960(soxB)
ATWC0099_11255(soxB)
DARDaro_3128
DEYHYN24_04385(soxB)
DDENKI615_12845(soxB)
QAUKI612_14910(soxB)
FLEKI610_07385(soxB)
ACOMCEW83_09800(soxB)
AZRCJ010_06885(soxB)
THUAC731_000140
AZQG3580_13930(soxB)
DDZDSYM_23330
BPRCD521_0979
BEBAEM42_07790
BEBABWI17_16375
TDNSuden_0264
SUASaut_0995
SPALFM071_04130(soxB)
SSEIFJR45_07370(soxB)
SBALHUE88_11855(soxB)
SMASHUE87_01055(soxB)
SKUSulku_0449
SULRB649_02210
SHALSHALO_2475
ABUAbu_0572(soxB)
ASKEI285_02210(soxB)
ATPATR_1131(soxB)
ACIBACBT_0940(soxB)
ACREACRYA_1218(soxB)
ALANALANTH_0587(soxB)
APOCAPORC_1658(soxB)
AFCAFAEC_0765(soxB)
ATHRATH_1565(soxB)
ANTArnit_1810
AELLAELL_0713(soxB)
AAQIAAQM_0619(soxB)
ASUIASUIS_0669(soxB)
ACLOACLO_0696(soxB)
AVPAVENP_0809(soxB)
ADZADFLV_0707(soxB)
ARCABLL_0693
PACOAACT_0817(soxB)
ALKALEK_2884(soxB)
ALPLPB137_11500
AHSAHALO_0643(soxB)
AMARAMRN_0703(soxB)
ACAAACAN_0723(soxB)
AMOLAMOL_0627(soxB)
APAIAPAC_0594(soxB)
HBVABIV_1377(soxB)
HEBRAEBR_1627(soxB)
AANAAANAER_1626(soxB)
NSANitsa_0368
SUNSUN_0501
SLHYH65_08710
SINUIMZ28_08600(soxB)
NISNIS_1828
DBADbac_1173
ADEAdeh_2279
ACPA2cp1_1672
ANKAnaeK_1596
MXAMXAN_4313
MSDMYSTI_00767
MFULILAB_24865
MMASMYMAC_003370
MRMA7982_02146
BBAEFRD01_03535
MESOBSQ44_10555
HOEIMCC20628_01339
NIYFQ775_21005(soxB)
ORMHTY61_03405(soxB)
AGCBSY240_3517(soxB)
RHTNT26_2613(soxB)
RFVRFYW14_02659
SHZshn_17885
BJAbll1009(soxB) blr3515(soxB)
BJUBJ6T_10350
BJPRN69_05045
BRABRADO3183 BRADO6851
BBTBBta_0692 BBta_3675
BRSS23_67990(soxB)
AOLS58_06180 S58_44030(soxB)
BRCBCCGELA001_34610
BRADBF49_7179
BICLMTR13_36680
BROBRAD285_2961 BRAD285_6992
BRKCWS35_09080(soxB) CWS35_37710 CWS35_37800(soxB) CWS35_37875
BOTCIT37_09255(soxB) CIT37_36640(soxB)
BRQCIT40_11180(soxB) CIT40_30415(soxB)
BGQX265_02705(soxB) X265_35000(soxB)
BGZXH91_21965(soxB) XH91_33350(soxB)
BSYMCIT39_10290(soxB) CIT39_29520(soxB)
BBETF8237_13340(soxB) F8237_34490(soxB) F8237_35435 F8237_35745
BARHWN72_46550(soxB)
BVZBRAD3257_8721
BELBE61_03070(soxB)
BDGLPJ38_02475(soxB)
BSEPHAP48_0012980(soxB)
BQBJ4P68_0016835(soxB) J4P68_0027355(soxB) J4P68_0034840(soxB)
RPARPA4465(soxB)
RPBRPB_4369
RPDRPD_4253
RPERPE_3073
RPTRpal_4958
RPXRpdx1_3143
NHANham_3671
OCAOCAR_5187
OCGOCA5_c27810(soxB)
OCOOCA4_c27800(soxB)
VGOGJW-30_1_01696(yfkN_1)
TRBHB776_12295(soxB)
BOSBSY19_751(soxB)
BOIBLM15_25515
XAUXaut_1519
XDIEZH22_00510(soxB)
SNOSnov_0969
ANCGBB76_12400(soxB)
MEAMex_1p2566(soxB)
MDIMETDI0755(soxB)
MPOMpop_4160
METM446_0141
METDC0214_09200(soxB)
MMESMMSR116_16040(soxB)
MOGMMB17_08230(soxB)
HDNHden_0706
FILBN1229_v1_3694
FIYBN1229_v1_3688
RHZRHPLAN_54770
BLAGBLTE_06830(soxB)
MSCBN69_0434
MBRYB1812_19020
MHEYH2LOC_016675
MTWCQW49_21585(soxB)
HDIHDIA_3889(cpdB)
AUBLXB15_05825(soxB)
BRND1F64_10960(soxB)
PSINCAK95_23430
PSFPSE_1363(soxB)
LAPACP90_06500
LABRCHH27_14115(soxB)
LABPFJ695_08780(soxB)
LABTFIU93_12140(yfkN1)
LAGGB0E33_18050
SIWGH266_01570(soxB)
PHRC6569_08450(soxB)
PSTGE8M01_30430(soxB)
BRDJL11_01795
BRGA4249_11520
BDMEQG53_01165
BREVE7T10_11760
BNDKWG56_08235
SILSPO0997(soxB)
RUAD1823_09090(soxB)
RUTFIU92_04315(yfkN1)
RDERD1_1515(soxB)
RLIRLO149_c031840(soxB1)
RPONG3256_14755(soxB)
DSHDshi_2803
PGAPGA1_c12460(soxB2)
PGLPGA2_c12440(soxB2)
PGDGal_02159
PHPPhaeoP97_01242(soxB2)
PPICPhaeoP14_01165(soxB2)
PHQD1820_02260(soxB)
OTMOSB_13230(yfkN_1)
OCTFTO60_10305(soxB)
LMDMETH_07410
LEJETW24_08455(soxB)
LAQUR2C4_10310(soxB)
LEVETW23_08345(soxB)
REDroselon_02250
CMARIMCC12053_767
CEHCEW89_07110(soxB)
MALGMALG_03482
CONTQ29_11430
YPACCEW88_16490(soxB)
YANAYJ57_01955
TPROGa0080559_TMP1024
PABYGa0080574_TMP1407
SUAMBOO69_10885
SULZC1J03_15085(soxB)
SULIC1J05_07890(soxB)
SULDB5M07_07535
SPOTG6548_05535(soxB)
SMEDJNX03_16550(soxB)
SINLDSM14862_01880(mggB)
RMMROSMUCSMR3_02025(mggB)
ROKRAK1035_1161
RIDRIdsm_01802(yfkN_4)
ROMEI983_17030(soxB)
ROHFIU89_03890(yfkN1)
AHTANTHELSMS3_02237
SAGUCDO87_03825(soxB)
THAACFI11_15415(soxB)
OCDFHY55_04235(soxB)
MARUFIU81_10285(cpdB)
ROTFIV09_13410(yfkN3)
RMHLVO79_08510(soxB)
MALUKU6B_10800(soxB_1)
TGLHFZ77_05215(soxB)
PALXGQA70_13945(soxB)
LSALKBK07_01280(soxB)
RSQRsph17025_3914
CAZTLV780_16100(soxB)
PDEPden_4154
PARUCYR75_11915(soxB)
PARSDRW48_07280(soxB)
PPANESD82_03390(soxB)
PSANHGN31_09865(soxB)
PTPRCA23_c17370(soxB2)
RSUNHU_02676(soxB)
RHMB5V46_11240
RHCRGUI_3429
DAAAKL17_3171
DONBSK21_10450
THWBMG03_14460
TECAKL02_013810(soxB)
RBGBG454_05030(soxB)
SALOEF888_14345(soxB)
SEDIEBB79_03315(soxB)
PSEBEOK75_07805(soxB)
PAEDG5B38_17685(soxB)
PAMOBAR1_03175(soxB)
PGVSL003B_2699
CACTHZ995_11870(soxB)
RBZB9057_03155
THASC6Y53_05105(soxB)
CMAGCBW24_10500
FAQG5B39_08785(soxB)
NREBES08_29760
QCINCF85_13365
ACRAcry_3048
AMVACMV_33940
SRFLHU95_15300(soxB)
ATIAL072_28030
SKTIGS68_23555(soxB)
SMUCJL100_018865(soxB) JL100_025435(soxB)
SROEJL101_021090(soxB)
MGYMGMSRv2__2087
MGRYMSR1_20830(yfkN)
TIIDY252_12650(soxB)
THAIIT893_08590(soxB)
MAGQMGMAQ_1860(soxB)
ELIOKO353_14375(soxB)
NACINUH88_07540(soxB)
MGMMmc1_1905
ACUAtc_2215 Atc_2370
ACZAcaty_c2057 Acaty_c2213
AFIAcife_2494
ATXGCD22_00897(mggB) GCD22_03168(nutA)
AFPK1Y48_08945(soxB)
HTLHPTL_0815(soxB)
HYIK2M58_11365
SHVAAT16_10895
PSTEPSTEL_14625
POWIJ21_35100
PTJJRJ22_14110
BTSBtus_2475
KYRCVV65_12385
JDABW727_101019(mggB_2)
CCHVBTM20_03975
SAYTPY_0088
SAPSulac_0079
CHMB842_04645
CMQB840_04075
TTHTT_C1052(soxB)
TTJTTHA1417(TTHA1417)
TTSThthe16_1428
TTLTtJL18_0630
TSCTSC_c21070
THCTCCBUS3UF1_5950
TOSTheos_1621
TBCA0O31_00638
TANTKNN15_02100(soxB)
MRBMrub_2861
MREK649_08220
MSVMesil_3451
MTAIMtai_v1c02320
PLHVT85_10605(yfkN_1) VT85_22465(yfkN_2)
NKONiako_4610
FLSGLV81_16155
LACSH4075_20495
FLVKJS94_05230
HHYHalhy_2538
MGOSDIU38_001635
ALMAO498_05880
PSEZHME7025_01045
AANHG9X63_00685
RSIRunsl_5781
RUNDR864_29545
RUPDTQ70_15615
EOLEmtol_3140
HYPA0257_02485
RUFTH63_07505
NIBGU926_05620
GFOGFO_1276(ushA) GFO_1279
GFLGRFL_3389
ZPRZPR_1814 ZPR_1818
CATCA2559_11803
MRSMurru_0077
SALTAO058_11520
SMISLDL76_15300
AALGAREALGSMS7_00606 AREALGSMS7_00608
EMARD1013_09580
AFLAFHG64_03295
ANPFK178_02265
CSHAEG350_06005
FTEFluta_3022
BBAUAEM51_05680
CTECT1021(soxB)
CPCCpar_1076
CLZBIU88_05975
CCHCag_1927
PVICvib_0143
PPHPpha_0816
PROCPtc2401_00854(yfkN_2)
AAEaq_1803(soxB)
HYAHY04AAS1_1467
HTHHTH_1520(soxB)
HTEHydth_1508
TALThal_0763
TRDTHERU_04700
SULSYO3AOP1_0513
SAFSULAZ_1685
PMXPERMA_1888
MSUBBK009_01345
METNBK008_09620
METTCIT01_08160
MEMMemar_0467
MBGBN140_0431
MEMAMMAB1_0540
MPLMpal_0972
HDLHALDL1_00195
HALHHTSR_0708
HHSRHSR6_0734(surE)
HAADMW046_18130
SALIL593_04315
HALJG9465_19130
HALIBV210_00580
HLAHlac_3035
HALUHUG12_10315
HAHHalar_3572
HXAHalxa_0163
NVRFEJ81_19420
NAYHYG81_20180 HYG81_25155
HRUHalru_2106
NASGCU68_17325 GCU68_19000
SAWLNGM29_08245
 » show all
Reference
1  [PMID:11513876]
  Authors
Quentmeier A, Friedrich CG
  Title
The cysteine residue of the SoxY protein as the active site of protein-bound sulfur oxidation of Paracoccus pantotrophus GB17.
  Journal
FEBS Lett 503:168-72 (2001)
DOI:10.1016/S0014-5793(01)02727-2
Reference
2  [PMID:11425697]
  Authors
Friedrich CG, Rother D, Bardischewsky F, Quentmeier A, Fischer J
  Title
Oxidation of reduced inorganic sulfur compounds by bacteria: emergence of a common mechanism?
  Journal
Appl Environ Microbiol 67:2873-82 (2001)
DOI:10.1128/AEM.67.7.2873-2882.2001
Reference
3  [PMID:14651972]
  Authors
Quentmeier A, Hellwig P, Bardischewsky F, Grelle G, Kraft R, Friedrich CG
  Title
Sulfur oxidation in Paracoccus pantotrophus: interaction of the sulfur-binding protein SoxYZ with the dimanganese SoxB protein.
  Journal
Biochem Biophys Res Commun 312:1011-8 (2003)
DOI:10.1016/j.bbrc.2003.11.021
Reference
4  [PMID:16133204]
  Authors
Epel B, Schafer KO, Quentmeier A, Friedrich C, Lubitz W
  Title
Multifrequency EPR analysis of the dimanganese cluster of the putative sulfate thiohydrolase SoxB of Paracoccus pantotrophus.
  Journal
J Biol Inorg Chem 10:636-42 (2005)
DOI:10.1007/s00775-005-0015-3
Reference
5  [PMID:16995898]
  Authors
Hensen D, Sperling D, Truper HG, Brune DC, Dahl C
  Title
Thiosulphate oxidation in the phototrophic sulphur bacterium Allochromatium vinosum.
  Journal
Mol Microbiol 62:794-810 (2006)
DOI:10.1111/j.1365-2958.2006.05408.x
  Sequence
Reference
6  [PMID:28257465]
  Authors
Grabarczyk DB, Berks BC
  Title
Intermediates in the Sox sulfur oxidation pathway are bound to a sulfane conjugate of the carrier protein SoxYZ.
  Journal
PLoS One 12:e0173395 (2017)
DOI:10.1371/journal.pone.0173395
Other DBs
ExplorEnz - The Enzyme Database: 3.1.6.20
IUBMB Enzyme Nomenclature: 3.1.6.20
ExPASy - ENZYME nomenclature database: 3.1.6.20
BRENDA, the Enzyme Database: 3.1.6.20

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