KEGG   ENZYME: 3.1.6.4
Entry
EC 3.1.6.4                  Enzyme                                 
Name
N-acetylgalactosamine-6-sulfatase;
chondroitin sulfatase;
chondroitinase;
galactose-6-sulfate sulfatase;
acetylgalactosamine 6-sulfatase;
N-acetylgalactosamine-6-sulfate sulfatase;
N-acetylgalactosamine 6-sulfatase
Class
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
Sysname
N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase
Reaction(IUBMB)
Hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate [RN:R07806]
Reaction(KEGG)
R07806(G)
History
EC 3.1.6.4 created 1961
Pathway
ec00531  Glycosaminoglycan degradation
ec01100  Metabolic pathways
Orthology
K01132  N-acetylgalactosamine-6-sulfatase
Genes
HSA2588(GALNS)
PTR736362(GALNS)
GGO101147331(GALNS)
PON100457027(GALNS)
NLE100602504(GALNS)
MCC697850(GALNS)
MCF102118579(GALNS)
CSAB103233460(GALNS)
CATY105588730(GALNS)
PANU101009427(GALNS)
TGE112613969(GALNS)
RRO104655978(GALNS) 115895245 115896020
RBB108519980(GALNS)
TFN117088216(GALNS)
PTEH111553847(GALNS)
CJC100389028(GALNS)
SBQ101046061(GALNS)
CSYR103277361(GALNS)
MMUR105855880(GALNS)
OGA100959495(GALNS)
MMU50917(Galns)
MCAL110300029(Galns)
MPAH110337430(Galns)
RNO292073(Galns)
MCOC116070337(Galns)
MUN110545224(Galns)
CGE100753973(Galns)
PLEU114700977(Galns)
NGI103740004(Galns)
HGL101712119(Galns)
CPOC100732880(Galns)
CCAN109692745(Galns)
DORD105983007(Galns)
DSP122127911(Galns)
NCAR124966494
OCU100356775(GALNS)
OPI101533979(GALNS)
TUP102495455(GALNS)
CFA489661(GALNS)
VVP112924627(GALNS)
VLG121500285(GALNS)
AML100479531(GALNS)
UMR103673849(GALNS)
UAH113252143(GALNS)
UAR123776601(GALNS)
ELK111152803
LLV125088735
MPUF101693199(GALNS)
ORO101366420(GALNS)
EJU114199244(GALNS)
ZCA113935705(GALNS)
MLX118023463(GALNS)
FCA101099168(GALNS)
PYU121009927(GALNS)
PBG122494604(GALNS)
PTG102972741(GALNS)
PPAD109245536(GALNS)
AJU106973500(GALNS)
HHV120228057(GALNS)
BTA515809(GALNS)
BOM102269249(GALNS)
BIU109572729(GALNS)
BBUB102408891(GALNS)
CHX102190539(GALNS)
OAS101107214(GALNS)
ODA120872955(GALNS)
CCAD122420353(GALNS)
SSC397000(GALNS)
CFR102509603
CBAI105079439(GALNS)
CDK105104689
VPC102538945(GALNS)
BACU103007439(GALNS)
LVE103068680(GALNS)
OOR101273563(GALNS)
DLE111179391(GALNS)
PCAD102995899
PSIU116743506(GALNS)
ECB100051284(GALNS)
EPZ103541880(GALNS)
EAI106828247(GALNS)
MYB102243422(GALNS)
MYD102759580(GALNS)
MMYO118674319(GALNS)
MLF102428724(GALNS)
MNA107543502(GALNS)
PKL118720682(GALNS)
DRO112300688(GALNS)
SHON118982962(GALNS)
AJM119047031(GALNS)
PDIC114488241(GALNS)
PHAS123805898(GALNS)
MMF118639488(GALNS)
RFQ117034469(GALNS)
PALE102887232(GALNS)
PGIG120622885(GALNS)
PVP105299912(GALNS)
RAY107502355(GALNS)
MJV108385617(GALNS)
TOD119248859(GALNS)
SARA101538760(GALNS)
LAV100666004(GALNS)
TMU101357559
DNM101425086(GALNS)
MDO100026247(GALNS)
GAS123236766(GALNS)
SHR100933785(GALNS)
PCW110210301(GALNS)
OAA100089863(GALNS)
PCOC116243926(GALNS)
MGP100543323(GALNS)
CJO107319490(GALNS)
NMEL110404190(GALNS)
APLA101792596(GALNS)
ACYG106046507(GALNS)
AFUL116493952(GALNS)
TGU100222785(GALNS)
LSR110468778(GALNS)
SCAN103816759(GALNS)
PMOA120496245(GALNS)
OTC121333791(GALNS)
PRUF121362139(GALNS)
GFR102043643(GALNS)
FAB101811724(GALNS)
PHI102101123(GALNS)
PMAJ107209820(GALNS)
CCAE111934402(GALNS)
CCW104691852(GALNS)
ETL114060570(GALNS)
ZAB102061073(GALNS) 102069306
FPG101915149(GALNS)
FCH102047887(GALNS)
CLV102096794(GALNS)
EGZ104127040(GALNS)
NNI104023569(GALNS)
ACUN113484623(GALNS)
TALA104363110(GALNS)
PADL103919464(GALNS)
ACHC115345352(GALNS)
AAM106491425(GALNS)
AROW112978484(GALNS)
NPD112949943(GALNS)
DNE112989077(GALNS)
ASN102384115(GALNS)
AMJ102560299(GALNS)
CPOO109310712(GALNS)
GGN109289387(GALNS)
PSS102445221(GALNS)
CMY102937794(GALNS)
CPIC101934226(GALNS)
TST117886379(GALNS)
CABI116815680(GALNS)
MRV120384171(GALNS)
ACS100556157(galns)
PVT110076238(GALNS)
SUND121914957(GALNS)
PBI103067280(GALNS)
PMUR107283519(GALNS)
TSR106552196(GALNS)
PGUT117671022(GALNS)
VKO123022275(GALNS)
PMUA114602133(GALNS)
ZVI118086417(GALNS)
GJA107115627(GALNS)
XLA495239(galns.L)
XTR100485376(galns)
NPR108787709(GALNS)
RTEM120917919(GALNS)
BBUF120980190(GALNS)
BGAR122920554(GALNS)
DRE791159(galns)
SRX107728036 107730157(galns)
SANH107663041 107685869
SGH107561424
CCAR109052187 109072047
CAUA113106343(galns)
IPU108259597(galns)
PHYP113546742(galns)
SMEO124380157(galns)
TFD113634223(galns)
AMEX103034478(galns)
EEE113575705(galns)
TRU101062701(galns)
TNGGSTEN00017886G001
LCO104922746
NCC104947090(galns)
CGOB115005461(galns)
ELY117256764(galns)
PLEP121948104(galns)
SLUC116034032(galns)
ECRA117950807(galns)
PFLV114552310(galns)
GAT120807952(galns)
PPUG119198284(galns)
MSAM119889945(galns)
CUD121507649(galns)
MZE101471725(galns)
ONL100694056(galns)
OAU116324295(galns)
OLA101171730(galns)
OML112160349(galns)
XMA102237545(galns)
XCO114142561(galns)
XHE116718196(galns)
PRET103462372(galns)
PFOR103139344(galns)
PLAI106947220(galns)
PMEI106928083(galns)
GAF122822484(galns)
CVG107090762(galns)
CTUL119782664(galns)
GMU124866905(galns)
NFU107381170(galns)
KMR108229109(galns)
ALIM106513999 106535460(galns)
NWH119428716(galns)
AOCE111588401(galns)
CSEM103378683(galns)
POV109624779(galns)
SSEN122772677(galns)
HHIP117759144(galns)
LCF108887657(galns)
SDU111238375(galns)
SLAL111668284(galns)
XGL120788744(galns)
HCQ109519694(galns)
BPEC110172948(galns)
MALB109966269(galns)
SASA106587262(galns)
OTW112249114
OMY110506416 110526298
OGO124033834(galns)
ONE115112157(galns)
SALP111969099
SNH120025054 120046281(galns)
ELS105017049(galns)
SFM108934575(galns)
PKI111832952(galns)
AANG118227539(galns)
LOC102682809(galns)
PSPA121325621(galns)
ARUT117425033
LCM102351372(GALNS)
CMK103188083(galns)
RTP109927191(galns)
BFO118417061
BBEL109487383
CIN100177085
SCLV120337476
SPU579130 588014
APLC110988485
SKO100369185
PVM113810897
PJA122250835 122265722
PCHN125024895
HAME121873258
PCLA123769173
PTRU123507765
HAZT108669890
EAF111703859
DSV119436208 119436209
RSAN119407081 119407091
RMP119177296 119177297
TUT107369286
DPTE113792048
DFR124500144
CSCU111634997
PTEP107451534
SDM118203759
HROHELRODRAFT_95956
LGILOTGIDRAFT_159001
PCAN112576502
BGT106058711
GAE121388395
HRF124112853
HRJ124266348
CRG105348100
MYI110464777 110467289
PMAX117327359 117337667
MMER123548759
OBI106880025
OSN115215877
LAK106161119 106180844
ADF107327708
AMIL114954146
PDAM113665844
SPIS111325693
DGT114516978 114542597
AQU100637906
MBRMONBRDRAFT_9186
PMESFX988_03340
SPHPLH20_14895
SMAZLH19_12295
STERAOA14_10930
SGISGRAN_1170
SPHXE5675_14210
SPAPH3Z74_11860
SMICSmB9_09240
PIRVN12_16015(atsA_21)
RULUC8_51720(atsA_48)
AAGGETAA8_41730(atsA_43)
PNDPla175_22360(atsA_36)
PBSPlabr_2973
GPNPan110_45830(atsA_48)
MRIMal4_02690(atsA_4) Mal4_26260(atsA_36)
PFERIRI77_14315
MCOSGM418_24990
CHKD4L85_03380
FNKE1750_03490
 » show all
Reference
1  [PMID:6939689]
  Authors
Epstein EH Jr, Leventhal ME.
  Title
Steroid sulfatase of human leukocytes and epidermis and the diagnosis of recessive X-linked ichthyosis.
  Journal
J Clin Invest 67:1257-62 (1981)
DOI:10.1172/JCI110153
Reference
2  [PMID:6213226]
  Authors
Glossl J, Kresse H.
  Title
Impaired degradation of keratan sulphate by Morquio A fibroblasts.
  Journal
Biochem J 203:335-8 (1982)
DOI:10.1042/bj2030335
Reference
3  [PMID:7213753]
  Authors
Lim CT, Horwitz AL.
  Title
Purification and properties of human N-acetylgalactosamine-6-sulfate sulfatase.
  Journal
Biochim Biophys Acta 657:344-55 (1981)
DOI:10.1016/0005-2744(81)90320-X
Reference
4  [PMID:6814909]
  Authors
Sorensen SH, Noren O, Sjostrom H, Danielsen EM.
  Title
Amphiphilic pig intestinal microvillus maltase/glucoamylase. Structure and specificity.
  Journal
Eur J Biochem 126:559-68 (1982)
DOI:10.1111/j.1432-1033.1982.tb06817.x
Reference
5  [PMID:6809361]
  Authors
Yutaka T, Okada S, Kato T, Inui K, Yabuuhi H.
  Title
Galactose 6-sulfate sulfatase activity in Morquio syndrome.
  Journal
Clin Chim Acta 122:169-80 (1982)
DOI:10.1016/0009-8981(82)90276-5
Other DBs
ExplorEnz - The Enzyme Database: 3.1.6.4
IUBMB Enzyme Nomenclature: 3.1.6.4
ExPASy - ENZYME nomenclature database: 3.1.6.4
BRENDA, the Enzyme Database: 3.1.6.4
CAS: 9025-60-9

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