KEGG   ENZYME: 3.1.6.4
Entry
EC 3.1.6.4                  Enzyme                                 
Name
N-acetylgalactosamine-6-sulfatase;
chondroitin sulfatase;
chondroitinase;
galactose-6-sulfate sulfatase;
acetylgalactosamine 6-sulfatase;
N-acetylgalactosamine-6-sulfate sulfatase;
N-acetylgalactosamine 6-sulfatase
Class
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
Sysname
N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase
Reaction(IUBMB)
Hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate [RN:R07806]
Reaction(KEGG)
R07806(G)
History
EC 3.1.6.4 created 1961
Pathway
ec00531  Glycosaminoglycan degradation
ec01100  Metabolic pathways
Orthology
K01132  N-acetylgalactosamine-6-sulfatase
Genes
HSA2588(GALNS)
PTR736362(GALNS)
GGO101147331(GALNS)
PON100457027(GALNS)
PPYG129015199(GALNS)
NLE100602504(GALNS)
HMH116470703(GALNS)
SSYN129457543(GALNS)
MCC697850(GALNS)
MCF102118579(GALNS)
MTHB126944297
MNI105488842(GALNS)
CSAB103233460(GALNS)
CATY105588730(GALNS)
PANU101009427(GALNS)
TGE112613969(GALNS)
MLEU105533415(GALNS)
RRO104655978(GALNS) 115895245 115896020
RBB108519980(GALNS)
TFN117088216(GALNS)
PTEH111553847(GALNS)
CANG105501931(GALNS)
CJC100389028(GALNS)
SBQ101046061(GALNS)
CIMI108292811(GALNS)
ANAN105726550(GALNS)
CSYR103277361(GALNS)
MMUR105855880(GALNS)
LCAT123625385(GALNS)
PCOQ105821060(GALNS)
OGA100959495(GALNS)
MMU50917(Galns)
MCAL110300029(Galns)
MPAH110337430(Galns)
RNO292073(Galns)
MCOC116070337(Galns)
ANU117722919(Galns)
MUN110545224(Galns)
CGE100753973(Galns)
MAUA101843866(Galns)
PROB127234651(Galns)
PLEU114700977(Galns)
MORG121446991(Galns)
MFOT126515499
AAMP119801966(Galns)
NGI103740004(Galns)
HGL101712119(Galns)
CPOC100732880(Galns)
CCAN109692745(Galns)
DORD105983007(Galns)
DSP122127911(Galns)
PLOP125358083(Galns)
NCAR124966494
MMMA107150819(Galns)
OPI101533979(GALNS)
TUP102495455(GALNS)
GVR103585012(GALNS)
CFA489661(GALNS)
CLUD112646823(GALNS)
VVP112924627(GALNS)
VLG121500285(GALNS)
NPO129497042(GALNS)
AML100479531(GALNS)
UMR103673849(GALNS)
UAH113252143(GALNS)
UAR123776601(GALNS)
ELK111152803
LLV125088735
MPUF101693199(GALNS)
MNP132005422(GALNS)
MLK131817433(GALNS)
NVS122911134(GALNS)
ORO101366420(GALNS)
EJU114199244(GALNS)
ZCA113935705(GALNS)
MLX118023463(GALNS)
NSU110591472(GALNS)
LWW102727198(GALNS) 102728108
FCA101099168(GALNS)
PYU121009927(GALNS)
PCOO112857533(GALNS)
PBG122494604(GALNS)
PVIV125158761(GALNS)
LRUF124511580
PTG102972741(GALNS)
PPAD109245536(GALNS)
PUC125916546
AJU106973500
HHV120228057(GALNS)
BTA515809(GALNS)
BOM102269249(GALNS)
BIU109572729(GALNS)
BBUB102408891(GALNS)
BBIS104991469(GALNS)
CHX102190539(GALNS)
OAS101107214(GALNS)
BTAX128063323(GALNS)
ODA120872955(GALNS)
CCAD122420353(GALNS)
MBEZ129547169(GALNS)
SSC397000(GALNS)
CFR102509603
CBAI105079439(GALNS)
CDK105104689
VPC102538945(GALNS)
BACU103007439(GALNS)
BMUS118884707(GALNS)
LVE103068680(GALNS)
OOR101273563(GALNS)
DLE111179391(GALNS)
PCAD102995899
PSIU116743506(GALNS)
NASI112393359(GALNS)
ECB100051284(GALNS)
EPZ103541880(GALNS)
EAI106828247(GALNS)
MYB102243422(GALNS)
MYD102759580(GALNS)
MMYO118674319(GALNS)
MLF102428724(GALNS)
PKL118720682(GALNS)
EFUS103284456(GALNS)
MNA107543502(GALNS)
DRO112300688(GALNS)
SHON118982962(GALNS)
AJM119047031(GALNS)
PDIC114488241(GALNS)
PHAS123805898(GALNS)
MMF118639488(GALNS)
PPAM129083148(GALNS)
RFQ117034469(GALNS)
PALE102887232(GALNS)
PGIG120622885(GALNS)
PVP105299912(GALNS)
RAY107502355(GALNS)
MJV108385617(GALNS)
TOD119248859(GALNS)
SARA101538760(GALNS)
SETR126027304(GALNS)
LAV100666004(GALNS)
TMU101357559
ETF101656997(GALNS)
DNM101425086(GALNS)
MDO100026247(GALNS)
GAS123236766(GALNS)
SHR100933785(GALNS)
AFZ127547785
PCW110210301(GALNS)
TVP118841725(GALNS)
OAA100089863(GALNS)
PCOC116243926(GALNS)
MGP100543323(GALNS)
CJO107319490(GALNS)
TPAI128082263(GALNS)
LMUT125699344(GALNS)
NMEL110404190(GALNS)
APLA101792596(GALNS)
ACYG106046507(GALNS)
CATA118257825(GALNS)
AFUL116493952(GALNS)
TGU100222785(GALNS)
LSR110468778(GALNS)
SCAN103816759(GALNS)
PMOA120496245(GALNS)
OTC121333791(GALNS)
PRUF121362139(GALNS)
GFR102043643(GALNS)
FAB101811724(GALNS)
OMA130257929(GALNS)
PHI102101123(GALNS)
PMAJ107209820(GALNS)
CCAE111934402(GALNS)
CCW104691852(GALNS)
CBRC103620531(GALNS)
ETL114060570(GALNS)
ZAB102061073(GALNS) 102069306
ZLE135452950(GALNS)
ACHL103801189(GALNS)
SVG106852073(GALNS)
MMEA130585964(GALNS)
HRT120757714(GALNS)
FPG101915149(GALNS)
FCH102047887(GALNS)
CLV102096794(GALNS)
EGZ104127040(GALNS)
NNI104023569(GALNS)
PCRI104028377(GALNS)
PLET104625077(GALNS)
EHS104514048(GALNS)
PCAO104050843(GALNS)
ACUN113484623(GALNS)
TALA104363110(GALNS)
PADL103919464(GALNS)
AFOR103893827(GALNS)
ACHC115345352(GALNS)
HALD104322368(GALNS)
HLE104839339(GALNS)
AGEN126041141
GCL127021315
CCRI104163967(GALNS)
CSTI104557832(GALNS)
CMAC104472925(GALNS)
MUI104538532(GALNS)
BREG104636034(GALNS)
FGA104069072(GALNS)
GSTE104263598(GALNS)
LDI104351583(GALNS)
MNB103776695(GALNS)
OHA104329136(GALNS)
NNT104409341(GALNS)
SHAB115619566(GALNS)
DPUB104303833(GALNS)
PGUU104458036(GALNS)
ACAR104517665(GALNS)
CPEA104398323(GALNS)
AVIT104273135(GALNS)
CVF104290871(GALNS)
RTD128908466(GALNS)
CUCA104061255(GALNS)
TEO104377077
BRHI104493548(GALNS)
AAM106491425(GALNS)
AROW112978484(GALNS)
NPD112949943(GALNS)
TGT104577576
DNE112989077(GALNS)
SCAM104145362(GALNS)
ASN102384115(GALNS)
AMJ102560299(GALNS)
CPOO109310712(GALNS)
GGN109289387(GALNS)
PSS102445221(GALNS)
CMY102937794(GALNS)
CCAY125645388(GALNS)
DCC119841115(GALNS)
CPIC101934226(GALNS)
TST117886379(GALNS)
CABI116815680(GALNS)
MRV120384171(GALNS)
ACS100556157(galns)
ASAO132783058(GALNS)
PVT110076238(GALNS)
SUND121914957(GALNS)
PBI103067280(GALNS)
PMUR107283519(GALNS)
CTIG120302469(GALNS)
TSR106552196(GALNS)
PGUT117671022(GALNS)
APRI131184122(GALNS)
PTEX113448913(GALNS)
NSS113427286(GALNS)
VKO123022275(GALNS)
PMUA114602133(GALNS)
PRAF128419373(GALNS)
ZVI118086417(GALNS)
HCG128334401(GALNS)
GJA107115627(GALNS)
STOW125443448(GALNS)
EMC129344217(GALNS)
XLA495239(galns.L)
XTR100485376(galns)
NPR108787709(GALNS)
RTEM120917919(GALNS)
BBUF120980190(GALNS)
BGAR122920554(GALNS)
MUO115470949(GALNS) 115470950
GSH117359132(GALNS)
DRE791159(galns)
SRX107728036 107730157(galns)
SANH107663041 107685869
SGH107561424
CCAR109052187 109072047
CAUA113106343(galns)
CGIB127962658
PTET122349543(galns)
LROH127168451(galns)
OMC131544947(galns)
PPRM120492607(galns)
RKG130070420(galns)
MAMB125265846(galns)
CIDE127516461
MASI127447379
TROS130558994(galns)
TDW130427992(galns)
MANU129452592(galns)
IPU108259597
IFU128602800(galns)
PHYP113546742(galns)
SMEO124380157(galns)
TFD113634223(galns)
TVC132838565(galns)
TRN134303909(galns)
AMEX103034478(galns)
CMAO118817604(galns)
EEE113575705(galns)
CHAR105892912(galns)
TRU101062701(galns)
TFS130521832(galns)
TNGGSTEN00017886G001
LCO104922746
NCC104947090(galns)
TBEN117471744(galns)
CGOB115005461(galns)
PGEO117466696(galns)
GACU117547444(galns)
EMAC134863047(galns)
ELY117256764(galns)
EFO125902169(galns)
PLEP121948104(galns)
SLUC116034032(galns)
ECRA117950807(galns)
ESP116696521(galns)
PFLV114552310(galns)
GAT120807952(galns)
PPUG119198284(galns)
AFB129104840(galns)
CLUM117725926(galns)
PSWI130193076(galns)
MSAM119889945(galns)
SCHU122880626(galns)
CUD121507649(galns)
ALAT119018165(galns)
MZE101471725(galns)
ONL100694056(galns)
OAU116324295(galns)
OLA101171730(galns)
OML112160349(galns)
CSAI133461121(galns)
XMA102237545(galns)
XCO114142561(galns)
XHE116718196(galns)
PRET103462372(galns)
PFOR103139344(galns)
PLAI106947220(galns)
PMEI106928083(galns)
GAF122822484(galns)
PPRL129369659(galns)
CVG107090762(galns)
CTUL119782664(galns)
GMU124866905(galns)
NFU107381170(galns)
KMR108229109(galns)
ALIM106513999 106535460(galns)
NWH119428716(galns)
AOCE111588401(galns)
MCEP125005486(galns)
CSEM103378683(galns)
POV109624779(galns)
SSEN122772677(galns)
HHIP117759144(galns)
HSP118106961(galns)
PPLT128443953(galns)
SMAU118302364(galns)
LCF108887657
SDU111238375(galns)
SLAL111668284(galns)
XGL120788744(galns)
HCQ109519694(galns)
SSCV125967321
SBIA133498299(galns)
PEE133399053(galns)
PTAO133472694(galns)
BPEC110172948(galns)
MALB109966269(galns)
BSPL114852174(galns)
SJO128357231(galns)
SASA106587262(galns)
STRU115167380(galns)
OTW112249114
OMY110506416 110526298
OGO124033834(galns)
ONE115112157(galns)
OKI109886553(galns)
OKE118358704(galns)
SALP111969099
SNH120025054 120046281(galns)
CCLU121548309(galns)
ELS105017049(galns)
SFM108934575(galns)
PKI111832952(galns)
AANG118227539(galns)
LOC102682809(galns)
PSPA121325621(galns)
ARUT117425033
PSEX120535428(galns)
LCM102351372(GALNS)
CMK103188083(galns)
RTP109927191(galns)
CPLA122558182(galns)
HOC132824049(galns)
LERI129715073(galns)
PMRN116944099(GALNS)
LRJ133350812(GALNS)
BFO118417061
BBEL109487383
CIN100177085
SCLV120337476
SPU579130 588014
LPIC129254082
APLC110988485
AJC117123524
SKO100369185
RZE108377917
PVM113810897
PJA122250835 122265722
PCHN125024895
PMOO119595418
HAME121873258
PCLA123769173
CQD128690115 128690116
PTRU123507765
ESN126998113
MNZ135214409
HAZT108669890
EAF111703859
TCF131885716
PPOI119105862 119105964
DSV119436208 119436209
RSAN119407081 119407091
RMP119177296 119177297
TUT107369286
DPTE113792048
DFR124500144
CSCU111634997
PTEP107451534
ABRU129984049
UDV129223889
SDM118203759
LPOL106468150
HROHELRODRAFT_95956
LGILOTGIDRAFT_159001
PVUL126814591
PCAN112576502
BGT106058711
GAE121388395
HRF124112853
HRJ124266348
CRG105348100
CANU128188777
CVN111134369 111134371
OED125651774
MYI110464777 110467289
PMAX117327359 117337667
MCAF127703049
MMER123548759
RPHI132758283 132758538
DPOL127844465 127846125
MAEA128243309
OBI106880025
OSN115215877
LJP135466270
LAK106161119 106180844
ADF107327708
AMIL114954146
PDAM113665844
SPIS111325693
DGT114516978 114542597
HSY130614798
AQU100637906
FPOAFPOAC1_009868
FVNFVRRES_10522
FMUJ7337_011392
PMESFX988_03340
SPHPLH20_14895
SMAZLH19_12295
STERAOA14_10930
SGISGRAN_1170
SPHXE5675_14210
SPAPH3Z74_11860
SMICSmB9_09240
PIRVN12_16015(atsA_21)
RULUC8_51720(atsA_48)
AAGGETAA8_41730(atsA_43)
PNDPla175_22360(atsA_36)
PBSPlabr_2973
GPNPan110_45830(atsA_48)
MRIMal4_02690(atsA_4) Mal4_26260(atsA_36)
PFERIRI77_14315
MCOSGM418_24990
CHKD4L85_03380
FNKE1750_03490
 » show all
Reference
1  [PMID:6939689]
  Authors
Epstein EH Jr, Leventhal ME.
  Title
Steroid sulfatase of human leukocytes and epidermis and the diagnosis of recessive X-linked ichthyosis.
  Journal
J Clin Invest 67:1257-62 (1981)
DOI:10.1172/JCI110153
Reference
2  [PMID:6213226]
  Authors
Glossl J, Kresse H.
  Title
Impaired degradation of keratan sulphate by Morquio A fibroblasts.
  Journal
Biochem J 203:335-8 (1982)
DOI:10.1042/bj2030335
Reference
3  [PMID:7213753]
  Authors
Lim CT, Horwitz AL.
  Title
Purification and properties of human N-acetylgalactosamine-6-sulfate sulfatase.
  Journal
Biochim Biophys Acta 657:344-55 (1981)
DOI:10.1016/0005-2744(81)90320-X
Reference
4  [PMID:6814909]
  Authors
Sorensen SH, Noren O, Sjostrom H, Danielsen EM.
  Title
Amphiphilic pig intestinal microvillus maltase/glucoamylase. Structure and specificity.
  Journal
Eur J Biochem 126:559-68 (1982)
DOI:10.1111/j.1432-1033.1982.tb06817.x
Reference
5  [PMID:6809361]
  Authors
Yutaka T, Okada S, Kato T, Inui K, Yabuuhi H.
  Title
Galactose 6-sulfate sulfatase activity in Morquio syndrome.
  Journal
Clin Chim Acta 122:169-80 (1982)
DOI:10.1016/0009-8981(82)90276-5
Other DBs
ExplorEnz - The Enzyme Database: 3.1.6.4
IUBMB Enzyme Nomenclature: 3.1.6.4
ExPASy - ENZYME nomenclature database: 3.1.6.4
BRENDA, the Enzyme Database: 3.1.6.4
CAS: 9025-60-9

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