Entry
Name
N-acetylgalactosamine-6-sulfatase;
chondroitin sulfatase;
chondroitinase;
galactose-6-sulfate sulfatase;
acetylgalactosamine 6-sulfatase;
N-acetylgalactosamine-6-sulfate sulfatase;
N-acetylgalactosamine 6-sulfatase
Class
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
BRITE hierarchy
Sysname
N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase
Reaction(IUBMB)
Hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate [RN:
R07806 ]
Reaction(KEGG)
History
EC 3.1.6.4 created 1961
Pathway
ec00531 Glycosaminoglycan degradation
Orthology
K01132 N-acetylgalactosamine-6-sulfatase
Genes
RRO : 104655978(GALNS) 115895245 115896020
LWW : 102727198(GALNS) 102728108
ZAB : 102061073(GALNS) 102069306
SRX : 107728036 107730157(galns)
SANH : 107663041 107685869
CCAR : 109052187 109072047
ALIM : 106513999 106535460(galns)
SNH : 120025054 120046281(galns)
PPOI : 119105862 119105964
RSAN : 119407081 119407091
PMAX : 117327359 117337667
DPOL : 127844465 127846125
AAGG : ETAA8_41730(atsA_43)
PND : Pla175_22360(atsA_36)
GPN : Pan110_45830(atsA_48)
MRI : Mal4_02690(atsA_4) Mal4_26260(atsA_36)
» show all
Taxonomy
Reference
Authors
Epstein EH Jr, Leventhal ME.
Title
Steroid sulfatase of human leukocytes and epidermis and the diagnosis of recessive X-linked ichthyosis.
Journal
Reference
Authors
Glossl J, Kresse H.
Title
Impaired degradation of keratan sulphate by Morquio A fibroblasts.
Journal
Reference
Authors
Lim CT, Horwitz AL.
Title
Purification and properties of human N-acetylgalactosamine-6-sulfate sulfatase.
Journal
Reference
Authors
Sorensen SH, Noren O, Sjostrom H, Danielsen EM.
Title
Amphiphilic pig intestinal microvillus maltase/glucoamylase. Structure and specificity.
Journal
Reference
Authors
Yutaka T, Okada S, Kato T, Inui K, Yabuuhi H.
Title
Galactose 6-sulfate sulfatase activity in Morquio syndrome.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.1.6.4
ExPASy - ENZYME nomenclature database: 3.1.6.4
BRENDA, the Enzyme Database: 3.1.6.4