KEGG   ENZYME: 3.1.7.10
Entry
EC 3.1.7.10                 Enzyme                                 
Name
(13E)-labda-7,13-dien-15-ol synthase;
labda-7,13E-dien-15-ol synthase
Class
Hydrolases;
Acting on ester bonds;
Diphosphoric-monoester hydrolases
Sysname
geranylgeranyl-diphosphate diphosphohydrolase [(13E)-labda-7,13-dien-15-ol-forming]
Reaction(IUBMB)
geranylgeranyl diphosphate + H2O = (13E)-labda-7,13-dien-15-ol + diphosphate [RN:R09874]
Reaction(KEGG)
R09874
Substrate
geranylgeranyl diphosphate [CPD:C00353];
H2O [CPD:C00001]
Product
(13E)-labda-7,13-dien-15-ol [CPD:C20158];
diphosphate [CPD:C00013]
Comment
The enzyme from the lycophyte Selaginella moellendorffii is bifunctional, initially forming (13E)-labda-7,13-dien-15-yl diphosphate, which is hydrolysed to the alcohol.
History
EC 3.1.7.10 created 2012
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K16086  (13E)-labda-7,13-dien-15-ol synthase
Genes
CJF: 131049641 131078742
SMO: SELMODRAFT_112927 SELMODRAFT_120716
Reference
1  [PMID:21751328]
  Authors
Mafu S, Hillwig ML, Peters RJ
  Title
A novel labda-7,13e-dien-15-ol-producing bifunctional diterpene synthase from Selaginella moellendorffii.
  Journal
Chembiochem 12:1984-7 (2011)
DOI:10.1002/cbic.201100336
  Sequence
[smo:SELMODRAFT_120716]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.7.10
IUBMB Enzyme Nomenclature: 3.1.7.10
ExPASy - ENZYME nomenclature database: 3.1.7.10
BRENDA, the Enzyme Database: 3.1.7.10

  All links  
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (3)   
   RefSeq(nuc) (1)   
   GenBank (1)   
   EMBL (1)   
Protein domain (8)   
   InterPro (8)   
All databases (15)   

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