| Entry |
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| Name |
tuberculosinol synthase;
Rv3378c
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| Class |
Hydrolases;
Acting on ester bonds;
Diphosphoric-monoester hydrolases
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| Sysname |
tuberculosinyl diphosphate diphosphohydrolase (tuberculosinol forming)
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| Reaction(IUBMB) |
tuberculosinyl diphosphate + H2O = tuberculosinol + diphosphate [RN: R09828]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Only found in species of Mycobacterium that cause tuberculosis. In addition, it also gives isotuberculosinol in 1:1 mixture, cf. EC 3.1.7.9, isotuberculosinol synthase.
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| History |
EC 3.1.7.8 created 2011
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| Orthology |
| K15911 | tuberculosinol/isotuberculosinol synthase |
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| Genes |
» show all
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| Reference |
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| Authors |
Nakano C, Ootsuka T, Takayama K, Mitsui T, Sato T, Hoshino T |
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| Title |
Characterization of the Rv3378c gene product, a new diterpene synthase for producing tuberculosinol and (13R, S)-isotuberculosinol (nosyberkol), from the Mycobacterium tuberculosis H37Rv genome. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Hoshino T, Nakano C, Ootsuka T, Shinohara Y, Hara T. |
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| Title |
Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.1.7.8 |
| ExPASy - ENZYME nomenclature database: | 3.1.7.8 |
| BRENDA, the Enzyme Database: | 3.1.7.8 |
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