KEGG   ENZYME: 3.1.8.1
Entry
EC 3.1.8.1                  Enzyme                                 

Name
aryldialkylphosphatase;
organophosphate hydrolase;
paraoxonase;
A-esterase;
aryltriphosphatase;
organophosphate esterase;
esterase B1;
esterase E4;
paraoxon esterase;
pirimiphos-methyloxon esterase;
OPA anhydrase (ambiguous);
organophosphorus hydrolase;
phosphotriesterase;
paraoxon hydrolase;
OPH;
organophosphorus acid anhydrase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-triester hydrolases
Sysname
aryltriphosphate dialkylphosphohydrolase
Reaction(IUBMB)
an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol [RN:R03979]
Reaction(KEGG)
R03979 > R05548;
(other) R05421
Substrate
aryl dialkyl phosphate [CPD:C03254];
H2O [CPD:C00001]
Product
dialkyl phosphate [CPD:C02534];
phenol [CPD:C15584]
Comment
Acts on organophosphorus compounds (such as paraoxon) including esters of phosphonic and phosphinic acids. Inhibited by chelating agents; requires divalent cations for activity. Previously regarded as identical with EC 3.1.1.2 arylesterase.
History
EC 3.1.8.1 created 1989
Pathway
ec00627  Aminobenzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K01045  arylesterase / paraoxonase
Genes
HSA: 5444(PON1) 5445(PON2) 5446(PON3)
PTR: 463547(PON1) 463548(PON3) 463549(PON2)
PPS: 100971627(PON1) 100971959(PON3) 100972315(PON2)
GGO: 101146649(PON1) 101147009(PON3) 101147360(PON2)
PON: 100436262(PON3) 100436640(PON1) 100437018(PON2)
NLE: 100602768(PON1) 100603110(PON3) 100603799(PON2)
MCC: 699107(PON2) 699236(PON3) 699355(PON1)
MCF: 102119827(PON2) 102120476(PON3) 102121098(PON1)
CSAB: 103226525(PON3) 103226526(PON2) 103226528(PON1)
RRO: 104656585(PON1) 104656587(PON3) 104656588(PON2)
RBB: 108513529(PON2) 108513530(PON3) 108513531(PON1)
CJC: 100407939(PON2) 100408549(PON3) 100408915(PON1)
SBQ: 101047829(PON3) 101048148(PON2) 101048681(PON1)
MMU: 18979(Pon1) 269823(Pon3) 330260(Pon2)
MCAL: 110296021(Pon2) 110296115(Pon3) 110296505(Pon1)
MPAH: 110315074(Pon2) 110315089(Pon3) 110316677(Pon1)
RNO: 296851(Pon2) 312086(Pon3) 84024(Pon1)
MUN: 110559637(Pon3) 110559638(Pon1) 110559640(Pon2)
CGE: 100762244(Pon1) 100762539(Pon2) 100762826(Pon3)
NGI: 103725227(Pon3) 103725228(Pon2) 103725260(Pon1)
HGL: 101696947(Pon1) 101697319(Pon3) 101697694(Pon2)
OCU: 100008754(PON3) 100009133(PON1) 100340152(PON2)
TUP: 102467949(PON3) 102482718(PON2) 102503295(PON1)
CFA: 403855(PON2) 475234(PON1) 475235(PON3)
VVP: 112923903(PON1) 112923904(PON3) 112923905(PON2)
UMR: 103658742(PON1) 103658743(PON3) 103658801(PON2)
UAH: 113260313(PON1) 113260329 113260347(PON2)
ORO: 101371249(PON2) 101371749(PON3) 101372042(PON1)
FCA: 101091522(PON1) 101091774(PON3) 101094492(PON2)
PTG: 102965359(PON2) 102969631(PON3) 102969909(PON1)
PPAD: 109263711(PON1) 109263712(PON3) 109263714(PON2)
AJU: 106969955(PON3) 106969956(PON2) 106970003(PON1)
BTA: 281417(PON2) 510953(PON3) 523798(PON1)
BOM: 102268223(PON1) 102268513(PON3) 102269334(PON2)
BIU: 109558220(PON1) 109558221(PON3) 109558222(PON2)
BBUB: 102413831(PON2) 102414943(PON1) 102415937(PON3)
CHX: 102183658(PON2) 102189091(PON1) 102189455(PON3)
OAS: 100145861(PON2) 100337686(PON3) 101116983(PON1)
SSC: 100048952(PON1) 100142663(PON2) 733674(PON3)
CFR: 102519221(PON3) 102519463(PON1) 102521631(PON2)
CDK: 105088724(PON2) 105088725(PON3) 105088728(PON1)
BACU: 103002002(PON2) 103002453(PON3) 103004502(PON1)
LVE: 103072098(PON3) 103072365(PON2) 103075141(PON1) 103079171
OOR: 101286851(PON2) 101287293(PON3)
DLE: 111181194(PON3) 111181203(PON1) 111181316(PON2)
PCAD: 102985460(PON3) 102985745(PON2) 102986866
ECB: 100051896(PON1) 100051959(PON3) 100062686(PON2)
EPZ: 103541442(PON1) 103542649(PON3) 103542650(PON2) 103566405
EAI: 106838926(PON2) 106838927(PON3) 106838928(PON1)
MYB: 102249558(PON3) 102250151(PON1) 102251833(PON2)
MYD: 102757128(PON2) 102772860(PON1) 102775231(PON3)
MNA: 107541647(PON3) 107541664 107541732(PON2)
HAI: 109393132 109393133(PON1)
DRO: 112319802(PON3) 112319857(PON1) 112319862(PON2)
MJV: 108406224(PON2) 108406225(PON1) 108406229(PON3)
LAV: 100667197(PON2) 100675274(PON3) 100675554(PON1)
MDO: 100017970(PON2) 100018559(PON3) 100028798
OAA: 103168141
GGA: 395830(PON2)
MGP: 100303695
CJO: 107309112
NMEL: 110393402
APLA: 101800414
ACYG: 106037501(PON2)
TGU: 100218152
LSR: 110474732
SCAN: 103812828
GFR: 102033037(PON2)
FAB: 101812552(PON2)
PHI: 102101075(PON2)
PMAJ: 107200070
CCAE: 111924234
CCW: 104689162
ETL: 114072935(PON2)
FPG: 101913744(PON2)
FCH: 102055053
CLV: 102089494
EGZ: 104128625
NNI: 104012814(PON2)
ACUN: 113477127
PADL: 103922433(PON2)
AAM: 106483521(PON2)
ASN: 102370400
AMJ: 102569523(PON2)
PSS: 102457846
CMY: 102930790(PON2)
CPIC: 101938475(PON2)
ACS: 100551677(pon2)
PVT: 110074724
PBI: 103052672
PMUR: 107283648
TSR: 106543984(PON2)
PMUA: 114607242
GJA: 107118000(PON2)
XLA: 108718843 380341(pon2.L) 432039(pon2.S)
XTR: 448598(pon2)
DRE: 335176(pon2) 447803(pon1) 554122(pon3.1) 568655(pon3.2)
CCAR: 109074161
IPU: 108271509
PHYP: 113526829
AMEX: 103046166
EEE: 113575646
TRU: 101062836
XCO: 114141748
CSEM: 103388494
POV: 109633519
BPEC: 110171411
OTW: 112225380
SFM: 108940718
PKI: 111844496
LCM: 102361851
CMK: 103176917
RTP: 109914992
OBI: 106873488
PDAM: 113678921
HMG: 100211341
AQU: 105316431
QSU: 112021952
MGR: MGG_13116
SSCK: SPSK_02462
MAW: MAC_03353
MBE: MBM_03697
PTE: PTT_18852
ABP: AGABI1DRAFT119181(AGABI1DRAFT_119181)
ABV: AGABI2DRAFT185052(AGABI2DRAFT_185052)
SPLY: Q5A_005815
PSPI: PS2015_622
PLA: Plav_2097
GAK: X907_2580
LBY: Lbys_0674
 » show all
Reference
1  [PMID:13032041]
  Authors
ALDRIDGE WN.
  Title
Serum esterases.  I.  Two types of esterase (A and B) hydrolysing p-nitrophenyl acetate, propionate and butyrate, and a method for their determination.
  Journal
Biochem J 53:110-7 (1953)
DOI:10.1042/bj0530110
Reference
2  [PMID:5047702]
  Authors
Bosmann HB.
  Title
Membrane marker enzymes. Characterization of an arylesterase of guinea pig cerebral cortex utilizing p-nitrophenyl acetate as substrate.
  Journal
Biochim Biophys Acta 276:180-91 (1972)
DOI:10.1016/0005-2744(72)90019-8
Reference
3  [PMID:2822017]
  Authors
Mackness MI, Thompson HM, Hardy AR, Walker CH.
  Title
Distinction between 'A'-esterases and arylesterases. Implications for esterase classification.
  Journal
Biochem J 245:293-6 (1987)
DOI:10.1042/bj2450293
Reference
4  [PMID:14420012]
  Authors
MAIN AR.
  Title
The differentiation of the A-type esterases in sheep serum.
  Journal
Biochem J 75:188-95 (1960)
DOI:10.1042/bj0750188
Reference
5
  Authors
In: Reiner, E., Aldridge, W.N. and Hoskin, C.G. (Eds.), Enzymes Hydrolysing Organophosphorus Compounds, Ellis Horwood, Chichester, UK, 1989.
Other DBs
ExplorEnz - The Enzyme Database: 3.1.8.1
IUBMB Enzyme Nomenclature: 3.1.8.1
ExPASy - ENZYME nomenclature database: 3.1.8.1
UM-BBD (Biocatalysis/Biodegradation Database): 3.1.8.1
BRENDA, the Enzyme Database: 3.1.8.1
CAS: 117698-12-1

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