KEGG ENZYME: 3.1.8.2

ENZYME: 3.1.8.2

Entry

EC 3.1.8.2 Enzyme

Name

diisopropyl-fluorophosphatase;
DFPase;
tabunase;
somanase;
organophosphorus acid anhydrolase;
organophosphate acid anhydrase;
OPA anhydrase (ambiguous);
diisopropylphosphofluoridase;
dialkylfluorophosphatase;
diisopropyl phosphorofluoridate hydrolase;
isopropylphosphorofluoridase;
diisopropylfluorophosphonate dehalogenase

Class

Hydrolases;
Acting on ester bonds;
Phosphoric-triester hydrolases

Sysname

diisopropyl-fluorophosphate fluorohydrolase

Reaction(IUBMB)

diisopropyl fluorophosphate + H2O = diisopropyl phosphate + fluoride [RN:R01533]

Reaction(KEGG)

R01533

Substrate

diisopropyl fluorophosphate [CPD:C00202];
H2O [CPD:C00001]

Product

diisopropyl phosphate [CPD:C03113];
fluoride [CPD:C00742]

Comment

Acts on phosphorus anhydride bonds (such as phosphorus-halide and phosphorus-cyanide) in organophosphorus compounds (including 'nerve gases'). Inhibited by chelating agents; requires divalent cations. Related to EC 3.1.8.1 aryldialkylphosphatase.

History

EC 3.1.8.2 created 1961 as EC 3.8.2.1, transferred 1992 to EC 3.1.8.2

Reference

Authors

Augustinsson, K.-B. and Heimburger, G.

Title

Enzymatic hydrolysis of organophosphorus compounds. I. Occurrence of enzymes hydrolysing dimethyl-amido-ethoxy-phosphoryl cyanide (Tabun).

Journal

Acta Chem Scand 8:753-761 (1954)

Reference

Authors

Augustinsson, K.-B. and Heimburger, G.

Title

Enzymatic hydrolysis of organophosphorus compounds. II. Analysis of reaction products in experiments with Tabun and some properties of blood plasma tabunase.

Journal

Acta Chem Scand 8:762-767 (1954)

Reference

Authors

Augustinsson, K.-B. and Heimburger, G.

Title

Enzymatic hydrolysis of organophosphorus compounds. IV. Specificity studies.

Journal

Acta Chem Scand 8:1533-1541 (1954)

Reference

4 [PMID:13479457]

Authors

COHEN JA, WARRINGA MG.

Title

Purification and properties of dialkylfluorophosphatase.

Journal

Biochim Biophys Acta 26:29-39 (1957)
DOI:10.1016/0006-3002(57)90050-1

Reference

Authors

Mounter, L.A.

Title

Enzymic hydrolysis of organophosphorus compounds.

Journal

In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 4, Academic Press, New York, 1960, p. 541-550.

Reference

Authors

In: Reiner, E., Aldridge, W.N. and Hoskin, C.G. (Eds.), Enzymes Hydrolysing Organophosphorus Compounds, Ellis Horwood, Chichester, UK, 1989

Other DBs

ExplorEnz - The Enzyme Database:

3.1.8.2

IUBMB Enzyme Nomenclature:

3.1.8.2

ExPASy - ENZYME nomenclature database:

3.1.8.2

BRENDA, the Enzyme Database:

3.1.8.2

CAS:

9032-18-2

All links

Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Protein sequence (59)   
   UniProt (8)   
   SWISS-PROT (3)   
   PDBSTR (46)   
   PMD (2)   
DNA sequence (34)   
   GenBank (17)   
   EMBL (17)   
3D Structure (32)   
   PDB (32)   
Protein domain (7)   
   InterPro (7)   
All databases (138)   

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