Entry
Name
UDP-sulfoquinovose synthase;
sulfite:UDP-glucose sulfotransferase;
UDPsulfoquinovose synthase;
UDP-6-sulfo-6-deoxyglucose sulfohydrolase
Class
Hydrolases;
Acting on carbon-sulfur bonds;
Acting on carbon-sulfur bonds
BRITE hierarchy
Sysname
UDP-6-sulfo-6-deoxy-alpha-D-glucose sulfohydrolase
Reaction(IUBMB)
UDP-alpha-D-sulfoquinovopyranose + H2O = UDP-alpha-D-glucose + sulfite [RN:
R05775 ]
Reaction(KEGG)
Substrate
UDP-alpha-D-sulfoquinovopyranose;
H2O [CPD:
C00001 ]
Product
Comment
Requires NAD+, which appears to oxidize UDP-alpha-D-glucose to UDP-4-dehydroglucose, which dehydrates to UDP-4-dehydro-6-deoxygluc-5-enose, to which sulfite is added. The reaction is completed when the substrate is rehydrogenated at C-4. The enzyme from Arabidopsis thaliana is specific for UDP-Glc and sulfite.
History
EC 3.13.1.1 created 2001, modified 2010
Pathway
ec00520 Amino sugar and nucleotide sugar metabolism
Orthology
K06118 UDP-sulfoquinovose synthase
Genes
CSAT : 104716862 104721515 104729959
BNA : 106364202 106368764 106410744 106423381 125609066
RSZ : 108823028 108855863 130511954
MINC : 123194834 123200518
CCAJ : 109791483 109814463
LJA : Lj1g3v4192290.1(Lj1g3v4192290.1) Lj1g3v4202330.1(Lj1g3v4202330.1)
SSPL : 121780412 121782579
AEW : 130765104 130765447 130765804
CQI : 110696977 110705433 110728373
PSOM : 113310776 113322379
DOSA : Os05t0387200-01(Os05g0387200)
TAES : 123054194 123078912 123181858
PVIR : 120665645 120698855
ZOF : 121970267 121975354 122008280 122014350
NCOL : 116245244 116245876
SMO : SELMODRAFT_179226 SELMODRAFT_234929
FCY : FRACYDRAFT_268690(SQD1_1)
TPS : THAPSDRAFT_269393(SQDB1)
EHX : EMIHUDRAFT_466230(SQD1)
MII : BTJ40_04740 BTJ40_21955
MICT : FIU95_04755 FIU95_08270(fcl)
MVB : MJO52_04895 MJO52_13110
SALN : SALB1_1418 SALB1_3330
ORM : HTY61_10060 HTY61_16385
SMEL : SM2011_c03961(sqdB)
SFD : USDA257_c52080(sqdB)
SAME : SAMCFNEI73_Ch3159(sqdB)
REC : RHECIAT_CH0003707(sqdB)
AUZ : Sa4125_39380(wcaG_2)
BVY : NCTC9239_03454(rfbE)
PALW : PSAL_015380(wbiB_1) PSAL_017830(wbiB_2)
THAS : C6Y53_00135 C6Y53_08810
HYT : HXX25_00155 HXX25_09785
PBR : PB2503_00455 PB2503_06652
MPOF : MPOR_04250(qdb) MPOR_10410(wcaG)
CCJ : UL81_03980 UL81_09345
CMIN : NCTC10288_01666(sqdB)
TOY : FO059_01460 FO059_16185
RMAR : GBA65_03175 GBA65_11540
SYR : SynRCC307_0054 SynRCC307_0204
SYH : Syncc8109_0057(sqdB)
CYN : Cyan7425_0273 Cyan7425_3915
LET : O77CONTIG1_03860(rfbB)
CHON : NIES4102_14300(wcaG_2)
SYP : SYNPCC7002_A0847(wcaG)
PAGH : NIES204_21460(sqdB_1)
NSPH : BDGGKGIB_02599(galE_1)
NAY : HYG81_04000 HYG81_04135 HYG81_05500
SAWL : NGM29_05935 NGM29_06905
TVO : TVG0519952(TVG0519952)
ABRI : DFR85_03700 DFR85_06330
AAMB : D1866_00260 D1866_08060
NGA : Ngar_c14870 Ngar_c30490
LOKI : Lokiarch_16040(fcl)
» show all
Taxonomy
Reference
Authors
Essigmann B, Guler S, Narang RA, Linke D, Benning C
Title
Phosphate availability affects the thylakoid lipid composition and the expression of SQD1, a gene required for sulfolipid biosynthesis in Arabidopsis thaliana.
Journal
Sequence
Reference
Authors
Essigmann B, Hespenheide BM, Kuhn LA, Benning C.
Title
Prediction of the active-site structure and NAD(+) binding in SQD1, a protein essential for sulfolipid biosynthesis in Arabidopsis.
Journal
Reference
Authors
Mulichak AM, Theisen MJ, Essigmann B, Benning C, Garavito RM.
Title
Crystal structure of SQD1, an enzyme involved in the biosynthesis of the plant sulfolipid headgroup donor UDP-sulfoquinovose.
Journal
Sequence
Reference
Authors
Sanda S, Leustek T, Theisen MJ, Garavito RM, Benning C.
Title
Recombinant Arabidopsis SQD1 converts udp-glucose and sulfite to the sulfolipid head group precursor UDP-sulfoquinovose in vitro.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.13.1.1
ExPASy - ENZYME nomenclature database: 3.13.1.1