KEGG   ENZYME: 3.13.1.7Help
Entry
EC 3.13.1.7                 Enzyme                                 

Name
carbonyl sulfide hydrolase;
COSase;
COS hydrolase;
cos (gene name)
Class
Hydrolases;
Acting on carbon-sulfur bonds;
Acting on carbon-sulfur bonds (only sub-subclass identified to date)
BRITE hierarchy
Sysname
carbonyl sulfide hydrogen-sulfide-lyase (decarboxylating)
Reaction(IUBMB)
carbonyl sulfide + H2O = hydrogen sulfide + CO2 [RN:R10535]
Reaction(KEGG)
Substrate
carbonyl sulfide [CPD:C07331];
H2O [CPD:C00001]
Product
hydrogen sulfide [CPD:C00283];
CO2 [CPD:C00011]
Comment
The enzyme, characterized from the bacterium Thiobacillus thioparus, catalyses a step in the degradation pathway of thiocyanate. This activity is also catalysed by the archaeal EC 3.13.1.5, carbon disulfide lyase.
History
EC 3.13.1.7 created 2018
Orthology
K22576  carbonyl sulfide hydrolase
Reference
1  [PMID:23406161]
  Authors
Ogawa T, Noguchi K, Saito M, Nagahata Y, Kato H, Ohtaki A, Nakayama H, Dohmae N, Matsushita Y, Odaka M, Yohda M, Nyunoya H, Katayama Y
  Title
Carbonyl sulfide hydrolase from Thiobacillus thioparus strain THI115 is one of the beta-carbonic anhydrase family enzymes.
  Journal
J Am Chem Soc 135:3818-25 (2013)
DOI:10.1021/ja307735e
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.13.1.7
IUBMB Enzyme Nomenclature: 3.13.1.7
ExPASy - ENZYME nomenclature database: 3.13.1.7
BRENDA, the Enzyme Database: 3.13.1.7

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