Hydrolases;
Acting on carbon-sulfur bonds;
Acting on carbon-sulfur bonds (only sub-subclass identified to date)
BRITE hierarchy

S-adenosyl-L-methionine hydrolase (adenosine-forming)

S-adenosyl-L-methionine + H2O = adenosine + L-methionine [RN:R12098]

R12098
Reaction

S-adenosyl-L-methionine [CPD:C00019];
H2O [CPD:C00001]

The enzyme, found in bacteria and archaea, catalyses a nucleophilic attack of water at the C5' carbon of S-adenosyl-L-methionine to generate adenosine and L-methionine. May be involved in regulating SAM levels in the cell. cf. EC 3.3.1.2, S-adenosyl-L-methionine hydrolase (L-homoserine-forming).

EC 3.13.1.8 created 2018

1  [PMID:18720493]

Eustaquio AS, Harle J, Noel JP, Moore BS

S-Adenosyl-L-methionine hydrolase (adenosine-forming), a conserved bacterial and archaeal protein related to SAM-dependent halogenases.

Chembiochem 9:2215-9 (2008)
DOI:10.1002/cbic.200800341

[saq:Sare_1364]

2  [PMID:19739191]

Deng H, McMahon SA, Eustaquio AS, Moore BS, Naismith JH, O'Hagan D

Mechanistic insights into water activation in SAM hydroxide adenosyltransferase (duf-62).

Chembiochem 10:2455-9 (2009)
DOI:10.1002/cbic.200900369

[pho:PH0463]