KEGG   ENZYME: 3.2.1.103
Entry
EC 3.2.1.103                Enzyme                                 
Name
keratan-sulfate endo-1,4-beta-galactosidase;
endo-beta-galactosidase (ambiguous);
keratan sulfate endogalactosidase;
keratanase;
keratan-sulfate 1,4-beta-D-galactanohydrolase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
Sysname
keratan-sulfate 4-beta-D-galactanohydrolase
Reaction(IUBMB)
Endohydrolysis of (1->4)-beta-D-galactosidic linkages in keratan sulfate [RN:R07805]
Reaction(KEGG)
R07805(G)
Comment
Hydrolyses the 1,4-beta-D-galactosyl linkages adjacent to 1,3-N-acetyl-alpha-D-glucosaminyl residues. Also acts on some non-sulfated oligosaccharides, but only acts on blood group substances when the 1,2-linked fucosyl residues have been removed (cf. EC 3.2.1.102 blood-group-substance endo-1,4-beta-galactosidase).
History
EC 3.2.1.103 created 1984
Pathway
ec00531  Glycosaminoglycan degradation
ec01100  Metabolic pathways
Reference
1  [PMID:135762]
  Authors
Fukuda MN, Matsumura G.
  Title
Endo-beta-galactosidase of Escherichia freundii. Purification and endoglycosidic action on keratan sulfates, oligosaccharides, and blood group active glycoprotein.
  Journal
J Biol Chem 251:6218-25 (1976)
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.103
IUBMB Enzyme Nomenclature: 3.2.1.103
ExPASy - ENZYME nomenclature database: 3.2.1.103
BRENDA, the Enzyme Database: 3.2.1.103
CAS: 55072-01-0

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Protein sequence (28)   
   UniProt (27)   
   SWISS-PROT (1)   
DNA sequence (42)   
   GenBank (21)   
   EMBL (21)   
Protein domain (5)   
   InterPro (5)   
All databases (75)   

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