KEGG   ENZYME: 3.2.1.105Help
Entry
EC 3.2.1.105                Enzyme                                 

Name
3alpha(S)-strictosidine beta-glucosidase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
strictosidine beta-D-glucohydrolase
Reaction(IUBMB)
strictosidine + H2O = D-glucose + strictosidine aglycone [RN:R03820]
Reaction(KEGG)
Substrate
strictosidine [CPD:C03470];
H2O [CPD:C00001]
Product
D-glucose [CPD:C00031];
strictosidine aglycone [CPD:C03309]
Comment
Does not act on a number of closely related glycosides. Strictosidine is a precursor of indole alkaloids.
History
EC 3.2.1.105 created 1984
Pathway
ec00901  Indole alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K12693  strictosidine beta-D-glucosidase
Reference
1  [PMID:6768587]
  Authors
Hemscheidt T, Zenk MH.
  Title
Glucosidases involved in indole alkaloid biosynthesis of Catharanthus cell cultures.
  Journal
FEBS Lett 110:187-91 (1980)
DOI:10.1016/0014-5793(80)80069-X
Reference
2  [PMID:15680242]
  Authors
Barleben L, Ma X, Koepke J, Peng G, Michel H, Stockigt J.
  Title
Expression, purification, crystallization and preliminary X-ray analysis of strictosidine glucosidase, an enzyme initiating biosynthetic pathways to a unique diversity of indole alkaloid skeletons.
  Journal
Biochim Biophys Acta 1747:89-92 (2005)
DOI:10.1016/j.bbapap.2004.09.026
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.105
IUBMB Enzyme Nomenclature: 3.2.1.105
ExPASy - ENZYME nomenclature database: 3.2.1.105
BRENDA, the Enzyme Database: 3.2.1.105
CAS: 73379-57-4

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