Entry
Name
mannosyl-oligosaccharide glucosidase;
Glc3Man9NAc2 oligosaccharide glucosidase;
trimming glucosidase I;
CWH41 (gene name);
MOGS (gene name);
mannosyl-oligosaccharide glucohydrolase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
Glc3Man9GlcNAc2-[protein] glucohydrolase (configuration-inverting)
Reaction(IUBMB)
Glc3Man9GlcNAc2-[protein] + H2O = Glc2Man9GlcNAc2-[protein] + beta-D-glucopyranose [RN:
R05979 ]
Reaction(KEGG)
Substrate
Glc3Man9GlcNAc2-[protein];
H2O [CPD:
C00001 ]
Product
Glc2Man9GlcNAc2-[protein];
beta-D-glucopyranose [CPD:
C00221 ]
Comment
This enzyme catalyses the first step in the processing of the N-glycan tetradecasaccharide precursor Glc3Man9GlcNAc2, which takes place in the endoplasmic reticulum, by removing the distal alpha-1,2-linked glucose residue. This and subsequent processing steps are required before complex N-glycans can be synthesized.
History
EC 3.2.1.106 created 1984, modified 2018
Pathway
Orthology
K01228 mannosyl-oligosaccharide glucosidase
Genes
MLEU : 105540197 105540225(MOGS)
CIMI : 108289311(MOGS) 108305664
TALA : 116965399 122154900
NPR : 108796278 108803080(MOGS)
SANH : 107689467 107692169
CCAR : 109067866 109068405 109076645
CGIB : 127949248 128019106
MASI : 127444422 127444877
PHYP : 113525839 113545786
SASA : 106602766 106609973
STRU : 115192010 115202092
SALP : 111958376 111964400
SNH : 120035170 120052786(mogs)
PSPA : 121325791 121331101
ARUT : 117408679 117420866
SPU : 115924219 591837(mogs)
DSI : Dsimw501_GD15993(Dsim_GD15993)
AALB : 109408217 115254177
CFEL : 113369400 113387615
FCD : 110857076 110857078 110861721 110861723
PMOO : 119575518 119577439
CEL : CELE_F13H10.4(mogs-1)
BMY : BM_BM3361(Bma-mogs-1)
ATH : AT1G24320 AT1G67490(GCS1)
CSAT : 104701354 104741330 104750548 104757041 104787756
EUS : EUTSA_v10006835mg EUTSA_v10018104mg
BNA : 106356351 106411018 106413559 106425420 125588628
HSYR : 120118001 120149406
GSJ : 114412819 114412821 114421609
PVU : PHAVU_002G174800g PHAVU_002G174900g
CCAJ : 109810676 109810719
APRC : 113855839 113856448
TPRA : 123914281 123914282
PSAT : 127100824 127100825
LANG : 109359940 109359950
QSA : O6P43_016954 O6P43_023873
PMUM : 103322046 103322055
PAVI : 110769517 110769798
PDUL : 117633557 117633563
MDM : 103403150 103414334 103431926
MSYL : 126596980 126608145
HBR : 110634955 110634979 110640454
CAVE : 132176975 132178849
CANN : 107856548 107866840
NTA : 107788762 107796835 107810418
SSPL : 121794579 121798415 121807521
PSOM : 113276595 113281500 113319001
TAES : 123063379 123080307
MFLO : 136451029 136457026
PVIR : 120672892 120709082
ZOF : 122018848 122020435 122022508
SMO : SELMODRAFT_101915 SELMODRAFT_165919
NCS : NCAS_0A01760(NCAS0A01760)
NDI : NDAI_0D03690(NDAI0D03690)
TPF : TPHA_0K01720(TPHA0K01720)
TBL : TBLA_0A08950(TBLA0A08950)
TDL : TDEL_0F02570(TDEL0F02570)
KAF : KAFR_0F03510(KAFR0F03510)
KNG : KNAG_0D03680(KNAG0D03680)
SPAA : SPAPADRAFT_146978(CWH41)
LBG : 92210354(LODBEIA_P51580)
CAL : CAALFM_C406100WA(CWH41)
YLI : 2908679(YALI2_F00297g)
NTE : NEUTE1DRAFT35029(NEUTE1DRAFT_35029)
SMP : 10809779(SMAC4_02532)
PBEL : QC761_205980(CWH41)
PPSD : QC762_205980(CWH41)
PPSP : QC763_205980(CWH41)
PPSA : QC764_205980(CWH41)
TTT : THITE_157561 THITE_2108507
PPEI : PpBr36_04524 PpBr36_10133
PGRI : PgNI_06869 PgNI_11931
TMN : UCRPA7_7539 UCRPA7_7817
TATV : 25774911(TrAtP1_011464)
TASP : 36612050(TrAFT101_008657)
MBRN : 26244530(G6M90_00g063010)
PLJ : 28890316(PLICBS_009650)
PTKZ : JDV02_004905(CWH41)
CDET : 87948064(CDEST_11564)
SAPO : SAPIO_CDS3042 SAPIO_CDS6484
ELA : UCREL1_392 UCREL1_4725
PFY : PFICI_04949 PFICI_08338
ALUC : AKAW2_60552A(CWH41)
CIM : CIMG_13554(CIMG10187)
PNO : SNOG_01504 SNOG_05140
PTRR : 6342078(PtrM4_094710) 6342244(PtrM4_092690)
BZE : COCCADRAFT_106371 COCCADRAFT_5608
BSC : COCSADRAFT_152571 COCSADRAFT_167604
BOR : COCMIDRAFT_94773 COCMIDRAFT_99881
AALT : CC77DRAFT_940352 CC77DRAFT_950947
ARAB : EKO05_0007370 EKO05_0008705
ABP : AGABI1DRAFT53637(AGABI1DRAFT_53637)
ABV : AGABI2DRAFT217075(AGABI2DRAFT_217075)
SCM : SCHCO_02525329(SCHCODRAFT_02525329)
TET : TTHERM_000636933 TTHERM_00305410 TTHERM_00329690
PTM : GSPATT00008864001 GSPATT00018064001
EHX : EMIHUDRAFT_114881 EMIHUDRAFT_198328
TCR : 509201.10 510895.9 511015.10 511805.10
LMAT : 92513311(LSCM1_03251)
LOI : 92359907(LSCM4_03981)
LEIS : 94179558(GH5_04107)
LENR : 94171813(CUR178_04596)
LEIN : 94186885(JIQ42_03198)
PHET : 94289723(JKF63_03645)
NGR : NAEGRDRAFT_57460 NAEGRDRAFT_79164
» show all
Taxonomy
Reference
Authors
Elting JJ, Chen WW, Lennarz WJ.
Title
Characterization of a glucosidase involved in an initial step in the processing of oligosaccharide chains.
Journal
J Biol Chem 255:2325-31 (1980)
Reference
Authors
Grinna LS, Robbins PW.
Title
Glycoprotein biosynthesis. Rat liver microsomal glucosidases which process oligosaccharides.
Journal
J Biol Chem 254:8814-8 (1979)
Reference
Authors
Kilker RD Jr, Saunier B, Tkacz JS, Herscovics A.
Title
Partial purification from Saccharomyces cerevisiae of a soluble glucosidase which removes the terminal glucose from the oligosaccharide Glc3Man9GlcNAc2.
Journal
J Biol Chem 256:5299-603 (1981)
Reference
Authors
Grinna LS, Robbins PW.
Title
Substrate specificities of rat liver microsomal glucosidases which process glycoproteins.
Journal
J Biol Chem 255:2255-8 (1980)
Reference
Authors
Michael JM, Kornfeld S.
Title
Partial purification and characterization of the glucosidases involved in the processing of asparagine-linked oligosaccharides.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 3.2.1.106