KEGG   ENZYME: 3.2.1.106
Entry
EC 3.2.1.106                Enzyme                                 

Name
mannosyl-oligosaccharide glucosidase;
Glc3Man9NAc2 oligosaccharide glucosidase;
trimming glucosidase I;
CWH41 (gene name);
MOGS (gene name);
mannosyl-oligosaccharide glucohydrolase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
Sysname
Glc3Man9GlcNAc2-[protein] glucohydrolase (configuration-inverting)
Reaction(IUBMB)
Glc3Man9GlcNAc2-[protein] + H2O = Glc2Man9GlcNAc2-[protein] + beta-D-glucopyranose [RN:R05979]
Reaction(KEGG)
R05979(G)
Substrate
Glc3Man9GlcNAc2-[protein];
H2O [CPD:C00001]
Product
Glc2Man9GlcNAc2-[protein];
beta-D-glucopyranose [CPD:C00221]
Comment
This enzyme catalyses the first step in the processing of the N-glycan tetradecasaccharide precursor Glc3Man9GlcNAc2, which takes place in the endoplasmic reticulum, by removing the distal alpha-1,2-linked glucose residue. This and subsequent processing steps are required before complex N-glycans can be synthesized.
History
EC 3.2.1.106 created 1984, modified 2018
Pathway
ec00510  N-Glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K01228  mannosyl-oligosaccharide glucosidase
Genes
HSA: 7841(MOGS)
PTR: 740472(MOGS)
PPS: 100989540(MOGS)
GGO: 101148967(MOGS)
PON: 100456318(MOGS)
NLE: 100587064(MOGS)
MCC: 708913(MOGS)
MCF: 102131903(MOGS)
CSAB: 103220027(MOGS)
CATY: 105596862(MOGS)
PANU: 101020139(MOGS)
RRO: 104674816(MOGS)
RBB: 108531677(MOGS)
TFN: 117062056(MOGS)
PTEH: 111523414(MOGS)
CJC: 100399857(MOGS)
SBQ: 101050054(MOGS)
MMUR: 105884584(MOGS)
MMU: 57377(Mogs)
MCAL: 110296892(Mogs)
MPAH: 110316001(Mogs)
RNO: 78947(Mogs)
MCOC: 116099128(Mogs)
MUN: 110559323(Mogs) 110559328
CGE: 100689098(Mogs)
PLEU: 114694418(Mogs)
NGI: 103726994(Mogs)
HGL: 101699668(Mogs)
CPOC: 100736016(Mogs)
CCAN: 109692434(Mogs)
OCU: 100349132(MOGS)
OPI: 101536109(MOGS)
TUP: 102469724(MOGS)
CFA: 483104(MOGS)
VVP: 112916713(MOGS)
VLG: 121490648(MOGS)
AML: 100473274(MOGS)
UMR: 103671412(MOGS)
UAH: 113243493(MOGS)
ORO: 101380088(MOGS)
ELK: 111148165
MPUF: 101677707(MOGS)
EJU: 114218993(MOGS)
MLX: 118007948(MOGS)
FCA: 101086221(MOGS)
PYU: 121019225(MOGS)
PBG: 122497043(MOGS)
PTG: 102965884(MOGS)
PPAD: 109263071(MOGS)
AJU: 106988593(MOGS)
HHV: 120237029(MOGS)
BTA: 516155(MOGS)
BOM: 102271661(MOGS)
BIU: 109565909
BBUB: 102393218(MOGS)
CHX: 102171985(MOGS)
OAS: 101118003(MOGS)
ODA: 120851236(MOGS)
CCAD: 122441482(MOGS)
SSC: 100513204(MOGS)
CFR: 102503430(MOGS)
CBAI: 105078082(MOGS)
CDK: 105105961(MOGS)
BACU: 102999832(MOGS)
LVE: 103084054(MOGS)
OOR: 101274685(MOGS)
DLE: 111169093(MOGS)
PCAD: 102973351(MOGS)
PSIU: 116764325(MOGS)
ECB: 100069105(MOGS)
EPZ: 103557690(MOGS)
EAI: 106823842(MOGS)
MYB: 102262392(MOGS)
MYD: 102775421(MOGS)
MLF: 102429020(MOGS)
MNA: 107529255(MOGS)
PKL: 118717563(MOGS)
HAI: 109371217(MOGS)
DRO: 112303069(MOGS)
SHON: 119000091(MOGS)
AJM: 119038382(MOGS)
PDIC: 114499650(MOGS)
MMF: 118630703(MOGS)
RFQ: 117032934(MOGS)
PALE: 102887551(MOGS)
PGIG: 120594554(MOGS)
RAY: 107502936(MOGS)
MJV: 108402288(MOGS)
TOD: 119259092(MOGS)
LAV: 100657938(MOGS)
TMU: 101345839
MDO: 100017334(MOGS)
GAS: 123253026(MOGS)
SHR: 100925812(MOGS)
PCW: 110221002(MOGS)
OAA: 114811204(MOGS)
GGA: 107049491(MOGS)
PCOC: 116225620(MOGS)
MGP: 104916406(MOGS)
CJO: 107306839(MOGS)
TGU: 115494857(MOGS)
LSR: 110468700(MOGS)
PMOA: 120509127(MOGS)
OTC: 121334937(MOGS)
PRUF: 121364692(MOGS)
PHI: 102101442(MOGS)
PMAJ: 107203112(MOGS)
CCW: 120409966(MOGS)
ETL: 114068886(MOGS)
FPG: 101910764(MOGS)
AROW: 112961117(MOGS)
NPD: 112954025(MOGS)
DNE: 112993223(MOGS)
ASN: 112548011(MOGS)
AMJ: 102576397(MOGS)
CMY: 102941231(MOGS)
CPIC: 101939841(MOGS)
TST: 117878271(MOGS)
CABI: 116829266(MOGS)
MRV: 120405983(MOGS)
ACS: 100558509(mogs)
PVT: 110079822(MOGS)
SUND: 121930509(MOGS)
PBI: 103067986(MOGS)
PMUR: 107292508(MOGS)
TSR: 106538914(MOGS)
PGUT: 117670708(MOGS)
VKO: 123022537(MOGS)
PMUA: 114604469(MOGS)
ZVI: 118094292(MOGS)
GJA: 107114281(MOGS)
XLA: 100158418(mogs.L)
XTR: 619362(mogs)
NPR: 108796278 108803080(MOGS)
DRE: 567913(mogs)
CAUA: 113109480
IPU: 108260492 108260493(Mogs)
AMEX: 103032841(mogs)
EEE: 113578999(mogs)
TRU: 101061971(mogs)
LCO: 104926976(mogs)
NCC: 104951177(mogs)
CGOB: 115014974(mogs)
ELY: 117254577(mogs)
PLEP: 121942341(mogs)
SLUC: 116034210(mogs)
ECRA: 117955271(mogs)
PFLV: 114568158(mogs)
GAT: 120825858(mogs)
PPUG: 119218365(mogs)
MSAM: 119898950(mogs)
CUD: 121508989(mogs)
MZE: 101475138(mogs)
ONL: 100708454(mogs)
OAU: 116330030(mogs)
OLA: 101164458(mogs)
OML: 112157387(mogs)
XMA: 102226259(mogs)
XCO: 114144736(mogs)
XHE: 116720326(mogs)
PRET: 103466387(mogs)
GAF: 122829917(mogs)
CVG: 107091135(mogs)
CTUL: 119796264(mogs)
NFU: 107375288(mogs)
KMR: 108231066(mogs)
ALIM: 106517046(mogs)
AOCE: 111575465(mogs)
CSEM: 103383539(mogs)
POV: 109638361(mogs)
SSEN: 122770911(mogs)
HHIP: 117766362(mogs)
LCF: 108896565(mogs)
SDU: 111236637(mogs)
SLAL: 111670425(mogs)
XGL: 120800908(mogs)
HCQ: 109511469(mogs)
BPEC: 110165316(mogs)
MALB: 109961400(mogs)
OTW: 112231722
OMY: 110534337
SNH: 120035170 120052786(mogs)
ELS: 105029335(mogs)
SFM: 108924334(mogs)
PKI: 111837272(mogs)
AANG: 118227281(mogs)
LOC: 102696758(mogs)
LCM: 102359377(MOGS)
RTP: 109934039(mogs)
BFO: 118413255
BBEL: 109470925
CIN: 100183132
SCLV: 120339076
SPU: 115924219 591837(mogs)
APLC: 110981262
SKO: 100372636
DME: Dmel_CG1597(GCS1)
DER: 6551432
DSE: 6617655
DSI: Dsimw501_GD15993(Dsim_GD15993)
DAN: 6504477
DSR: 110181677
DPE: 6602679
DMN: 108152970
DWI: 6648708
DGR: 6565583
DAZ: 108619758
DNV: 115565244
DHE: 111603188
DVI: 6632177
CCAT: 101450781
BOD: 106620448
MDE: 101894492
SCAC: 106087614
LCQ: 111674816
AAG: 5576381
CPII: 120413722
AME: 411730
ACER: 107997995
BIM: 100745926
BBIF: 117209675
BVK: 117238616
BVAN: 117164363
BTER: 100642977
BPYO: 122575624
CCAL: 108631859
OBB: 114876763
MGEN: 117219508
NMEA: 116431471
CGIG: 122405190
SOC: 105201295
MPHA: 105838053
AEC: 105151670
ACEP: 105621167
PBAR: 105428250
VEM: 105561383
HST: 105189509
DQU: 106745826
CFO: 105249065
FEX: 115246272
LHU: 105674772
PGC: 109853555
OBO: 105275198
PCF: 106788557
PFUC: 122518116
VPS: 122628233
NVI: 100119845
CSOL: 105365662
TPRE: 106659062
MDL: 103570799
CGLO: 123265664
FAS: 105266550
DAM: 107048825
AGIF: 122849290
CCIN: 107265939
TCA: 661492
DPA: 109543454
ATD: 109597104
AGB: 108914645
LDC: 111508595
NVL: 108567459
APLN: 108733382
PPYR: 116164345
OTU: 111428326
BMOR: 101742535
BMAN: 114243551
MSEX: 115447157
BANY: 112052836
PMAC: 106710507
PPOT: 106110665
PXU: 106122821
PRAP: 110996650
ZCE: 119839272
HAW: 110380113
TNL: 113492303
API: 100159015
DNX: 107161371
AGS: 114118986
RMD: 113559408
BTAB: 109030234
DCI: 103515416
CLEC: 106670041
HHAL: 106690855
NLU: 111047775
FOC: 113215351
ZNE: 110837085
CSEC: 111875707
DMK: 116930296
PVM: 113810984
PJA: 122247223
HAME: 121873302
HAZT: 108677023
EAF: 111710007
DSV: 119458461
RSAN: 119379255
RMP: 119175791
VDE: 111251352
VJA: 111267014
TUT: 107359578
DPTE: 113789944
CSCU: 111619659
PTEP: 107441175
SDM: 118199717
CEL: CELE_F13H10.4(mogs-1)
CBR: CBG_05981
BMY: BM_BM3361(Bma-mogs-1)
PCAN: 112564864
BGT: 106074605
CRG: 105331294
MYI: 110460508
PMAX: 117339100
OBI: 106869785
LAK: 106158814
EGL: EGR_08968
NVE: 5511507
EPA: 110250425
ATEN: 116301958
ADF: 107327751
AMIL: 114960255
PDAM: 113667488
SPIS: 111320660
DGT: 114538040
HMG: 100204917
ATH: AT1G24320 AT1G67490(GCS1)
THJ: 104807884
CPAP: 110815960
CIT: 102626422
PVY: 116126429
MINC: 123214948
TCC: 18609047
GRA: 105785861
GAB: 108467160
EGR: 104433660
LJA: Lj4g3v2539160.1(Lj4g3v2539160.1) Lj4g3v2949800.1(Lj4g3v2949800.1)
ADU: 107482112
AIP: 107632002
FVE: 101304833
RCN: 112200307
MNT: 21388932
CSV: 101210818
CMO: 103488898
BHJ: 120081361
MCHA: 111019700
CMAX: 111492274
CMOS: 111458598
CPEP: 111801444
RCU: 8286815
JCU: 105636116
MESC: 110629359
POP: 7477030
PEU: 105137467
PALZ: 118048788
JRE: 109003148
QLO: 115982239
VVI: 100264375
VRI: 117911660
SLY: 101267114
SPEN: 107020771
SOT: 102580572
NSY: 104228399
NAU: 109244799
INI: 109172062
ITR: 116025923
SIND: 105168395
EGT: 105970889
HAN: 110926203
ECAD: 122578897
LSV: 111881539
CCAV: 112527654
CSIN: 114310315
BVG: 104897586
SOE: 110794228
NNU: 104591694
MING: 122074570
NCOL: 116248809
OSA: 4327748
DOSA: Os01t0921200-01(Os01g0921200)
BDI: 100822845
ATS: 109778661
SBI: 8059369
ZMA: 103652327
PHAI: 112892061
PDA: 103706515
EGU: 105051156
MUS: 103987628
DCT: 110097965
PEQ: 110032801
AOF: 109823842
ATR: 18438178
PPP: 112289032
MNG: MNEG_6941
APRO: F751_4830
SCE: YGL027C(CWH41)
ERC: Ecym_1427
KMX: KLMA_20048(CWH41)
NCS: NCAS_0A01760(NCAS0A01760)
NDI: NDAI_0D03690(NDAI0D03690)
TPF: TPHA_0K01720(TPHA0K01720)
TBL: TBLA_0A08950(TBLA0A08950)
TDL: TDEL_0F02570(TDEL0F02570)
KAF: KAFR_0F03510(KAFR0F03510)
PIC: PICST_39865(CWH41)
SPAA: SPAPADRAFT_146978(CWH41)
CAL: CAALFM_C406100WA(CWH41)
CDU: CD36_45640(CWH41)
SLB: AWJ20_2073(CWH41)
NCR: NCU03657(gh63-1)
NTE: NEUTE1DRAFT35029(NEUTE1DRAFT_35029)
SSCK: SPSK_05967
MAW: MAC_03939
MAJ: MAA_01473
CMT: CCM_07809
MBE: MBM_05686
ANI: AN6606.2
ANG: ANI_1_240134(An15g01420)
CIM: CIMG_13554(CIMG10187)
ABE: ARB_07582
TVE: TRV_07006
ABP: AGABI1DRAFT53637(AGABI1DRAFT_53637)
ABV: AGABI2DRAFT217075(AGABI2DRAFT_217075)
MGL: MGL_1071
MRT: MRET_3083
DFA: DFA_05938
SMIN: v1.2.029725.t1(symbB.v1.2.029725.t1)
SPAR: SPRG_06895
 » show all
Reference
1  [PMID:7358674]
  Authors
Elting JJ, Chen WW, Lennarz WJ.
  Title
Characterization of a glucosidase involved in an initial step in the processing of oligosaccharide chains.
  Journal
J Biol Chem 255:2325-31 (1980)
Reference
2  [PMID:479161]
  Authors
Grinna LS, Robbins PW.
  Title
Glycoprotein biosynthesis. Rat liver microsomal glucosidases which process oligosaccharides.
  Journal
J Biol Chem 254:8814-8 (1979)
Reference
3  [PMID:7014569]
  Authors
Kilker RD Jr, Saunier B, Tkacz JS, Herscovics A.
  Title
Partial purification from Saccharomyces cerevisiae of a soluble glucosidase which removes the terminal glucose from the oligosaccharide Glc3Man9GlcNAc2.
  Journal
J Biol Chem 256:5299-603 (1981)
Reference
4  [PMID:7358666]
  Authors
Grinna LS, Robbins PW.
  Title
Substrate specificities of rat liver microsomal glucosidases which process glycoproteins.
  Journal
J Biol Chem 255:2255-8 (1980)
Reference
5  [PMID:7356331]
  Authors
Michael JM, Kornfeld S.
  Title
Partial purification and characterization of the glucosidases involved in the processing of asparagine-linked oligosaccharides.
  Journal
Arch Biochem Biophys 199:249-58 (1980)
DOI:10.1016/0003-9861(80)90278-7
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.106
IUBMB Enzyme Nomenclature: 3.2.1.106
ExPASy - ENZYME nomenclature database: 3.2.1.106
BRENDA, the Enzyme Database: 3.2.1.106
CAS: 78413-07-7

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