KEGG   ENZYME: 3.2.1.114
Entry
EC 3.2.1.114                Enzyme                                 
Name
mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase;
MAN2A1 (gene name);
MAN2A2 (gene name);
mannosidase II;
exo-1,3-1,6-alpha-mannosidase;
alpha-D-mannosidase II;
alpha-mannosidase II;
alpha1-3,6-mannosidase;
GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase;
Golgi alpha-mannosidase II;
ManII;
1,3(1,6)-alpha-D-mannosidase;
1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase;
(1->3)-(1->6)-mannosyl-oligosaccharide alpha-D-mannohydrolase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
Sysname
(1->3)-(1->6)-mannosyl-oligosaccharide alpha-D-mannohydrolase (configuration-retaining)
Reaction(IUBMB)
Man5GlcNAc3-[protein] + 2 H2O = Man3GlcNAc3-[protein] + 2 alpha-D-mannopyranose [RN:R05984]
Reaction(KEGG)
R05984(G)
Substrate
Man5GlcNAc3-[protein];
H2O [CPD:C00001]
Product
Man3GlcNAc3-[protein];
alpha-D-mannopyranose [CPD:C00936]
Comment
The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus. It removes two mannosyl residues, one linked by alpha1,3 linkage, and the other linked by alpha1,6 linkage, both of which are removed by the same catalytic site. The enzyme is sensitive to swainsonine.
History
EC 3.2.1.114 created 1986, modified 2018
Pathway
ec00510  N-Glycan biosynthesis
ec00513  Various types of N-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K01231  alpha-mannosidase II
Genes
HSA4122(MAN2A2) 4124(MAN2A1)
PTR461982(MAN2A1) 745986(MAN2A2)
PPS100973826(MAN2A1) 100975142(MAN2A2)
GGO101130735(MAN2A2) 101130746(MAN2A1)
PON100449341(MAN2A2) 100455258(MAN2A1)
NLE100581120(MAN2A1) 100598002(MAN2A2)
MCC705480(MAN2A1) 715720(MAN2A2)
MCF101865831(MAN2A1) 102118107(MAN2A2)
CSAB103231182(MAN2A2) 103244316(MAN2A1)
CATY105576648(MAN2A1) 105601196(MAN2A2)
PANU101004326(MAN2A1) 101020239(MAN2A2)
TGE112626169(MAN2A1) 112628732(MAN2A2)
RRO104675604(MAN2A1) 104679282(MAN2A2)
RBB108517212(MAN2A2)
TFN117064837(MAN2A1) 117070195(MAN2A2)
PTEH111528634(MAN2A2) 111542679(MAN2A1)
CJC100394604(MAN2A2) 100415670(MAN2A1)
SBQ101028436(MAN2A1) 101032034(MAN2A2)
CSYR103251650(MAN2A2) 103258927(MAN2A1)
MMUR105870622(MAN2A2) 105885357(MAN2A1)
OGA100953447(MAN2A1) 100957305(MAN2A2)
MMU140481(Man2a2) 17158(Man2a1)
MCAL110298418(Man2a2) 110302683 110312160(Man2a1)
MPAH110327713(Man2a2) 110335524(Man2a1)
RNO25478(Man2a1) 308757(Man2a2)
MCOC116088842(Man2a1) 116102462(Man2a2)
MUN110552374(Man2a1) 110553370 110553376
CGE100757006(Man2a1) 100764014(Man2a2)
PLEU114696192(Man2a2) 114696324(Man2a1)
NGI103749886(Man2a2) 103752287(Man2a1)
HGL101697315(Man2a1) 101717094(Man2a2)
CPOC100722220(Man2a1) 100734282(Man2a2)
CCAN109695085(Man2a2) 109699084(Man2a1)
DORD105982460(Man2a2) 105988705(Man2a1)
DSP122099994(Man2a2) 122118070(Man2a1)
NCAR124975905 124986848
OCU100345634(MAN2A2) 100350334(MAN2A1)
OPI101522683(MAN2A2) 101535285(MAN2A1)
TUP102469872(MAN2A2) 102485972(MAN2A1)
CFA488745(MAN2A2) 488878(MAN2A1)
VVP112915442(MAN2A1) 112921479(MAN2A2)
VLG121488991(MAN2A2) 121489296(MAN2A1)
AML100474640(MAN2A1) 100475150(MAN2A2)
UMR103660265(MAN2A2) 103675784(MAN2A1)
UAH113255007(MAN2A1) 113263716(MAN2A2)
UAR123799253(MAN2A1) 123802468(MAN2A2)
ELK111148294 111152536
LLV125099905 125104118
MPUF101673986(MAN2A2) 101676924(MAN2A1)
ORO101368244(MAN2A1) 101371875(MAN2A2)
EJU114208623(MAN2A1) 114223292(MAN2A2)
ZCA113909908(MAN2A2) 113928715(MAN2A1)
MLX118023074(MAN2A2)
FCA101086451(MAN2A1) 101101317(MAN2A2)
PYU121012159(MAN2A1) 121042360(MAN2A2)
PBG122467536(MAN2A2) 122491884(MAN2A1)
PTG102953845(MAN2A1) 102959757(MAN2A2)
PPAD109267616(MAN2A1) 109273465(MAN2A2)
AJU106965940(MAN2A2) 106975671(MAN2A1)
HHV120222486(MAN2A1) 120249001(MAN2A2)
BTA521539(MAN2A1) 527449(MAN2A2)
BOM102269911(MAN2A2) 102286530(MAN2A1)
BIU109562380(MAN2A1) 109575464(MAN2A2)
BBUB102393495(MAN2A2) 102396245(MAN2A1)
CHX102171012(MAN2A2) 102182591(MAN2A1)
OAS101106798(MAN2A2) 101116572(MAN2A1)
ODA120863464(MAN2A1) 120875582(MAN2A2)
CCAD122419747(MAN2A2) 122439466(MAN2A1)
SSC100154397(MAN2A2) 100514631(MAN2A1)
CFR102512093(MAN2A2) 102513706(MAN2A1)
CBAI105069081(MAN2A2) 105082023(MAN2A1)
CDK105094696(MAN2A2) 105095392(MAN2A1)
VPC102539333(MAN2A1) 102542027(MAN2A2)
BACU103020657(MAN2A1) 103021128(MAN2A2)
LVE103074675(MAN2A2) 103076739(MAN2A1)
OOR101272169(MAN2A1) 101272204(MAN2A2)
DLE111169626(MAN2A2) 111183761(MAN2A1)
PCAD102974194(MAN2A2) 102974411(MAN2A1)
PSIU116747493(MAN2A2) 116751733(MAN2A1)
ECB100053432(MAN2A2) 100064575(MAN2A1)
EPZ103546211(MAN2A2) 103551677(MAN2A1)
EAI106832048(MAN2A2) 106832412(MAN2A1)
MYB102239755(MAN2A2) 102241544(MAN2A1)
MYD102760778(MAN2A1) 102764752(MAN2A2)
MMYO118656377(MAN2A1) 118679225(MAN2A2)
MLF102429994 102435674(MAN2A1) 102439002
MNA107540397(MAN2A2) 107546496(MAN2A1)
PKL118703963(MAN2A1) 118706308(MAN2A2)
HAI109371540(MAN2A1) 109381472(MAN2A2)
DRO112305889(MAN2A2) 112307206(MAN2A1)
SHON118977338(MAN2A1) 118991941(MAN2A2)
AJM119052124(MAN2A2) 119065110(MAN2A1)
PDIC114488515(MAN2A2) 114494997(MAN2A1)
PHAS123809609(MAN2A2) 123818093(MAN2A1)
MMF118640879(MAN2A2) 118642854(MAN2A1)
RFQ117018934(MAN2A2) 117024814(MAN2A1)
PALE102878318(MAN2A1) 102884371(MAN2A2)
PGIG120590802(MAN2A1) 120599240(MAN2A2)
PVP105295470(MAN2A1) 105302879(MAN2A2)
RAY107506530(MAN2A1) 107514130(MAN2A2)
MJV108385796(MAN2A2) 108407113(MAN2A1)
TOD119244240(MAN2A2) 119260546(MAN2A1)
SARA101541026(MAN2A2) 101541110(MAN2A1)
LAV100669338(MAN2A1) 100671385(MAN2A2)
TMU101344297 101354641
DNM101436317(MAN2A2) 101439931(MAN2A1)
MDO100010442(MAN2A1) 100014504(MAN2A2)
GAS123234215(MAN2A2) 123236188(MAN2A1)
SHR100913308(MAN2A1) 100922248(MAN2A2)
PCW110193635(MAN2A2) 110195899(MAN2A1)
OAA100082559(MAN2A1) 100090754(MAN2A2)
GGA415585(MAN2A2) 415611(MAN2A1)
PCOC116225521(MAN2A2) 116234843(MAN2A1)
MGP100539000(MAN2A2) 104915174(MAN2A1)
CJO107306350(MAN2A1) 107318993(MAN2A2)
NMEL110389397(MAN2A1) 110403851(MAN2A2)
APLA101790343(MAN2A2) 101792614(MAN2A1)
ACYG106042345(MAN2A1) 106048641(MAN2A2)
AFUL116493695(MAN2A2) 116501098(MAN2A1)
TGU100226019(MAN2A2) 100227845(MAN2A1)
LSR110467593(MAN2A1) 110476670(MAN2A2)
SCAN103816135(MAN2A2) 103824196(MAN2A1)
PMOA120509098(MAN2A2) 120513740(MAN2A1)
OTC121331463(MAN2A1) 121343669(MAN2A2)
PRUF121352247(MAN2A2) 121354031(MAN2A1)
GFR102041186(MAN2A1) 102041635(MAN2A2)
FAB101806895(MAN2A2) 101819402(MAN2A1)
PHI102101154(MAN2A2) 102113458(MAN2A1)
PMAJ107209587(MAN2A2) 107216400(MAN2A1)
CCAE111940865(MAN2A1) 111943021(MAN2A2)
CCW104683853(MAN2A2) 104693206(MAN2A1)
ETL114056033(MAN2A1) 114064253(MAN2A2)
ZAB102061220(MAN2A1) 102071919(MAN2A2)
FPG101913159(MAN2A2) 101921020
FCH102048168(MAN2A2) 102050767(MAN2A1)
CLV102090971(MAN2A2) 102097702(MAN2A1)
EGZ104133484(MAN2A2) 104135037(MAN2A1)
NNI104017021(MAN2A2) 104022201(MAN2A1)
ACUN113484037(MAN2A2) 113489918(MAN2A1)
TALA104358494(MAN2A1) 116961121(MAN2A2)
PADL103914784(MAN2A2) 103920875(MAN2A1)
ACHC115336851(MAN2A1) 115342030(MAN2A2)
AAM106491449(MAN2A2)
AROW112964263(MAN2A1) 112976300(MAN2A2)
NPD112948334(MAN2A2) 112951728(MAN2A1)
DNE112994987(MAN2A2) 112995230(MAN2A1)
ASN102369470(MAN2A1) 102383379(MAN2A2)
AMJ102561641(MAN2A1) 102566705(MAN2A2)
CPOO109308162(MAN2A1)
GGN109297471(MAN2A1)
PSS102459905(MAN2A1)
CMY102941559(MAN2A2) 102944199(MAN2A1)
CPIC101937670 101953630(MAN2A2)
TST117878692(MAN2A1) 117884331(MAN2A2)
CABI116814770(MAN2A1) 116833017(MAN2A2)
MRV120373280(MAN2A2) 120407767(MAN2A1)
ACS100555933(man2a1) 100568077(man2a2)
PVT110072017(MAN2A1) 110084439(MAN2A2)
SUND121924154(MAN2A1) 121933219(MAN2A2)
PBI103053695(MAN2A1) 103058391(MAN2A2)
PMUR107289784(MAN2A2) 107293675(MAN2A1)
TSR106543694(MAN2A1) 106553803(MAN2A2)
PGUT117674626(MAN2A1) 117676225(MAN2A2)
VKO123030714(MAN2A2) 123031172(MAN2A1)
PMUA114584355(MAN2A2) 114606107(MAN2A1)
ZVI118076729(MAN2A1) 118092868(MAN2A2)
GJA107120457(MAN2A1) 107125467(MAN2A2)
STOW125424513(MAN2A2) 125436400(MAN2A1)
XLA108707218(man2a1.S) 108712863(man2a2.S) 108717353(man2a1.L) 443991(man2a2.L)
XTR100036612(man2a1) 448465(man2a2)
NPR108789334(MAN2A1) 108798147(MAN2A2)
RTEM120931239(MAN2A2) 120931614(MAN2A1)
BBUF120985902(MAN2A2) 120992563(MAN2A1)
BGAR122924645(MAN2A1) 122927556(MAN2A2)
DRE100333987(man2a2) 560219(man2a1)
SRX107720774 107721641(man2a1) 107750719 107751258
SANH107663767 107670215 107673231(man2a2) 107691725(man2a1)
SGH107564047(man2a1) 107564609 107581805 107603169
CCAR109078545
CAUA113043692 113049817 113066713 113082394
PPRM120468300(man2a2) 120472040(man2a1)
MAMB125246718(man2a2) 125267915(man2a1)
IPU108274717(man2a2)
PHYP113529699(man2a2)
SMEO124392803(man2a2)
TFD113660003(man2a2)
AMEX103023301(man2a1) 103041860(man2a2)
EEE113572463 113588518(man2a2)
TRU101061792(man2a2) 101077627(man2a1)
TNGGSTEN00003927G001 GSTEN00022835G001
LCO104925267(man2a2) 104932414
NCC104944004(man2a2)
ELY117262193(man2a2) 117270133(man2a1)
PLEP121949968(man2a2) 121959715(man2a1)
SLUC116038801(man2a2) 116065613
ECRA117949100(man2a2) 117959781(man2a1)
PFLV114552021 114560151(man2a2) 114570585(man2a1)
GAT120809442(man2a2) 120812180 120831692(man2a1)
PPUG119196376(man2a2) 119226927(man2a1)
MSAM119893108(man2a2) 119914086 119914087
CUD121514902(man2a2) 121524694(man2a1)
MZE101474154 101483319(man2a2)
ONL100708597(man2a2) 102081444
OAU116321290 116335402(man2a2)
OLA101158104(man2a2) 101174073
OML112152466(man2a2) 112162978(man2a1)
XMA102218498(man2a1) 102232197(man2a2)
XCO114136954 114155110(man2a2)
XHE116724829(man2a1) 116733889(man2a2)
PRET103460455(man2a1) 103466353(man2a2)
PFOR103131079(man2a1) 103133657(man2a2)
PLAI106943897 106945048(man2a2)
PMEI106909111 106927549(man2a2)
GAF122819277(man2a1) 122835727(man2a2)
CVG107098036(man2a1) 107104235(man2a2)
CTUL119774472(man2a1) 119793068(man2a2)
GMU124872651(man2a1) 124884982(man2a2)
NFU107374983(man2a1) 107388979(man2a2)
KMR108228395 108239965(man2a2)
ALIM106515631(man2a2) 106536243
NWH119415567(man2a2) 119424942
AOCE111563148(man2a2) 111564348
CSEM103380513(man2a2) 103390365(man2a1)
POV109624583(man2a2) 109642276
SSEN122775906(man2a2) 122776385
HHIP117762833(man2a2) 117771297(man2a1)
LCF108874626(man2a1) 108875305(man2a2)
SDU111228707(man2a2) 111238819(man2a1)
SLAL111651803 111655358(man2a2)
XGL120792691(man2a2) 120806732(man2a1)
HCQ109530362(man2a2)
BPEC110153167 110165893(man2a2)
MALB109968742(man2a2) 109973112(man2a1)
SASA106561301 106562091(man2a1) 106568341 106573342(man2a2)
OTW112214463(man2a1) 112218991 112252518 112257442
OMY110522404(man2a2) 110523878 110536799
OGO124000099 124002196 124048631(man2a1)
ONE115105938 115109522(man2a2) 115126674
SALP111952337(man2a2) 111961325(man2a1) 111962448 111981710
SNH120025911 120044213 120054035 120065912(man2a2)
ELS105018384(man2a2) 105027936(man2a1)
SFM108932015(man2a1) 108941123(man2a2)
PKI111835779(man2a1) 111845078(man2a2)
AANG118212479(man2a1) 118227271(man2a2)
LOC102691193(man2a2) 102696037(man2a1)
PSPA121294610 121299015 121301854 121315950
ARUT117409290 117428313 117429435 117973182
LCM102355620 102360088(MAN2A2)
CMK103178412(man2a1) 103188552(man2a2)
RTP109930439 109938999
BFO118411916
BBEL109468568
CIN100180083
SCLV120343811
SPU594620
APLC110979321
SKO102802038
DMEDmel_CG18802(alpha-Man-IIa)
DER6552301
DSE6607114
DSIDsimw501_GD18615(Dsim_GD18615)
DYADyak_GE25950
DAN6500000
DSR110191164
DPODpse_GA15085
DPE6595142
DMN108155782
DWI6647583
DGR6563084
DMODmoj_GI24010
DAZ108614123
DNV108653307
DHE111593673
DVI6629947
CCAT101462695
BOD106615218
MDE101898268
SCAC106086721
LCQ111685869
AGAAgaP_AGAP004020
ACOZ120949537
AARA120895003
AAG5575653
AALB109402419 109405454
CQUCpipJ_CPIJ009720
CPII120423830
CNS116349279
AME552382
ACER107994422
ALAB122714930
BIM100749601
BBIF117205087
BVK117231097
BVAN117157558
BTER100646824
BPYO122567772
CCAL108623658
OBB114880562
MGEN117224144
NMEA116423930
CGIG122398868
SOC105198479
MPHA105836778
AEC105154407
ACEP105623777
PBAR105423365
VEM105565777
HST105190974
DQU106750368
CFO105253605
FEX115237693
LHU105674564
PGC109851679
OBO105274664
PCF106789840
PFUC122513263
VPS122636855
NVI100116564
CSOL105364669
TPRE106650757
MDL103577084 103579008
CGLO123259501 123274900
FAS105270282
DAM107035984
AGIF122857485 122857617
CCIN107264491
TCA660728
DPA109544976
SOY115888958
ATD109605290
CSET123307622
AGB108912629
LDC111514244
NVL108562674
APLN108743170 108743178
PPYR116159269
OTU111420892
BMOR101742043
BMAN114250890
MSEX115449114 119189147
DPLKGM_214574
BANY112058378
PMAC106721685
PPOT106103852
PXU106120187
PRAP110993078
ZCE119828502
HAW110380432
TNL113499077
SLIU111350250
OFU114356108
PXY105380392
API100169064
DNX107161638
AGS114131656
RMD113555742
BTAB109044339
CLEC106666206
HHAL106677705 106677835
NLU111054344
PHUPhum_PHUM459490
FOC113214831
ZNE110835247
CSEC111868354
FCD110848037
DMK116923686
PVM113815567
PJA122246341
PCHN125044374
HAME121876770
PCLA123775118
PTRU123514813
HAZT108678706
EAF111710355
LSM121120461
ISCIscW_ISCW018027
DSV119456041
RSAN119393875
RMP119172694
VDE111246456
VJA111261034
TUT107360206
DPTE113797886
DFR124494692
CSCU111620191 111620547
PTEP107455528
SDM118186080 118200216 118204655
CELCELE_F58H1.1(aman-2)
CBRCBG_23330(Cbr-aman-2)
BMYBM_BM4567(Bma-aman-2)
LOALOAG_06074 LOAG_08114 LOAG_18290
NAINECAME_08623 NECAME_08624
TSPTsp_10745
HROHELRODRAFT_110840
LGILOTGIDRAFT_164424 LOTGIDRAFT_188902
PCAN112556419 112570581 112570746
BGT106053755 106061128 106069804
GAE121371265 121373761 121384824
HRF124122870 124143923 124148741
HRJ124255342 124260264 124285348
CRG105331810 105332200 105341572 105343542 117687453
MYI110442311 110449962 110450072 110450325 110454737 110465474
PMAX117314924 117323212 117324211 117324627 117326963
MMER123530261 123530275 123531139 123537102 123537266 123541858 123541918 123543018 123546697 123550153 123553765 123560815
OBI106875435 106875688
OSN115231032 115231539
LAK106153188 106156030 106166353 106176305
SMMSmp_143430
SHXMS3_0018343
OVIT265_07096
EGLEGR_08871
NVE5512609
EPA110234138
ATEN116299384
ADF107347367
AMIL114961754
PDAM113670726
SPIS111324658
DGT114525319
XEN124451115
HMG100198326 100202382
TADTRIADDRAFT_60265
ATHAT5G14950(GMII)
ALY9309767
CRB17881567
CSAT104709139 104735512 104769734
EUSEUTSA_v10012487mg
BRP103850958 103856103
BNA106367195 106429929
BOE106327011 106334765
RSZ108842391 108845613 108847660
THJ104821170
CIT102615196
CICCICLE_v10014083mg
PVY116142958
MINC123195543
TCC18601342
GRA105768375 105798286
GHI107888651 107892313 107955563 107958597
GAB108454878 108457471
DZI111291640 111316658
EGR104422581
GMX100806647 100811858
GSJ114381996 114398155
PVUPHAVU_004G022500g
VRA106770832
VAR108345656
VUN114180334
CCAJ109817438
APRC113867315
MTRMTR_4g071680 MTR_6g008850
CAM101499632(MAN2A2)
LJALj2g3v1022240.1(Lj2g3v1022240.1)
ADU107471073
AIP107622688
AHF112716315 112784225
LANG109335920 109347307 109347309
FVE101296768
RCN112184196
PPER18782416
PMUM103329931
PAVI110756683
PDUL117620960
MDM103404378 103442297
PXB103928463
ZJU107415425
MNT21393801
CSV101208332
CMO103487047
BHJ120090184
MCHA111018346
CMAX111469337 111482230
CMOS111433153 111441463
CPEP111790312 111792352
RCU8280600
JCU105642251
HBR110641257 110654833
MESC110601253
POP18095306 7495932
PEU105114251 105141682
PALZ118036907 118058267
JRE108992841
QSU111999605
QLO115976745
TWL120008882
VVI100243903(MAN2A2)
VRI117929602
SLY101266287
SPEN107011510
SOT102605224
CANN107860595
NTA107777832 107829947
NSY104211404
NTO104108022
NAU109205422
INI109158199 109180593
ITR116000145 116012756
SIND105177181
OEU111409226
EGT105968893
SSPL121767131 121771656
HAN110903921
ECAD122603697
LSV111891915
CCAV112523600
DCR108214457
CSIN114263477 114296797
BVG104905356
SOE110786831
CQI110715303 110724888
NNU104607979
MING122075952 122079250
TSS122654368 122670711
PSOM113276377 113343777
NCOL116250575 116258674
OSA4340636
DOSAOs06t0245700-00(Os06g0245700)
OBR102707404
BDI100822520
ATS109783252
TDC119329460 119336349
TAES123149332 123156793 123165270
SBI8061493
ZMA100502340 103629954
SITA101761357
SVS117852889
PVIR120669859 120703002
PHAI112889969
PDA103710003
EGU105039124 105050069
MUS103990861
DCT110092430
PEQ110026121
AOF109820905
ATR18446724
SMOSELMODRAFT_104910 SELMODRAFT_116442 SELMODRAFT_154366 SELMODRAFT_228
PPP112275693
SREPTSG_03147 PTSG_07075 PTSG_11582
DPPDICPUDRAFT_45100 DICPUDRAFT_74852
DFADFA_02000 DFA_07693(manD)
ACANACA1_068820
TETTTHERM_00230960
FCYFRACYDRAFT_250184
NGRNAEGRDRAFT_57722
 » show all
Reference
1  [PMID:863880]
  Authors
Tulsiani DR, Opheim DJ, Touster O.
  Title
Purification and characterization of alpha-D-mannosidase from rat liver golgi membranes.
  Journal
J Biol Chem 252:3227-33 (1977)
Reference
2  [PMID:212436]
  Authors
Tabas I, Kornfeld S
  Title
The synthesis of complex-type oligosaccharides. III. Identification of an alpha-D-mannosidase activity involved in a late stage of processing of complex-type oligosaccharides.
  Journal
J Biol Chem 253:7779-86 (1978)
Reference
3  [PMID:6445359]
  Authors
Harpaz N, Schachter H.
  Title
Control of glycoprotein synthesis. Processing of asparagine-linked oligosaccharides by one or more rat liver Golgi alpha-D-mannosidases dependent on the prior action of UDP-N-acetylglucosamine: alpha-D-mannoside beta 2-N-acetylglucosaminyltransferase I.
  Journal
J Biol Chem 255:4894-902 (1980)
Reference
4  [PMID:7061502]
  Authors
Tulsiani DR, Hubbard SC, Robbins PW, Touster O.
  Title
alpha-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases Ia and IB are the enzymes converting Man9 precursors to Man5 intermediates.
  Journal
J Biol Chem 257:3660-8 (1982)
Reference
5  [PMID:1757461]
  Authors
Moremen KW, Robbins PW
  Title
Isolation, characterization, and expression of cDNAs encoding murine alpha-mannosidase II, a Golgi enzyme that controls conversion of high mannose to  complex N-glycans.
  Journal
J Cell Biol 115:1521-34 (1991)
DOI:10.1083/jcb.115.6.1521
  Sequence
[hsa:4124] [mmu:17158]
Reference
6  [PMID:8524845]
  Authors
Misago M, Liao YF, Kudo S, Eto S, Mattei MG, Moremen KW, Fukuda MN
  Title
Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme.
  Journal
Proc Natl Acad Sci U S A 92:11766-70 (1995)
DOI:10.1073/pnas.92.25.11766
  Sequence
[hsa:4124 4122]
Reference
7  [PMID:11406577]
  Authors
van den Elsen JM, Kuntz DA, Rose DR
  Title
Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.
  Journal
EMBO J 20:3008-17 (2001)
DOI:10.1093/emboj/20.12.3008
  Sequence
Reference
8  [PMID:15721331]
  Authors
Athanasopoulos VI, Niranjan K, Rastall RA.
  Title
The production, purification and characterisation of two novel alpha-D-mannosidases from Aspergillus phoenicis.
  Journal
Carbohydr Res 340:609-17 (2005)
DOI:10.1016/j.carres.2005.01.005
Reference
9  [PMID:18599462]
  Authors
Shah N, Kuntz DA, Rose DR
  Title
Golgi alpha-mannosidase II cleaves two sugars sequentially in the same catalytic  site.
  Journal
Proc Natl Acad Sci U S A 105:9570-5 (2008)
DOI:10.1073/pnas.0802206105
  Sequence
Reference
10 [PMID:22819743]
  Authors
Rose DR
  Title
Structure, mechanism and inhibition of Golgi alpha-mannosidase II.
  Journal
Curr Opin Struct Biol 22:558-62 (2012)
DOI:10.1016/j.sbi.2012.06.005
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.114
IUBMB Enzyme Nomenclature: 3.2.1.114
ExPASy - ENZYME nomenclature database: 3.2.1.114
BRENDA, the Enzyme Database: 3.2.1.114
CAS: 82047-77-6

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