KEGG   ENZYME: 3.2.1.123Help
Entry
EC 3.2.1.123                Enzyme                                 

Name
endoglycosylceramidase;
endoglycoceramidase;
EGCase;
glycosyl-N-acetyl-sphingosine 1,1-beta-D-glucanohydrolase, oligoglycosylglucosylceramide glycohydrolase;
oligoglycosylglucosyl(1<->1)ceramide glycohydrolase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
oligoglycosylglucosyl-(1<->1)-ceramide glycohydrolase
Reaction(IUBMB)
oligoglycosylglucosyl-(1<->1)-ceramide + H2O = ceramide + oligoglycosylglucose [RN:R04118 R06157]
Reaction(KEGG)
R04118 R06157(G);
(other) R06283(G)
Show
Substrate
oligoglycosylglucosyl-(1<->1)-ceramide;
H2O [CPD:C00001]
Product
ceramide [CPD:C00195];
oligoglycosylglucose [CPD:C03018]
Comment
An enzyme from Rhodococcus sp. that degrades various acidic and neutral glycosphingolipids to oligosaccharides and ceramides, by cleaving a glucosyl bond. Does not act on monoglycosylceramides. cf. EC 3.2.1.62 glycosylceramidase.
History
EC 3.2.1.123 created 1989
Orthology
K05991  endoglycosylceramidase
Genes
BFO: BRAFLDRAFT_102437 BRAFLDRAFT_77844 BRAFLDRAFT_77846
FCD: 110852051
HRO: HELRODRAFT_86747
LAK: 106179962
SMM: Smp_120050 Smp_155570 Smp_164170 Smp_181910 Smp_187070 Smp_193630
SHX: MS3_09773 MS3_09774 MS3_10772 MS3_11487
OVI: T265_04204 T265_13449
NVE: NEMVE_v1g140417
EPA: 110232166
ADF: 107334423
HMG: 100192295(egcase)
PPP: 112281139
MAW: MAC_02340
MAJ: MAA_10290
CMT: CCM_04551
SMIN: v1.2.006292.t1(symbB.v1.2.006292.t1) v1.2.023617.t1(symbB.v1.2.023617.t1) v1.2.023617.t2(symbB.v1.2.023617.t2)
AAF: AURANDRAFT_23504(EGN1)
BCN: Bcen_5206
COA: DR71_1819
SGR: SGR_2234
SGB: WQO_24285
SHY: SHJG_7711
SVE: SVEN_4954
SFI: SFUL_5095
SALU: DC74_8045
SALL: SAZ_41555
STRE: GZL_00745
SLD: T261_7793
SPRI: SPRI_2608
SRN: A4G23_03887(celC)
SLAU: SLA_5106
SALJ: SMD11_2261
SFK: KY5_5124
ARM: ART_1927
NCA: Noca_3558
NAL: B005_1763
SRO: Sros_1713
SEN: SACE_3752
ACTI: UA75_06875
ACAD: UA74_06880
SNA: Snas_0664
CWO: Cwoe_0370
SACI: Sinac_0727
 » show all
Taxonomy
Reference
1  [PMID:3771534]
  Authors
Ito M, Yamagata T.
  Title
A novel glycosphingolipid-degrading enzyme cleaves the linkage between the oligosaccharide and ceramide of neutral and acidic glycosphingolipids.
  Journal
J Biol Chem 261:14278-82 (1986)
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.123
IUBMB Enzyme Nomenclature: 3.2.1.123
ExPASy - ENZYME nomenclature database: 3.2.1.123
BRENDA, the Enzyme Database: 3.2.1.123
CAS: 105503-61-5

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