KEGG ENZYME: 3.2.1.166

ENZYME: 3.2.1.166

Entry

EC 3.2.1.166                Enzyme

Name

heparanase;
Hpa1 heparanase;
Hpa1;
heparanase 1;
heparanase-1;
C1A heparanase;
HPSE

Class

Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

Sysname

heparan sulfate N-sulfo-D-glucosamine endoglucanase

Reaction(IUBMB)

endohydrolysis of (1->4)-beta-D-glycosidic bonds of heparan sulfate chains in heparan sulfate proteoglycan

Reaction(KEGG)

(other) R07811(G)

Comment

Heparanase cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group [2]. Heparanase-1 cuts macromolecular heparin into fragments of 5000--20000 Da [5]. The enzyme cleaves the heparan sulfate glycosaminoglycans from proteoglycan core proteins and degrades them to small oligosaccharides. Inside cells, the enzyme is important for the normal catabolism of heparan sulfate proteoglycans, generating glycosaminoglycan fragments that are then transported to lysosomes and completely degraded. When secreted, heparanase degrades basement membrane heparan sulfate glycosaminoglycans at sites of injury or inflammation, allowing extravasion of immune cells into nonvascular spaces and releasing factors that regulate cell proliferation and angiogenesis [1].

History

EC 3.2.1.166 created 2010

Pathway

ec00531

Glycosaminoglycan degradation

ec01100

Metabolic pathways

Orthology

K07964

heparanase

Genes

HSA:	10855(HPSE)

PTR:	461206(HPSE)

PPS:	100996218(HPSE)

GGO:	101150800(HPSE)

PON:	100448281(HPSE)

PPYG:

129035543(HPSE)

NLE:	100596185(HPSE)

HMH:	116465068(HPSE)

SSYN:

129492172(HPSE)

MCC:	707583(HPSE)

MCF:	102123028(HPSE)

MTHB:

126954547

MNI:	105496865(HPSE)

CSAB:

103235901(HPSE)

CATY:

105576795(HPSE)

PANU:

101008008(HPSE)

TGE:	112624635(HPSE)

MLEU:

105543474(HPSE)

RRO:	104658833(HPSE)

RBB:	108531149(HPSE)

TFN:	117085378(HPSE)

PTEH:

111549300(HPSE)

CANG:

105511628(HPSE)

CJC:	100402671(HPSE)

SBQ:	101043067(HPSE)

CIMI:

108305561(HPSE)

ANAN:

105713362(HPSE)

CSYR:

103265158(HPSE)

MMUR:

105872605(HPSE)

LCAT:

123627236(HPSE)

PCOQ:

105812648(HPSE)

OGA:	100965397(HPSE)

MMU:	15442(Hpse)

MCAL:

110294241(Hpse)

MPAH:

110330557(Hpse)

RNO:	64537(Hpse)

MCOC:

116067960(Hpse)

ANU:	117699917(Hpse)

ASYL:

127695911(Hpse)

MUN:	110553884(Hpse)

CGE:	100755610(Hpse)

MAUA:

101839579(Hpse)

PROB:

127232247(Hpse)

PLEU:

114691766(Hpse)

MORG:

121440967(Hpse) 121460823

MFOT:

126509736

AAMP:

119824849(Hpse)

NGI:	103744984(Hpse)

HGL:	101721140(Hpse)

CPOC:

100721886(Hpse)

CCAN:

109683307(Hpse)

DORD:

105988588(Hpse)

DSP:	122097868(Hpse)

DMER:

138821057(Hpse)

PLOP:

125364815(Hpse)

NCAR:

124995081

MMMA:

107153680(Hpse)

ITI:	101968870(Hpse)

OCU:

100101601

OPI:	101525206(HPSE)

TUP:	102501533(HPSE)

GVR:	103587321(HPSE)

CFA:	608707(HPSE)

CLUD:

112646173(HPSE)

VVP:	112919568(HPSE)

VLG:	121493930(HPSE)

NPO:	129501722(HPSE)

AML:	100470911(HPSE)

UMR:	103665420(HPSE)

UAH:	113263199(HPSE)

UAR:	123787859(HPSE)

ELK:

111149020

LLV:

125093934

MPUF:

101688281(HPSE)

MNP:	132007887(HPSE)

MLK:	131814912(HPSE)

NVS:	122889522(HPSE)

ORO:	101371822(HPSE)

EJU:	114224914(HPSE)

ZCA:	113925912(HPSE)

MLX:	118010381(HPSE)

NSU:	110591430(HPSE)

LWW:

102748085

FCA:	101090101(HPSE)

PYU:	121033261(HPSE)

PCOO:

112858381(HPSE)

PBG:	122478708(HPSE)

PVIV:

125164291(HPSE)

LRUF:

124520139

LGF:	123595752(HPSE)

AJU:

106987077

PTG:	102965445(HPSE)

PPAD:

109276572(HPSE)

PUC:

125922883

PLEZ:

122218085(HPSE)

HHV:	120246450(HPSE)

BTA:	281230(HPSE)

BOM:	102265641(HPSE)

BIU:	109560640(HPSE)

BBUB:

102395500(HPSE)

BBIS:

104992948(HPSE)

CHX:	102188207(HPSE)

OAS:	101118612(HPSE)

BTAX:

128049931(HPSE)

CSUM:

138082356(HPSE)

ODA:	120861521(HPSE)

CCAD:

122428283(HPSE)

MREE:

136152706(HPSE)

OVR:	110136882(HPSE)

MBEZ:

129561768(HPSE)

SSC:	100271932(HPSE)

CFR:	102517816(HPSE)

CBAI:

105065287(HPSE)

CDK:	105092018(HPSE)

VPC:	102541772(HPSE)

BACU:

102999760(HPSE)

BMUS:

118896155(HPSE)

LVE:	103084178(HPSE)

OOR:	101283118(HPSE)

LALB:

132519254(HPSE)

GMF:	115864396(HPSE)

DDP:	132425362(HPSE)

DLE:	111187577(HPSE)

PCAD:

102985869(HPSE)

PSIU:

116754204(HPSE)

PPHC:

136123093(HPSE)

NASI:

112406874(HPSE)

ECB:	100061267(HPSE)

EPZ:	103549090(HPSE)

EAI:	106846420(HPSE)

MYB:	102245458(HPSE)

MYD:	102774009(HPSE)

MMYO:

118670781(HPSE)

MLF:	102436832(HPSE)

MDT:	132216909(HPSE)

MYUM:

138994004(HPSE)

PKL:	118704413(HPSE)

EFUS:

103287993(HPSE)

MNA:	107537105(HPSE)

DRO:	112317780(HPSE)

SHON:

118979540(HPSE)

AJM:	119054621(HPSE)

PDIC:

114492003(HPSE)

PHAS:

123806934(HPSE)

MMF:	118640491(HPSE)

PPAM:

129085206(HPSE)

HAI:	109387924(HPSE)

RFQ:	117022519(HPSE)

PALE:

102888805(HPSE)

PGIG:

120588285(HPSE)

PVP:	105289595(HPSE)

RAY:	107516475(HPSE)

MJV:	108394108(HPSE)

TOD:	119260898(HPSE)

SFUM:

130020548(HPSE)

SETR:

126032602(HPSE)

LAV:	100676520(HPSE)

TMU:

101360212

ETF:	101641929(HPSE)

DNM:	101444076(HPSE)

MDO:	100026183(HPSE)

GAS:	123251465(HPSE)

SHR:	100923804(HPSE)

AFZ:

127540048

PCW:	110209762(HPSE)

TVP:	118853648(HPSE)

PBRV:

138164414(HPSE)

MLAO:

141517476(HPSE)

GGA:	373981(HPSE)

PCOC:

116231114(HPSE)

MGP:	100545679(HPSE)

CJO:	107313425(HPSE)

TPAI:

128080525(HPSE)

LMUT:

125692261(HPSE)

NMEL:

110399069(HPSE)

APLA:

101797825(HPSE)

ACYG:

106041934(HPSE)

CATA:

118251572(HPSE)

AFUL:

116489002(HPSE)

TGU:	100218163(HPSE)

LSR:	110468522(HPSE)

SCAN:

103826088(HPSE)

PMOA:

120496083(HPSE)

OTC:	121339835(HPSE)

PRUF:

121360463(HPSE)

ATRC:

139592068(HPSE)

GFR:	102040930(HPSE)

FAB:	101809526(HPSE)

OMA:	130252833(HPSE)

PHI:	102109966(HPSE)

PMAJ:

107203573(HPSE)

CCAE:

111928869(HPSE)

CCW:	104697252(HPSE)

CBRC:

103622394(HPSE)

ACOE:

138109429(HPSE)

ETL:	114057759(HPSE)

ZAB:	102062765(HPSE)

ZLE:	135446847(HPSE)

SVG:	106854859(HPSE)

MMEA:

130575366(HPSE)

HRT:	120752846(HPSE)

SATI:

136360629(HPSE)

CCIC:

134044076(HPSE)

FPG:	101912317(HPSE)

FCH:	102057366(HPSE)

CCRI:

104165685(HPSE)

NNT:	104406605(HPSE)

SHAB:

115610347(HPSE)

ACUN:

113479584(HPSE)

TALA:

104365048(HPSE)

ACHC:

115338962(HPSE)

HALD:

104323272(HPSE)

HLE:	104841545(HPSE)

AGEN:

126044994

HHAR:

128134615(HPSE)

GCL:

127016231

LDI:	104339906(HPSE)

PPUS:

135179069(HPSE)

AVIT:

104267560(HPSE)

BRHI:

104495750(HPSE)

EGZ:	104127343(HPSE)

NNI:	104014988(HPSE)

PCRI:

104023907(HPSE)

PADL:

103919913(HPSE)

AFOR:

103899753(HPSE)

FGA:	104070099(HPSE)

GSTE:

104259781(HPSE)

CBOY:

140652292(HPSE)

CLV:	102085346(HPSE)

CNIC:

135988338(HPSE)

MUI:	104533312(HPSE)

PGUU:

104464706(HPSE)

PLET:

104626554(HPSE)

EHS:	104514871(HPSE)

CMAC:

104473092(HPSE)

CUCA:

104058089(HPSE)

TEO:	104379522(HPSE)

BREG:

104633986(HPSE)

OHA:	104331655(HPSE)

ACAR:

104517534(HPSE)

CPEA:

104398857(HPSE)

CVF:	104291527(HPSE)

RTD:	128910337(HPSE)

CRID:

134516475(HPSE)

AAM:	106494822(HPSE)

AROW:

112970688(HPSE)

NPD:	112951906(HPSE)

TGT:	104580647(HPSE)

DNE:	112990443(HPSE)

SCAM:

104145179(HPSE)

ASN:

102369021

AMJ:	102571669(HPSE)

CPOO:

109321870(HPSE)

GGN:	109303678(HPSE)

PSS:	102450514(HPSE)

CMY:	102946031(HPSE)

CCAY:

125635758(HPSE)

DCC:	119855262(HPSE)

CPIC:

101942907(HPSE)

TST:	117878215(HPSE)

CABI:

116836664(HPSE)

MRV:	120406245(HPSE)

ACS:	100565376(hpse)

ASAO:

132777033(HPSE)

PVT:	110083349(HPSE)

SUND:

121932136(HPSE)

PBI:	103050955(HPSE)

PMUR:

107303159(HPSE)

CTIG:

120311401(HPSE)

PGUT:

117673663(HPSE)

PCAE:

139320243(HPSE)

APRI:

131203402(HPSE)

PTEX:

113434882(HPSE)

NSS:	113425149(HPSE)

VKO:	123022631(HPSE)

PMUA:

114604526(HPSE)

PRAF:

128421426(HPSE)

ZVI:	118083498(HPSE)

HCG:	128328506(HPSE)

GJA:	107116059(HPSE)

STOW:

125440274(HPSE)

EMC:	129336633(HPSE)

XLA:	108719705(hpse.L)

XTR:	100145320(hpse)

NPR:	108804446(HPSE)

RTEM:

120915912(HPSE)

ACAT:

141108337(HPSE)

BBUF:

120989721(HPSE)

BGAR:

122945288(HPSE)

DTC:	141046934(HPSE)

MUO:	115459306 115462488(HPSE)

GSH:	117369356(HPSE)

DRE:	563020(hpse)

SRX:	107722827(hpse)

SANH:

107681091(hpse) 107703469

SGH:	107589237(hpse) 107591750

CCAR:

109046365(hpse) 109083888

CAUA:

113038734 113064200

CGIB:

127941320 127986662

PTET:

122326508(hpse)

LROH:

127152972(hpse)

GRF:	141292742(hpse)

OMC:	131528876(hpse)

PPRM:

120490755(hpse)

RKG:	130102280(hpse)

MAMB:

125252769(hpse)

CIDE:

127503685

CERY:

137013052(hpse)

MASI:

127431305

TROS:

130570506(hpse)

TDW:	130407903(hpse)

MANU:

129423172(hpse)

PDAB:

135776206(hpse)

IPU:

108278991

IFU:	128622755(hpse)

PHYP:

113543026(hpse)

SMEO:

124398473(hpse)

TFD:	113638668(hpse)

TVC:	132859613(hpse)

CGAR:

128508028(hpse)

NGRA:

132895395(hpse)

TRN:	134330742(hpse)

AMEX:

103027675(hpse)

CMAO:

118819832(hpse)

EEE:	113570752(hpse)

CHAR:

105909106(hpse)

SPIL:

134101320(hpse)

TRU:	101076415(hpse)

TFS:	130517022(hpse)

TNG:	GSTEN00001168G001 GSTEN00010356G001

LCO:	104939605(hpse)

NCC:

104957343

TBEN:

117497815(hpse)

CGOB:

115005073(hpse)

GACU:

117534941(hpse)

EMAC:

134868819(hpse)

ELY:	117270168(hpse)

EFO:	125906016(hpse)

PLEP:

121959693(hpse)

SLUC:

116041823(hpse)

PFLV:

114571209(hpse)

PPUG:

119227058(hpse)

AFB:	129102244(hpse)

CLUM:

117740304(hpse)

PSWI:

130205180(hpse)

CANA:

137783822(hpse)

CVE:	137868534(hpse)

MSAM:

119914560(hpse)

SCHU:

122865317(hpse)

CUD:	121524728(hpse)

SPUL:

138602143(hpse)

LMIX:

132992140(hpse)

ALAT:

119029693(hpse)

ASTR:

137608260(hpse)

MZE:	101471023(hpse)

ONL:	100704102(hpse)

OAU:	116321504(hpse)

OLA:	101156941(hpse)

OML:	112162914(hpse)

CSAI:

133454789(hpse)

XMA:	102231016(hpse)

XCO:	114150028(hpse)

XHE:	116724936(hpse)

PRET:

103473150(hpse)

PFOR:

103152308(hpse)

PLAI:

106947039(hpse)

PMEI:

106904036(hpse)

GAF:	122819209(hpse)

PPRL:

129379729(hpse)

CVG:	107100851(hpse)

CTUL:

119797736(hpse)

GMU:	124873152(hpse)

NFU:	107390264(hpse)

KMR:	108242518(hpse)

ALIM:

106524410(hpse)

NWH:	119425089(hpse)

EJA:	138208957(hpse)

BFRE:

138622308(hpse)

MCEP:

124996229(hpsE)

CSEM:

103390393(hpse)

POV:

109648055

SSEN:

122787041(hpse)

SSOE:

131445915(hpse)

HHIP:

117771320(hpse)

HSP:	118125879(hpse)

PPLT:

128425111(hpse)

SMAU:

118284843(hpse)

LCF:

108892286

SDU:	111238027(hpse)

SLAL:

111651357 111652372

XGL:	120806035(hpse)

HCQ:	109517543(hpse)

SBIA:

133490508(hpse)

PEE:	133413448(hpse)

PTAO:

133465016(hpse)

BPEC:

110161656(hpse)

ENY:	140367614(hpse)

BSPL:

114866523(hpse)

SJO:	128379940 128379957

SSCO:

133995046(hpse)

GMH:	115541973(hpse)

SASA:

106563622(hpse) 106568158

STRU:

115149247 115159329

OTW:	112219520(hpse)

OMY:	110523793(hpse)

OGO:	124048738(hpse)

ONE:	115105879 115125824

OKI:	109868008(hpse)

OKE:	118375605 118387737(hpse)

OMM:	135517772(hpse)

OCLA:

139408798 139421908

SALP:

111961401 111981971

SNH:	120026458(hpse) 120044991

CCLU:

121573982 121582206(hpse)

ELS:	105014724(hpse)

OEP:	134038521(hpse)

SFM:	108935179(hpse)

PKI:	111842231(hpse)

AANG:

118212115(hpse)

AROT:

135239841(hpse)

CCOG:

133105670(hpse)

LOC:	102686050(hpse)

PSPA:

121303644(hpse)

ARUT:

117408892 117420934

PSEX:

120533056(hpse)

LCM:	102346905(HPSE)

CMK:	103187960(hpse)

RTP:	109935286(hpse)

CPLA:

122539446(hpse)

HOC:	132833239(hpse)

LERI:

129701247(hpse)

HAKA:

140726331(hpse)

PMRN:

116940692

LRJ:	133343517(HPSE)

BFO:

118413989

BBEL:

109471425

CIN:	100178996 100185909

SCLV:

120344732 120345034

SPU:	586860 763558

LPIC:

129254557

AJJ:

139967561

APLC:

110974251 110984533

ARUN:

117287996 117288584 117298637

AAMU:

139937499 139937505 139941381

AFIL:

140141796 140142730 140148771

AJC:

117118818

SKO:	100376015 102801119 102804856

PFLL:

139116200 139120618

AME:

725623

ACER:

107996324

ALAB:

122712848

ADR:

102671581

AFLR:

100865509

BIM:

100745198

BBIF:

117209398

BVK:

117240191

BVAN:

117164389

BHUN:

126870280

BTER:

105666557

BAFF:

126924172

BPYO:

122575821

BPAS:

132912231

FVI:

122532798

CCAL:

108630640

OBB:

114877484

OLG:

117610507

MGEN:

117218147

NMEA:

116431518

CGIG:

122405059

SOC:

105193112

MPHA:

105836142

AEC:

105154939

ACEP:

105626290

ACOC:

108694811

MZT:

108729129

CCOA:

108772315

PBAR:

105430094

VEM:

105559915

COBS:

139108027

TLN:

139807939

HST:

105180876

DQU:

106751247

CFO:

105248467

FEX:

115237339

PMEC:

138934466

LHU:

105671110

PGC:

109853681

OBO:

105281678

PCF:

106786988

PFUC:

122515261

VPS:

122636119

VCRB:

124431722

VVE:

124955519

NVI:

100113700

CSOL:

105368274

TPRE:

106659608

LBD:	127280844 127282638

MDL:

103580115

CGLO:

123271325

CTYP:

141533267

FAS:

105263758

DAM:

107038411

AGIF:

122852847 122852848

VCAN:

122405882

CCIN:

107263116

DSM:

124413877

NPT:

124222858

NFB:

124186177

NLO:

107219737

NVG:

124308616

AROA:

105686912

TCA:

659639

TMOL:

138132502

DPA:	109535884 109541637 109545353 109545371

ESIM:

136411428 136412991

EFOR:

136343781

SOY:

115874561

AGRG:

126734175 126739847 126744691

ATD:

109608715

CSET:

123310036

HAXR:

123685118

AGB:

108905388

LDC:

111502285

DVV:

126887497

NVL:

108564172

PPYR:

116168839 116169481 116169945

OTU:

111415667

BMOR:

100141461(Hepa)

BMAN:

114250016

MSEX:

115451084

DPL:	KGM_207163

BANY:

112042805

MJU:

123871289

NIQ:

126780697

VCD:

124542951

MCIX:

123669060

PMAC:

106717291

PPOT:

106104492

PXU:

106126423

BPHI:

137919220

PRAP:

110998158

ZCE:

119835673

LSIN:

126978848

AAGE:

121738806

HAW:

110374496

HZE:

124645105

TNL:

113506141

SLIU:

111360717

OFU:

114359330

ONU:

135087069

ATRA:

106134035

GMW:

113520008

PXY:

105384116

PGW:

126379781

LGLY:

125241245

CSTB:

134754300

CFUM:

141436645

CCRN:

123292360

AGS:

114122244

CLEC:

106664391

HHAL:

106688101

HVI:

124359750

PHU:	Phum_PHUM168420

FOC:

113208080

TPAL:

117653255

ZNE:

110830469

CSEC:

111863723

PAME:

138703743

BROR:

134534192 134539214

IEL:

124154110

HAMR:

139688235

FCD:

110856956

AFRA:

136027329

PJA:

122259003

PCHN:

125037630

HAME:

121872914

CQD:

128700757

PTRU:

123515456

MNZ:	135219502 135220090

MRJ:	136847040 136848560 136848561

PORN:

139747426 139747427

HAZT:

108683161

TCF:

131886022

PPOI:

119095089 119095397

DSV:	119444644 119452400

RSAN:

119391492 119400889

RMP:

119180320

GOE:

100898075

CSCU:

111641472

CVS:

136982275

LPOL:

106467512

HRO:	HELRODRAFT_161090

LGI:	LOTGIDRAFT_159759 LOTGIDRAFT_159761 LOTGIDRAFT_231761

PVUL:

126814751 126815304 126815364 126815901 126815913 126815921 126818105 126818935 130012281 130012320 130012321 130012322 130014268

PCAN:

112556154 112556225 112556228 112557171 112557172 112558223

LSAX:

138953409 138954970 138956002 138957652 138963777 138963778 138977876 138978051 138978053 138978079 138978081 138978082 138978083 138978113 138978170 138978173 138978174 138978175 138978176 138978177 138978612 138979158 138979180 138979183 138979192

BGT:	106057424 106058459 106059621 106074413

GAE:

121385459

HRF:

124110777 124110789 124110790 124116504 124116509 124116511 124116512 124116513 124116514 124116521 124116522 124116523 124116527 124116534 124116535 124116536 124116537 124121777 124121783 124121785 124125343 124125344 124125350 124125351 124129035 124129036 124129047 124129102 124129103 124139296 125371634 125378660 125378662 125378664 125378666 125378667 125378668 125378680 125378681 125378682 125378683

HRJ:	124263021 124263022 124263026 124263028 124263029 124263038 124273906 124273970 124273972 124275049 124278350 124278401 124279718 124279724 124291163 124291166 124291175

HASI:

137267567 137267601 137267602 137267604 137267605 137267724 137267800 137267803 137267804 137267807 137267962 137268229 137268267 137268268 137268374 137268401 137268466 137268486 137268516 137268528 137272498

HCRA:

139458964 139470931 139470938 139470942 139477789 139477790 139477791 139477792 139477795 139477796 139477809 139477834 139477835 139477837 139477838 139477839 139477841 139477851 139477853

CRG:	105320771 105335864

CANU:

128182588 128192569

CVN:	111122507 111133429

OED:

125658907

MYI:

110448663

PMAX:

117320605 117339362

AIRR:

138334763

MCAF:

127736096 127736098

RPHI:

132728837 132745911

DPOL:

127841833

MAEA:

128212350

OBI:	106874146 106878007

OSN:	115219045 115223331

LJP:	135467062 135467126 135467556 135467557 135467558 135467727 135467739 135468454 135469132 135469186 135469290

LAK:

106153669

LLON:

135486856

NVE:	5503802 5514619

EPA:	110238002 110246297 110251524

ATEN:

116296587 116297207

ADF:	107330651 107338790 107354788

AMIL:

114958108 114973352

MCAZ:

138040795 138043771 138044052

MFOO:

138006367 138006690

PDAM:

113670022 113683983

SPIS:

111329059 111340113

DGT:	114530656 114531089

XEN:	124452785 124452977

HMG:	100197518 100208368 100209357 100212115

HSY:	130622621 130623327

RES:	135682081 135682082 135687394 135691362

AQU:

100632989

ATH:	AT5G07830(GUS2) AT5G34940(GUS3) AT5G61250(GUS1)

ALY:	9300803 9304475 9309395

CRB:	17876259 17879794 17882401

CSAT:

104708318 104723958 104726711 104732492 104734801 104738603 104762235 104768989 109124769

EUS:	EUTSA_v10003449mg EUTSA_v10003960mg EUTSA_v10013186mg

BRP:	103833744 103847113 103860580

BNA:	106411460 106418750 106419402 106442442 106446111 106449539

BOE:	106306275 106311798 106318846

RSZ:	108805374 108805377 108818286 108822215 108822216 130498872 130499783

THJ:	104808955 104818330 104823068

CPAP:

110807038 110813997 110814890 110814892 110826122

CIT:	102608348 102610770 102611386 102614850

CIC:	CICLE_v10007919mg CICLE_v10010401mg CICLE_v10019304mg CICLE_v10033641mg

PVY:	116107765 116110729 116127842 116138112

MINC:

123194235 123194317 123200101 123204673 123211671 123215087

TCC:	18587757 18588859 18604781 18610294

GRA:	105764689 105772991 105775698 105775737 105784888 105784980 105791045 105793016 105797371 105800791

GHI:

107889831 107889837 107889841 107889855 107889857 107889859 107889860 107889861 107892792 107892793 107892794 107898765 107901340 107912568 107921522 107931497 107931769 107931771 107935298 107936659 107940072 107940344 107940350 107944290 107944415 107944416 107944490 107948692 107951250 107962572 121206435 121211039 121222585

GAB:	108454253 108455030 108455679 108455680 108462532 108465217 108468340 108476607 128279331 128280737 128280742

HSYR:

120122010 120145218 120149304 120150317 120156736 120163768 120176908 120176909 120176924 120183625 120202455 120202458

DZI:	111284000 111284616 111285922 111289766 111299019 111300444 111309868

EGR:	104420262 104425993 104435597 104437643 104437644 104437646 104438623 104455742

RARG:

115733738 115734923 115741664 115751025 115753738 115753740 115754360 115756248

GMX:	100778008 100782283 100791916 100792087 100792792 100802477 100803057 100804120 100806170 100807012 100813746 102662422 106797823

GSJ:	114367922 114370927 114373529 114387148 114387173 114388511 114391814 114394259 114409685 114411824 114416590

PVU:	137807598 137807728 137809620 137820016 137821693

VRA:	106755278 106757654 106759630 106765702 106766847 106779320

VAR:	108324912 108332102 108334817 108341585 108345696

VUN:	114164379 114174552 114174993 114176086 114195991

VUM:	124821666 124821872 124841854 124843915 124848900

CCAJ:

109790939 109791987 109800324 109808388 109808708 109809088 109816308 109817145

APRC:

113846764 113847019 113847674 113874397

MTR:	11413278 11437772 120579640 25488361 25488660 25488661 25488662 25493866

TPRA:

123881890 123884114 123885751 123911452 123917468

CAM:	101492700 101493679 101494689 101512767

PSAT:

127073470 127073748 127081125 127085449

VVO:	131594723 131604669 131606312 131631163 131632760

LJA:	130715123 130716263 130726013 130734617 130735707 130738613

ADU:	107461469 107463529 107467607 107467610 107468441 107479641 107483006 110273829

AIP:	107616242 107616246 107622715 107630530 107632651 107634143 107635977 107640604 110269501

AHF:	112701435 112701647 112708197 112709578 112709839 112713110 112722554 112723342 112732305 112732934 112741400 112742190 112779114 112779116 112782406 112790775 112794576

LANG:

109328476 109328497 109344408 109346015 109346028 109354727 109359565 109361472 109362217

PCIN:

129308109 129320908 129321682 129322523

QSA:	O6P43_002000 O6P43_022886 O6P43_023982 O6P43_025527 O6P43_032935

FVE:	101292576 101293484 101295230 101309586

AANS:

126782931 126786290 126792021 126795932

RCN:	112174790 112179656 112186967 112195831

PPER:

18771157 18777307 18777487 18789359 18790621

PMUM:

103319726 103321505 103338454 103341177

PAVI:

110751373 110752594 110762334 110763760

PDUL:

117614286 117622566 117627179 117628841 117633846

MDM:	103400053 103403264 103437866 103447604 103455399 103456224

MSYL:

126599615 126601640 126602393 126603988 126607798 126626307

PXB:	103930738 103930972 103931364 103946731 103949167 103953861

PCOX:

137710364 137712853 137716524 137731324 137737140 137748672

ZJU:	107415693 107419148 107421895 107428862 107428871 107428875 107428889 125418725

MNT:	21387755 21391881 21398356 21406434

CSAV:

115698934 115701149 115709658

CSV:	101205085 101212628 101213640 101213905 101214214 101215378 101220813

CMO:	103483878 103489169 103489677 103494021 103494371 103496979 103504453 127151447

BHJ:	120069563 120071404 120074064 120080459 120082143 120083544

MCHA:

111006827 111008890 111009126 111009315 111013018 111019094 111023940 111024442

CMAX:

111465495 111466170 111466171 111466172 111470271 111471079 111479365 111482540 111492865 111493713

CMOS:

111432361 111440858 111444334 111446673 111450316 111450381 111452576 111457886 111458782

CPEP:

111777618 111781603 111787560 111791689 111793488 111798526 111800534 111800538 111805339

RCU:	8259416 8277627 8284471 8289141

MEAN:

126655612 126667989 126674405 126686236 126687598

JCU:	105630519 105630955 105637606 105640593 105641248

HBR:	110636252 110639175 110642663 110643395 110646174 110646178 110646179 110646183 110649820 110654012 110656929 110672735

MESC:

110599811 110610876 110616739 110617506 110619421 110631248

POP:	18099898 18111056 7453857 7465402 7492893

PEU:	105116645 105117201 105121093 105122679 105134054

PALZ:

118032623 118037326 118042979 118051264 118052025

PNZ:	133674442 133674701 133675783 133688862 133696838

JRE:	108990997 108992197 109002527 109002802 109005442

CILL:

122281678 122305211 122305213 122305214 122305215 122308440 122316705 122318418

CAVE:

132165689 132165733 132166258 132173999 132174640 132191144

AGLU:

133856887 133857263 133870704 133875644 133875778 133875970 133875971 133876073

QSU:	111985586 111989393 112029649 112029650 112040761

QLO:	115963513 115963514 115964675 115964693 115974913 115977140

TWL:	119980344 119987101 119987102 119996257 119997687 120002555 120016673

VVI:	100254131 100255842 100257028 100259360 100264535

VRI:	117904698 117912445 117913450 117914322 117925155

SLY:	101256537 101257181 101258638 101258669 101264423

SPEN:

107015467 107019237 107023336 107025866 107032105

SOT:	102579755 102580456 102580531 102602354 102606348

SSTN:

125860146 125864118 125867183 125873015 125876704

SDUL:

129876066 129876776 129880105 129891442 129894290 129898619

CANN:

107843440 107846992 107852403 107855392 107862297

LBB:	132600469 132603103 132606993 132632891 132641990

NTA:	107789624 107798119 107799043 107813165 107813759 107827511 107828335 107829601(GUS2) 107830348 107832071

NSY:	104210356 104213374 104231812 104239748 104247501

NTO:	104091671 104106070 104114370 104116644 104121626

NAU:	109211330 109220091 109220417 109227490 109233303

INI:	109162793 109164147 109166262 109178730 109193594

ITR:	115996754 116011009 116014068 116026340 116031656

SIND:

105156507 105157963 105160089 105162244 105164556

OEU:	111366012 111368355 111372375 111398847 111400505

EGT:	105951046 105956966 105956987 105960660 105967433 105974584 105977117

SSPL:

121748249 121752016 121752909 121752994 121762008 121765232 121769498 121770056 121785257 121798055

SMIL:

130988186 130995863 131015568 131020332 131025157

SHIS:

125190666 125206423 125207588 125213589

APAN:

127240833 127255577 127260694 127262854

PEBU:

140808132 140809615 140816308 140819580 140828195 140842761

HAN:	110865632 110877363 110886626 110893915 110898566 110912161 110917272 110944865

ECAD:

122584969 122588862 122593794 122596194 122602000 122606856

LSV:	111881906 111882268 111889027 111895156 111908364 111909925 111910485

CCAV:

112507267 112509880 112511274 112516687 112519873 112520204 112521617

DCR:	108192341 108193209 108194272 108198601 108198690 108208766 108211803 108215837 108220198

CSIN:

114278227 114284424 114285617 114305380 114309939 114309940 114310467

RVL:	131298108 131299594 131310723 131310981 131317742 131320278

AEW:	130750295 130751224 130756631 130766849 130773169 130780051 130784842 130790696 130793837

DLT:	127793273 127796873 127796874 127796875 127806237 127813012

BVG:	104882804 104893978 104901937 104902375

SOE:	110789406 110799945 110801137

CQI:	110685651 110700661 110705461 110708041 110722142 110725531 110726389 110733623

ATRI:

130800410 130802779 130816022

SLAF:

141600293 141606086 141607867 141653174

MOF:	131144596 131146317 131151091 131158182 131158183

NNU:	104592548 104598002 104598612

MING:

122079887 122083645 122090927 122090928

TSS:	122650329 122654626 122654870 122671697

PSOM:

113272674 113279136 113300231 113319478 113343128 113349882

OSA:	4331042 4332033 4340299 4343804 4352626

DOSA:

Os02g0802200 Os03g0211700 Os06g0179000 Os07g0598400 Os12g0578400

OBR:	102704215 102707920 102718196 102718721 102720994

OGL:	127757018 127761221 127768400 127777931 127780096

BDI:	100827936 100834568 100837386 100838514

ATS:	109736222 109750281 109770916 109777268 109780669

TDC:	119284894 119291241 119299596 119307664 119318364 119324056 119329056 119336914 119357750 119360787

TAES:

123041047 123049055 123085047 123093006 123098288 123102439 123110614 123119642 123128828 123139260 123145970 123147564 123160521 123161544 123167860 123168459 123185037

TUA:	125508021 125515222 125520335 125525690 125535430

LPER:

127296533 127299103 127305222 127317987 127332780

LRD:	124652992 124654347 124672755 124685142 124693604 124696598 124696690

SBI:	8065389 8067461 8068132 8084653

ZMA:	100192026 100193781 100279495 100285720 100501670 103640342

MFLO:

136467926 136478277 136504294 136505690 136509548 136509636 136521231 136521415 136528364 136528839 136535526 136550247

SITA:

101758357 101761220 101762752 101785921

SVS:	117839915 117841426 117848276 117852916

PVIR:

120645233 120646895 120657509 120666582 120670089 120691015 120699897 120702797

PHAI:

112874533 112879016 112884792 112891166

PAUA:

133905244 133906324 133911884 133916667 133920016 133920997 133926347 133930761

TANG:

140760414 140763453 140774328

PDA:	103704453 103709282 103710119 103715887 103718168

EGU:	105032253 105033054 105046630 105049420 105055993 105056031

MUS:	103979337 103980064 103982167 103983605 135609037 135617517

ZOF:	121979732 121984063 121989638 121998583 122002734 122006982 122040642 122041028 122042403 122044071 122045176 122045540 122046911 122048652 122051703 122056233

DCT:	110095528 110097241 110098134 110099407 110109652 110114766 110116311

PEQ:	110020130 110024422 110026960 110029134 110030614 110031280 110032014 110035536

AOF:	109822035 109834102 109835733 109849518 109851214

MSIN:

131218132 131218134 131219237 131219238 131229221 131254758

ACAK:

137936632 137941402 137951523 137953009 137953726

NCOL:

116252237 116255575 116256388 116256495 116257956

ATR:	18427936 18427937 18442559

CJF:	131031062 131031063 131054333 131054335 131076196 131079949

SMO:	SELMODRAFT_105931 SELMODRAFT_133100 SELMODRAFT_133227 SELMODRAFT_32458 SELMODRAFT_52894

PPP:	112274848 112286717 112287451 112289377

MBR:	MONBRDRAFT_22110 MONBRDRAFT_24839 MONBRDRAFT_26729 MONBRDRAFT_29948 MONBRDRAFT_30511 MONBRDRAFT_34413

SRE:	PTSG_00821

TPS:	THAPSDRAFT_bd1944

AAF:	AURANDRAFT_3240 AURANDRAFT_64495

EHX:	EMIHUDRAFT_194815 EMIHUDRAFT_52085

GTT:	GUITHDRAFT_142083

CATE:

C2869_18390

SDE:

Sde_3124

TTU:	TERTU_3487

SPOI:

IMCC21906_01609

MMW:	Mmwyl1_1639

MME:	Marme_2892

MPC:	Mar181_2151

MPRI:

MP3633_2421

MARD:

IBG28_13470

MFOI:

JSY38_02980

MRHI:

KDW99_12980

MPON:

MACH16_11460

GSN:	YC6258_03119

NAR:

Saro_3674

NOV:	TQ38_017855

SYA:	A6768_14080

NTD:	EGO55_04735

SSM:	Spirs_0259

SCD:	Spica_0071

TSA:	AciPR4_4030

TALB:

FTW19_21690

SUS:

Acid_3120

PFER:

IRI77_15190

ABAC:

LuPra_05369

MCOS:

GM418_21645

SPIR:

CWM47_02705

RUN:	DR864_23200

RUP:	DTQ70_06315

EMAR:

D1013_08510

OCN:	CUC15_05820

OCB:	CV093_06150

SUB:

SUB1200

STB:

SGPB_0956

SIK:

K710_0674

SIQ:	DQ08_03240

SIO:	DW64_03230

SMEN:

SAMEA4412692_0439

SACO:

SAME_01686

SZG:	J5M87_06845

RHO:	RHOM_14650

» show all

Reference

1 [PMID:11445547]

Authors

Bame KJ

Title

Heparanases: endoglycosidases that degrade heparan sulfate proteoglycans.

Journal

Glycobiology 11:91R-98R (2001)
DOI:10.1093/glycob/11.6.91R

Reference

2 [PMID:20181948]

Authors

Peterson SB, Liu J

Title

Unraveling the specificity of heparanase utilizing synthetic substrates.

Journal

J Biol Chem 285:14504-13 (2010)
DOI:10.1074/jbc.M110.104166

Sequence

[hsa:10855]

Reference

3 [PMID:9668050]

Authors

Pikas DS, Li JP, Vlodavsky I, Lindahl U

Title

Substrate specificity of heparanases from human hepatoma and platelets.

Journal

J Biol Chem 273:18770-7 (1998)
DOI:10.1074/jbc.273.30.18770

Reference

4 [PMID:12213822]

Authors

Okada Y, Yamada S, Toyoshima M, Dong J, Nakajima M, Sugahara K

Title

Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence.

Journal

J Biol Chem 277:42488-95 (2002)
DOI:10.1074/jbc.M206510200

Sequence

[hsa:10855]

Reference

5 [PMID:17635638]

Authors

Vreys V, David G

Title

Mammalian heparanase: what is the message?

Journal

J Cell Mol Med 11:427-52 (2007)
DOI:10.1111/j.1582-4934.2007.00039.x

Reference

6 [PMID:12837765]

Authors

Gong F, Jemth P, Escobar Galvis ML, Vlodavsky I, Horner A, Lindahl U, Li JP

Title

Processing of macromolecular heparin by heparanase.

Journal

J Biol Chem 278:35152-8 (2003)
DOI:10.1074/jbc.M300925200

Sequence

[mmu:15442]

Reference

7 [PMID:10446189]

Authors

Toyoshima M, Nakajima M

Title

Human heparanase. Purification, characterization, cloning, and expression.

Journal

J Biol Chem 274:24153-60 (1999)
DOI:10.1074/jbc.274.34.24153

Sequence

[hsa:10855]

Reference

8 [PMID:12460766]

Authors

Miao HQ, Navarro E, Patel S, Sargent D, Koo H, Wan H, Plata A, Zhou Q, Ludwig D, Bohlen P, Kussie P

Title

Cloning, expression, and purification of mouse heparanase.

Journal

Protein Expr Purif 26:425-31 (2002)
DOI:10.1016/S1046-5928(02)00558-2

Sequence

[mmu:15442]

Reference

9 [PMID:19748475]

Authors

Hammond E, Li CP, Ferro V

Title

Development of a colorimetric assay for heparanase activity suitable for kinetic analysis and inhibitor screening.

Journal

Anal Biochem 396:112-6 (2010)
DOI:10.1016/j.ab.2009.09.007

Other DBs

ExplorEnz - The Enzyme Database:

3.2.1.166

IUBMB Enzyme Nomenclature:

3.2.1.166

ExPASy - ENZYME nomenclature database:

3.2.1.166

BRENDA, the Enzyme Database:

3.2.1.166

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   GenBank (18)   
   EMBL (10)   
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   PDB (13)   
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