Entry
Name
protein O-GlcNAcase;
OGA;
glycoside hydrolase O-GlcNAcase;
O-GlcNAcase;
BtGH84;
O-GlcNAc hydrolase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine/threonine N-acetylglucosaminyl hydrolase
Reaction(IUBMB)
(1) [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H2O = [protein]-L-serine + N-acetyl-D-glucosamine [RN:
R09672 ];
(2) [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-theronine + H2O = [protein]-L-threonine + N-acetyl-D-glucosamine [RN:
R09673 ]
Reaction(KEGG)
Substrate
[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine [CPD:
C19802 ];
H2O [CPD:
C00001 ];
[protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-theronine
Product
[protein]-L-serine [CPD:
C02189 ];
N-acetyl-D-glucosamine [CPD:
C00140 ];
[protein]-L-threonine [CPD:
C19803 ]
Comment
Within higher eukaryotes post-translational modification of protein serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic, inducible and abundant, regulating many cellular processes by interfering with protein phosphorylation. EC
2.4.1.255 (protein O-GlcNAc transferase) transfers GlcNAc onto substrate proteins and EC
3.2.1.169 (protein O-GlcNAcase) cleaves GlcNAc from the modified proteins.
History
EC 3.2.1.169 created 2011
Orthology
K15719 protein O-GlcNAcase / histone acetyltransferase
Genes
OGA : 100955878 100966970(MGEA5)
VPC : 102529685(OGA) 102541709
PCOC : 116226056 116231682(OGA)
MGP : 100550244(OGA) 116216702
CJO : 107306849 107315982(OGA)
TPAI : 128071978 128077675(OGA)
NMEL : 110390931 110399611(MGEA5)
ACYG : 106035955(OGA) 106043195
AFUL : 116488955 116491128(OGA)
TGU : 100217691 100222791(OGA)
LSR : 110468741 110473663(OGA)
SCAN : 103814148(OGA) 103823117
PMOA : 120502106(OGA) 120509741
OTC : 121335221 121341962(OGA)
PRUF : 121350033(OGA) 121364720
GFR : 102039689(MGEA5) 102041996
FAB : 101807026(MGEA5) 101820674
PHI : 102099607 102100524(MGEA5)
PMAJ : 107203361 107206955(OGA)
CCAE : 111929151 111930940(MGEA5)
CCW : 104690840 104697891(OGA)
CBRC : 103621146 103624547(MGEA5)
ETL : 114068881 114070525(OGA)
ZAB : 102063529(OGA) 102073146
SVG : 106853115 106859001(MGEA5)
FPG : 101911645 101920070(MGEA5)
FCH : 102050212 102050673(OGA)
CLV : 102086261 102092419(MGEA5)
ACUN : 113481496(OGA) 113490509
TALA : 104359393(OGA) 116962506
PADL : 103916317(MGEA5) 103922179
AFOR : 103897881(MGEA5) 103902150
ACHC : 115338036 115348140(OGA)
HLE : 104830120(MGEA5) 104832337
AGEN : 126035202 126042589
BREG : 104632655 104632999(MGEA5)
SHAB : 115603599 115607924(OGA)
CPEA : 104390870(MGEA5) 104398133
CUCA : 104056877 104059798(MGEA5)
AAM : 106487392 106496884(MGEA5)
AROW : 112967879(OGA) 112978201
ASN : 102378650 102387046(OGA)
AMJ : 102563356(MGEA5) 106740206
CPOO : 109323917(MGEA5) 109324416
XLA : 108696157(oga.L) 108697432(oga.S)
DRE : 100538182(si:dkey-183c6.8) 324487(oga) 571547(mgea5l)
SRX : 107726775 107733669 107742283 107747552(mgea5) 107753935
SANH : 107666422 107667060 107668868 107691946 107700507
SGH : 107562569 107567635 107569412 107585241 107588144
CCAR : 109069987 109083210(mgea5)
CAUA : 113055552 113055557 113057088 113105718 113111272 113112823
CGIB : 127934348 127961040(si:dkey-183c6.8) 127967902 127970709 128021947 128026333
PTET : 122347855(si:dkey-183c6.8) 122353940(ogal) 122356819(oga)
LROH : 127168460(si:dkey-183c6.8) 127173249(ogal) 127175658(oga)
PPRM : 120462600(si:dkey-183c6.8) 120479772(oga) 120491971(ogal)
MAMB : 125256134(ogal) 125264490(si:dkey-183c6.8) 125276537(oga)
CIDE : 127516482(si:dkey-183c6.8) 127522866 127524623
MASI : 127412440 127413966 127426483 127440801(si:dkey-183c6.8) 127450333
IPU : 108263439(oga) 108267925(si:dkey-183c6.8) 108270888(ogal)
PHYP : 113536642 113537792(oga) 113540315
SMEO : 124387264(si:dkey-183c6.8) 124391245(ogal) 124400441(oga)
TFD : 113644933(oga) 113653429(ogal) 113663159(si:dkey-183c6.8)
AMEX : 103032082(mgea5) 103039791 103046573
CMAO : 118810260(oga) 118818845(ogal) 118826561(si:dkey-183c6.8)
EEE : 113578274 113585838(oga) 113589695
CHAR : 105896616(si:dkey-183c6.8) 105910134(ogal) 122129963(oga)
TRU : 101062608(oga) 101067324 105418539 105419290
TNG : GSTEN00030608G001 GSTEN00032524G001
LCO : 104922274(oga) 104925209
NCC : 104950187 104955157(mgea5) 104955566
CGOB : 115010304 115019889(oga) 115023625
ELY : 117248314(oga) 117255350(ogal) 117272795(si:dkey-183c6.8)
EFO : 125884337(si:dkey-183c6.8) 125885650(ogal) 125903250(oga)
PLEP : 121941846(ogal) 121954223(oga) 121962152(si:dkey-183c6.8)
SLUC : 116042246(si:dkey-183c6.8) 116042595(ogal) 116053576(oga)
ECRA : 117934563(si:dkey-183c6.8) 117936653(ogal) 117960762(oga)
ESP : 116704963 116705213(oga) 116707043
PFLV : 114570775 114571885(oga) 114573956
GAT : 120820615(oga) 120822207(si:dkey-183c6.8) 120825243(ogal)
PPUG : 119214134(oga) 119218258(ogal) 119222545(si:dkey-183c6.8)
MSAM : 119899547(ogal) 119912245 119917666(oga)
SCHU : 122870494(si:dkey-183c6.8) 122873977(ogal) 122883955(oga)
CUD : 121504818(si:dkey-183c6.8) 121508370(ogal) 121511590(oga)
ALAT : 119021638(ogal) 119027865(si:dkey-183c6.8) 119033510(oga)
MZE : 101471567 101472149(oga) 101474519
ONL : 100699721 100706413 100709857(oga)
OAU : 116319631(oga) 116322277(si:dkey-183c6.8) 116330977(ogal)
OLA : 101163611 101166655(mgea5) 101172880
OML : 112137423(ogal) 112155772(si:dkey-183c6.8) 112161614(oga)
XMA : 102223372 102231453 102232442(mgea5)
XCO : 114138448(oga) 114144358 114157373
XHE : 116713837(oga) 116719744 116733219
PRET : 103465403 103476931(mgea5) 103480785
PFOR : 103131168 103150495 103152236(mgea5)
PLAI : 106948276 106951257(mgea5) 106961065
PMEI : 106904343 106907807 106917533(mgea5)
GAF : 122820190(si:dkey-183c6.8) 122829586(ogal) 122842221(oga)
CVG : 107086606(mgea5) 107090773 107096471 107099030
CTUL : 119772716(si:dkey-183c6.8) 119783282(ogal) 119790729(oga)
GMU : 124859670(oga) 124867952(ogal) 124881277(si:dkey-183c6.8)
NFU : 107375656(mgea5) 107376946 107392405
KMR : 108234080(oga) 108236421(ogal) 108242892(si:dkey-183c6.8)
ALIM : 106521436 106525001 106535674(mgea5)
NWH : 119411948(oga) 119416968(si:dkey-183c6.8) 119422833(ogal)
AOCE : 111578864(mgea5) 111581963 111585373
MCEP : 124995892(si:dkey-183c6.8) 125003797(ogal) 125019184(oga)
CSEM : 103383859 103387380(mgea5)
POV : 109627221 109633895(mgea5) 109634891
SSEN : 122766735(si:dkey-183c6.8) 122771484(ogal) 122781668(oga)
HHIP : 117751790(si:dkey-183c6.8) 117767478(ogal) 117775389(oga)
HSP : 118102410(si:dkey-183c6.8) 118114720(ogal) 118118701(oga)
LCF : 108875631 108888297(oga) 108888756(si:dkey-183c6.8)
SDU : 111229432 111231335 111234087(mgea5)
SLAL : 111657301(mgea5) 111666433 111666684
XGL : 120796260(oga) 120797482(si:dkey-183c6.8) 120800240(ogal)
HCQ : 109511913 109512679(mgea5) 109527421
SSCV : 125966956(si:dkey-183c6.8) 125968601
BPEC : 110156792(mgea5) 110165196 110174701
MALB : 109952730 109957845 109961022(mgea5)
BSPL : 114842102(oga) 114851042 114865352(ogal)
SASA : 106564358 106576856 106591477 106604352(mgea5) 106609082
STRU : 115147542 115152980(oga) 115184176 115194036 115198612
OTW : 112214489(si:dkey-183c6.8) 112242091(ogal) 112252425(oga) 112252769
OMY : 110485509(ogal) 110493422 110500330(si:dkey-183c6.8) 110502247(oga) 110526041
OGO : 124014489(si:dkey-183c6.8) 124027507 124038090(oga) 124041468
ONE : 115113408(oga) 115133304 115135339
SALP : 111951659 111951809 111977735(mgea5)
SNH : 120017500 120018110 120041436 120046445(oga) 120049052(si:dkey-183c6.8)
CCLU : 121534281(ogal) 121553616 121568515(oga) 121571252(si:dkey-183c6.8)
ELS : 105010738(oga) 105012043 105031421
SFM : 108920620 108930276(oga)
PKI : 111846625(mgea5) 111849569 111857372
AANG : 118217811(oga) 118218961 118231584(si:dkey-183c6.8)
LOC : 102683302 102694479(mgea5)
PSPA : 121294585(si:dkey-183c6.8) 121321684 121325549
ARUT : 117409458(si:dkey-183c6.8) 117415414 117418184
PSEX : 120527964(si:dkey-183c6.8) 120542659(oga)
LCM : 102346400(MGEA5) 102358152
RTP : 109923289(mgea5) 109924748
CPLA : 122550812(si:dkey-183c6.8) 122561283(oga)
DSI : Dsimw501_GD19407(Dsim_GD19407)
AALB : 109410078 115253996 115257574
CQU : CpipJ_CPIJ004076 CpipJ_CPIJ014846
CFEL : 113375574 113378687
CSCU : 111615007 111636175
LPOL : 106462405 106463687
BMY : BM_BM5855(Bma-oga-1)
PCAN : 112563760 112564338
DPOL : 127841352 127875973
SMM : Smp_000020 Smp_210490
SHX : MS3_00001585(MGEA5_1)
» show all
Taxonomy
Reference
Authors
Gao Y, Wells L, Comer FI, Parker GJ, Hart GW
Title
Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain.
Journal
Sequence
Reference
Authors
Wells L, Gao Y, Mahoney JA, Vosseller K, Chen C, Rosen A, Hart GW
Title
Dynamic O-glycosylation of nuclear and cytosolic proteins: further characterization of the nucleocytoplasmic beta-N-acetylglucosaminidase, O-GlcNAcase.
Journal
Sequence
Reference
Authors
Cetinbas N, Macauley MS, Stubbs KA, Drapala R, Vocadlo DJ
Title
Identification of Asp174 and Asp175 as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants.
Journal
Reference
Authors
Dennis RJ, Taylor EJ, Macauley MS, Stubbs KA, Turkenburg JP, Hart SJ, Black GN, Vocadlo DJ, Davies GJ
Title
Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity.
Journal
Sequence
Reference
Authors
Kim EJ, Kang DO, Love DC, Hanover JA
Title
Enzymatic characterization of O-GlcNAcase isoforms using a fluorogenic GlcNAc substrate.
Journal
Reference
Authors
Dong DL, Hart GW
Title
Purification and characterization of an O-GlcNAc selective N-acetyl-beta-D-glucosaminidase from rat spleen cytosol.
Journal
J Biol Chem 269:19321-30 (1994)
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 3.2.1.169