KEGG   ENZYME: 3.2.1.208Help
Entry
EC 3.2.1.208                Enzyme                                 

Name
glucosylglycerate hydrolase;
GG hydrolase;
GgH
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
2-O-(alpha-D-glucopyranosyl)-D-glycerate D-glucohydrolase
Reaction(IUBMB)
2-O-(alpha-D-glucopyranosyl)-D-glycerate + H2O = D-glucopyranose + D-glycerate [RN:R12250]
Reaction(KEGG)
Substrate
2-O-(alpha-D-glucopyranosyl)-D-glycerate [CPD:C19792];
H2O [CPD:C00001]
Product
D-glucopyranose [CPD:C00031];
D-glycerate [CPD:C00258]
Comment
The enzyme has been isolated from nontuberculous mycobacteria (e.g. Mycobacterium hassiacum), which accumulate 2-O-(alpha-D-glucopyranosyl)-D-glycerate during growth under nitrogen deprivation.
History
EC 3.2.1.208 created 2018
Orthology
K23086  glucosylglycerate hydrolase
Genes
MSA: Mycsm_06486
MMC: Mmcs_5386
MKM: Mkms_5475
MJL: Mjls_5762
MYV: G155_30065
MYE: AB431_29155
MYN: MyAD_02255
MDX: BTO20_00165
MSM: MSMEG_6914
MSG: MSMEI_6727
MVA: Mvan_6050
MGI: Mflv_0855
MVQ: MYVA_5979
MHAS: MHAS_04250
MAB: MAB_4920c
MABB: MASS_4921
MCHE: BB28_24665
MSTE: MSTE_05003
NSR: NS506_00440(treA)
REY: O5Y_28595
REQ: REQ_46910
RHB: NY08_3630
GOR: KTR9_4692
MMAR: MODMU_1256
 » show all
Taxonomy
Reference
1  [PMID:25341489]
  Authors
Alarico S, Costa M, Sousa MS, Maranha A, Lourenco EC, Faria TQ, Ventura MR, Empadinhas N
  Title
Mycobacterium hassiacum recovers from nitrogen starvation with up-regulation of a novel glucosylglycerate hydrolase and depletion of the accumulated glucosylglycerate.
  Journal
Sci Rep 4:6766 (2014)
DOI:10.1038/srep06766
  Sequence
[mhas:MHAS_04250]
Reference
2  [PMID:28876234]
  Authors
Cereija TB, Alarico S, Empadinhas N, Pereira PJB
  Title
Production, crystallization and structure determination of a mycobacterial glucosylglycerate hydrolase.
  Journal
Acta Crystallogr F Struct Biol Commun 73:536-540 (2017)
DOI:10.1107/S2053230X17012419
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.208
IUBMB Enzyme Nomenclature: 3.2.1.208
ExPASy - ENZYME nomenclature database: 3.2.1.208
BRENDA, the Enzyme Database: 3.2.1.208

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