KEGG ENZYME: 3.2.1.209

ENZYME: 3.2.1.209

Entry

EC 3.2.1.209                Enzyme

Name

endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase;
MAN1B1 (gene name);
MNS1 (gene name);
MNS3 (gene name)

Class

Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

Sysname

Man9GlcNAc2-[protein]2-alpha-mannohydrolase (configuration-inverting)

Reaction(IUBMB)

Man9GlcNAc2-[protein] + H2O = Man8GlcNAc2-[protein] (isomer 8A1,2,3B1,3) + D-mannopyranose [RN:R12477]

Reaction(KEGG)

R12477(G);
(other) R06722(G)

Substrate

Man9GlcNAc2-[protein];
H2O [CPD:C00001]

Product

Man8GlcNAc2-[protein] (isomer 8A1,2,3B1,3);
D-mannopyranose [CPD:C00159]

Comment

The enzyme, located in the endoplasmic reticulum, primarily trims a single alpha-1,2-linked mannose residue from Man9GlcNAc2 to produce Man8GlcNAc2 isomer 8A1,2,3B1,3 (the names of the isomers listed here are based on a nomenclature system proposed by Prien et al [7]). The removal of the single mannosyl residue occurs in all eukaryotes as part of the processing of N-glycosylated proteins, and is absolutely essential for further elongation of the outer chain of properly-folded N-glycosylated proteins in yeast. In addition, the enzyme is involved in glycoprotein quality control at the ER quality control compartment (ERQC), helping to target misfolded glycoproteins for degradation. When present at very high concentrations in the ERQC, the enzyme can trim the carbohydrate chain further to Man(5-6)GlcNAc2.

History

EC 3.2.1.209 created 2019

Pathway

ec00510

N-Glycan biosynthesis

ec00513

Various types of N-glycan biosynthesis

ec01100

Metabolic pathways

Orthology

K23741

endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase

Genes

HSA:	11253(MAN1B1)

PTR:	473099(MAN1B1)

PPS:	100987343(MAN1B1)

GGO:	101134859(MAN1B1)

PON:	100432279(MAN1B1)

PPYG:

129044749(MAN1B1)

NLE:	100594686(MAN1B1)

HMH:	116475908(MAN1B1)

SSYN:

129478645(MAN1B1)

MCC:	706918(MAN1B1)

MCF:	101867098(MAN1B1)

MTHB:

126937137

MNI:	105472056(MAN1B1)

CSAB:

103239582(MAN1B1)

CATY:

105580607(MAN1B1)

PANU:

101010071

TGE:	112607962(MAN1B1)

MLEU:

105543278(MAN1B1)

RRO:	104669636(MAN1B1)

RBB:	108542887(MAN1B1)

TFN:	117099113(MAN1B1)

PTEH:

111553018(MAN1B1)

CANG:

105522686(MAN1B1)

CJC:	100392624(MAN1B1)

SBQ:	101032054(MAN1B1)

CIMI:

108287256(MAN1B1)

ANAN:

105712240(MAN1B1)

CSYR:

103269499(MAN1B1)

MMUR:

105882249(MAN1B1)

LCAT:

123645584(MAN1B1)

PCOQ:

105818712(MAN1B1)

OGA:	100964793(MAN1B1)

MMU:	227619(Man1b1)

MCAL:

110289782(Man1b1)

MPAH:

110317719(Man1b1)

RNO:	499751(Man1b1)

MCOC:

116089811(Man1b1)

ANU:	117710801(Man1b1)

MUN:	110556996(Man1b1)

CGE:

100756512

MAUA:

101844958(Man1b1)

PROB:

127222589(Man1b1)

PLEU:

114692781(Man1b1)

MORG:

121462990(Man1b1)

MFOT:

126509260

AAMP:

119819214(Man1b1)

NGI:	103732606 103741172(Man1b1)

HGL:	101724891(Man1b1)

CPOC:

100715996(Man1b1)

CCAN:

109697987(Man1b1)

DORD:

105995572(Man1b1)

DSP:	122099726(Man1b1)

PLOP:

125345282 125351632(Man1b1)

NCAR:

124964822

MMMA:

107159191(Man1b1)

OPI:	101527587(MAN1B1)

TUP:	102470543(MAN1B1)

GVR:	103593497(MAN1B1)

CFA:

480667

CLUD:

112677479 112677480

VVP:	112911405(MAN1B1)

VLG:	121473188 121473189

NPO:	129505860 129507747(MAN1B1)

AML:

100478118

UMR:

103675308

UAH:	113248587(MAN1B1) 113248656

UAR:	123796283 123796320(MAN1B1)

ELK:	111145781 111145782

LLV:	125083756 125083757

MPUF:

106003295(MAN1B1)

MNP:	132008750(MAN1B1)

MLK:	131813066 131813068

NVS:	122917070 122917072

ORO:	101377733 101380090 101380385

EJU:	114203748(MAN1B1)

ZCA:	113934586 113934587

MLX:	118000541(MAN1B1)

NSU:	110581259(MAN1B1)

LWW:	102737692(MAN1B1)

FCA:	111557571 123381672

PYU:	121020233(MAN1B1) 121024619

PCOO:

112860956(MAN1B1)

PBG:	122474766 122475133

PVIV:

125150296 125150297

LRUF:

124522323 124522354

PTG:	102948947(MAN1B1)

PPAD:

109260237(MAN1B1)

PUC:	125917694 125923662

AJU:	106989099 128312030

HHV:	120222776 120226452 120227604

BTA:	100336900 107131137(MAN1B1)

BOM:	102277240 102277814

BBUB:

102392446(MAN1B1) 102401107

CHX:	102182048 106501835

OAS:	105605821 105605822(MAN1B1)

BTAX:

128055112(MAN1B1) 128055766

ODA:	120852329(MAN1B1)

CCAD:

122442403 122442546(MAN1B1)

MBEZ:

129539240(MAN1B1) 129539648

SSC:	100627465(MAN1B1)

CFR:	102513732(MAN1B1)

CBAI:

105073372(MAN1B1)

CDK:	105106772(MAN1B1) 105106783

VPC:	102542693(MAN1B1)

BACU:

103003282 103008754(MAN1B1)

BMUS:

118896702(MAN1B1)

LVE:	103086557(MAN1B1)

OOR:	101275150(MAN1B1)

DLE:	111176994(MAN1B1)

PCAD:

102987847 112065486

PSIU:

116755439(MAN1B1)

NASI:

112411294(MAN1B1)

ECB:	100147103(MAN1B1) 100147680

EPZ:	103568009(MAN1B1)

EAI:	106845522 123289508

MYB:	102240083(MAN1B1)

MYD:	102775495(MAN1B1)

MMYO:

118655271(MAN1B1)

MLF:	102439240(MAN1B1)

MDT:	132212608(MAN1B1)

PKL:	118707019(MAN1B1)

EFUS:

103296099(MAN1B1)

MNA:	107536151(MAN1B1)

DRO:	112306395(MAN1B1)

SHON:

118980096(MAN1B1)

AJM:	119036097(MAN1B1)

PDIC:

114507914(MAN1B1) 118499400

PHAS:

123823586(MAN1B1)

MMF:

118629766

PPAM:

129079150(MAN1B1)

HAI:	109381800(MAN1B1)

RFQ:	117032113(MAN1B1)

PALE:

102890593(MAN1B1)

PGIG:

120599824(MAN1B1)

PVP:	105298604(MAN1B1)

RAY:	107503110(MAN1B1)

MJV:	108406826(MAN1B1)

TOD:	119231168(MAN1B1)

SARA:

105943175(MAN1B1)

SETR:

126020945(MAN1B1)

LAV:	100664627(MAN1B1) 100670902

TMU:

101354994

ETF:	101639164(MAN1B1) 101652943

DNM:	101438190(MAN1B1)

MDO:	100022731(MAN1B1)

GAS:	123237192(MAN1B1)

SHR:	100918683(MAN1B1)

AFZ:

127549102

PCW:	110205295(MAN1B1)

TVP:	118844094(MAN1B1)

OAA:	100080650(MAN1B1)

GGA:	417296(MAN1B1)

PCOC:

116234097(MAN1B1)

MGP:	100543997(MAN1B1)

CJO:	107321628(MAN1B1)

TPAI:

128079770(MAN1B1)

LMUT:

125702407(MAN1B1)

NMEL:

110407012(MAN1B1)

APLA:

101803362(MAN1B1)

ACYG:

106037118(MAN1B1)

CATA:

118260736(MAN1B1)

AFUL:

116497078(MAN1B1)

TGU:	100223461(MAN1B1)

LSR:	110472180(MAN1B1)

SCAN:

103819092(MAN1B1)

PMOA:

120507335(MAN1B1)

OTC:	121336947(MAN1B1)

PRUF:

121357496(MAN1B1)

GFR:	102031555(MAN1B1)

FAB:	101816081(MAN1B1)

OMA:	130259971(MAN1B1)

PHI:	102103624(MAN1B1)

CCAE:

111936881(MAN1B1)

CCW:	104688195(UAP1L1)

CBRC:

103625032(MAN1B1)

ETL:	114064126(MAN1B1)

ZAB:	102067672(MAN1B1)

ZLE:	135455016(MAN1B1)

ACHL:

103808811(MAN1B1)

SVG:	106855959(MAN1B1)

MMEA:

130584229(MAN1B1)

HRT:	120761820(MAN1B1)

SATI:

136369647(MAN1B1)

FPG:	101914433(MAN1B1)

FCH:	102045806(MAN1B1)

CCRI:

104165548(MAN1B1)

SHAB:

115616922(MAN1B1)

ACUN:

113486627(MAN1B1)

TALA:

104359832(MAN1B1)

ACHC:

115334793(MAN1B1)

HLE:	104829975(MAN1B1)

AGEN:

126052501

GCL:

127023863

CSTI:

104562552(MAN1B1)

LDI:	104340447(MAN1B1)

MNB:

103770701

DPUB:

104300168(MAN1B1)

AVIT:

104271161(MAN1B1)

BRHI:

104495170(MAN1B1)

EGZ:	104124017(MAN1B1)

NNI:	104018375(MAN1B1)

PCAO:

104043329(MAN1B1)

PADL:

103915501(MAN1B1)

AFOR:

103908283(MAN1B1)

FGA:

104081354

GSTE:

104258519(MAN1B1)

CLV:	102083787(MAN1B1)

MUI:	104547182(MAN1B1)

PGUU:

104465156(MAN1B1)

PLET:

104628617(MAN1B1)

EHS:	104514332(MAN1B1)

CUCA:

104059115(MAN1B1)

TEO:	104384241(MAN1B1)

BREG:

104633499(MAN1B1)

OHA:	104329737(MAN1B1)

ACAR:

104526839(MAN1B1)

CPEA:

104397862(MAN1B1)

CVF:	104291065(MAN1B1)

RTD:	128917355(MAN1B1)

AAM:	106494264(MAN1B1)

AROW:

112969739(MAN1B1)

NPD:	112955862(MAN1B1)

TGT:	104573516(MAN1B1)

DNE:	112986766(MAN1B1)

SCAM:

104139731(MAN1B1)

ASN:	102387590(MAN1B1)

AMJ:	102567138(MAN1B1)

CPOO:

109313770(MAN1B1)

GGN:	109292847(MAN1B1)

PSS:	102455673(MAN1B1)

CMY:	102942408(MAN1B1)

CCAY:

125623274(MAN1B1)

DCC:	119844066(MAN1B1)

CPIC:

101947106(MAN1B1)

TST:	117889404(MAN1B1)

CABI:

116823284(MAN1B1)

MRV:	120386610(MAN1B1)

ACS:	100562395(man1b1)

ASAO:

132763599(MAN1B1)

PVT:	110078803(MAN1B1)

SUND:

121937293(MAN1B1)

PBI:	103052908(MAN1B1)

PMUR:

107295058(MAN1B1)

CTIG:

120308653(MAN1B1)

TSR:	106542597(MAN1B1)

PGUT:

117676613(MAN1B1)

APRI:

131186017(MAN1B1)

PTEX:

113443861(MAN1B1)

NSS:	113424229(MAN1B1)

VKO:	123028264(MAN1B1)

PMUA:

114589499(MAN1B1)

PRAF:

128406399(MAN1B1)

ZVI:	118083881(MAN1B1)

HCG:	128338836(MAN1B1)

GJA:	107123282(MAN1B1)

STOW:

125441874(MAN1B1)

EMC:	129342488(MAN1B1)

XLA:	447291(man1b1.L)

XTR:	100145194(man1b1)

NPR:	108797130(MAN1B1)

RTEM:

120914028(MAN1B1)

BBUF:

120977844(MAN1B1)

BGAR:

122919491 122946129

MUO:	115472697(MAN1B1)

GSH:	117368170(MAN1B1)

DRE:	556237(man1b1b) 562592(man1b1a)

SRX:	107709694 107736907 107739703 107757969

SANH:

107661470 107681241 107690671 107692283

SGH:	107548773 107560236 107587425 107595674

CCAR:

109045768 109052759 109081650

CAUA:

113038798 113049299 113064119 113074139

CGIB:

127942375 127957672 127986268 128009014

PTET:

122326695(man1b1a) 122345419 122345543(man1b1b)

LROH:

127152714(man1b1a) 127165219(man1b1b)

OMC:	131529058(man1b1a) 131540666(man1b1b)

PPRM:

120469500(man1b1b) 120490694(man1b1a)

RKG:	130079619(man1b1a) 130089821(man1b1b)

MAMB:

125253113(man1b1a) 125266720(man1b1b)

CIDE:

127504051 127512633

CERY:

137012967(man1b1a) 137034220(man1b1b)

MASI:

127421073 127428602 127430587 127439488

TROS:

130568045(man1b1b) 130569760(man1b1a)

TDW:	130408484(man1b1a) 130419197(man1b1b)

MANU:

129424047(man1b1a) 129440146(man1b1b)

IPU:	108255760(man1b1b) 108279088(man1b1a)

IFU:	128622767(man1b1a) 128625614(man1b1b)

PHYP:

113535490 113536854

SMEO:

124380546(man1b1b) 124398172(man1b1a)

TFD:	113640073(man1b1a) 113653304(man1b1b)

TVC:	132854352(man1b1b) 132860123(man1b1a)

TRN:	134330618(man1b1a) 134335513(man1b1b)

AMEX:

103022471(man1b1b) 103024141(man1b1a)

CMAO:

118819900(man1b1a) 118826958(man1b1b)

EEE:	113573453 113577930(man1b1)

CHAR:

105890051(man1b1b) 105912629(man1b1a)

TRU:	101072461 105418968

TFS:	130517319(man1b1a) 130525559

TNG:	GSTEN00004960G001 GSTEN00009295G001

LCO:	104923806 104930877(man1b1)

NCC:	104944586(man1b1)

TBEN:

117472485(man1b1b) 117478935(man1b1a)

CGOB:

115013303(man1b1) 115016675

PGEO:

117451914(man1b1b) 117456011(man1b1a)

GACU:

117541201(man1b1b) 117562350

EMAC:

134868654(man1b1a) 134873495(man1b1b)

ELY:	117251930(man1b1b) 117270132(man1b1a)

EFO:	125890950(man1b1b) 125905925(man1b1a)

PLEP:

121944325 121959882(man1b1a)

SLUC:

116034794(man1b1a) 116050665(man1b1b)

ECRA:

117944690(man1b1b) 117959386(man1b1a)

ESP:	116686931 116704761

PFLV:

114555183(man1b1) 114571584

GAT:	120830398(man1b1b) 120831937(man1b1a)

PPUG:

119226654(man1b1a)

AFB:	129101119(man1b1b) 129102477(man1b1a)

CLUM:

117736100(man1b1b) 117740520(man1b1a)

PSWI:

130196346(man1b1b) 130205488(man1b1a)

MSAM:

119883771 119892352 119914215 119917792

SCHU:

122865521(man1b1a) 122875944(man1b1b)

CUD:	121509526 121524878(man1b1a)

ALAT:

119019033(man1b1b) 119029617(man1b1a)

ASTR:

137592971(man1b1b) 137608190(man1b1a)

MZE:	101475381(man1b1)

ONL:	100700979 112841850

OAU:	116319660(man1b1a) 116332782(man1b1b)

OLA:	101156826(man1b1) 101168136

OML:	112137701(man1b1b) 112162853(man1b1a)

CSAI:

133455434(man1b1a)

XMA:	102232900(man1b1) 102236792

XCO:	114149976 114155129

XHE:	116724506 116729397

PRET:

103469620 103473953

PFOR:

103141937 103155541

PLAI:

106936359 106951546

PMEI:

106904614 106906201

GAF:	122819517(man1b1a) 122827851(man1b1b)

PPRL:

129351596(man1b1b) 129366577(man1b1a)

CVG:	107083730 107088025

CTUL:

119771995(man1b1a) 119789284(man1b1b)

GMU:	124872048(man1b1a) 124878115(man1b1b)

NFU:

107375119

KMR:	108241416(man1b1a) 108245625(man1b1b)

ALIM:

106529420 106535448 106535552

NWH:	119424279(man1b1a)

AOCE:

111578422 111582694

MCEP:

124997015(man1b1a) 125012078(man1b1b)

CSEM:

103389019 103397364

POV:	109639093(man1b1) 109641232

SSEN:

122758578(man1b1a) 122769261

HHIP:

117767827(man1b1b) 117772246(man1b1a)

HSP:	118114997(man1b1b) 118125686(man1b1a)

PPLT:

128424662(man1b1a) 128439036(man1b1b)

SMAU:

118285032(man1b1a) 118313379(man1b1b)

LCF:	108878392(man1b1b) 108889011

SDU:	111221245 111226918(man1b1)

SLAL:

111647914(man1b1) 111650117

XGL:	120805701(man1b1b) 120806846(man1b1a)

HCQ:	109527092(man1b1)

SSCV:

125979203

SBIA:

133490440(man1b1a)

PEE:	133413806(man1b1a)

PTAO:

133489860(man1b1a)

BPEC:

110154656(man1b1) 110164288

MALB:

109959672 109968690

BSPL:

114867107(man1b1a)

SJO:	128365124(man1b1b) 128380384(man1b1a)

SASA:

106563131 106579997 106585427

STRU:

115164724 115199910 115203984

OTW:	112232797 112234451(man1b1a) 112263106

OMY:	110509710(man1b1a) 110522854 110525472(man1b1b) 110535854

OGO:	124016952(man1b1a) 124033369 124036136

ONE:	115111439 115139862 115147146

OKI:	109874094 109877695 109895743

OKE:	118358168 118385504(man1b1a) 118393042(man1b1b)

SALP:

111960863 111963948 111974854(man1b1) 111974855

SNH:	120021738(man1b1a) 120025509 120054209 120063123

CCLU:

121541597 121550180 121565887 121582601

ELS:	105014133 105014927

SFM:	108922690 108938629(man1b1)

PKI:	111854001 111857531(man1b1)

AANG:

118213031(man1b1a) 118237521(man1b1b)

LOC:	102690638(man1b1)

PSPA:

121306681

ARUT:

117397023 117962293

PSEX:

120542392(man1b1b)

LCM:	102347754(MAN1B1)

CMK:

103180403

RTP:	109927301(man1b1b)

CPLA:

122564767(man1b1b)

HOC:	132825817(man1b1b)

LERI:

129711933(man1b1b)

PMRN:

116944925(MAN1B1)

LRJ:	133341800(MAN1B1)

BFO:

118420800

BBEL:

109466152

CIN:

100180827

SCLV:

120344397

SPU:	115919045 592701

LPIC:

129277912

APLC:

110984825

ARUN:

117303061

AJC:

117105146

SKO:

100378677

DME:	Dmel_CG11874(alpha-Man-Ib)

DER:

6555014

DSE:

6612651

DSI:	Dsimw501_GD17996(Dsim_GD17996)

DYA:	Dyak_GE10478

DAN:

6501495

DSR:

110177400

DPO:

4801253

DPE:

6587772

DMN:

108155025

DWI:	26529661 6649837

DGR:

6564284

DMO:	Dmoj_GI23409

DAZ:

108609054

DNV:

108656217

DHE:

111599442

DVI:

6632758

CCAT:

101453662

BOD:

106616058

BDR:

105229826

RZE:

108369675

AOQ:

129236282

TDA:	119680179 119680631

MDE:	101889535 131805429

SCAC:

106095719

LCQ:

111690671

LSQ:

119605727

GFS:	119644112 119644128

ECOE:

129939160

CLON:

129609177

HIS:

119651345

AGA:

1269471

ACOZ:

120961362

AARA:

120895336

AMER:

121589765 121601504

ASTE:

118502543

AFUN:

125765261

AMOU:

128309989

AALI:

118468661

AAG:	110681198 5567412

AALB:

109415549

ASUA:

134205112

CQU:	CpipJ_CPIJ003661

CPII:

120420766

CNS:

116345876

BCOO:

119067882

LLL:

129789348

AME:

413579

ACER:

108003139

ALAB:

122719410

ADR:

102674268

AFLR:

100871755

BIM:

100746318

BBIF:

117217221

BVK:

117242501

BVAN:

117155078

BTER:

100651817

BAFF:

126923414

BPYO:

122575283

BPAS:

132913604

FVI:

122531219

CCAL:

108622226

OBB:

114874226

OLG:

117609623

MGEN:

117226426

NMEA:

116432770

CGIG:

122402115

SOC:

105204046

MPHA:

105832593

AEC:

105149600

ACEP:

105622350

PBAR:

105426911

VEM:

105568559

HST:

105184363

DQU:

106749327

CFO:

105248014

FEX:

115239828

LHU:	105669682(alpha-Man-Ib)

PGC:

109855950

OBO:

105284082

PCF:

106784288

PFUC:

122520610

VPS:

122627052

VCRB:

124431711

VVE:

124947299

NVI:

100119267

CSOL:

105360197

TPRE:

106656965

LHT:

122499091

LBD:

127287430

MDL:

103575736

CGLO:

123267022

FAS:

105274150

DAM:

107044372

AGIF:

122856784

CINS:

118068270

VCAN:

122417201

CCIN:

107269210

DSM:

124407240

NPT:

124213573

NFB:

124178744

NLO:

107224050

NVG:

124300016

AROA:

105689388

TCA:

659709

DPA:

109541778

SOY:

115890163

AGRG:

126739403

ATD:

109598739

CSET:

123318587

AGB:

108910434

LDC:

111502095

DVV:

114329217

NVL:

108565052

APLN:

108740733

PPYR:

116173235

OTU:

111428171

BMOR:

101746534

BMAN:

114244560

MSEX:

115441177

DPL:	KGM_206782

BANY:

112049746

MJU:

123880011

NIQ:

126780489

VCD:

124543252

MCIX:

123668888

PMAC:

106717133

PPOT:

106104501

PXU:

106126459

PRAP:

110997563

PBX:

123718588

PNAP:

125062344

ZCE:

119835478

CCRC:

123705119

LSIN:

126978723

AAGE:

121739501

HAW:

110377795

HZE:

124644780

TNL:

113493937

SLIU:

111360532

OFU:

114361194

ATRA:

106133978

GMW:

113517516

PXY:

125491206

PGW:

126380727

LGLY:

125240614

CFEL:

113383288

CCRN:

123295362

API:

100158868

DNX:

107171166

AGS:

114130037

RMD:

113553488

ACOO:

126836422

DVT:

126896100

BTAB:

109029927

DCI:	103512631 103521396

CLEC:

106662400

HHAL:

106684496(alpha-Man-Ib)

NLU:

111052078

HVI:

124358537

MQU:	128994277 128994294

PHU:	Phum_PHUM530360

FOC:

113217995

TPAL:

117653390

ZNE:

110838192

CSEC:

111873921

SGRE:

126267052

BROR:

134533907

IEL:

124167214

FCD:

110856238

DPX:	DAPPUDRAFT_194674

DMK:

116932879

DPZ:

124349546

PVM:

113818476

PJA:

122264293

PCHN:

125038136

PMOO:

119575095

HAME:

121860164 121875029

PCLA:

123755455

CQD:

128691872

PTRU:

123511212

ESN:

127008424

MNZ:

135219666

MRJ:	136826755(alpha-Man-Ib)

HAZT:

108676336

EAF:

111713012

LSM:

121130135

TCF:

131887780

PPOI:

119100862 119101518

DSV:

119432855

RSAN:

119380999

RMP:

119187535

VDE:

111245990

VJA:

111259442

TUT:

107368943

DPTE:

113792907

DFR:

124493645

CSCU:

111620023 111631894

CVS:	136984070(alpha-Man-Ib)

PTEP:

107453367

ABRU:

129958786

UDV:

129223954

SDM:

118197594

LPOL:

106459474 106462474

PMEO:

129588584

CEL:	CELE_T03G11.4(mans-3)

CBR:

CBG_14624

CRQ:	GCK72_024375

NAI:	NECAME_15419

BMY:	BM_BM5524(Bma-mans-3)

LOA:	LOAG_01198

TSP:

Tsp_04164

HRO:	HELRODRAFT_113976 HELRODRAFT_178867 HELRODRAFT_193110

LGI:	LOTGIDRAFT_120396

PVUL:

126808531

PCAN:

112575110

BGT:

106053864

GAE:	121366616 121384018

HRF:

124152763

HRJ:

124275180

CRG:

105334865

CANU:

128191893

CVN:

111124585

OED:

125678329

MYI:

110447565

PMAX:

117322084

MCAF:

127730826

MMER:

123554918

RPHI:

132749953

DPOL:

127833452 127835664

MAEA:

128224092

OBI:

106884360

OSN:

115227945

LJP:

135480889

LAK:	106161727 106176115

OVI:	T265_03386

EGL:

EGR_00365

LLON:

135501415

NVE:	116607129 5501352

EPA:

110237771

ATEN:

116294530

ADF:

107335017

AMIL:

114946959

PDAM:

113665639 113673540

SPIS:

111332673

DGT:

114519075

XEN:

124438093

HMG:

100198486

HSY:	130613264 130662458

RES:

135693399

TAD:	TRIADDRAFT_53127

AQU:	100638524 100640055

ATH:	AT1G30000(MNS3)

ALY:

9326907

CRB:

17898338

CSAT:

104741591 104757343 104777030

EUS:	EUTSA_v10007084mg

BRP:	103835247 103840441

BNA:	106361602 106367368 106375950 111212331

BOE:	106295385 106328390

RSZ:

108806417

THJ:

104812670

CPAP:

110807600

CIT:

102616435

CIC:	CICLE_v10014607mg

PVY:

116114769

MINC:

123192943 123218754

TCC:

18596509

GRA:	105768906 105772769

GHI:	107905885 107958416 121230865

GAB:	108453420 108459983

HSYR:

120148449

DZI:	111274860 111280996

EGR:

104440790

GMX:	100789211 100806551

GSJ:	114375271 114387749

PVU:	PHAVU_006G164400g

VRA:

106775885

VAR:

108343148

VUN:

114187820

VUM:

124825957

CCAJ:

109789197

APRC:

113871446

MTR:

11438869

TPRA:

123895530

CAM:

101515695

PSAT:

127079524

VVO:

131595544

LJA:

130722204

ADU:

107468140

AIP:

107622562

AHF:	112714314 112785361

LANG:

109345269

PCIN:

129285465 129299604

QSA:	O6P43_012964

FVE:

101313190

RCN:

112164535

PPER:

18780386

PMUM:

103325119

PAVI:

110773985

PDUL:

117623865

MDM:	103444000 103446189

MSYL:

126585793 126621123

PXB:

103951272

ZJU:

107413762

MNT:

21404524

CSAV:

115697176

CSV:

101216212

CMO:

103484372

BHJ:

120073818

MCHA:

111015717

CMAX:

111478371 111496964

CMOS:

111433252 111433756

CPEP:

111781525 111804180

RCU:

8264122

MEAN:

126680383

JCU:

105633984

HBR:

110651587

MESC:

110601605 110605198

POP:

7472574

PEU:

105118639

PALZ:

118050747

PNZ:

133698551

JRE:

108988627

CILL:

122275973

CAVE:

132168679

QSU:	112015529 136066894

QLO:

115988411

TWL:

120015206

VVI:

100243430

VRI:

117923521

SLY:

101246787

SPEN:

107011307

SOT:

102583221

SSTN:

125846558

SDUL:

129875210

CANN:

107859093

LBB:

132623598

NTA:	107782104 107783782

NSY:

104249918

NTO:

104097810

NAU:

109216453

INI:

109192025

ITR:

116025989

SIND:

105175706

OEU:

111402240

EGT:

105962464

SSPL:

121758773

SHIS:

125194497

APAN:

127247321

HAN:

110911812

ECAD:

122592643

LSV:

111880716

CCAV:

112526325

DCR:

108209987

CSIN:

114301034

RVL:

131315863

AEW:	130753343 130759387

BVG:

104883805

SOE:

110794113

CQI:	110698318 110728570

ATRI:

130814479

MOF:

131144859

NNU:

104613507

MING:

122059792

TSS:

122652168

PSOM:

113289725 113299707

OSA:

4338088

OBR:

102699961

OGL:

127773768

BDI:

100820902

ATS:

109759492

TDC:	119329569 119368635

TAES:

123041929 123116155 123180779

TUA:

125551972

LPER:

127296019

LRD:	124648879 124649244

SBI:

8055739

ZMA:

100282405

MFLO:

136512001 136517710

SITA:

101773458

SVS:

117850070

PVIR:

120663968 120697123

PHAI:

112888039

PDA:	103702402 103703024

EGU:	105040640 105048159

MUS:	103987808 104000849

ZOF:	121980323 121984236

DCT:

110116511

PEQ:

110022272

AOF:

109828813

MSIN:

131240843

NCOL:

116247349

ATR:

18435237

SMO:	SELMODRAFT_168485 SELMODRAFT_176646

PPP:

112287912

CRE:	CHLRE_07g336600v5

VCN:	VOLCADRAFT_119746(amd1)

MNG:	MNEG_2789 MNEG_9467

CSL:	COCSUDRAFT_48568

CVR:	CHLNCDRAFT_133855

APRO:

F751_6268

BPG:	Bathy13g00050

MIS:	MICPUN_112689(MANA)

MPP:	MICPUCDRAFT_15822

CME:	CYME_CMF045C

CCP:	CHC_T00008598001 CHC_T00009079001

SCE:	YJR131W(MNS1)

SEUB:

DI49_3139

SPAO:

SPAR_J03070

AGO:	AGOS_AER165W

ERC:

Ecym_5170

KLA:	KLLA0_B04356g

KMX:	KLMA_40509(MNS1)

LTH:	KLTH0D17908g

VPO:	Kpol_1028p79

ZRO:	ZYRO0B08360g

CGR:	2891591(GVI51_M00429)

NCS:	NCAS_0J02160(NCAS0J02160)

NDI:	NDAI_0J02870(NDAI0J02870)

TPF:	TPHA_0L00320(TPHA0L00320)

TBL:	TBLA_0B06140(TBLA0B06140)

TGB:	HG536_0C06190

TDL:	TDEL_0D00600(TDEL0D00600)

KAF:	KAFR_0E04290(KAFR0E04290)

KNG:	KNAG_0B06730(KNAG0B06730)

ZMK:	HG535_0E01530

SLUD:

SCDLUD_004365

DHA:	DEHA2D09218g

PIC:	PICST_84949(MNS1)

PGU:	PGUG_04716

SPAA:

SPAPADRAFT_57837(MNS1.1)

LEL:	PVL30_001305(MNS1)

LBG:	92208261(LODBEIA_P30650)

CAL:	CAALFM_C103730CA(MNS1)

CTP:	CTRG_04351

COT:	CORT_0B11480

CDU:	CD36_03470

CTEN:

18246214(MNS1)

CLU:	CLUG_04485

CLUS:

A9F13_04g00121

CAUR:

CJI96_0001765

PPA:	PAS_chr2-1_0753

PKZ:	C5L36_0C09850

BNN:	FOA43_002911

BBRX:

BRETT_005208

OPA:	HPODL_01630

YLI:	2911298(YALI2_D00353g)

SLB:	AWJ20_4611(MNS1)

NCR:	NCU02778(gh47-1)

NTE:	NEUTE1DRAFT74512(NEUTE1DRAFT_74512)

SMP:	10804969(SMAC4_04842)

PAN:	PODANSg09987

PBEL:

QC761_0007830(MNS1)

PPSD:

QC762_0005220(MNS1)

PPSP:

QC763_0008700(MNS1)

PPSA:

QC764_0008760(MNS1)

TTT:	THITE_2057638 THITE_2085147

MTM:	MYCTH_2294863

CTHR:

CTHT_0054060

MGR:

MGG_11408

PPEI:

PpBr36_00159

PGRI:

PgNI_04971

TMN:	UCRPA7_1844 UCRPA7_7249

SSCK:

SPSK_05990

FGR:	FGSG_00612

FPU:	FPSE_04518 FPSE_04589

FPOA:

FPOAC1_000637

FVN:	FVRRES_00790

FVR:	FVEG_01076

FOX:	FOXG_00435

NHE:	NECHADRAFT_105814

FFC:	NCS54_00089500

FKR:	NCS57_00087800

FMU:	J7337_000927

TRE:	TRIREDRAFT_2662

TRR:	M419DRAFT_6341

TATV:

25778339(TrAtP1_007784)

TASP:

36616778(TrAFT101_007671)

MAW:	19247384(MNS1_1)

MAJ:

MAA_04109

MBRN:

26240709(MNS1)

PCHM:

VFPPC_00495

CMT:

CCM_08185

AMUS:

LMH87_005884

PLJ:	28885842(PLICBS_007363)

PTKZ:

JDV02_007186(MNS1)

VAL:	VDBG_06023

VDA:	VDAG_03184

CFJ:	CFIO01_01386 CFIO01_11192

CLUP:

CLUP02_06100 CLUP02_09057

CHIG:

CH63R_01056 CH63R_07235

CDET:

87939794(CDEST_03291) 87944412(CDEST_07909)

SAPO:

SAPIO_CDS3217

ELA:	UCREL1_10905 UCREL1_115

PFY:	PFICI_00615

SSL:	SS1G_04513

BFU:	BCIN_01g06120(Bcmns1)

MBE:

MBM_06132

PSCO:

LY89DRAFT_295383

GLZ:	GLAREA_11212

ANI:	ANIA_00551 ANIA_05748

AFM:	AFUA_6G06790

ACT:	ACLA_088570

NFI:	NFIA_052440

AOR:	AO090003000057

ANG:	An18g06220

AFV:	AFLA_001640

ALUC:

AKAW2_31015S(MNS1)

ACHE:

ACHE_11175A(MNS1)

APUU:

APUU_41130S(MNS1)

PCS:	N7525_000174

PDP:	PDIP_68610

POU:	POX_a00742 POX_e06585

TMF:	EYB26_007163

TRG:	TRUGW13939_09818

CIM:	CIMG_07325

CPW:	CPC735_001190

URE:	UREG_07868

ABE:

ARB_01040

TVE:

TRV_02790

PBL:	PAAG_00769

PBN:	PADG_04061

AJE:	HCAG_04182 HCAG_08449

BGH:	BDBG_01802 BDBG_03796

PNO:	SNOG_03652

PTE:

PTT_19626

PTRR:

6341067(PtrM4_064330)

BZE:	COCCADRAFT_2121

BSC:	COCSADRAFT_38869

BOR:	COCMIDRAFT_8408

AALT:

CC77DRAFT_988245

ARAB:

EKO05_0008400

ZTR:	MYCGRDRAFT_45066(MgAMN9)

PFJ:	MYCFIDRAFT_204581 MYCFIDRAFT_88410

FFU:	CLAFUR5_12352

CBET:

CB0940_11533

BCOM:

BAUCODRAFT_80378

NPA:	UCRNP2_2127

TML:	GSTUM_00001932001

SPO:	2541719(mns1)

SOM:	SOMG_00776(mns1)

CNE:

CNE04550

CNB:

CNBE4550

CNG:	CNAG_02081

CGI:	CGB_E6120W

CDEU:

CNBG_5230

CDEP:

91089619(L203_105410)

KMG:	30160232(I203_104634)

KNE:	92180901(IAR55_003643)

TMS:	TREMEDRAFT_33664

TASA:

A1Q1_06697

CCAC:

CcaHIS019_0211650(MNS1)

PPL:	POSPLDRAFT_111281 POSPLDRAFT_130143 POSPLDRAFT_49494 POSPLDRAFT_99932

TVS:	TRAVEDRAFT_123722 TRAVEDRAFT_54985

DSQ:	DICSQDRAFT_131718

PCO:	PHACADRAFT_248627 PHACADRAFT_28202

SHS:	STEHIDRAFT_63527 STEHIDRAFT_68181

HIR:	HETIRDRAFT_30389 HETIRDRAFT_64121

PSQ:	PUNSTDRAFT_113060 PUNSTDRAFT_140588

ADL:	AURDEDRAFT_110124 AURDEDRAFT_112600

FME:	FOMMEDRAFT_143158

GTR:	GLOTRDRAFT_105477 GLOTRDRAFT_134936

RSX:	RhiXN_00909 RhiXN_06777 RhiXN_10964

LBC:	LACBIDRAFT_228999 LACBIDRAFT_255188 LACBIDRAFT_305436

CCI:	CC1G_00625 CC1G_12305

ABP:	AGABI1DRAFT117691(AGABI1DRAFT_117691) AGABI1DRAFT130713(AGABI1DRAFT_130713) AGABI1DRAFT54540(AGABI1DRAFT_54540) AGABI1DRAFT70315(AGABI1DRAFT_70315)

ABV:	AGABI2DRAFT176302(AGABI2DRAFT_176302) AGABI2DRAFT181939(AGABI2DRAFT_181939) AGABI2DRAFT206040(AGABI2DRAFT_206040) AGABI2DRAFT222683(AGABI2DRAFT_222683)

PCUB:

JR316_0000257 JR316_0001427

MPR:	MPER_07540 MPER_09462 MPER_10851 MPER_11974

MRR:	Moror_11662 Moror_1765 Moror_9085

E1B28_001821 E1B28_001822 E1B28_007591

SCM:	SCHCO_02524481(SCHCODRAFT_02524481)

CPUT:

CONPUDRAFT_96550

SLA:	SERLADRAFT_480395

WSE:	WALSEDRAFT_35272

WIC:	J056_001603

UMA:	UMAG_02227

PFP:	PFL1_05588

SGRA:

EX895_005073

MRT:

MRET_4039

MSYM:

MSY001_0287

PGR:	PGTG_14908

PTRC:

PtA15_8A531

PSTR:

Pst134EA_015428

MLR:	MELLADRAFT_32725

RIE:	OCT59_005093

MBR:	MONBRDRAFT_13888

SRE:	PTSG_01891

FCY:	FRACYDRAFT_261302(MNS2_1)

TPS:	THAPSDRAFT_34968

NGD:	NGA_2009400(MAN1) NGA_2024900

AAF:	AURANDRAFT_10610 AURANDRAFT_71340

PIF:	PITG_01855 PITG_10149

PSOJ:

PHYSODRAFT_313654 PHYSODRAFT_557352

SPAR:

SPRG_01621 SPRG_08812

EHX:	EMIHUDRAFT_455715 EMIHUDRAFT_464075 EMIHUDRAFT_64898 EMIHUDRAFT_76998

GTT:	GUITHDRAFT_75084

TVA:	TVAG_2v0045470 TVAG_2v0272050 TVAG_2v0340170 TVAG_2v0862460 TVAG_2v1001150 TVAG_2v1088290

» show all

Reference

1 [PMID:3049586]

Authors

Jelinek-Kelly S, Herscovics A

Title

Glycoprotein biosynthesis in Saccharomyces cerevisiae. Purification of the alpha-mannosidase which removes one specific mannose residue from Man9GlcNAc.

Journal

J Biol Chem 263:14757-63 (1988)

Reference

2 [PMID:1822240]

Authors

Ziegler FD, Trimble RB

Title

Glycoprotein biosynthesis in yeast: purification and characterization of the endoplasmic reticulum Man9 processing alpha-mannosidase.

Journal

Glycobiology 1:605-14 (1991)
DOI:10.1093/glycob/1.6.605

Reference

3 [PMID:10409699]

Authors

Gonzalez DS, Karaveg K, Vandersall-Nairn AS, Lal A, Moremen KW

Title

Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis.

Journal

J Biol Chem 274:21375-86 (1999)
DOI:10.1074/jbc.274.30.21375

Sequence

[hsa:11253]

Reference

4 [PMID:12090241]

Authors

Herscovics A, Romero PA, Tremblay LO

Title

The specificity of the yeast and human class I ER alpha 1,2-mannosidases involved in ER quality control is not as strict previously reported.

Journal

Glycobiology 12:14G-15G (2002)

Reference

5 [PMID:18003979]

Authors

Avezov E, Frenkel Z, Ehrlich M, Herscovics A, Lederkremer GZ

Title

Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradation.

Journal

Mol Biol Cell 19:216-25 (2008)
DOI:10.1091/mbc.e07-05-0505

Sequence

[hsa:11253]

Reference

6 [PMID:20023195]

Authors

Liebminger E, Huttner S, Vavra U, Fischl R, Schoberer J, Grass J, Blaukopf C, Seifert GJ, Altmann F, Mach L, Strasser R

Title

Class I alpha-mannosidases are required for N-glycan processing and root development in Arabidopsis thaliana.

Journal

Plant Cell 21:3850-67 (2009)
DOI:10.1105/tpc.109.072363