KEGG   ENZYME: 3.2.1.211
Entry
EC 3.2.1.211                Enzyme                                 
Name
endo-(1->3)-fucoidanase;
alpha-L-fucosidase (incorrect);
poly(1,3-alpha-L-fucoside-2/4-sulfate) glycanohydrolase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
Sysname
poly[(1->3)-alpha-L-fucoside-2/4-sulfate] glycanohydrolase
Reaction(IUBMB)
endohydrolysis of (1->3)-alpha-L-fucoside linkages in fucan
Comment
The enzyme specifically hydrolyses (1->3)-alpha-L-fucoside linkages in fucan. Fucans are found mainly in different species of seaweed and are sulfated polysaccharides with a backbone of (1->3)-linked or alternating (1->3)- and (1->4)-linked alpha-L-fucopyranosyl residues. In the literature, the sulfated polysaccharides are often called fucoidans. Fucoidans include polysaccharides with a relatively low proportion of fucose and some polysaccharides that have a backbone composed of other saccharides with fucose in the branching side chains. The sulfation of the alpha-L-fucopyranosyl residues may occur at positions 2 and 4. The enzyme degrades fucan to sulfated alpha-L-fucooligosaccharides but neither L-fucose nor small fucooligosaccharides are produced.
History
EC 3.2.1.211 created 1972 as EC 3.2.1.44, part transferred 2020 to EC 3.2.1.211
Reference
1
  Authors
Thanassi NM, Nakada HI.
  Title
Enzymic degradation of fucoidan by enzymes from the hepatopancreas of abalone, Halotus species.
  Journal
Arch Biochem Biophys 118:172-177 (1967)
Reference
2  [PMID:11910806]
  Authors
Bakunina IIu, Nedashkovskaia OI, Alekseeva SA, Ivanova EP, Romanenko LA, Gorshkova NM, Isakov VV, Zviagintseva TN, Mikhailov VV
  Title
[Degradation of fucoidan by the marine proteobacterium Pseudoalteromonas citrea].
  Journal
Mikrobiologiia 71:49-55 (2002)
Reference
3  [PMID:12626402]
  Authors
Berteau O, Mulloy B
  Title
Sulfated fucans, fresh perspectives: structures, functions, and biological properties of sulfated fucans and an overview of enzymes active toward this class of polysaccharide.
  Journal
Glycobiology 13:29R-40R (2003)
DOI:10.1093/glycob/cwg058
Reference
4  [PMID:16417453]
  Authors
Bilan MI, Kusaykin MI, Grachev AA, Tsvetkova EA, Zvyagintseva TN, Nifantiev NE, Usov AI
  Title
Effect of enzyme preparation from the marine mollusk Littorina kurila on fucoidan from the brown alga Fucus distichus.
  Journal
Biochemistry (Mosc) 70:1321-6 (2005)
DOI:10.1007/s10541-005-0264-3
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.211
IUBMB Enzyme Nomenclature: 3.2.1.211
ExPASy - ENZYME nomenclature database: 3.2.1.211
BRENDA, the Enzyme Database: 3.2.1.211

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