EC 18.104.22.168 Enzyme
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
endohydrolysis of (1->3)-alpha-L-fucoside linkages in fucan
The enzyme specifically hydrolyses (1->3)-alpha-L-fucoside linkages in fucan. Fucans are found mainly in different species of seaweed and are sulfated polysaccharides with a backbone of (1->3)-linked or alternating (1->3)- and (1->4)-linked alpha-L-fucopyranosyl residues. In the literature, the sulfated polysaccharides are often called fucoidans. Fucoidans include polysaccharides with a relatively low proportion of fucose and some polysaccharides that have a backbone composed of other saccharides with fucose in the branching side chains. The sulfation of the alpha-L-fucopyranosyl residues may occur at positions 2 and 4. The enzyme degrades fucan to sulfated alpha-L-fucooligosaccharides but neither L-fucose nor small fucooligosaccharides are produced.
EC 22.214.171.124 created 1972 as EC 126.96.36.199, part transferred 2020 to EC 188.8.131.52
Thanassi, N.M. and Nakada, H.I.
Enzymic degradation of fucoidan by enzymes from the hepatopancreas of abalone, Halotus species.
Arch Biochem Biophys 118:172-177 (1967)
Bakunina IIu, Nedashkovskaia OI, Alekseeva SA, Ivanova EP, Romanenko LA, Gorshkova NM, Isakov VV, Zviagintseva TN, Mikhailov VV
[Degradation of fucoidan by the marine proteobacterium Pseudoalteromonas citrea].
Mikrobiologiia 71:49-55 (2002)
Berteau O, Mulloy B
Sulfated fucans, fresh perspectives: structures, functions, and biological properties of sulfated fucans and an overview of enzymes active toward this class of polysaccharide.
Glycobiology 13:29R-40R (2003)
Bilan MI, Kusaykin MI, Grachev AA, Tsvetkova EA, Zvyagintseva TN, Nifantiev NE, Usov AI
Effect of enzyme preparation from the marine mollusk Littorina kurila on fucoidan from the brown alga Fucus distichus.
Biochemistry (Mosc) 70:1321-6 (2005)
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