KEGG   ENZYME: 3.2.1.212
Entry
EC 3.2.1.212                Enzyme                                 

Name
endo-(1->4)-fucoidanase;
alpha-L-fucosidase (incorrect);
poly(1,4-alpha-L-fucoside-2/3-sulfate) glycanohydrolase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
Sysname
poly[(1->4)-alpha-L-fucoside-2/3-sulfate] glycanohydrolase
Reaction(IUBMB)
endohydrolysis of (1->4)-alpha-L-fucoside linkages in fucan
Comment
The enzyme specifically hydrolyses (1->4)-alpha-L-fucoside linkages in fucan. Fucans are found mainly in different species of seaweed and are sulfated polysaccharides with a backbone of (1->3)-linked or alternating (1->3)- and (1->4)-linked alpha-L-fucopyranosyl residues. In the literature, the sulfated polysaccharides are often called fucoidans. Fucoidans include polysaccharides with a relatively low proportion of fucose and some polysaccharides that have a backbone composed of other saccharides with fucose in the branching side chains. The sulfation of the alpha-L-fucopyranosyl residues may occur at positions 2 and 3. The enzyme degrades fucan to sulfated alpha-L-fucooligosaccharides but neither L-fucose nor small fucooligosaccharides are produced.
History
EC 3.2.1.212 created 1972 as EC 3.2.1.44, part transferred 2020 to EC 3.2.1.212
Reference
1
  Authors
Thanassi, N.M. and Nakada, H.I.
  Title
Enzymic degradation of fucoidan by enzymes from the hepatopancreas of abalone, Halotus species.
  Journal
Arch Biochem Biophys 118:172-177 (1967)
Reference
2  [PMID:12626402]
  Authors
Berteau O, Mulloy B
  Title
Sulfated fucans, fresh perspectives: structures, functions, and biological properties of sulfated fucans and an overview of enzymes active toward this class of polysaccharide.
  Journal
Glycobiology 13:29R-40R (2003)
DOI:10.1093/glycob/cwg058
Reference
3  [PMID:16222488]
  Authors
Descamps V, Colin S, Lahaye M, Jam M, Richard C, Potin P, Barbeyron T, Yvin JC, Kloareg B
  Title
Isolation and culture of a marine bacterium degrading the sulfated fucans from marine brown algae.
  Journal
Mar Biotechnol (NY) 8:27-39 (2006)
DOI:10.1007/s10126-005-5107-0
Reference
4  [PMID:18467852]
  Authors
Kim WJ, Kim SM, Lee YH, Kim HG, Kim HK, Moon SH, Suh HH, Jang KH, Park YI
  Title
Isolation and characterization of marine bacterial strain degrading fucoidan from Korean Undaria pinnatifida Sporophylls.
  Journal
J Microbiol Biotechnol 18:616-23 (2008)
Reference
5  [PMID:23852092]
  Authors
Silchenko AS, Kusaykin MI, Kurilenko VV, Zakharenko AM, Isakov VV, Zaporozhets TS, Gazha AK, Zvyagintseva TN
  Title
Hydrolysis of fucoidan by fucoidanase isolated from the marine bacterium, Formosa algae.
  Journal
Mar Drugs 11:2413-30 (2013)
DOI:10.3390/md11072413
Reference
6
  Authors
Silchenko, A.S., Kusaykin, M.I., Zakharenko, A.M., Menshova, R.V., Khanh, H.H.N., Dmitrenok, P.S., Isakov, V.V., Zvyagintseva, T.N.
  Title
Endo-1,4-fucoidanase from vietnamese marine mollusk Lambis sp. which producing sulphated fucooligosaccharides.
  Journal
J Mol Catal B 102:154-160 (2014)
Reference
7  [PMID:28031251]
  Authors
Silchenko AS, Ustyuzhanina NE, Kusaykin MI, Krylov VB, Shashkov AS, Dmitrenok AS, Usoltseva RV, Zueva AO, Nifantiev NE, Zvyagintseva TN
  Title
Expression and biochemical characterization and substrate specificity of the fucoidanase from Formosa algae.
  Journal
Glycobiology 27:254-263 (2017)
DOI:10.1093/glycob/cww138
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.212
IUBMB Enzyme Nomenclature: 3.2.1.212
ExPASy - ENZYME nomenclature database: 3.2.1.212
BRENDA, the Enzyme Database: 3.2.1.212

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