KEGG   ENZYME: 3.2.1.221
Entry
EC 3.2.1.221                Enzyme                                 
Name
MMP endo-(1,4)-3-O-methyl-alpha-D-mannosidase;
MMP alpha-(1->4)-endomannosidase;
mmpH (gene name)
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
Sysname
(1,4)-3-O-methyl-alpha-D-mannan 4-alpha-3-O-methyl-D-mannohydrolase
Reaction(IUBMB)
Endohydrolysis of 3-O-methyl-alpha-D-mannosyl-(1->4)-3-O-methyl-D-mannose linkages within (1,4)-3-O-methyl-alpha-D-mannnan substrates
Comment
The enzyme, present in mycobacterial species that produce 3-O-methylmannose polysaccharide (MMP), is involved in recycling and biosynthesis of the polymer. The enzyme has been shown to cleave substrates in the range of 11--14 mannose residues.
History
EC 3.2.1.221 created 2023
Orthology
K27194  MMP endo-(1,4)-3-O-methyl-alpha-D-mannosidase
Genes
CJACJA_0068
CEBB0D95_15190
CELLCBR65_15410
CEKD0B88_03465
CEGD0C16_16560
SDESde_0483
TTUTERTU_0411
SAGAM5M_14245
MARQMARGE09_P2916
SPOIIMCC21906_00273
SNANI6N98_17910
STAWNCG89_08705
ZALAZF00_17590
OSGBST96_06840
MTHDA3224_06810
MICCAUP74_03006
MAGAMag101_10300
MIIBTJ40_15105
MICTFIU95_07055
MHYDGTQ55_10865
MCELLPW13_05470
MICZGL2_43000
MVBMJO52_14280
MPAFR5R33_02425
MBRGPVT68_00265
MICLGNX18_03405
MICYHUW35_17630
MSPNM8T91_08755
HJABST95_02420
HALCEY643_00370
AFUSEYZ66_00270
PAQME0F26_02975
PLAPlav_2492
PECTBN1012_Phect387
RBSRHODOSMS8_01705
MMRMmar10_2008
GAKX907_1359
HYTHXX25_02510
DOLDole_3220
DALDalk_2453
DATHRM2_48400
DTOTOL2_C01670
DOVDSCO28_41190
DWDDSCW_36680
DALKDSCA_35070
DMLDmul_35640
DLIdnl_04760
DEKDSLASN_34520
DBRDeba_1047
MPAMAP_1664c
MAOMAP4_2172
MAVIRC58_10815
MAVURE97_10825
MAVMAV_2757
MITOCO_25840
MIAOCU_25700
MIDMIP_03593
MYOOEM_24280
MCHIAN480_13575
MIROCQ_24400
MMALCKJ54_11645
MLPMLM_2088
MMANMMAN_13210
MSERMTY59_41590
MSAMycsm_06272
MMIMMAR_2923
MMAEMMARE11_28440
MLIMULP_02911
MPSEMPSD_30270
MSHOMSHO_43560
MMCMmcs_5100
MKMMkms_5188
MJLMjls_5479
MMMW7S_12485
MYVG155_29035
MYEAB431_14930
MDXBTO20_01870
MSHGMSG_02744
MFJMFLOJ_04370
MSTOMSTO_05750
MSIMMSIM_50030
MSAKMSAS_08420
MKUI2456_14210
MLWMJO58_14680
MXEMYXE_23780
MNVMNVI_42820
MPAGC0J29_16725
MNMMNVM_30720
MGORH0P51_15565
MCOOMCOO_10810
MBAIMB901379_02702
MSEOMSEO_16060
MHEKJMUB5695_02301
MGAUMGALJ_44370
MBRDMBRA_37660
MMAMK3U93_13130
MPAAMKK62_13095
MKYIWGMT90018_28670
MADIA7U43_04455
MWUPT015_06500
MYWBVC93_24210
MSMMSMEG_6481
MSGMSMEI_6310
MSBLJ00_32040
MSNLI99_32045
MSHLI98_32050
MVAMvan_5716
MGIMflv_1101
MSPMspyr1_50870
MCBMycch_5061
MNED174_00765
MYNMyAD_00735
MFTXA26_58730
MPHLMPHLCCUG_00125
MVQMYVA_5638
MLLB1R94_12115
MRHMycrhN_2462
MTHN4412656_04482
MHASMHAS_04404
MDUMDUV_45180
MCHTMCHIJ_39790
MDRMDOR_36200
MAUUNCTC10437_05482
MMAGMMAD_52480
MMORMMOR_06910
MAICMAIC_26170
MIJMINS_26430
MALVMALV_37760
MTYMTOK_53010
MPSCMPSYJ_11630
MARZMARA_43520
MGADMGAD_41550
MHEVMHEL_49350
MSARMSAR_41760
MANYMANY_12540
MPOFMPOR_03210
MMATMMAGJ_27530
MBOKMBOE_10050
MFGK6L26_02510
MSEIMSEDJ_07250
MFLVNCTC10271_00129
MCEEMCEL_33460
MMONEWR22_27495
MGOAFA91_04710
MHOLK3U96_25720
MSENK3U95_27910
MPAEK0O64_14320
MRFMJO55_26325
MDFK0O62_27980
MCROMI149_15120
MGROFZ046_04905
MAUSJN090_28610
MFREEXE63_16325
MJDJDM601_2998
NFANFA_25760
NFRERS450000_01519
NNONONO_c03380
NSLBOX37_22020
NODFOH10_29865
NWLNWFMUON74_03270
RHARHA1_ro04658
ROPROP_47560
ROAPd630_LPD01160
RPYY013_20110
RBYCEJ39_06525
RAVAAT18_05400
RHWBFN03_14750
RRZCS378_20900
RHUA3Q40_02417
RHQIM25_09850
RRT4535765_00816
RCRNCTC10994_01899
RKOJWS14_25685
ROZCBI38_04855
RPSKJWS13_18705
RGORNMQ04_03550
RHOUKZJ41_05935
RHOWA4U64_19150
RHOJJVH1_12960
RHOSQWW67_22880
RHOQQWW98_22890
RHOYQNA09_03470
WHROG579_07860
GBRGbro_3875
GPOGPOL_c37270
GORKTR9_3813
GOQACH46_16410
GTABCM27_20000
GOCCXX93_18630
GRUGCWB2_19555
GOMD7316_04847
GAVC5O27_08565
GODGKZ92_18490
GOSQAD21_18900
GOJGR168_18265
GAMGII34_06190
GPDGII33_05570
GJIH1R19_18405
GOILK459_15245
GHNMVF96_18900
GAMIIHQ52_22490
GMGNWF22_03900
GSIP5P27_02075
SPINKV203_10845
DTMBJL86_2478
DITC3V38_01880
DIZCT688_12130
DPCA6048_12675
DLUA6035_11765
DKNNHB83_12130
DCDVYL96_11990
TOYFO059_16550
SCOSCO2316(SCC53.07c)
SALBXNR_4565
SMASAVERM_5857
SGRSGR_5189
SGBWQO_09375
SFISFUL_1901
SANLKZO11_09200
SGRFSGFS_081270
SCYER2B67_26905
SCBSCAB_65461
SSXSACTE_1814
SVLStrvi_7402
SHYSHJG_3808
SHOSHJGH_3573
SRCM271_34085
SMALSMALA_2258
SSOII1A49_14460
SFASfla_4513
SBHSBI_07602
SVESVEN_2031
SDVBN159_6077
SALSSLNWT_5523
STRPF750_2177
SCIB446_12150
SLVSLIV_26140
SGUSGLAU_10630
SVTSVTN_11405
STREGZL_06192
SCWTU94_10000
SLDT261_5770
SLCSL103_07605
SXISXIM_12580
STRMM444_11735
STRCAA958_07770
SAMBSAM23877_2389
SPRISPRI_5183
SCZABE83_26345
SCXAS200_31100
SRWTUE45_02903
STRFASR50_11225
SLEsle_48700(sle_48700)
SRNA4G23_01459
SPAVSpa2297_09685
STRTA8713_08950
SCLFBB341_20465
SGSAVL59_38645
STSIA4E84_12025
SKYD0C37_24635
SALWCP975_10385
SGMGCM10017557_58480
SCADDN051_26820
SPHWNFX46_32385
SLSSLINC_2653
SNRSNOUR_28705
SALUDC74_2797
SALLSAZ_15365
SPLULK06_008480
STRDNI25_27500
SNWBBN63_24755
SAUOBV401_14750
SSIAA7J05_25290
SVUB1H20_08505
SPUNBFF78_29480
SGVB1H19_13430
SLAUSLA_1936
SALFSMD44_02551
SALJSMD11_4774
SLXSLAV_25645
STROSTRMOE7_12425
SFKKY5_2381c
SNZDC008_09885
SGEDWG14_05980
SRJSRO_5131
SLKSLUN_11500
SDXC4B68_28285
SGDELQ87_27685
SQZFQU76_08340
SCYAEJ357_13620
SASTCD934_23590
SNQCP978_11110
STIRDDW44_04825
SKACP970_30670
SGZC0216_24560
SVNCP980_23290
SNKCP967_24325
SHAWCEB94_12505
SRKFGW37_09845
SFICEIZ62_23490
SGALCP966_10450
SSPODDQ41_04535
SVRCP971_23725
SPADDVK44_07630
SFYGFH48_28285
SAQUEJC51_15420
SGFHEP81_05435
SCAVCVT27_08335
SSEOD0Z67_08285
SBYH7H31_25925
SRIMCP984_28660
SSUBCP968_23185
SPHVF9278_12185
SCINCP977_10495
SFUGCNQ36_10580
SPACB1H29_25795
STSUB7R87_08270
SCHACP983_30505
SGXH4W23_12030
SCOECP976_13540
SBATG4Z16_24780
SSPBCP982_13595
SNFJYK04_03024
SPLACP981_11710
SBROGQF42_14580
STUIGCM10017668_19600
SATAC5746_12745
SCHFIPT68_11100
SHUNDWB77_05390
SHARHUT13_06990
SCYGS1361_12805
SFEUIM697_10045
SLIAHA039_24545
SDWK7C20_11120
SVDCP969_12750
SCALI6J39_08680
SAUHSU9_009470
SFBCP974_07985
SMOBJ7W19_09490
SPRACP972_10745
SPEUCGZ69_10415
SROIIAG44_28540
SXNIAG42_25005
SGJIAG43_09065
SHKJ2N69_10250
SANUK7396_25360
STRYEQG64_08455
SDDD9753_24975
SACTDMT42_12030
SMAOCAG99_21285
SGOBtest1122_04910
SINEKI385_14660
SLFJEQ17_32425
SDECL3078_13725
SAOVG3H79_26340
SDURM4V62_29295
SYANNRK68_10620
SRUGF0345_07230
SAKBK1J60_31875
STAALDH80_27590
SNIGHEK616_11740
SVIOHWN34_23065
SCAEIHE65_31905
STUBMMF93_10030
SSPNLXH13_12510
SCIRSTRCI_002549
SXTKPP03845_102547
SLONLGI35_15575
SDRZNEH16_22515
STUDSTRTU_005029
STEEF3L20_25125
SENGOJ254_16530
SGKPET44_10360
SANTQR300_30380
SYUNMOV08_28790
SARGHKX69_24360
SJNRI060_30085
SCYNN8I84_12890
SOVQZH56_25870
SFIYF0344_26795
SHAUK9S39_31445
SKGKJK29_27130
SCOAQU709_30955
SLAIP8A22_27595
SROCRGF97_24155
SFPQUY26_28420
SCHGNRO40_08010
STTNBSL84_10320
SINNABB07_26755
STRZOYE22_25210
SCAYPYS65_25605
KBUQ4V64_14680
SARMDVA86_22100
SPRFK4G22_22955
SLUOPS467_13235
STPBQR97_02430
SRPAHEP86_12925
SMIBSMIR_27230
SCAJO1G22_29455
STRWQHG49_24505
STRLHEP84_17695
STSDHEP87_18060
SRPZHEP85_12880
SCHEQRN89_10280
SCTSCAT_1407
SCYSCATT_14110
KSKKSE_24180
KABB7C62_08370
KAUB6264_18300
KITCFP65_2122
KISHUT16_10190
KCHO1G21_26750
STRIC7M71_007660
YIALO772_10700
STRHGXP74_08875
ABRYNYE86_08015
AGLAOIE69_27595
DERMH7F30_04400
LMOIVV02_03780
YIMJ5M86_13665
ALXLVQ62_04940
BEIGCM100_34170
NCANoca_2797
NDKI601_3492
NOYEXE57_01120
NOIFCL41_07975
NOOFE634_11095
NDPE2C04_08585
NSNEXE58_18280
NBEBack2_02900
NANOG5V58_09600
NMESH9L09_21285
NAROCFH99_11645
NAQUENKNEFLB_02541
NROK8W59_09580
NOQLN652_04150
NCQK6T13_08410
NPCKUV85_04175
NPSKRR39_07190
NMARHPC71_09245
NFCKG111_10115
NRNSHK17_12225
NBISHK19_12715
NOFMF408_20900
PSIMKR76_12285
AERAERYTH_02155
AEZC3E78_12215
AEBC6I20_10175
AEFGEV26_12275
ASEZH9L21_13730
ADBNP095_13665
AWNNQV15_12885
TFUTfu_0571
THAONI17_023675
TALXFOF52_20765
NDANdas_0389
NALB005_3260
NGVCDO52_22815
NEXNE857_08205
NECKGD82_21250
NAKEKGD83_23860
NCGKGD84_25500
STRREKD16_05575
SNAHOUQ99_25320
TCUTcur_3660
ACTWF7P10_32410
AGRAAGRA3207_006094
AMAZLUW76_38115
ACIROG979_07945
SPIQOHA34_31825
ACTQOG417_15030
SROSros_8232
NOABKM31_52785
NOWGBF35_43345
NCXNocox_35695
NGNLCN96_48580
NFSOIE67_00430
TBITbis_2875
MHAIOHB01_03455
FRAFrancci3_0012
FALFRAAL0023
FREFranean1_0010
FRIFraEuI1c_0010
GOBGobs_3593
BSDBLASA_3345
BLAPMVA48_01060
BBRGU6N30_18480
MMARMODMU_3961
MOMKUM42_03305
SACGFDZ84_22780
AJAAJAP_24975
AMYYYIM_32500
AROONQK81_08260
AMYZHUW46_07823
KPHYAOZ06_41045
SACEGIY23_13425
CROSN8J89_39850
AMSAMIS_45040
ASICQ0Z83_054800
ACTEACTI_60780
CAICaci_2139
AEYCDG81_08875
ABAIIMCC26256_111672
AFOAfer_0491
AYMYM304_09250
ATQGH723_15490
AQZKSP35_11735
IAMHC251_04110
IMAPO878_03825
DHILH044_14855
HTUHtur_0771
HSALJMJ58_05060
HAKZJ0X25_11045
NATNJ7G_2680
NPENatpe_3351
NVRFEJ81_02295
NPLFGF80_09235
NAYHYG81_12260
HALYHYG82_19755
HJTDVR14_06900
HLOJ0X27_06625
 » show all
Reference
1  [PMID:36707645]
  Authors
Maranha A, Costa M, Ripoll-Rozada J, Manso JA, Miranda V, Mendes VM, Manadas B, Macedo-Ribeiro S, Ventura MR, Pereira PJB, Empadinhas N.
  Title
Self-recycling and partially conservative replication of mycobacterial methylmannose polysaccharides.
  Journal
Commun Biol 6:108 (2023)
DOI:10.1038/s42003-023-04448-3
  Sequence
[mhas:MHAS_04404]
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.221
IUBMB Enzyme Nomenclature: 3.2.1.221
ExPASy - ENZYME nomenclature database: 3.2.1.221
BRENDA, the Enzyme Database: 3.2.1.221

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