KEGG ENZYME: 3.2.1.46

ENZYME: 3.2.1.46

Entry

EC 3.2.1.46                 Enzyme

Name

galactosylceramidase;
cerebroside galactosidase;
galactocerebroside.beta-galactosidase;
galactosylcerebrosidase;
galactocerebrosidase;
ceramide galactosidase;
galactocerebroside galactosidase;
galactosylceramide.beta-galactosidase;
cerebroside beta-galactosidase;
galactosylceramidase I;
beta-galactosylceramidase;
galactocerebroside-beta-D-galactosidase;
lactosylceramidase I;
beta-galactocerebrosidase;
lactosylceramidase

Class

Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

Sysname

D-galactosyl-N-acylsphingosine galactohydrolase

Reaction(IUBMB)

a D-galactosyl-N-acylsphingosine + H2O = D-galactose + a ceramide [RN:R03617]

Reaction(KEGG)

R03617;
(other) R13179

Substrate

D-galactosyl-N-acylsphingosine [CPD:C02686];
H2O [CPD:C00001]

Product

D-galactose [CPD:C00124];
ceramide [CPD:C00195]

Comment

cf. EC 3.2.1.62 glycosylceramidase.

History

EC 3.2.1.46 created 1972

Pathway

ec00600

Sphingolipid metabolism

ec01100

Metabolic pathways

Orthology

K01202

galactosylceramidase

Genes

HSA:	2581(GALC)

PTR:	736519(GALC)

PPS:	100986325(GALC)

GGO:	101137325(GALC)

PON:	100458475(GALC)

PPYG:

129012221(GALC)

NLE:	100587134(GALC)

HMH:	116484567(GALC)

SSYN:

129487564(GALC)

MCC:	693322(GALC)

MCF:	101925411(GALC)

MTHB:

126960081

MNI:	105467587(GALC)

CSAB:

103229484(GALC)

CATY:

105596538(GALC)

PANU:

100997466(GALC)

TGE:	112628582(GALC)

MLEU:

105535270(GALC)

RRO:	104668560(GALC)

RBB:	108522791(GALC)

TFN:	117071576(GALC)

PTEH:

111538192(GALC)

CANG:

105517075(GALC)

CJC:	100412515(GALC)

SBQ:	101046485(GALC)

CIMI:

108301471(GALC)

ANAN:

105734098(GALC)

CSYR:

103276354(GALC)

MMUR:

105876317(GALC)

LCAT:

123645869(GALC)

PCOQ:

105807113(GALC)

OGA:	100940600(GALC)

MMU:	14420(Galc)

MCAL:

110307036(Galc)

MPAH:

110324405(Galc)

RNO:	314360(Galc)

MCOC:

116079609(Galc)

ANU:	117697366(Galc)

ASYL:

127687051(Galc)

MUN:	110551253(Galc)

CGE:	100751905(Galc)

MAUA:

101833576(Galc)

PROB:

127230863(Galc)

PLEU:

114697580(Galc)

MORG:

121434359 121452303

MFOT:

126507178

AAMP:

119819691(Galc)

NGI:	103744394(Galc)

HGL:	101721890(Galc)

CPOC:

100731753(Galc)

CCAN:

109700619(Galc)

DORD:

105983491(Galc)

DSP:	122118696(Galc)

PLOP:

125362902(Galc)

NCAR:

124976777

MMMA:

107149758(Galc)

ITI:	101965319(Galc)

OCU:

100351605

OPI:	101531251(GALC)

TUP:	102488515(GALC)

GVR:	103597380(GALC)

CFA:	403916(GALC)

CLUD:

112657728(GALC)

VVP:	112930186(GALC)

VLG:	121493447(GALC)

NPO:	129496075(GALC)

AML:	100481872(GALC)

UMR:	103670525(GALC)

UAH:	113267389(GALC)

UAR:	123798919(GALC)

ELK:

111148622

LLV:

125104811

MPUF:

101670763(GALC)

MNP:	132000116(GALC)

MLK:	131836791(GALC)

NVS:	122894233(GALC)

ORO:	101363316(GALC)

EJU:	114204706(GALC)

ZCA:	113909641(GALC)

MLX:	118002521(GALC)

NSU:	110571500(GALC)

LWW:	102738990(GALC)

FCA:	101084116(GALC)

PYU:	121032151(GALC)

PCOO:

112855332(GALC)

PBG:	122469414(GALC)

PVIV:

125167770(GALC)

LRUF:

124512590

LGF:	123584180(GALC)

AJU:

106989912

PTG:	102954621(GALC)

PPAD:

109274421(GALC)

PUC:

125909279

PLEZ:

122223018(GALC)

HHV:	120232070(GALC)

BTA:	533428(GALC)

BOM:	102281426(GALC)

BIU:	109565404(GALC)

BBUB:

102412612(GALC)

BBIS:

104987109(GALC)

CHX:	102188052(GALC)

OAS:	101118106(GALC)

BTAX:

128054215(GALC)

CSUM:

138073090(GALC)

ODA:	120853561(GALC)

CCAD:

122443933(GALC)

MREE:

136172503(GALC)

OVR:	110149025(GALC)

MBEZ:

129562635(GALC)

SSC:	100156917(GALC)

CFR:	102522511(GALC)

CBAI:

105079842(GALC)

CDK:	105105382(GALC)

VPC:	102528269(GALC)

BACU:

103010897(GALC)

BMUS:

118890514(GALC)

LVE:	103089768(GALC)

OOR:	101279086(GALC)

LALB:

132506417(GALC)

DLE:	111176185(GALC)

PCAD:

102981911(GALC) 102988804

PSIU:

116748922(GALC)

NASI:

112393867(GALC)

ECB:	100034130(GALC)

EPZ:	103551800(GALC)

EAI:	106834294(GALC)

MYB:	102257416(GALC)

MYD:	102765447(GALC)

MMYO:

118658903(GALC)

MLF:	102426787(GALC)

MDT:	132230799(GALC)

MYUM:

139010672(GALC)

PKL:	118714416(GALC)

EFUS:

103292221(GALC)

MNA:	107534864(GALC)

DRO:	112311819(GALC)

SHON:

118976730(GALC)

AJM:	119037921(GALC)

PDIC:

114492570(GALC)

PHAS:

123808797(GALC)

MMF:	118639330(GALC)

PPAM:

129065849(GALC)

HAI:	109382678(GALC)

RFQ:	117024189(GALC)

PALE:

102880991(GALC)

PGIG:

120619586(GALC)

PVP:	105290139(GALC)

RAY:	107499539(GALC)

MJV:	108396143(GALC)

TOD:	119239304(GALC)

SARA:

101543390(GALC)

SFUM:

130041448(GALC)

SETR:

126004154(GALC)

LAV:	100658478(GALC)

TMU:

101340632

ETF:	101640956(GALC)

DNM:	101417864(GALC)

MDO:	100019504(GALC) 100019541 100019605 100019857 100020089

GAS:	123235890 123237825 123237827(GALC)

SHR:	100915302(GALC)

AFZ:

127549431

PCW:	110217749(GALC)

TVP:	118829328(GALC)

PBRV:

138164488(GALC)

OAA:	100081052(GALC)

TACU:

119928194(GALC)

GGA:	423394(GALC)

PCOC:

116228932(GALC)

MGP:	100549468(GALC)

CJO:	107315242(GALC)

TPAI:

128085716(GALC)

LMUT:

125694813(GALC)

NMEL:

110401396(GALC)

APLA:

101796301(GALC)

ACYG:

106033531(GALC)

CATA:

118244374(GALC)

AFUL:

116489582(GALC)

TGU:	100224899(GALC)

LSR:	110476194(GALC)

SCAN:

103826899(GALC)

PMOA:

120503795(GALC)

OTC:	121334199(GALC)

PRUF:

121356045(GALC)

ATRC:

139589857(GALC)

GFR:	102034660(GALC)

FAB:	101810873(GALC)

OMA:	130254060(GALC)

PHI:	102113858(GALC)

PMAJ:

107205967(GALC)

CCAE:

111929558(GALC)

CCW:	104688651(GALC)

CBRC:

103612204(GALC)

ACOE:

138111752(GALC)

ETL:	114069327(GALC)

ZAB:	102060794(GALC)

ZLE:	135448259(GALC)

ACHL:

103811511(GALC)

SVG:	106849317(GALC)

MMEA:

130583493(GALC)

HRT:	120754585(GALC)

SATI:

136362954(GALC)

CCIC:

134044931(GALC)

FPG:	101914337(GALC)

FCH:	102059116(GALC)

CCRI:

104165255(GALC)

NNT:	104402632(GALC)

SHAB:

115606595(GALC)

ACUN:

113480749(GALC)

TALA:

104356982(GALC)

ACHC:

115333758(GALC)

HALD:

104315849(GALC)

HLE:	104841961(GALC)

AGEN:

126050552

HHAR:

128139867(GALC)

GCL:

127016657

CSTI:

104553566 104558092

LDI:	104348345(GALC)

MNB:	103775229(GALC)

DPUB:

104304132(GALC)

PPUS:

135179431(GALC)

AVIT:

104277260(GALC)

BRHI:

104493482(GALC)

EGZ:	104126309(GALC)

NNI:	104022246(GALC)

PCRI:

104033234(GALC)

PCAO:

104044006(GALC)

PADL:

103913072(GALC)

AFOR:

103900285(GALC)

FGA:	104081294(GALC)

GSTE:

104253899(GALC)

CLV:	102098299(GALC)

MUI:	104544022(GALC)

PGUU:

104467023(GALC)

PLET:

104622192(GALC)

EHS:	104503545(GALC)

CMAC:

104487213(GALC)

CUCA:

104059631(GALC)

TEO:	104373252(GALC)

BREG:

104633263(GALC)

OHA:	104331529(GALC)

ACAR:

104525364(GALC)

CPEA:

104394180(GALC)

CVF:	104286084(GALC)

RTD:	128909451(GALC)

CRID:

134514671(GALC)

AAM:	106483066(GALC)

AROW:

112972624(GALC)

NPD:	112955011(GALC)

TGT:	104577497(GALC)

DNE:	112990437(GALC)

SCAM:

104153813(GALC)

ASN:	102374264(GALC)

AMJ:	102575324(GALC)

CPOO:

109321658(GALC)

GGN:	109298550(GALC)

PSS:	102445851(GALC)

CMY:	102931374(GALC)

CCAY:

125637845(GALC)

DCC:	119857767(GALC)

CPIC:

101952897(GALC)

TST:	117876698(GALC)

CABI:

116821219(GALC)

MRV:	120403801(GALC)

ACS:	100564761(galc)

ASAO:

132763551(GALC)

PVT:	110090986(GALC)

SUND:

121916267(GALC)

PBI:	103054662(GALC)

PMUR:

107291164(GALC)

CTIG:

120303737(GALC)

TSR:	106555258(GALC)

PGUT:

117665890(GALC)

APRI:

131187826(GALC)

PTEX:

113438765(GALC)

NSS:	113419651(GALC)

VKO:	123026574(GALC)

PMUA:

114591297(GALC)

PRAF:

128408195(GALC)

ZVI:	118081269(GALC)

HCG:	128340490(GALC)

GJA:	107123345(GALC)

STOW:

125426760(GALC)

EMC:	129324552(GALC)

XLA:	446948(galc.L)

XTR:	779723(galc)

NPR:	108792556(GALC)

RTEM:

120920305(GALC)

BBUF:

120981714(GALC)

PWL:	138260037(GALC)

MUO:	115477291(GALC)

GSH:	117364141(GALC)

DRE:	406385(galcb) 449649(galca)

SRX:	107742352 107747942 107750876 107751776

SANH:

107668594 107671107 107678679

SGH:	107560205 107583495 107588298

CCAR:

109044880 109071112 109113493(galca)

CAUA:

113117428 113121250

CGIB:

127976364 127983797

PTET:

122325431(galca) 122361425(galcb)

LROH:

127179778(galcb) 127183022(galca)

OMC:	131523743(galcb) 131527443(galca)

PPRM:

120478828(galcb) 120493598(galca)

RKG:	130070582(galcb) 130096012(galca)

MAMB:

125268534(galcb) 125277795(galca)

CIDE:

127498815 127502066

CERY:

137006935(galcb) 137019312(galca)

MASI:

127415807 127454776

TROS:

130560691(galcb) 130565463(galca)

TDW:	130434468(galca) 130436866(galcb)

MANU:

129417933(galcb) 129429538(galca)

PDAB:

135727127 135733363 135750027(galca)

IPU:	108258153(galca) 108269778(galcb)

IFU:	128601207(galca) 128612376(galcb)

PHYP:

113532124 113534233

SMEO:

124377408(galca) 124390533(galcb)

TFD:	113648311(galca) 113651188(galcb)

TVC:	132843136(galca) 132852945(galcb)

CGAR:

128515394(galca) 128536347(galcb)

NGRA:

132883888(galca) 132894201(galcb)

TRN:	134319763(galca) 134325112(galcb)

AMEX:

103028593(galca) 103041717(galcb)

CMAO:

118815785(galca) 118823457(galcb)

EEE:	113570357 113579786

CHAR:

105899436 105908248(galcb)

SPIL:

134067818(galcb) 134098189

TRU:	101074089(galc)

TFS:	130540014(galcb)

TNG:	GSTEN00011741G001

LCO:	104928261(galc)

NCC:	104943827(galc)

TBEN:

117486328(galcb)

CGOB:

115027150(galc)

PGEO:

117443413

GACU:

117542828

EMAC:

134881232(galcb)

ELY:	117267361(galcb)

EFO:	125900948(galcb)

PLEP:

121954022(galcb)

SLUC:

116036754(galcb)

ECRA:

117935887(galcb)

ESP:	116670208(galc)

PFLV:

114546547(galc)

GAT:	120832973(galcb)

PPUG:

119227641(galcb)

AFB:	129103196(galcb)

CLUM:

117751495(galcb)

CANA:

137798602(galcb)

CVE:	137877743(galcb)

MSAM:

119909989(galcb)

SCHU:

122862361(galcb)

CUD:	121526643(galcb)

SPUL:

138591099(galcb)

LMIX:

132992999(galcb)

ALAT:

119004783(galcb)

ASTR:

137610489(galcb)

MZE:	101473828(galc)

ONL:	100707150 100707418

OAU:

116324212

OLA:	101163287(galc)

OML:	112142668(galcb)

CSAI:

133462221 133462731(galcb)

XMA:	102226991(galc)

XCO:	114134259(galc)

XHE:	116709385(galc)

PRET:

103458970(galc)

PFOR:

103138759(galc)

PLAI:

106959042(galc)

PMEI:

106926859(galc)

GAF:	122846419(galcb)

PPRL:

129365445(galcb)

CVG:	107095226(galc)

CTUL:

119787060(galcb)

GMU:	124855698(galcb)

NFU:	107373460 107374597

KMR:	108245031(galcb)

ALIM:

106519976(galc)

NWH:	119427773(galcb)

AOCE:

111574154(galcb)

EJA:	138212167(galcb)

BFRE:

138632335(galcb)

MCEP:

125023998(galcb)

CSEM:

103384287(galc)

POV:	109639554(galc)

SSEN:

122782634(galcb)

SSOE:

131444648(galcb)

HHIP:

117756559(galcb)

HSP:	118116615(galcb)

PPLT:

128450422(galcb)

SMAU:

118286205(galcb)

LCF:	108897907(galcb)

SDU:	111225520(galc)

SLAL:

111667257(galc)

XGL:	120795384(galcb)

HCQ:	109522741(galc)

SSCV:

125983232(galcb)

SBIA:

133514084(galcb)

PEE:	133415404(galcb)

PTAO:

133466060(galcb)

BPEC:

110165479(galc)

MALB:

109959716(galc)

BSPL:

114849022(galcb)

SJO:	128375109(galcb)

SSCO:

134000518(galcb)

GMH:	115543845(galc)

SASA:

100195231(galc)

STRU:

115172317(galc)

OTW:	112245106(galcb)

OMY:	110497649(galcb)

OGO:	124001517(galcb)

ONE:

115145972

OKI:	109894304(galc)

OKE:	118362775(galcb)

OMM:	135507949(galcb)

OCLA:

139375021

SALP:

111968475

SNH:	120060472(galcb)

CCLU:

121539552(galcb) 121544678

ELS:	105024731 105024733

SFM:	108924125(galc)

PKI:	111850944(galc)

AANG:

118230365

AROT:

135256995

CCOG:

133129519

LOC:	102684996(galc)

PSPA:

121330306

ARUT:

117421835(galcb)

PSEX:

120518493(galcb)

LCM:	102356089(GALC)

CMK:	103185410(galcb)

RTP:

109912864

CPLA:

122553421(galcb)

HOC:	132817983(galcb)

LERI:

129693404

PMRN:

116940702(GALC)

LRJ:	133343528(GALC)

BFO:	118425041 118425146

BBEL:

109474545 109474644

CIN:

100182893

SCLV:

120347149

SPU:	584869 584891

LPIC:

129273666

AJJ:

139967350

APLC:

110973820

ARUN:

117294593

AAMU:

139940624

AFIL:

140152424

AJC:

117102613

SKO:

100376265

PFLL:

139119972

CEL:	CELE_C29E4.10(C29E4.10)

CRQ:	GCK72_009178

HRO:	HELRODRAFT_157218 HELRODRAFT_85047 HELRODRAFT_98272

LGI:	LOTGIDRAFT_159095 LOTGIDRAFT_174010 LOTGIDRAFT_195251 LOTGIDRAFT_206940 LOTGIDRAFT_218637 LOTGIDRAFT_92651

PVUL:

126815104 126815111 126815295 126815298 126815850 126817284 126817286 126821389 130012121 130012280

PCAN:

112555422 112563838

LSAX:

138981568 138982239 138982243

BGT:	106050669 106050916 106060466 106063876

GAE:	121383276 121383458

HRF:	124116671 124116698 124116721 124116725 124116741 124116744 124116758 124116768 124117044 124117049 124117386 124117806 124118021 124118031 124131421

HRJ:	124258272 124258274 124258275 124258283 124258336 124258340 124258341 124258342 124258343 124258348 124258351 124258352 124258367 124258369 124258370 124258372 124258373 124267383 124280395

HASI:

137265283 137265284 137265285 137265286 137265287 137265289 137265290 137265291 137265292 137265293 137265294 137265403 137265404 137265518 137265776 137278187

HCRA:

139451788 139452371 139452497 139452756 139452769 139452770 139452771 139452772 139452773 139452775 139452776 139452777 139452778 139452779 139453114 139464854

CRG:	105334333 117689623 117689624

CANU:

128181438 128182289

CVN:

111133742

OED:

125666726

MYI:

110460487

PMAX:

117320602 117339236

AIRR:

138335048

MCAF:

127709336 127735822

MMER:

123546698 123546785

RPHI:

132713294 132726947 132728892 132732408

DPOL:

127841267 127841268 127842249 127842259 127857707 127859064 127859943 127860432

MAEA:

128211248 128211566 128211685

OBI:

106876977

OSN:

115219738

LJP:	135465433 135465584 135467113 135467114 135467526 135467538 135469384

LAK:	106155714 106166909 106168495

OVI:	T265_08669

LLON:

135489886

TAD:	TRIADDRAFT_28351

MBR:	MONBRDRAFT_480 MONBRDRAFT_566

SRE:	PTSG_00266

CFH:	C1707_15925

PBU:	L21SP3_00388 L21SP3_01812

PBP:	STSP1_01101 STSP1_02287

SCC:	Spico_0384

BSA:	Bacsa_1415

ARK:	D6B99_12110

AGI:	FSB73_03510

SPDR:

G6053_07245

MGK:	FSB76_22815

SZE:	AW14_13450

WFU:	AXE80_06115

LBH:

Lbuc_0208

LBN:	LBUCD034_0249

LPAR:

FAM21731_00775

LCU:	PL11_002695

LSUA:

H3M12_00940

LHB:	D1010_02565

RCH:

RUM_07020

RUS:	RBI_I00669

ESR:

ES1_17580

ESU:

EUS_13590

PRY:	Prubr_11070

THR:	TRQ7_09010

» show all

Reference

1 [PMID:5320641]

Authors

Brady RO, Gal AE, Kanfer JN, Bradley RM.

Title

The metabolism of glucocerebrosides. 3. Purification and properties of a glucosyl- and galactosylceramide-cleaving enzyme from rat intestinal tissue.

Journal

J Biol Chem 240:3766-70 (1965)

Other DBs

ExplorEnz - The Enzyme Database:

3.2.1.46

IUBMB Enzyme Nomenclature:

3.2.1.46

ExPASy - ENZYME nomenclature database:

3.2.1.46

BRENDA, the Enzyme Database:

3.2.1.46

CAS:

9027-89-8

All links

Gene (1630)   
   MGENES (365)   
   RefGene (1265)   
Protein sequence (2523)   
   UniProt (2431)   
   SWISS-PROT (21)   
   RefSeq(pep) (51)   
   PDBSTR (17)   
   PMD (3)   
DNA sequence (77)   
   RefSeq(nuc) (56)   
   GenBank (11)   
   EMBL (10)   
3D Structure (14)   
   PDB (14)   
Protein domain (17)   
   InterPro (17)   
All databases (4261)   

Download RDF

DBGET integrated database retrieval system