KEGG   ENZYME: 3.2.1.46
Entry
EC 3.2.1.46                 Enzyme                                 
Name
galactosylceramidase;
cerebroside galactosidase;
galactocerebroside.beta-galactosidase;
galactosylcerebrosidase;
galactocerebrosidase;
ceramide galactosidase;
galactocerebroside galactosidase;
galactosylceramide.beta-galactosidase;
cerebroside beta-galactosidase;
galactosylceramidase I;
beta-galactosylceramidase;
galactocerebroside-beta-D-galactosidase;
lactosylceramidase I;
beta-galactocerebrosidase;
lactosylceramidase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
Sysname
D-galactosyl-N-acylsphingosine galactohydrolase
Reaction(IUBMB)
a D-galactosyl-N-acylsphingosine + H2O = D-galactose + a ceramide [RN:R03617]
Reaction(KEGG)
R03617
Substrate
D-galactosyl-N-acylsphingosine [CPD:C02686];
H2O [CPD:C00001]
Product
D-galactose [CPD:C00124];
ceramide [CPD:C00195]
Comment
cf. EC 3.2.1.62 glycosylceramidase.
History
EC 3.2.1.46 created 1972
Pathway
ec00600  Sphingolipid metabolism
ec01100  Metabolic pathways
Orthology
K01202  galactosylceramidase
Genes
HSA2581(GALC)
PTR736519(GALC)
PPS100986325(GALC)
GGO101137325(GALC)
PON100458475(GALC)
NLE100587134(GALC)
MCC693322(GALC)
MCF101925411(GALC)
MTHB126960081
MNI105467587(GALC)
CSAB103229484(GALC)
CATY105596538(GALC)
PANU100997466(GALC)
TGE112628582(GALC)
RRO104668560(GALC)
RBB108522791(GALC)
TFN117071576(GALC)
PTEH111538192(GALC)
CANG105517075(GALC)
CJC100412515(GALC)
SBQ101046485(GALC)
CSYR103276354(GALC)
MMUR105876317(GALC)
LCAT123645869(GALC)
PCOQ105807113(GALC)
OGA100940600(GALC)
MMU14420(Galc)
MCAL110307036(Galc)
MPAH110324405(Galc)
RNO314360(Galc)
MCOC116079609(Galc)
MUN110551253(Galc)
CGE100751905(Galc)
MAUA101833576(Galc)
PLEU114697580(Galc)
MORG121434359 121452303
MFOT126507178
AAMP119819691(Galc)
NGI103744394(Galc)
HGL101721890(Galc)
CPOC100731753(Galc)
CCAN109700619(Galc)
DORD105983491(Galc)
DSP122118696(Galc)
NCAR124976777
OCU100351605
OPI101531251(GALC)
TUP102488515(GALC)
GVR103597380(GALC)
CFA403916(GALC)
CLUD112657728(GALC)
VVP112930186(GALC)
VLG121493447(GALC)
AML100481872(GALC)
UMR103670525(GALC)
UAH113267389(GALC)
UAR123798919(GALC)
ELK111148622
LLV125104811
MPUF101670763(GALC)
NVS122894233(GALC)
ORO101363316(GALC)
EJU114204706(GALC)
ZCA113909641(GALC)
MLX118002521(GALC)
NSU110571500(GALC)
LWW102738990(GALC)
FCA101084116(GALC)
PYU121032151(GALC)
PBG122469414(GALC)
LRUF124512590
PTG102954621(GALC)
PPAD109274421(GALC)
AJU106989912(GALC)
HHV120232070(GALC)
BTA533428(GALC)
BOM102281426(GALC)
BIU109565404(GALC)
BBUB102412612(GALC)
BBIS104987109(GALC)
CHX102188052(GALC)
OAS101118106(GALC)
ODA120853561(GALC)
CCAD122443933(GALC)
SSC100156917(GALC)
CFR102522511(GALC)
CBAI105079842(GALC)
CDK105105382(GALC)
VPC102528269(GALC)
BACU103010897(GALC)
LVE103089768(GALC)
OOR101279086(GALC)
DLE111176185(GALC)
PCAD102981911(GALC) 102988804
PSIU116748922(GALC)
ECB100034130(GALC)
EPZ103551800(GALC)
EAI106834294(GALC)
MYB102257416(GALC)
MYD102765447(GALC)
MMYO118658903(GALC)
MLF102426787(GALC)
MNA107534864(GALC)
PKL118714416(GALC)
HAI109382678(GALC)
DRO112311819(GALC)
SHON118976730(GALC)
AJM119037921(GALC)
PDIC114492570(GALC)
PHAS123808797(GALC)
MMF118639330(GALC)
RFQ117024189(GALC)
PALE102880991(GALC)
PGIG120619586(GALC)
PVP105290139(GALC)
RAY107499539(GALC)
MJV108396143(GALC)
TOD119239304(GALC)
SARA101543390(GALC)
LAV100658478(GALC)
TMU101340632
ETF101640956(GALC)
DNM101417864(GALC)
MDO100019504(GALC) 100019541 100019605 100019857 100020089
GAS123235890 123237825 123237827(GALC)
SHR100915302(GALC)
PCW110217749(GALC)
OAA100081052(GALC)
GGA423394(GALC)
PCOC116228932(GALC)
MGP100549468(GALC)
CJO107315242(GALC)
NMEL110401396(GALC)
APLA101796301(GALC) 113841758
ACYG106033531(GALC)
AFUL116489582(GALC)
TGU100224899(GALC)
LSR110476194(GALC)
SCAN103826899(GALC)
PMOA120503795(GALC)
OTC121334199(GALC)
PRUF121356045(GALC)
GFR102034660(GALC)
FAB101810873(GALC)
PHI102113858(GALC)
PMAJ107205967(GALC)
CCAE111929558(GALC)
CCW104688651(GALC)
CBRC103612204(GALC)
ETL114069327(GALC)
ZAB102060794(GALC)
ACHL103811511(GALC)
FPG101914337(GALC)
FCH102059116(GALC)
CLV102098299(GALC)
EGZ104126309(GALC)
NNI104022246(GALC)
PLET104622192(GALC)
PCRI104033234(GALC)
PCAO104044006(GALC)
ACUN113480749(GALC)
TALA104356982(GALC)
PADL103913072(GALC)
AFOR103900285(GALC)
ACHC115333758(GALC)
HALD104315849(GALC)
HLE104841961(GALC)
AGEN126050552
GCL127016657
CCRI104165255(GALC)
CSTI104553566 104558092
EHS104503545(GALC)
CMAC104487213(GALC)
MUI104544022(GALC)
FGA104081294(GALC)
GSTE104253899(GALC)
LDI104348345(GALC)
MNB103775229(GALC)
OHA104331529(GALC)
NNT104402632(GALC)
DPUB104304132(GALC)
PGUU104467023(GALC)
ACAR104525364(GALC)
CPEA104394180(GALC)
AVIT104277260(GALC)
CVF104286084(GALC)
CUCA104059631(GALC)
TEO104373252(GALC)
BRHI104493482(GALC)
AAM106483066(GALC)
AROW112972624(GALC)
NPD112955011(GALC)
TGT104577497(GALC)
DNE112990437(GALC)
SCAM104153813(GALC)
ASN102374264(GALC)
AMJ102575324(GALC)
CPOO109321658(GALC)
GGN109298550(GALC)
PSS102445851(GALC)
CMY102931374(GALC)
CPIC101952897(GALC)
TST117876698(GALC)
CABI116821219(GALC)
MRV120403801(GALC)
ACS100564761(galc)
PVT110090986(GALC)
SUND121916267(GALC)
PBI103054662(GALC)
PMUR107291164(GALC)
CTIG120303737(GALC)
TSR106555258(GALC)
PGUT117665890(GALC)
VKO123026574(GALC)
PMUA114591297(GALC)
ZVI118081269(GALC)
GJA107123345(GALC)
STOW125426760(GALC)
XLA446948(galc.L)
XTR779723(galc)
NPR108792556(GALC)
RTEM120920305(GALC)
BBUF120981714(GALC)
DRE406385(galcb) 449649(galca)
SRX107742352 107747942 107750876 107751776
SANH107668594 107671107 107678679
SGH107560205 107583495 107588298
CCAR109044880 109046970 109071112 109113493
CAUA113117428 113121250
PPRM120478828(galcb) 120493598(galca)
MAMB125268534(galcb) 125277795(galca)
IPU108258153(galca) 108269778(galcb)
PHYP113532124 113534233
SMEO124377408(galca) 124390533(galcb)
TFD113648311(galca) 113651188(galcb)
AMEX103028593 103041717
EEE113570357 113579786
TRU101074089(galc)
TNGGSTEN00011741G001
LCO104928261(galc)
NCC104943827(galc)
CGOB115027150(galc)
ELY117267361(galcb)
EFO125900948(galcb)
PLEP121954022(galcb)
SLUC116036754(galcb)
ECRA117935887(galcb)
ESP116670208(galc)
PFLV114546547(galc)
GAT120832973(galcb)
PPUG119227641(galcb)
MSAM119909989(galcb)
CUD121526643(galcb)
ALAT119004783(galcb)
MZE101473828(galc)
ONL100707150 100707418
OAU116324212
OLA101163287(galc)
OML112142668(galcb)
XMA102226991(galc)
XCO114134259(galc)
XHE116709385(galc)
PRET103458970(galc)
PFOR103138759(galc)
PLAI106959042(galc)
PMEI106926859(galc)
GAF122846419(galcb)
CVG107095226(galc)
CTUL119787060(galcb)
GMU124855698(galcb)
NFU107373460 107374597
KMR108245031(galcb)
ALIM106519976(galc)
NWH119427773(galcb)
AOCE111574154(galc)
MCEP125023998(galcb)
CSEM103384287(galc)
POV109639554(galc)
SSEN122782634(galcb)
HHIP117756559(galcb)
HSP118116615(galcb)
LCF108897907(galcb)
SDU111225520(galc)
SLAL111667257(galc)
XGL120795384(galcb)
HCQ109522741(galc)
BPEC110165479(galc)
MALB109959716(galc)
BSPL114849022(galcb)
SASA100195231(galc)
STRU115172317(galc)
OTW112245106(galcb)
OMY110497649(galcb)
OGO124001517(galcb)
ONE115145972
SALP111968475
SNH120060472(galcb)
CCLU121539552(galcb) 121544678
ELS105024731 105024733
SFM108924125(galc)
PKI111850944(galc)
AANG118230365
LOC102684996(galc)
PSPA121330306
ARUT117421835(galcb)
PSEX120518493(galcb)
LCM102356089(GALC)
CMK103185410(galcb)
RTP109912864
BFO118425041 118425146
BBEL109474545 109474644
CIN100182893
SCLV120347149
SPU584869 584891
APLC110973820
AJC117102613
SKO100376265
CELCELE_C29E4.10(C29E4.10)
HROHELRODRAFT_157218 HELRODRAFT_85047 HELRODRAFT_98272
LGILOTGIDRAFT_159095 LOTGIDRAFT_174010 LOTGIDRAFT_195251 LOTGIDRAFT_206940 LOTGIDRAFT_218637 LOTGIDRAFT_92651
PCAN112555422 112563838
BGT106050669 106050916 106060466 106063876
GAE121383276 121383458
HRF124116671 124116721 124116725 124116741 124116744 124116758 124116768 124117044 124117049 124117386 124117806 124118021 124118031 124131421
HRJ124258272 124258274 124258275 124258283 124258336 124258340 124258341 124258342 124258343 124258348 124258351 124258352 124258367 124258369 124258370 124258372 124258373 124267383 124280395
CRG105334333
MYI110460487
PMAX117320602 117339236
MMER123546654 123546698 123546785
OBI106876977
OSN115219738
LAK106155714 106166909 106168495
OVIT265_08669
TADTRIADDRAFT_28351
MBRMONBRDRAFT_480 MONBRDRAFT_566
SREPTSG_00266
SMINv1.2.004702.t1(symbB.v1.2.004702.t1) v1.2.024887.t1(symbB.v1.2.024887.t1) v1.2.025387.t1(symbB.v1.2.025387.t1)
CFHC1707_15925
LROLOCK900_0057
LBHLbuc_0208
LBNLBUCD034_0249
LPARFAM21731_00775
LCUPL11_002695
LSUAH3M12_00940
LHBD1010_02565
ESRES1_17580
ESUEUS_13590
RCHRUM_07020
RUSRBI_I00669
PRYPrubr_11070
PBUL21SP3_00388 L21SP3_01812
PBPSTSP1_01101 STSP1_02287
SCCSpico_0384
BSABacsa_1415
ARKD6B99_12110
AGIFSB73_03510
SPDRG6053_07245
MGKFSB76_22815
SZEAW14_13450
WFUAXE80_06115
THRTRQ7_09010
 » show all
Reference
1  [PMID:5320641]
  Authors
Brady RO, Gal AE, Kanfer JN, Bradley RM.
  Title
The metabolism of glucocerebrosides. 3. Purification and properties of a glucosyl- and galactosylceramide-cleaving enzyme from rat intestinal tissue.
  Journal
J Biol Chem 240:3766-70 (1965)
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.46
IUBMB Enzyme Nomenclature: 3.2.1.46
ExPASy - ENZYME nomenclature database: 3.2.1.46
BRENDA, the Enzyme Database: 3.2.1.46
CAS: 9027-89-8

DBGET integrated database retrieval system