KEGG   ENZYME: 3.2.1.46
Entry
EC 3.2.1.46                 Enzyme                                 
Name
galactosylceramidase;
cerebroside galactosidase;
galactocerebroside.beta-galactosidase;
galactosylcerebrosidase;
galactocerebrosidase;
ceramide galactosidase;
galactocerebroside galactosidase;
galactosylceramide.beta-galactosidase;
cerebroside beta-galactosidase;
galactosylceramidase I;
beta-galactosylceramidase;
galactocerebroside-beta-D-galactosidase;
lactosylceramidase I;
beta-galactocerebrosidase;
lactosylceramidase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
Sysname
D-galactosyl-N-acylsphingosine galactohydrolase
Reaction(IUBMB)
a D-galactosyl-N-acylsphingosine + H2O = D-galactose + a ceramide [RN:R03617]
Reaction(KEGG)
R03617;
(other) R13179
Substrate
D-galactosyl-N-acylsphingosine [CPD:C02686];
H2O [CPD:C00001]
Product
D-galactose [CPD:C00124];
ceramide [CPD:C00195]
Comment
cf. EC 3.2.1.62 glycosylceramidase.
History
EC 3.2.1.46 created 1972
Pathway
ec00600  Sphingolipid metabolism
ec01100  Metabolic pathways
Orthology
K01202  galactosylceramidase
Genes
HSA2581(GALC)
PTR736519(GALC)
PPS100986325(GALC)
GGO101137325(GALC)
PON100458475(GALC)
NLE100587134(GALC)
HMH116484567(GALC)
MCC693322(GALC)
MCF101925411(GALC)
MTHB126960081
MNI105467587(GALC)
CSAB103229484(GALC)
CATY105596538(GALC)
PANU100997466(GALC)
TGE112628582(GALC)
MLEU105535270(GALC)
RRO104668560(GALC)
RBB108522791(GALC)
TFN117071576(GALC)
PTEH111538192(GALC)
CANG105517075(GALC)
CJC100412515(GALC)
SBQ101046485(GALC)
CIMI108301471(GALC)
CSYR103276354(GALC)
MMUR105876317(GALC)
LCAT123645869(GALC)
PCOQ105807113(GALC)
OGA100940600(GALC)
MMU14420(Galc)
MCAL110307036(Galc)
MPAH110324405(Galc)
RNO314360(Galc)
MCOC116079609(Galc)
ANU117697366(Galc)
MUN110551253(Galc)
CGE100751905(Galc)
MAUA101833576(Galc)
PROB127230863(Galc)
PLEU114697580(Galc)
MORG121434359 121452303
MFOT126507178
AAMP119819691(Galc)
NGI103744394(Galc)
HGL101721890(Galc)
CPOC100731753(Galc)
CCAN109700619(Galc)
DORD105983491(Galc)
DSP122118696(Galc)
PLOP125362902(Galc)
NCAR124976777
MMMA107149758(Galc)
OCU100351605
OPI101531251(GALC)
TUP102488515(GALC)
GVR103597380(GALC)
CFA403916(GALC)
CLUD112657728(GALC)
VVP112930186(GALC)
VLG121493447(GALC)
NPO129496075(GALC)
AML100481872(GALC)
UMR103670525(GALC)
UAH113267389(GALC)
UAR123798919(GALC)
ELK111148622
LLV125104811
MPUF101670763(GALC)
MNP132000116(GALC)
MLK131836791(GALC)
NVS122894233(GALC)
ORO101363316(GALC)
EJU114204706(GALC)
ZCA113909641(GALC)
MLX118002521(GALC)
NSU110571500(GALC)
LWW102738990(GALC)
FCA101084116(GALC)
PYU121032151(GALC)
PCOO112855332(GALC)
PBG122469414(GALC)
PVIV125167770(GALC)
LRUF124512590
PTG102954621(GALC)
PPAD109274421(GALC)
PUC125909279
AJU106989912
HHV120232070(GALC)
BTA533428(GALC)
BOM102281426(GALC)
BIU109565404(GALC)
BBUB102412612(GALC)
BBIS104987109(GALC)
CHX102188052(GALC)
OAS101118106(GALC)
BTAX128054215(GALC)
ODA120853561(GALC)
CCAD122443933(GALC)
MBEZ129562635(GALC)
SSC100156917(GALC)
CFR102522511(GALC)
CBAI105079842(GALC)
CDK105105382(GALC)
VPC102528269(GALC)
BACU103010897(GALC)
BMUS118890514(GALC)
LVE103089768(GALC)
OOR101279086(GALC)
DLE111176185(GALC)
PCAD102981911(GALC) 102988804
PSIU116748922(GALC)
NASI112393867(GALC)
ECB100034130(GALC)
EPZ103551800(GALC)
EAI106834294(GALC)
MYB102257416(GALC)
MYD102765447(GALC)
MMYO118658903(GALC)
MLF102426787(GALC)
PKL118714416(GALC)
EFUS103292221(GALC)
MNA107534864(GALC)
DRO112311819(GALC)
SHON118976730(GALC)
AJM119037921(GALC)
PDIC114492570(GALC)
PHAS123808797(GALC)
MMF118639330(GALC)
PPAM129065849(GALC)
HAI109382678(GALC)
RFQ117024189(GALC)
PALE102880991(GALC)
PGIG120619586(GALC)
PVP105290139(GALC)
RAY107499539(GALC)
MJV108396143(GALC)
TOD119239304(GALC)
SARA101543390(GALC)
SETR126004154(GALC)
LAV100658478(GALC)
TMU101340632
ETF101640956(GALC)
DNM101417864(GALC)
MDO100019504(GALC) 100019541 100019605 100019857 100020089
GAS123235890 123237825 123237827(GALC)
SHR100915302(GALC)
AFZ127549431
PCW110217749(GALC)
OAA100081052(GALC)
GGA423394(GALC)
PCOC116228932(GALC)
MGP100549468(GALC)
CJO107315242(GALC)
TPAI128085716(GALC)
LMUT125694813(GALC)
NMEL110401396(GALC)
APLA101796301(GALC)
ACYG106033531(GALC)
CATA118244374(GALC)
AFUL116489582(GALC)
TGU100224899(GALC)
LSR110476194(GALC)
SCAN103826899(GALC)
PMOA120503795(GALC)
OTC121334199(GALC)
PRUF121356045(GALC)
GFR102034660(GALC)
FAB101810873(GALC)
OMA130254060(GALC)
PHI102113858(GALC)
PMAJ107205967(GALC)
CCAE111929558(GALC)
CCW104688651(GALC)
CBRC103612204(GALC)
ETL114069327(GALC)
ZAB102060794(GALC)
ZLE135448259(GALC)
ACHL103811511(GALC)
SVG106849317(GALC)
MMEA130583493(GALC)
HRT120754585(GALC)
FPG101914337(GALC)
FCH102059116(GALC)
CLV102098299(GALC)
EGZ104126309(GALC)
NNI104022246(GALC)
PCRI104033234(GALC)
PLET104622192(GALC)
EHS104503545(GALC)
PCAO104044006(GALC)
ACUN113480749(GALC)
TALA104356982(GALC)
PADL103913072(GALC)
AFOR103900285(GALC)
ACHC115333758(GALC)
HALD104315849(GALC)
HLE104841961(GALC)
AGEN126050552
GCL127016657
CCRI104165255(GALC)
CSTI104553566 104558092
CMAC104487213(GALC)
MUI104544022(GALC)
BREG104633263(GALC)
FGA104081294(GALC)
GSTE104253899(GALC)
LDI104348345(GALC)
MNB103775229(GALC)
OHA104331529(GALC)
NNT104402632(GALC)
SHAB115606595(GALC)
DPUB104304132(GALC)
PGUU104467023(GALC)
ACAR104525364(GALC)
CPEA104394180(GALC)
AVIT104277260(GALC)
CVF104286084(GALC)
RTD128909451(GALC)
CUCA104059631(GALC)
TEO104373252(GALC)
BRHI104493482(GALC)
AAM106483066(GALC)
AROW112972624(GALC)
NPD112955011(GALC)
TGT104577497(GALC)
DNE112990437(GALC)
SCAM104153813(GALC)
ASN102374264(GALC)
AMJ102575324(GALC)
CPOO109321658(GALC)
GGN109298550(GALC)
PSS102445851(GALC)
CMY102931374(GALC)
CCAY125637845(GALC)
DCC119857767(GALC)
CPIC101952897(GALC)
TST117876698(GALC)
CABI116821219(GALC)
MRV120403801(GALC)
ACS100564761(galc)
ASAO132763551(GALC)
PVT110090986(GALC)
SUND121916267(GALC)
PBI103054662(GALC)
PMUR107291164(GALC)
CTIG120303737(GALC)
TSR106555258(GALC)
PGUT117665890(GALC)
APRI131187826(GALC)
PTEX113438765(GALC)
NSS113419651(GALC)
VKO123026574(GALC)
PMUA114591297(GALC)
PRAF128408195(GALC)
ZVI118081269(GALC)
HCG128340490(GALC)
GJA107123345(GALC)
STOW125426760(GALC)
EMC129324552(GALC)
XLA446948(galc.L)
XTR779723(galc)
NPR108792556(GALC)
RTEM120920305(GALC)
BBUF120981714(GALC)
MUO115477291(GALC)
GSH117364141(GALC)
DRE406385(galcb) 449649(galca)
SRX107742352 107747942 107750876 107751776
SANH107668594 107671107 107678679
SGH107560205 107583495 107588298
CCAR109044880 109046970 109071112 109113493
CAUA113117428 113121250
CGIB127976364 127983797
PTET122325431(galca) 122361425(galcb)
LROH127179778(galcb) 127183022(galca)
OMC131523743(galcb) 131527443(galca)
PPRM120478828(galcb) 120493598(galca)
RKG130070582(galcb) 130096012(galca)
MAMB125268534(galcb) 125277795(galca)
CIDE127498815 127502066
MASI127415807 127454776
TROS130560691(galcb) 130565463(galca)
TDW130434468(galca) 130436866(galcb)
MANU129417933(galcb) 129429538(galca)
IPU108258153(galca) 108269778(galcb)
IFU128601207(galca) 128612376(galcb)
PHYP113532124 113534233
SMEO124377408(galca) 124390533(galcb)
TFD113648311(galca) 113651188(galcb)
TVC132843136(galca) 132852945(galcb)
TRN134319763(galca) 134325112(galcb)
AMEX103028593 103041717
CMAO118815785(galca) 118823457(galcb)
EEE113570357 113579786
CHAR105899436 105908248(galcb)
TRU101074089(galc)
TFS130540014(galcb)
TNGGSTEN00011741G001
LCO104928261(galc)
NCC104943827(galc)
TBEN117486328(galcb)
CGOB115027150(galc)
PGEO117443413(galcb)
GACU117542828
EMAC134881232(galcb)
ELY117267361(galcb)
EFO125900948(galcb)
PLEP121954022(galcb)
SLUC116036754(galcb)
ECRA117935887(galcb)
ESP116670208(galc)
PFLV114546547(galc)
GAT120832973(galcb)
PPUG119227641(galcb)
AFB129103196(galcb)
CLUM117751495(galcb)
MSAM119909989(galcb)
SCHU122862361(galcb)
CUD121526643(galcb)
ALAT119004783(galcb)
MZE101473828(galc)
ONL100707150 100707418
OAU116324212
OLA101163287(galc)
OML112142668(galcb)
CSAI133462221 133462731(galcb)
XMA102226991(galc)
XCO114134259(galc)
XHE116709385(galc)
PRET103458970(galc)
PFOR103138759(galc)
PLAI106959042(galc)
PMEI106926859(galc)
GAF122846419(galcb)
PPRL129365445(galcb)
CVG107095226(galc)
CTUL119787060(galcb)
GMU124855698(galcb)
NFU107373460 107374597
KMR108245031(galcb)
ALIM106519976(galc)
NWH119427773(galcb)
AOCE111574154(galc)
MCEP125023998(galcb)
CSEM103384287(galc)
POV109639554(galc)
SSEN122782634(galcb)
HHIP117756559(galcb)
HSP118116615(galcb)
PPLT128450422(galcb)
SMAU118286205(galcb)
LCF108897907(galcb)
SDU111225520(galc)
SLAL111667257(galc)
XGL120795384(galcb)
HCQ109522741(galc)
SSCV125983232
SBIA133514084(galcb)
PEE133415404(galcb)
PTAO133466060(galcb)
BPEC110165479(galc)
MALB109959716(galc)
BSPL114849022(galcb)
SJO128375109(galcb)
SASA100195231(galc)
STRU115172317(galc)
OTW112245106(galcb)
OMY110497649(galcb)
OGO124001517(galcb)
ONE115145972
OKI109894304(galc)
OKE118362775(galcb)
SALP111968475
SNH120060472(galcb)
CCLU121539552(galcb) 121544678
ELS105024731 105024733
SFM108924125(galc)
PKI111850944(galc)
AANG118230365
LOC102684996(galc)
PSPA121330306
ARUT117421835(galcb)
PSEX120518493(galcb)
LCM102356089(GALC)
CMK103185410(galcb)
RTP109912864
CPLA122553421(galcb)
HOC132817983(galcb)
LERI129693404
PMRN116940702(GALC)
LRJ133343528(GALC)
BFO118425041 118425146
BBEL109474545 109474644
CIN100182893
SCLV120347149
SPU584869 584891
LPIC129273666
APLC110973820
AJC117102613
SKO100376265
CELCELE_C29E4.10(C29E4.10)
CRQGCK72_009178
HROHELRODRAFT_157218 HELRODRAFT_85047 HELRODRAFT_98272
LGILOTGIDRAFT_159095 LOTGIDRAFT_174010 LOTGIDRAFT_195251 LOTGIDRAFT_206940 LOTGIDRAFT_218637 LOTGIDRAFT_92651
PVUL126815104 126815111 126815295 126815298 126815850 126817284 126817286 126821389 130012121 130012280
PCAN112555422 112563838
BGT106050669 106050916 106060466 106063876
GAE121383276 121383458
HRF124116671 124116698 124116721 124116725 124116741 124116744 124116758 124116768 124117044 124117049 124117386 124117806 124118021 124118031 124131421
HRJ124258272 124258274 124258275 124258283 124258336 124258340 124258341 124258342 124258343 124258348 124258351 124258352 124258367 124258369 124258370 124258372 124258373 124267383 124280395
CRG105334333
CVN111133742
CANU128181438 128182289
OED125666726
MYI110460487
PMAX117320602 117339236
MCAF127709336 127735822
MMER123546698 123546785
RPHI132713294 132726947 132728892 132732408
DPOL127841267 127841268 127842249 127842259 127857707 127859064 127859943 127860432
OBI106876977
OSN115219738
LJP135465433 135465584 135467113 135467114 135467526 135467538 135469384
LAK106155714 106166909 106168495
OVIT265_08669
LLON135489886
TADTRIADDRAFT_28351
MBRMONBRDRAFT_480 MONBRDRAFT_566
SREPTSG_00266
SMINv1.2.004702.t1(symbB.v1.2.004702.t1) v1.2.024887.t1(symbB.v1.2.024887.t1) v1.2.025387.t1(symbB.v1.2.025387.t1)
CFHC1707_15925
LROLOCK900_0057
LBHLbuc_0208
LBNLBUCD034_0249
LPARFAM21731_00775
LCUPL11_002695
LSUAH3M12_00940
LHBD1010_02565
ESRES1_17580
ESUEUS_13590
RCHRUM_07020
RUSRBI_I00669
PRYPrubr_11070
PBUL21SP3_00388 L21SP3_01812
PBPSTSP1_01101 STSP1_02287
SCCSpico_0384
BSABacsa_1415
ARKD6B99_12110
AGIFSB73_03510
SPDRG6053_07245
MGKFSB76_22815
SZEAW14_13450
WFUAXE80_06115
THRTRQ7_09010
 » show all
Reference
1  [PMID:5320641]
  Authors
Brady RO, Gal AE, Kanfer JN, Bradley RM.
  Title
The metabolism of glucocerebrosides. 3. Purification and properties of a glucosyl- and galactosylceramide-cleaving enzyme from rat intestinal tissue.
  Journal
J Biol Chem 240:3766-70 (1965)
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.46
IUBMB Enzyme Nomenclature: 3.2.1.46
ExPASy - ENZYME nomenclature database: 3.2.1.46
BRENDA, the Enzyme Database: 3.2.1.46
CAS: 9027-89-8

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