KEGG ENZYME: 3.2.1.46

ENZYME: 3.2.1.46

Entry

EC 3.2.1.46                 Enzyme

Name

galactosylceramidase;
cerebroside galactosidase;
galactocerebroside.beta-galactosidase;
galactosylcerebrosidase;
galactocerebrosidase;
ceramide galactosidase;
galactocerebroside galactosidase;
galactosylceramide.beta-galactosidase;
cerebroside beta-galactosidase;
galactosylceramidase I;
beta-galactosylceramidase;
galactocerebroside-beta-D-galactosidase;
lactosylceramidase I;
beta-galactocerebrosidase;
lactosylceramidase

Class

Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

Sysname

D-galactosyl-N-acylsphingosine galactohydrolase

Reaction(IUBMB)

a D-galactosyl-N-acylsphingosine + H2O = D-galactose + a ceramide [RN:R03617]

Reaction(KEGG)

R03617;
(other) R13179

Substrate

D-galactosyl-N-acylsphingosine [CPD:C02686];
H2O [CPD:C00001]

Product

D-galactose [CPD:C00124];
ceramide [CPD:C00195]

Comment

cf. EC 3.2.1.62 glycosylceramidase.

History

EC 3.2.1.46 created 1972

Pathway

ec00600

Sphingolipid metabolism

ec01100

Metabolic pathways

Orthology

K01202

galactosylceramidase

Genes

HSA:	2581(GALC)

PTR:	736519(GALC)

PPS:	100986325(GALC)

GGO:	101137325(GALC)

PON:	100458475(GALC)

PPYG:

129012221(GALC)

NLE:	100587134(GALC)

HMH:	116484567(GALC)

SSYN:

129487564(GALC)

MCC:	693322(GALC)

MCF:	101925411(GALC)

MTHB:

126960081

MNI:	105467587(GALC)

CSAB:

103229484(GALC)

CATY:

105596538(GALC)

PANU:

100997466(GALC)

TGE:	112628582(GALC)

MLEU:

105535270(GALC)

RRO:	104668560(GALC)

RBB:	108522791(GALC)

TFN:	117071576(GALC)

PTEH:

111538192(GALC)

CANG:

105517075(GALC)

CJC:	100412515(GALC)

SBQ:	101046485(GALC)

CIMI:

108301471(GALC)

ANAN:

105734098(GALC)

CSYR:

103276354(GALC)

MMUR:

105876317(GALC)

LCAT:

123645869(GALC)

PCOQ:

105807113(GALC)

OGA:	100940600(GALC)

MMU:	14420(Galc)

MCAL:

110307036(Galc)

MPAH:

110324405(Galc)

RNO:	314360(Galc)

MCOC:

116079609(Galc)

ANU:	117697366(Galc)

ASYL:

127687051(Galc)

MUN:	110551253(Galc)

CGE:	100751905(Galc)

MAUA:

101833576(Galc)

PROB:

127230863(Galc)

PLEU:

114697580(Galc)

MORG:

121434359 121452303

MFOT:

126507178

AAMP:

119819691(Galc)

NGI:	103744394(Galc)

HGL:	101721890(Galc)

CPOC:

100731753(Galc)

CCAN:

109700619(Galc)

DORD:

105983491(Galc)

DSP:	122118696(Galc)

PLOP:

125362902(Galc)

NCAR:

124976777

MMMA:

107149758(Galc)

ITI:	101965319(Galc)

OCU:

100351605

OPI:	101531251(GALC)

TUP:	102488515(GALC)

GVR:	103597380(GALC)

CFA:	403916(GALC)

CLUD:

112657728(GALC)

VVP:	112930186(GALC)

VLG:	121493447(GALC)

NPO:	129496075(GALC)

AML:	100481872(GALC)

UMR:	103670525(GALC)

UAH:	113267389(GALC)

UAR:	123798919(GALC)

ELK:

111148622

LLV:

125104811

MPUF:

101670763(GALC)

MNP:	132000116(GALC)

MLK:	131836791(GALC)

NVS:	122894233(GALC)

ORO:	101363316(GALC)

EJU:	114204706(GALC)

ZCA:	113909641(GALC)

MLX:	118002521(GALC)

NSU:	110571500(GALC)

LWW:	102738990(GALC)

FCA:	101084116(GALC)

PYU:	121032151(GALC)

PCOO:

112855332(GALC)

PBG:	122469414(GALC)

PVIV:

125167770(GALC)

LRUF:

124512590

LGF:	123584180(GALC)

AJU:

106989912

PTG:	102954621(GALC)

PPAD:

109274421(GALC)

PUC:

125909279

PLEZ:

122223018(GALC)

HHV:	120232070(GALC)

BTA:	533428(GALC)

BOM:	102281426(GALC)

BIU:	109565404(GALC)

BBUB:

102412612(GALC)

BBIS:

104987109(GALC)

CHX:	102188052(GALC)

OAS:	101118106(GALC)

BTAX:

128054215(GALC)

CSUM:

138073090(GALC)

ODA:	120853561(GALC)

CCAD:

122443933(GALC)

MREE:

136172503(GALC)

OVR:	110149025(GALC)

MBEZ:

129562635(GALC)

SSC:	100156917(GALC)

CFR:	102522511(GALC)

CBAI:

105079842(GALC)

CDK:	105105382(GALC)

VPC:	102528269(GALC)

BACU:

103010897(GALC)

BMUS:

118890514(GALC)

LVE:	103089768(GALC)

OOR:	101279086(GALC)

LALB:

132506417(GALC)

DLE:	111176185(GALC)

PCAD:

102981911(GALC) 102988804

PSIU:

116748922(GALC)

NASI:

112393867(GALC)

ECB:	100034130(GALC)

EPZ:	103551800(GALC)

EAI:	106834294(GALC)

MYB:	102257416(GALC)

MYD:	102765447(GALC)

MMYO:

118658903(GALC)

MLF:	102426787(GALC)

MDT:	132230799(GALC)

MYUM:

139010672(GALC)

PKL:	118714416(GALC)

EFUS:

103292221(GALC)

MNA:	107534864(GALC)

DRO:	112311819(GALC)

SHON:

118976730(GALC)

AJM:	119037921(GALC)

PDIC:

114492570(GALC)

PHAS:

123808797(GALC)

MMF:	118639330(GALC)

PPAM:

129065849(GALC)

HAI:	109382678(GALC)

RFQ:	117024189(GALC)

PALE:

102880991(GALC)

PGIG:

120619586(GALC)

PVP:	105290139(GALC)

RAY:	107499539(GALC)

MJV:	108396143(GALC)

TOD:	119239304(GALC)

SARA:

101543390(GALC)

SFUM:

130041448(GALC)

SETR:

126004154(GALC)

LAV:	100658478(GALC)

TMU:

101340632

ETF:	101640956(GALC)

DNM:	101417864(GALC)

MDO:	100019504(GALC) 100019541 100019605 100019857 100020089

GAS:	123235890 123237825 123237827(GALC)

SHR:	100915302(GALC)

AFZ:

127549431

PCW:	110217749(GALC)

TVP:	118829328(GALC)

PBRV:

138164488(GALC)

OAA:	100081052(GALC)

TACU:

119928194(GALC)

GGA:	423394(GALC)

PCOC:

116228932(GALC)

MGP:	100549468(GALC)

CJO:	107315242(GALC)

TPAI:

128085716(GALC)

LMUT:

125694813(GALC)

NMEL:

110401396(GALC)

APLA:

101796301(GALC)

ACYG:

106033531(GALC)

CATA:

118244374(GALC)

AFUL:

116489582(GALC)

TGU:	100224899(GALC)

LSR:	110476194(GALC)

SCAN:

103826899(GALC)

PMOA:

120503795(GALC)

OTC:	121334199(GALC)

PRUF:

121356045(GALC)

ATRC:

139589857(GALC)

GFR:	102034660(GALC)

FAB:	101810873(GALC)

OMA:	130254060(GALC)

PHI:	102113858(GALC)

PMAJ:

107205967(GALC)

CCAE:

111929558(GALC)

CCW:	104688651(GALC)

CBRC:

103612204(GALC)

ACOE:

138111752(GALC)

ETL:	114069327(GALC)

ZAB:	102060794(GALC)

ZLE:	135448259(GALC)

ACHL:

103811511(GALC)

SVG:	106849317(GALC)

MMEA:

130583493(GALC)

HRT:	120754585(GALC)

SATI:

136362954(GALC)

CCIC:

134044931(GALC)

FPG:	101914337(GALC)

FCH:	102059116(GALC)

CCRI:

104165255(GALC)

NNT:	104402632(GALC)

SHAB:

115606595(GALC)

ACUN:

113480749(GALC)

TALA:

104356982(GALC)

ACHC:

115333758(GALC)

HALD:

104315849(GALC)

HLE:	104841961(GALC)

AGEN:

126050552

HHAR:

128139867(GALC)

GCL:

127016657

CSTI:

104553566 104558092

LDI:	104348345(GALC)

MNB:	103775229(GALC)

DPUB:

104304132(GALC)

PPUS:

135179431(GALC)

AVIT:

104277260(GALC)

BRHI:

104493482(GALC)

EGZ:	104126309(GALC)

NNI:	104022246(GALC)

PCRI:

104033234(GALC)

PCAO:

104044006(GALC)

PADL:

103913072(GALC)

AFOR:

103900285(GALC)

FGA:	104081294(GALC)

GSTE:

104253899(GALC)

CLV:	102098299(GALC)

MUI:	104544022(GALC)

PGUU:

104467023(GALC)

PLET:

104622192(GALC)

EHS:	104503545(GALC)

CMAC:

104487213(GALC)

CUCA:

104059631(GALC)

TEO:	104373252(GALC)

BREG:

104633263(GALC)

OHA:	104331529(GALC)

ACAR:

104525364(GALC)

CPEA:

104394180(GALC)

CVF:	104286084(GALC)

RTD:	128909451(GALC)

CRID:

134514671(GALC)

AAM:	106483066(GALC)

AROW:

112972624(GALC)

NPD:	112955011(GALC)

TGT:	104577497(GALC)

DNE:	112990437(GALC)

SCAM:

104153813(GALC)

ASN:	102374264(GALC)

AMJ:	102575324(GALC)

CPOO:

109321658(GALC)

GGN:	109298550(GALC)

PSS:	102445851(GALC)

CMY:	102931374(GALC)

CCAY:

125637845(GALC)

DCC:	119857767(GALC)

CPIC:

101952897(GALC)

TST:	117876698(GALC)

CABI:

116821219(GALC)

MRV:	120403801(GALC)

ACS:	100564761(galc)

ASAO:

132763551(GALC)

PVT:	110090986(GALC)

SUND:

121916267(GALC)

PBI:	103054662(GALC)

PMUR:

107291164(GALC)

CTIG:

120303737(GALC)

TSR:	106555258(GALC)

PGUT:

117665890(GALC)

APRI:

131187826(GALC)

PTEX:

113438765(GALC)

NSS:	113419651(GALC)

VKO:	123026574(GALC)

PMUA:

114591297(GALC)

PRAF:

128408195(GALC)

ZVI:	118081269(GALC)

HCG:	128340490(GALC)

GJA:	107123345(GALC)

STOW:

125426760(GALC)

EMC:	129324552(GALC)

XLA:	446948(galc.L)

XTR:	779723(galc)

NPR:	108792556(GALC)

RTEM:

120920305(GALC)

BBUF:

120981714(GALC)

PWL:	138260037(GALC)

MUO:	115477291(GALC)

GSH:	117364141(GALC)

DRE:	406385(galcb) 449649(galca)

SRX:	107742352 107747942 107750876 107751776

SANH:

107668594 107671107 107678679

SGH:	107560205 107583495 107588298

CCAR:

109044880 109071112 109113493(galca)

CAUA:

113117428 113121250

CGIB:

127976364 127983797

PTET:

122325431(galca) 122361425(galcb)

LROH:

127179778(galcb) 127183022(galca)

OMC:	131523743(galcb) 131527443(galca)

PPRM:

120478828(galcb) 120493598(galca)

RKG:	130070582(galcb) 130096012(galca)

MAMB:

125268534(galcb) 125277795(galca)

CIDE:

127498815 127502066

CERY:

137006935(galcb) 137019312(galca)

MASI:

127415807 127454776

TROS:

130560691(galcb) 130565463(galca)

TDW:	130434468(galca) 130436866(galcb)

MANU:

129417933(galcb) 129429538(galca)

PDAB:

135727127 135733363 135750027(galca)

IPU:	108258153(galca) 108269778(galcb)

IFU:	128601207(galca) 128612376(galcb)

PHYP:

113532124 113534233

SMEO:

124377408(galca) 124390533(galcb)

TFD:	113648311(galca) 113651188(galcb)

TVC:	132843136(galca) 132852945(galcb)

CGAR:

128515394(galca) 128536347(galcb)

NGRA:

132883888(galca) 132894201(galcb)

TRN:	134319763(galca) 134325112(galcb)

AMEX:

103028593(galca) 103041717(galcb)

CMAO:

118815785(galca) 118823457(galcb)

EEE:	113570357 113579786

CHAR:

105899436 105908248(galcb)

SPIL:

134067818(galcb) 134098189

TRU:	101074089(galc)

TFS:	130540014(galcb)

TNG:	GSTEN00011741G001

LCO:	104928261(galc)

NCC:	104943827(galc)

TBEN:

117486328(galcb)

CGOB:

115027150(galc)

PGEO:

117443413

GACU:

117542828

EMAC:

134881232(galcb)

ELY:	117267361(galcb)

EFO:	125900948(galcb)

PLEP:

121954022(galcb)

SLUC:

116036754(galcb)

ECRA:

117935887(galcb)

ESP:	116670208(galc)

PFLV:

114546547(galc)

GAT:	120832973(galcb)

PPUG:

119227641(galcb)

AFB:	129103196(galcb)

CLUM:

117751495(galcb)

CANA:

137798602(galcb)

CVE:	137877743(galcb)

MSAM:

119909989(galcb)

SCHU:

122862361(galcb)

CUD:	121526643(galcb)

SPUL:

138591099(galcb)

LMIX:

132992999(galcb)

ALAT:

119004783(galcb)

ASTR:

137610489(galcb)

MZE:	101473828(galc)

ONL:	100707150 100707418

OAU:

116324212

OLA:	101163287(galc)

OML:	112142668(galcb)

CSAI:

133462221 133462731(galcb)

XMA:	102226991(galc)

XCO:	114134259(galc)

XHE:	116709385(galc)

PRET:

103458970(galc)

PFOR:

103138759(galc)

PLAI:

106959042(galc)

PMEI:

106926859(galc)

GAF:	122846419(galcb)

PPRL:

129365445(galcb)

CVG:	107095226(galc)

CTUL:

119787060(galcb)

GMU:	124855698(galcb)

NFU:	107373460 107374597

KMR:	108245031(galcb)

ALIM:

106519976(galc)

NWH:	119427773(galcb)

AOCE:

111574154(galcb)

EJA:	138212167(galcb)

BFRE:

138632335(galcb)

MCEP:

125023998(galcb)

CSEM:

103384287(galc)

POV:	109639554(galc)

SSEN:

122782634(galcb)

SSOE:

131444648(galcb)

HHIP:

117756559(galcb)

HSP:	118116615(galcb)

PPLT:

128450422(galcb)

SMAU:

118286205(galcb)

LCF:	108897907(galcb)

SDU:	111225520(galc)

SLAL:

111667257(galc)

XGL:	120795384(galcb)

HCQ:	109522741(galc)

SSCV:

125983232(galcb)

SBIA:

133514084(galcb)

PEE:	133415404(galcb)

PTAO:

133466060(galcb)

BPEC:

110165479(galc)

ENY:	140370728(galcb)

MALB:

109959716(galc)

BSPL:

114849022(galcb)

SJO:	128375109(galcb)

SSCO:

134000518(galcb)

GMH:	115543845(galc)

SASA:

100195231(galc)

STRU:

115172317(galc)

OTW:	112245106(galcb)

OMY:	110497649(galcb)

OGO:	124001517(galcb)

ONE:

115145972

OKI:	109894304(galc)

OKE:	118362775(galcb)

OMM:	135507949(galcb)

OCLA:

139375021

SALP:

111968475

SNH:	120060472(galcb)

CCLU:

121539552(galcb) 121544678

ELS:	105024731 105024733

OEP:	134026788(galcb)

SFM:	108924125(galc)

PKI:	111850944(galc)

AANG:

118230365

AROT:

135256995

CCOG:

133129519

LOC:	102684996(galc)

PSPA:

121330306

ARUT:

117421835(galcb)

PSEX:

120518493(galcb)

LCM:	102356089(GALC)

CMK:	103185410(galcb)

RTP:

109912864

CPLA:

122553421(galcb)

HOC:	132817983(galcb)

LERI:

129693404

PMRN:

116940702(GALC)

LRJ:	133343528(GALC)

BFO:	118425041 118425146

BBEL:

109474545 109474644

CIN:

100182893

SCLV:

120347149

SPU:	584869 584891

LPIC:

129273666

AJJ:

139967350

APLC:

110973820

ARUN:

117294593

AAMU:

139940624

AFIL:

140152424

AJC:

117102613

SKO:

100376265

PFLL:

139119972

CEL:	CELE_C29E4.10(C29E4.10)

CRQ:	GCK72_009178

HRO:	HELRODRAFT_157218 HELRODRAFT_85047 HELRODRAFT_98272

LGI:	LOTGIDRAFT_159095 LOTGIDRAFT_174010 LOTGIDRAFT_195251 LOTGIDRAFT_206940 LOTGIDRAFT_218637 LOTGIDRAFT_92651

PVUL:

126815104 126815111 126815295 126815298 126815850 126817284 126817286 126821389 130012121 130012280

PCAN:

112555422 112563838

LSAX:

138981568 138982239 138982243

BGT:	106050669 106050916 106060466 106063876

GAE:	121383276 121383458

HRF:	124116671 124116698 124116721 124116725 124116741 124116744 124116758 124116768 124117044 124117049 124117386 124117806 124118021 124118031 124131421

HRJ:	124258272 124258274 124258275 124258283 124258336 124258340 124258341 124258342 124258343 124258348 124258351 124258352 124258367 124258369 124258370 124258372 124258373 124267383 124280395

HASI:

137265283 137265284 137265285 137265286 137265287 137265289 137265290 137265291 137265292 137265293 137265294 137265403 137265404 137265518 137265776 137278187

HCRA:

139451788 139452371 139452497 139452756 139452769 139452770 139452771 139452772 139452773 139452775 139452776 139452777 139452778 139452779 139453114 139464854

CRG:	105334333 117689623 117689624

CANU:

128181438 128182289

CVN:

111133742

OED:

125666726

MYI:

110460487

PMAX:

117320602 117339236

AIRR:

138335048

MCAF:

127709336 127735822

MMER:

123546698 123546785

RPHI:

132713294 132726947 132728892 132732408

DPOL:

127841267 127841268 127842249 127842259 127857707 127859064 127859943 127860432

MAEA:

128211248 128211566 128211685

OBI:

106876977

OSN:

115219738

LJP:	135465433 135465584 135467113 135467114 135467526 135467538 135469384

LAK:	106155714 106166909 106168495

OVI:	T265_08669

LLON:

135489886

TAD:	TRIADDRAFT_28351

MBR:	MONBRDRAFT_480 MONBRDRAFT_566

SRE:	PTSG_00266

CFH:	C1707_15925

PBU:	L21SP3_00388 L21SP3_01812

PBP:	STSP1_01101 STSP1_02287

SCC:	Spico_0384

BSA:	Bacsa_1415

ARK:	D6B99_12110

AGI:	FSB73_03510

SPDR:

G6053_07245

MGK:	FSB76_22815

SZE:	AW14_13450

WFU:	AXE80_06115

LBH:

Lbuc_0208

LBN:	LBUCD034_0249

LPAR:

FAM21731_00775

LCU:	PL11_002695

LSUA:

H3M12_00940

LHB:	D1010_02565

RCH:

RUM_07020

RUS:	RBI_I00669

ESR:

ES1_17580

ESU:

EUS_13590

PRY:	Prubr_11070

THR:	TRQ7_09010

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Reference

1 [PMID:5320641]

Authors

Brady RO, Gal AE, Kanfer JN, Bradley RM.

Title

The metabolism of glucocerebrosides. 3. Purification and properties of a glucosyl- and galactosylceramide-cleaving enzyme from rat intestinal tissue.

Journal

J Biol Chem 240:3766-70 (1965)

Other DBs

ExplorEnz - The Enzyme Database:

3.2.1.46

IUBMB Enzyme Nomenclature:

3.2.1.46

ExPASy - ENZYME nomenclature database:

3.2.1.46

BRENDA, the Enzyme Database:

3.2.1.46

CAS:

9027-89-8

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