KEGG ENZYME: 3.2.1.48

ENZYME: 3.2.1.48

Entry

EC 3.2.1.48                 Enzyme

Name

sucrose alpha-glucosidase;
sucrose alpha-glucohydrolase;
sucrase;
sucrase-isomaltase;
sucrose.alpha.-glucohydrolase;
intestinal sucrase;
sucrase(invertase)

Class

Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

Sysname

sucrose-alpha-D-glucohydrolase

Reaction(IUBMB)

Hydrolysis of sucrose and maltose by an alpha-D-glucosidase-type action [RN:R00801 R06087]

Reaction(KEGG)

R00801 R06087(G) > R00802 R06088(G)

Comment

This enzyme is isolated from intestinal mucosa as a single polypeptide chain that also displays activity towards isomaltose (EC 3.2.1.10 oligo-1,6-glucosidase).

History

EC 3.2.1.48 created 1972

Pathway

ec00500

Starch and sucrose metabolism

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K01203

sucrase-isomaltase

Genes

HSA:

6476(SI)

PTR:	470988(SI)

PPS:	100973298(SI)

GGO:	101135022(SI)

PON:	100454405(SI)

PPYG:

129033434(SI)

NLE:	100585192(SI)

HMH:	116480289(SI)

SSYN:

134732951(SI)

MCC:	700840(SI)

MCF:	102128108(SI)

MTHB:

126947525

MNI:	105466450(SI)

CSAB:

103221316(SI)

CATY:

105586092(SI)

PANU:

101010666(SI)

TGE:	112618787(SI)

MLEU:

105535226(SI)

RRO:	104658581(SI)

RBB:	108540915(SI)

TFN:	117083676(SI)

PTEH:

111543532(SI)

CANG:

105513688(SI)

CJC:	100410281(SI)

SBQ:	101041197(SI)

CIMI:

108285818(SI)

ANAN:

105713612(SI)

CSYR:

103275008(SI)

MMUR:

105881524(SI)

LCAT:

123641648(SI)

OGA:	100959990(SI)

MMU:	69983(Sis)

MCAL:

110291317(Si)

MPAH:

110320350(Si)

RNO:	497756(Si)

MCOC:

116094065(Si)

ANU:	117707170(Si)

MUN:	110539420(Si)

CGE:	100773620(Si)

MAUA:

101823828(Si)

PROB:

127232655(Si)

PLEU:

114691704(Si)

MORG:

121452871(Si)

MFOT:

126504928

AAMP:

119826420(Si)

NGI:	103731721(Si)

HGL:	101711933(Si)

CPOC:

100731286(Si)

CCAN:

109679496(Si)

DORD:

105985553(Si)

DSP:	122107271(Si)

PLOP:

125351132(Si)

NCAR:

124993018

MMMA:

107149573(Si)

OCU:	100009093(SI)

OPI:	101520389(SI)

TUP:	102498900(SI)

GVR:	103597531(SI)

CFA:	488141(SI)

CLUD:

112645901(SI)

VVP:	112926645(SI)

VLG:	121477625(SI)

NPO:	129498671(SI)

AML:	100464408(SI)

UMR:	103664425(SI)

UAH:	113254160(SI)

UAR:	123801259(SI)

ELK:

111149399

LLV:

125099908

MPUF:

101676590(SI)

MNP:	132010108(SI)

MLK:	131824907(SI)

NVS:	122910467(SI)

ORO:	101381119(SI)

EJU:	114209109(SI)

ZCA:	113917271(SI)

MLX:	117999506(SI)

NSU:	110591708(SI)

LWW:	102741121(SI)

FCA:	100144605(SI)

PYU:	121033946(SI)

PCOO:

112849594(SI)

PBG:	122491769(SI)

PVIV:

125175012(SI)

LRUF:

124526713

PTG:	102964729(SI)

PPAD:

109262083(SI)

PUC:

125921182

AJU:

106987454

HHV:	120247215(SI)

BTA:	504366(SI)

BOM:	102268612(SI)

BIU:	109564411(SI)

BBUB:

102403856(SI)

BBIS:

104989290(SI)

CHX:	102187897(SI)

OAS:	101102774(SI)

BTAX:

128043833(SI)

CSUM:

138072862(SI)

ODA:	120869087(SI)

CCAD:

122444972(SI)

MREE:

136173261(SI)

MBEZ:

129551780(SI)

SSC:	100623884(SI)

CFR:	102523832(SI)

CBAI:

105066664(SI)

CDK:	105085981(SI)

VPC:	102527278(SI)

BACU:

103011824(SI)

BMUS:

118894529(SI)

LVE:	103080987(SI)

OOR:	101284967(SI)

DLE:	111174371(SI)

PCAD:

102981017(SI)

PSIU:

116753068(SI)

NASI:

112412120(SI)

ECB:	100063242(SI)

EPZ:	103566440(SI)

EAI:	106842405(SI)

MYB:	102254382(SI)

MYD:	102754902(SI)

MMYO:

118676712(SI)

MLF:	102435625(SI)

MDT:	132229150(SI)

PKL:	118723506(SI)

EFUS:

103286703(SI)

MNA:	107539283(SI)

DRO:	112304750(SI)

SHON:

118987514(SI)

AJM:	119046285(SI)

PDIC:

114490799(SI)

PHAS:

123827031(SI)

MMF:	118617283(SI)

PPAM:

129073206(SI)

RFQ:	117031133(SI)

PALE:

102885979(SI)

PGIG:

120598504(SI)

PVP:	105305949(SI)

RAY:	107519382(SI)

MJV:	108395638(SI)

TOD:	119258175(SI)

SARA:

101554601(SI)

LAV:	100666668(SI)

TMU:

101355803

ETF:	101654601(SI)

DNM:	101429055(SI)

MDO:	100013945(SI)

GAS:	123240281(SI)

SHR:	100932100(SI)

AFZ:

127552844

PCW:	110210220(SI)

TVP:	118847719(SI)

PBRV:

138157869(SI)

OAA:	100681776(SI)

BFO:

118427979

BBEL:

109466543 109485708

ARUN:

117298641

MNZ:

135205203

MRJ:

136855769

TSP:

Tsp_01057

PVUL:

126813344

HRF:

124112471

HRJ:

124261832

HASI:

137269844 137270388 137281576 137281577 137281578

CVN:

111099718

MYI:

110459523

PMAX:

117342860

AIRR:

138308261

LJP:

135479549

LLON:

135494988

TAD:	TRIADDRAFT_25103

» show all

Reference

1 [PMID:807575]

Authors

Conklin KA, Yamashiro KM, Gray GM.

Title

Human intestinal sucrase-isomaltase. Identification of free sucrase and isomaltase and cleavage of the hybrid into active distinct subunits.

Journal

J Biol Chem 250:5735-41 (1975)

Reference

2 [PMID:291933]

Authors

Hauri HP, Quaroni A, Isselbacher KJ.

Title

Biogenesis of intestinal plasma membrane: posttranslational route and cleavage of sucrase-isomaltase.

Journal

Proc Natl Acad Sci U S A 76:5183-6 (1979)
DOI:10.1073/pnas.76.10.5183

Reference

3 [PMID:5073761]

Authors

Kolinska J, Kraml J.

Title

Separation and characterization of sucrose-isomaltase and of glucoamylase of rat intestine.

Journal

Biochim Biophys Acta 284:235-47 (1972)
DOI:10.1016/0005-2744(72)90062-9

Reference

4 [PMID:1182172]

Authors

Sigrist H, Ronner P, Semenza G.

Title

A hydrophobic form of the small-intestinal sucrase-isomaltase complex.

Journal

Biochim Biophys Acta 406:433-46 (1975)
DOI:10.1016/0005-2736(75)90022-X

Reference

5 [PMID:7002920]

Authors

Sjostrom H, Noren O, Christiansen L, Wacker H, Semenza G.

Title

A fully active, two-active-site, single-chain sucrase.isomaltase from pig small intestine. Implications for the biosynthesis of a mammalian integral stalked membrane protein.

Journal

J Biol Chem 255:11332-8 (1980)

Reference

6 [PMID:5804876]

Authors

Takesue Y.

Title

Purification and properties of rabbit intestinal sucrase.

Journal

J Biochem (Tokyo) 65:545-52 (1969)
DOI:10.1093/oxfordjournals.jbchem.a129048

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