KEGG   ENZYME: 3.2.1.49
Entry
EC 3.2.1.49                 Enzyme                                 
Name
alpha-N-acetylgalactosaminidase;
alpha-acetylgalactosaminidase;
N-acetyl-alpha-D-galactosaminidase;
N-acetyl-alpha-galactosaminidase;
alpha-NAGAL;
alpha-NAGA;
alpha-GalNAcase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
Sysname
alpha-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase
Reaction(IUBMB)
Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids
Reaction(KEGG)
(other) R04183 R05966(G)
Comment
The human lysosomal enzyme is involved in the degradation of blood type A epitope.
History
EC 3.2.1.49 created 1972, modified 2011
Pathway
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec01100  Metabolic pathways
Orthology
K01204  alpha-N-acetylgalactosaminidase
Genes
HSA4668(NAGA)
PTR470279(NAGA)
PPS100991597(NAGA)
GGO101132690(NAGA)
PON100450338(NAGA)
NLE100605546(NAGA)
MCC713068(NAGA)
MCF102145379(NAGA)
CSAB103223407(NAGA)
CATY105572167(NAGA)
PANU101016466(NAGA)
TGE112633355(NAGA)
RRO104670530(NAGA)
RBB108543578(NAGA)
TFN117096393(NAGA)
PTEH111548936(NAGA)
CJC100397642(NAGA)
SBQ101052589(NAGA)
CSYR103264351(NAGA)
MMUR105858599(NAGA)
LCAT123640287(NAGA)
OGA100954557(NAGA)
MMU17939(Naga)
MCAL110310380(Naga)
MPAH110334850(Naga)
RNO315165(Naga)
MCOC116076661(Naga)
MUN110554096(Naga)
CGE100751670(Naga)
MAUA101840437(Naga)
PLEU114694320(Naga)
MORG121461193(Naga)
AAMP119823607(Naga)
NGI103743459(Naga)
HGL101726122(Naga)
CPOC100719787(Naga)
CCAN109689379(Naga)
DORD105992105(Naga)
DSP122123599(Naga)
NCAR124982310
OCU100350048(NAGA)
OPI101536106(NAGA)
TUP102490461(NAGA)
CFA481226(NAGA)
CLUD112666708(NAGA)
VVP112934013(NAGA)
VLG121492200(NAGA)
AML100471467(NAGA)
UMR103674070(NAGA)
UAH113241706(NAGA)
UAR123780544(NAGA)
ELK111157598
LLV125106372
MPUF101673551(NAGA)
ORO101381151(NAGA)
EJU114218390(NAGA)
ZCA113922578(NAGA)
MLX117998614(NAGA)
FCA101083277(NAGA)
PYU121040244(NAGA)
PBG122472839(NAGA)
PTG102963636(NAGA)
PPAD109265652(NAGA)
AJU106979923(NAGA)
HHV120235028(NAGA)
BTA533357(NAGA)
BOM102280167(NAGA)
BIU109559874(NAGA)
BBUB102404704(NAGA)
CHX102170679(NAGA)
OAS100145858(NAGA)
ODA120857579(NAGA)
CCAD122423544(NAGA)
SSC100142667(NAGA)
CFR102511662(NAGA)
CBAI105073060(NAGA)
CDK105091882(NAGA)
VPC102541563(NAGA)
BACU103005673(NAGA)
LVE103072389(NAGA)
OOR101272207(NAGA)
DLE111186345(NAGA)
PCAD102973583(NAGA)
PSIU116760277(NAGA)
ECB100070793(NAGA)
EPZ103541990(NAGA)
EAI106848492(NAGA)
MYB102258282(NAGA)
MYD102754122(NAGA)
MMYO118651848(NAGA)
MLF102422016(NAGA)
MNA107534967(NAGA)
PKL118712063(NAGA)
HAI109371486(NAGA)
DRO112321929(NAGA)
SHON119002460(NAGA)
AJM119060491(NAGA)
PDIC114513182(NAGA)
PHAS123816241(NAGA)
MMF118624061(NAGA)
RFQ117028886(NAGA)
PALE102887437(NAGA)
PVP105298028(NAGA)
RAY107505567(NAGA)
MJV108387109(NAGA)
TOD119247191(NAGA)
SARA101552815(NAGA)
LAV100657188(NAGA)
TMU101340834
DNM101412227(NAGA)
MDO100018362(NAGA)
GAS123248507(NAGA)
SHR100925898(NAGA)
PCW110205858(NAGA)
OAA100086854(NAGA)
GGA396547(NAGA)
PCOC116233406(NAGA)
MGP100548783(NAGA)
CJO107313216(NAGA)
NMEL110391010(NAGA)
APLA101792497(NAGA)
ACYG106045224(NAGA)
AFUL116501933(NAGA)
TGU100229129(NAGA)
LSR110483094(NAGA)
SCAN103813308(NAGA)
PMOA120510061(NAGA)
OTC121342303(NAGA)
PRUF121361071(NAGA)
GFR102040040(NAGA)
FAB101821644(NAGA)
PHI102103812(NAGA)
PMAJ107204588(NAGA)
CCAE111934375(NAGA)
CCW104696358(NAGA)
CBRC103618258(NAGA)
ETL114058038(NAGA)
ZAB102070897(NAGA)
FPG101922362(NAGA)
FCH102047533(NAGA)
CLV102085181
EGZ104134264(NAGA)
NNI104021651(NAGA)
PLET104621952(NAGA)
PCRI104030655(NAGA)
ACUN113491563(NAGA)
TALA104366462(NAGA)
PADL103915835(NAGA)
ACHC115352699(NAGA)
HALD104323585(NAGA)
CCRI104162967(NAGA)
CSTI104560837(NAGA)
EHS104514134(NAGA)
CMAC104483227(NAGA)
FGA104078318(NAGA)
GSTE104255667(NAGA)
LDI104352511(NAGA)
MNB103774977(NAGA)
OHA104329835(NAGA)
AAM106488675(NAGA)
AROW112967690(NAGA)
NPD112946458(NAGA)
DNE112984590(NAGA)
ASN102387946(NAGA)
AMJ102561061(NAGA)
CPOO109316752(NAGA)
GGN109295927(NAGA)
PSS102457826 102463470(NAGA)
CMY102938681 102948025(NAGA)
CPIC101940500 101949244(NAGA)
TST117879763(NAGA) 117884012
CABI116824402 116828655(NAGA)
MRV120372978 120388241(NAGA)
ACS100558544(naga) 100561397
PVT110076094(NAGA) 110087036
SUND121914721 121930837(NAGA)
PBI103050555(NAGA) 103062412
PMUR107284005 107285348(NAGA)
TSR106537803(NAGA) 106551524
PGUT117655846(NAGA) 117679480
VKO123024956 123036014(NAGA)
PMUA114584858 114605424(NAGA)
ZVI118090684(NAGA) 118092720
GJA107109285 107124086(NAGA)
STOW125431786 125434385(NAGA)
XLA443592(naga.S) 443753(naga.L)
XTR779501(naga)
NPR108791730(NAGA)
RTEM120943521(NAGA)
BBUF121007375(NAGA)
BGAR122945688(NAGA)
DRE560778(naga)
SRX107758144(naga)
SANH107669032(naga)
SGH107572590 107577412
CCAR109044975(naga) 109044979
CAUA113048520 113048521 113064738
PPRM120471042(naga)
MAMB125245754(naga)
IPU108279976(naga)
PHYP113532108(naga)
SMEO124401815(naga)
TFD113645809(naga)
AMEX103026015 103035758
EEE113578116(naga)
TRU101073468(naga)
TNGGSTEN00012743G001
LCO104925622 104939011
NCC104944830 104959892
CGOB115004066 115021387
ELY117266424 117271065
EFO125892867 125896852
PLEP121946152 121955894
SLUC116064585 116066291
ECRA117946601 117961153
PFLV114557187 114572938
GAT120808355 120810359
PPUG119194579 119197929
MSAM119887973 119898153 119909038
CUD121521601(naga)
ALAT119005321 119012882
MZE101471811 105940732
ONL100703787(naga)
OAU116309574(naga)
OLA101155483(naga)
OML112158553(naga)
XMA102234608(naga)
XCO114159062(naga)
XHE116734632(naga)
PRET103457699(naga)
PFOR103144121(naga)
PLAI106957335(naga)
PMEI106920818(naga)
GAF122825137(naga)
CVG107094481(naga)
CTUL119777585(naga)
GMU124882107(naga)
NFU107378045(naga)
KMR108247662(naga)
ALIM106520049(naga)
NWH119418143(naga)
AOCE111578929(naga)
MCEP124999552(naga)
CSEM103380792 103388750
POV109632473(naga)
SSEN122775154 122783991(naga)
HHIP117758879(naga)
HSP118099815(naga)
LCF108886088 108896867
SDU111227730 111239406
SLAL111664120 111672770
XGL120784719 120789171 120789172
HCQ109523497(naga)
BPEC110159082 110170156
MALB109973040 109973819
BSPL114850166(naga)
SASA100195244(nagab) 106605016(NAGAB)
OTW112223180 112250394
OMY110490166 110529695
OGO123991645 123997615
ONE115107842 115141424
SALP111954345 111965311
SNH120024125 120047526
CCLU121542471 121552400 121585419
ELS105017628
SFM108929235(naga)
PKI111851557(naga)
AANG118220561 118230805
LOC102689279(naga)
PSPA121300536 121306145(naga) 121330809
ARUT117418220(naga)
LCM102361487 102366389
RTP109912737(naga) 109918425
BFO118419659
BBEL109470720
CIN100182270
SCLV120335584 120335840 120335841 120336669 120336670 120336671
SPU581755 587840
APLC110979801 110983724 110983725 110983726
SKO100372870 100373018 100374673
DMEDmel_CG5731(CG5731)
DER6543326
DSE6611926
DSIDsimw501_GD22296(Dsim_GD22296)
DYADyak_GE26351
DAN6496959
DSR110183385
DPO6903316
DPE6589878
DMN108164177
DGR6567052
DMODmoj_GI17617
DAZ108610423
DNV115563046
DHE111603988
DVI6634139
MDE101901723
HIS119660415
AGAAgaP_AGAP009621
ACOZ120960109
AARA120900627
ASTE118511646
AAG5566514
AALB109409620 109413741
CQUCpipJ_CPIJ005600
CPII120416306
CNS116340507
BCOO119075334
AME725899
ACER107998803
ALAB122715262
BIM100749267
BBIF117207441
BVK117241661
BVAN117158270
BTER100650051
BPYO122573707
CCAL108629032
OBB114877136
MGEN117220488 117228319
NMEA116424449
CGIG122395648
SOC105208200 105208212
MPHA105839861
AEC105145873
ACEP105618932
PBAR105432733
VEM105562785
HST105189481
DQU106748903
CFO105249395
FEX115236284
LHU105673165
PGC109855212
OBO105274738
PCF106786516
PFUC122520278
VPS122635643
NVI100117222
CSOL105365441
TPRE106653074
MDL103570227
CGLO123262809
FAS105263599
DAM107042922
AGIF122854841
LHT122498484
CCIN107271861
TCA662163 663249
DPA109533489
SOY115880959
ATD109601137
CSET123309972
AGB108903557
LDC111518252
NVL108564677
APLN108736374
PPYR116168065
OTU111416168
BMOR101736031
BMAN114246283
MSEX115446055
DPLKGM_213240
BANY112054114
PMAC106720851
PPOT106111620
PXU106120756
PRAP110997336
ZCE119837506
HAW110376691
HZE124635683 124638130 124638131 124642282
TNL113499879
SLIU111354373
OFU114351665
PXY105382303 105386672
API100159965 100161159 100161679 100163871
DNX107166489 107170563 107171670
AGS114129775
RMD113550417 113555041
BTAB109031143
DCI103524481
CLEC106667230
HHAL106686038
NLU111052906 111059935
PHUPhum_PHUM061380 Phum_PHUM476700 Phum_PHUM476710
FOC113209723
TPAL117644394
ZNE110833336
CSEC111868046
FCD110857972
DPXDAPPUDRAFT_309394 DAPPUDRAFT_309434
DMK116924432 116931840
PVM113810366 113821065
PJA122251463 122266112
PCHN125044678 125044716
HAME121859550 121870400
PCLA123745643 123757610
PTRU123500089 123513846
HAZT108666989 108666993
EAF111696100 111702601
LSM121117202 121132043
PPOI119090892 119090896 119092962
ISCIscW_ISCW017346 IscW_ISCW018185 IscW_ISCW018187
DSV119448283 119449552 119449553 119449557 119449859
RSAN119382560 119382561 119382562 119382563 119382759
RMP119170107 119179705 119179714 119179725 119179740
VDE111244156
VJA111266613
TUT107359742 107371157
DPTE113795622
DFR124499487
CSCU111637616 111637617 111639968
PTEP107442827 107454496 107457045
SDM118184115 118192968 118202592
CELCELE_R07B7.11(gana-1)
CBRCBG_23373(Cbr-gana-1)
BMYBM_BM5269(Bma-gana-1)
LOALOAG_00060
NAINECAME_03019
TSPTsp_02508 Tsp_02909
HROHELRODRAFT_111560 HELRODRAFT_182706
LGILOTGIDRAFT_158234 LOTGIDRAFT_178842 LOTGIDRAFT_209340 LOTGIDRAFT_235899
PCAN112559739 112560249 112560712 112560713 112560714 112560715
BGT106057326 106057369 106057370
GAE121374342 121374920 121376283 121376303
HRF124119945 124119947 124129756 124129757 124139615 124139680 124143661 124148129 124148132 124148942 124148995 124148997 124148998 124148999
HRJ124256424 124256433 124256435 124256437 124256447 124256448 124256450 124280221 124283107 124283108 124283138
CRG105326821 105331657 105339434
MYI110454106 110459235 110465170
PMAX117328990 117329669
MMER123556288 123556509 123556588 123557012 123557021 123557150 123557964
OBI106872822
OSN115213936
LAK106173465 106177951
SMMSmp_170830 Smp_179260
NVE116608331 5498815 5501245 5508946 5513905
EPA110243080 110243193
ATEN116299918 116299920 116299921
ADF107330554 107331315 107334325 107334332
AMIL114958680 114958713 114968339 114968344
PDAM113672638 113672725 113681613 113681615
SPIS111321754 111340747 111340767
DGT114529372
XEN124453811
HMG100204126
TADTRIADDRAFT_23253
AQU100636085
DDIDDB_G0291524
DPPDICPUDRAFT_58841
DFADFA_08734
ACANACA1_257940
TETTTHERM_00136050
SMINv1.2.010510.t1(symbB.v1.2.010510.t1)
EHXEMIHUDRAFT_205415 EMIHUDRAFT_460708
 » show all
Reference
1  [PMID:9741689]
  Authors
Asfaw B, Schindler D, Ledvinova J, Cerny B, Smid F, Conzelmann E
  Title
Degradation of blood group A glycolipid A-6-2 by normal and mutant human skin fibroblasts.
  Journal
J Lipid Res 39:1768-80 (1998)
  Sequence
[hsa:4668]
Reference
2  [PMID:8954893]
  Authors
Zhu A, Monahan C, Wang ZK, Goldstein J
  Title
Expression, purification, and characterization of recombinant alpha-N-acetylgalactosaminidase produced in the yeast Pichia pastoris.
  Journal
Protein Expr Purif 8:456-62 (1996)
DOI:10.1006/prep.1996.0124
Reference
3  [PMID:19683538]
  Authors
Clark NE, Garman SC
  Title
The 1.9 a structure of human alpha-N-acetylgalactosaminidase: The molecular basis of Schindler and Kanzaki diseases.
  Journal
J Mol Biol 393:435-47 (2009)
DOI:10.1016/j.jmb.2009.08.021
  Sequence
[hsa:4668]
Reference
4  [PMID:9065462]
  Authors
Hoskins LC, Boulding ET, Larson G
  Title
Purification and characterization of blood group A-degrading isoforms of alpha-N-acetylgalactosaminidase from Ruminococcus torques strain IX-70.
  Journal
J Biol Chem 272:7932-9 (1997)
DOI:10.1074/jbc.272.12.7932
Reference
5  [PMID:20139603]
  Authors
Harun-Or-Rashid M, Matsuzawa T, Satoh Y, Shiraishi T, Ando M, Sadik G, Uda Y
  Title
Purification and characterization of alpha-N-acetylgalactosaminidases I and II from the starfish Asterina amurensis.
  Journal
Biosci Biotechnol Biochem 74:256-61 (2010)
DOI:10.1271/bbb.90178
Reference
6  [PMID:18443780]
  Authors
Weignerova L, Filipi T, Manglova D, Kren V
  Title
Induction, purification and characterization of alpha-N-acetylgalactosaminidase from Aspergillus Niger.
  Journal
Appl Microbiol Biotechnol 79:769-74 (2008)
DOI:10.1007/s00253-008-1485-3
Reference
7  [PMID:11368317]
  Authors
Ashida H, Tamaki H, Fujimoto T, Yamamoto K, Kumagai H
  Title
Molecular cloning of cDNA encoding alpha-N-acetylgalactosaminidase from Acremonium sp. and its expression in yeast.
  Journal
Arch Biochem Biophys 384:305-10 (2000)
DOI:10.1006/abbi.2000.2114
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.49
IUBMB Enzyme Nomenclature: 3.2.1.49
ExPASy - ENZYME nomenclature database: 3.2.1.49
BRENDA, the Enzyme Database: 3.2.1.49
CAS: 9075-63-2

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