KEGG   ENZYME: 3.2.2.14
Entry
EC 3.2.2.14                 Enzyme                                 
Name
NMN nucleosidase;
NMNase;
nicotinamide mononucleotide nucleosidase;
nicotinamide mononucleotidase;
NMN glycohydrolase;
NMNGhase
Class
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
Sysname
nicotinamide-nucleotide phosphoribohydrolase
Reaction(IUBMB)
beta-nicotinamide D-ribonucleotide + H2O = D-ribose 5-phosphate + nicotinamide [RN:R01270]
Reaction(KEGG)
R01270
Substrate
beta-nicotinamide D-ribonucleotide [CPD:C00455];
H2O [CPD:C00001]
Product
D-ribose 5-phosphate [CPD:C00117];
nicotinamide [CPD:C00153]
Comment
The enzyme is thought to participate in an NAD+-salvage pathway. In eukaryotic organisms this activity has been attributed to EC 3.2.2.6, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
History
EC 3.2.2.14 created 1976, modified 2018
Pathway
ec00760  Nicotinate and nicotinamide metabolism
Reference
1  [PMID:4342726]
  Authors
Andreoli AJ, Okita TW, Bloom R, Grover TA.
  Title
The pyridine nucleotide cycle: presence of a nicotinamide mononucleotide-specific glycohydrolase in Escherichia coli.
  Journal
Biochem Biophys Res Commun 49:264-9 (1972)
DOI:10.1016/0006-291X(72)90039-3
Reference
2  [PMID:457634]
  Authors
Imai T
  Title
Isolation and properties of a glycohydrolase specific for nicotinamide mononucleotide from Azotobacter vinelandii.
  Journal
J Biochem 85:887-99 (1979)
DOI:10.1093/oxfordjournals.jbchem.a132420
Reference
3  [PMID:3571198]
  Authors
Imai T
  Title
Properties of allosteric nicotinamide mononucleotide glycohydrolase from Azotobacter vinelandii: activation and inhibition.
  Journal
J Biochem 101:163-73 (1987)
DOI:10.1093/oxfordjournals.jbchem.a121887
Other DBs
ExplorEnz - The Enzyme Database: 3.2.2.14
IUBMB Enzyme Nomenclature: 3.2.2.14
ExPASy - ENZYME nomenclature database: 3.2.2.14
BRENDA, the Enzyme Database: 3.2.2.14
CAS: 37237-49-3

  All links  
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Protein sequence (1)   
   UniProt (1)   
DNA sequence (4)   
   GenBank (3)   
   EMBL (1)   
All databases (14)   

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