KEGG ENZYME: 3.2.2.16

ENZYME: 3.2.2.16

Entry

EC 3.2.2.16                 Enzyme

Name

methylthioadenosine nucleosidase;
5'-methylthioadenosine nucleosidase;
MTA nucleosidase;
MeSAdo nucleosidase;
methylthioadenosine methylthioribohydrolase;
MTN1 (gene name)

Class

Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds

Sysname

S-methyl-5'-thioadenosine adeninehyrolase

Reaction(IUBMB)

S-methyl-5'-thioadenosine + H2O = 5-(methylsulfanyl)-D-ribose + adenine [RN:R01401]

Reaction(KEGG)

R01401

Substrate

S-methyl-5'-thioadenosine [CPD:C00170];
H2O [CPD:C00001]

Product

5-(methylsulfanyl)-D-ribose [CPD:C03089];
adenine [CPD:C00147]

Comment

Unlike EC 3.2.2.9, adenosylhomocysteine nucleosidase, this plant enzyme has little or no activity with S-adenosyl-L-homocysteine.

History

EC 3.2.2.16 created 1983, modified 2004

Pathway

ec00270

Cysteine and methionine metabolism

ec01100

Metabolic pathways

Orthology

K01244

5'-methylthioadenosine nucleosidase

Genes

ATH:	AT4G34840 AT4G38800(MTN1)

ALY:	9302889 9305194

CRB:	17879840 17880545

CSAT:

104716161 104720792 104729184 104729734

EUS:	EUTSA_v10025990mg EUTSA_v10026821mg

BRP:	103834385 103835162

BNA:	106357695 106361013 106361473 106410453 106421765

BOE:	106329576 106336199

RSZ:	108822950 108823051 130498902 130499137 130506257

THJ:	104807783 104819635

CPAP:

110816481

CIT:

102629213

PVY:

116143735

MINC:

123212693

TCC:

18607620

GRA:

105795383

GHI:	107908676 107927941

GAB:

108474555

HSYR:

120175602 120184817 120214791

DZI:	111297586 111308777

EGR:	104453395 104453397 104455508

GMX:	100779419 100800253 100809191

GSJ:	114408268 114408416 114414438 114414439

PVU:	PHAVU_009G000600g PHAVU_009G0007001

VRA:

106759877

VAR:	108330532 108330689

VUN:	114196149 114196248

VUM:	124837300 124837308

CCAJ:

109801994 109801996

APRC:

113864404

MTR:

11418454

TPRA:

123899330

CAM:

101501070

PSAT:

127079839

VVO:

131660462

LJA:

130729091

ADU:

107460479

AIP:

107605910

AHF:	112705915 112764535

LANG:

109326550

PCIN:

129287075

QSA:	O6P43_002076 O6P43_011507

FVE:

101300865

RCN:

112174805

PPER:

18767211 18767338

PMUM:

103334978 103334979

PAVI:

110757212 110757213 110757220

PDUL:

117636434 117636436

MDM:

114827619

MSYL:

126585735

PXB:	103930328 103942490 103958479

ZJU:

125424362

MNT:

21386772

CSAV:

115704327

CSV:

101204791

CMO:

103490311

BHJ:

120078625

MCHA:

111008032

CMAX:

111468484 111486247

CMOS:

111435267 111455148

CPEP:

111792501 111811193

RCU:

8285153

MEAN:

126683296

JCU:

105643791

HBR:	110633970 110668972

MESC:

110613712

POP:	7463974 7477858

PEU:	105134509 105141382

PALZ:

118038300 118040528 118058772

JRE:	108986981 109006565

CILL:

122313164

CAVE:

132164507

QSU:

112008433

QLO:

115967314

TWL:	119991715 120002419

VVI:	100233110(GRIP58)

VRI:

117911481

SLY:

101256428

SPEN:

107008065

SOT:

102581476

SSTN:

125852225

SDUL:

129885358

CANN:

107840524 124887257

LBB:

132599280

NTA:	107771706 107803169

NSY:

104245452

NTO:

104112984

NAU:

109217211

INI:	109154012 109165147

ITR:	115999016 116032600

SIND:

105169720 105172944

OEU:	111388561 111410104

EGT:

105959747

SSPL:

121762291 121765485

SMIL:

131001013

SHIS:

125222684

APAN:

127252587

HAN:

110885112

ECAD:

122581794 122598189

LSV:	111884303 111886116

CCAV:

112520373 112523486 112527412

DCR:	108200450 108204741

CSIN:

114299229

RVL:	131308022 131308023 131308027 131325098

AEW:	130774650 130779917 130780552

BVG:

104903996

SOE:

110786505

CQI:	110718597 110739875

ATRI:

130803397

MOF:

131155364

NNU:

104605304

MING:

122073332 122073333 122083366

TSS:	122660292 122661914

PSOM:

113286047 113288860 113290211 113330136

OSA:

4339898

OBR:

102702761

OGL:

127776663

BDI:

100839737

ATS:	109764083 109770233

TDC:	119282035 119288195 119318699 119329303

TAES:

123066270 123075326 123088407 123106100 123150583 123165959

TUA:

125521374

LPER:

127311624

LRD:	124684921 124684947

SBI:

8060610

ZMA:	100193148 100286299

MFLO:

136472900 136501433

SITA:

101781591

SVS:

117852624

PVIR:

120669956 120702363

PHAI:

112888968

PDA:	103716367 103722735

EGU:	105033910 105061156

MUS:

103973409

ZOF:	122009319 122016354

DCT:

110116757

PEQ:

110031405

AOF:

109819449

MSIN:

131237349

NCOL:

116246876

ATR:	18427002 18428323

SMO:	SELMODRAFT_268876 SELMODRAFT_98535

PPP:	112277775 112278323 112291955

CRE:	CHLRE_03g162550v5

VCN:	VOLCADRAFT_109917

MNG:	MNEG_14105

CSL:	COCSUDRAFT_19401

CVR:	CHLNCDRAFT_26505

APRO:

F751_3141

OLU:	OSTLU_26221

OTA:	OT_ostta10g02660

BPG:	Bathy11g02740

MIS:	MICPUN_59971

MPP:	MICPUCDRAFT_46284

PTI:	PHATRDRAFT_14626

FCY:	FRACYDRAFT_211031

TPS:	THAPSDRAFT_36459

AAF:	AURANDRAFT_36652

PAGR:

E2H98_13720

MAGA:

Mag101_12680

HAX:	BALOs_2115

COPR:

Cop2CBH44_30260

ASX:	CDL62_13135

» show all

Reference

1 [PMID:6783408]

Authors

Guranowski AB, Chiang PK, Cantoni GL.

Title

5'-Methylthioadenosine nucleosidase. Purification and characterization of the enzyme from Lupinus luteus seeds.

Journal

Eur J Biochem 114:293-9 (1981)
DOI:10.1111/j.1432-1033.1981.tb05148.x

Reference

2 [PMID:17339651]

Authors

Rzewuski G, Cornell KA, Rooney L, Burstenbinder K, Wirtz M, Hell R, Sauter M

Title

OsMTN encodes a 5'-methylthioadenosine nucleosidase that is up-regulated during submergence-induced ethylene synthesis in rice (Oryza sativa L.).

Journal

J Exp Bot 58:1505-14 (2007)
DOI:10.1093/jxb/erm014

Reference

3 [PMID:18342331]

Authors

Siu KK, Lee JE, Sufrin JR, Moffatt BA, McMillan M, Cornell KA, Isom C, Howell PL

Title

Molecular determinants of substrate specificity in plant 5'-methylthioadenosine nucleosidases.

Journal

J Mol Biol 378:112-28 (2008)
DOI:10.1016/j.jmb.2008.01.088

Reference

4 [PMID:19249293]

Authors

Park EY, Choi WS, Oh SI, Kim KN, Shin JS, Song HK

Title

Biochemical and structural characterization of 5'-methylthioadenosine nucleosidases from Arabidopsis thaliana.

Journal

Biochem Biophys Res Commun 381:619-24 (2009)
DOI:10.1016/j.bbrc.2009.02.106

Other DBs

ExplorEnz - The Enzyme Database:

3.2.2.16

IUBMB Enzyme Nomenclature:

3.2.2.16

ExPASy - ENZYME nomenclature database:

3.2.2.16

BRENDA, the Enzyme Database:

3.2.2.16

CAS:	50812-28-7

DBGET integrated database retrieval system