| Entry |
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| Name |
[protein ADP-ribosylarginine] hydrolase;
ADP-ribose-L-arginine cleavage enzyme;
ADP-ribosylarginine hydrolase;
Nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase;
protein-omega-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase
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| Class |
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
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| Sysname |
protein-Nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase
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| Reaction(IUBMB) |
(1) protein-Nomega-(ADP-D-ribosyl)-L-arginine + H2O = ADP-D-ribose + protein-L-arginine [RN: R07626];
(2) Nomega-(ADP-D-ribosyl)-L-arginine + H2O = ADP-D-ribose + L-arginine [RN: R01886]
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| Reaction(KEGG) |
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| Substrate |
protein-Nomega-(ADP-D-ribosyl)-L-arginine [CPD: C16011];
H2O [CPD: C00001];
Nomega-(ADP-D-ribosyl)-L-arginine [CPD: C01201]
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| Product |
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| Comment |
The enzyme will remove ADP-D-ribose from arginine residues in ADP-ribosylated proteins.
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| History |
EC 3.2.2.19 created 1989, modified 2004
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| Orthology |
| K01245 | ADP-ribosylarginine hydrolase |
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| Genes |
| PCOC: | 116238875 116242110(ADPRH) |
| MGP: | 100540673(ADPRH) 104916026 |
| CJO: | 107322016(ADPRH) 107325783 |
| LMUT: | 125685508 125685783(ADPRH) |
| NMEL: | 110401341(ADPRH) 110402643 |
| APLA: | 101795135(ADPRH) 119714812 |
| ACYG: | 106039946(ADPRH) 136787780 |
| CATA: | 118244909(ADPRH) 118261313 118261315 118261317 |
| AFUL: | 116501476(ADPRH) 116501650 |
| TGU: | 100225609 100226233(ADPRH) |
| LSR: | 110474901 110476539(ADPRH) |
| SCAN: | 103818418(ADPRH) 103819895 |
| PMOA: | 120504029(ADPRH) 120505586 |
| OTC: | 121344704(ADPRH) 121348155 |
| PRUF: | 121349252 121360411(ADPRH) |
| FAB: | 101806150(ADPRH) 101808754 |
| OMA: | 130256553(ADPRH) 130260493 |
| PHI: | 102101461(ADPRH) 102112496 |
| PMAJ: | 107209760(ADPRH) 107212272 |
| CCAE: | 111937223 111941677(ADPRH) |
| CCW: | 104689397(ADPRH) 104695645 |
| CBRC: | 103613724(ADPRH) 103621695 |
| ETL: | 114059619(ADPRH) 114065648 |
| ZLE: | 135454877(ADPRH) 135455489 |
| SVG: | 106856988(ADPRH) 106858395 |
| MMEA: | 130578175 130588905(ADPRH) |
| HRT: | 120748433(ADPRH) 120760993 |
| SATI: | 136369170 136375384(ADPRH) |
| TALA: | 104364187(ADPRH) 116962294 |
| ACHC: | 115337800 115343780(ADPRH) |
| HLE: | 104831586(ADPRH) 104835803 |
| AGEN: | 126034964 126048945 |
| CSTI: | 104559003(ADPRH) 104560117 |
| NNI: | 104014985(ADPRH) 104023367 |
| PADL: | 103916851(ADPRH) 103925986 |
| AFOR: | 103894075 103894983(ADPRH) |
| CLV: | 102084426 102087478(ADPRH) |
| CUCA: | 104054854 104055985(ADPRH) |
| BREG: | 104635267(ADPRH) 104635367 |
| ACAR: | 104529867 104531015(ADPRH) |
| RTD: | 128901543 128903438 128904158(ADPRH) |
| AMJ: | 102562154(ADPRH) 102567119 |
| CMY: | 102934922(ADPRH) 119566298 |
| CCAY: | 125637966 125644811(ADPRH) |
| DCC: | 119856952(ADPRH) 119857896 |
| CPIC: | 101931729(ADPRH) 101936712 |
| MRV: | 120394810(ADPRH) 120404512 |
| ACS: | 100563208(adprh) 100565391 |
| ASAO: | 132771955(ADPRH) 132777968 |
| PVT: | 110078575 110088473(ADPRH) |
| SUND: | 121926624(ADPRH) 121935601 |
| PBI: | 103049757(ADPRH) 103050993 |
| PMUR: | 107282553 107289021(ADPRH) |
| CTIG: | 120303882(ADPRH) 120304568 |
| TSR: | 106557080 106557382(ADPRH) |
| PGUT: | 117663793(ADPRH) 117669151 |
| APRI: | 131198605 131200282(ADPRH) |
| PTEX: | 113436334(ADPRH) 113443700 |
| NSS: | 113409822(ADPRH) 113418573 |
| VKO: | 123029470(ADPRH) 123032210 |
| PMUA: | 114582790 114595963(ADPRH) |
| PRAF: | 128400974 128412895(ADPRH) |
| ZVI: | 118085653(ADPRH) 118095262 |
| HCG: | 128331547 128350761(ADPRH) |
| GJA: | 107117555(ADPRH) 107122687 |
| STOW: | 125430542(ADPRH) 125445296 |
| EMC: | 129325432(ADPRH) 129338674 |
| XLA: | 108704185 432184(adprh.L) 447554(adprh.S) 495095(adprh) |
| XTR: | 100135190(adprh) 493544(adprh) |
| NPR: | 108784947 108784953 108789187 |
| RTEM: | 120943082 120943841(ADPRH) |
| BBUF: | 121007570 121007979(ADPRH) |
| BGAR: | 122944489 122945050(ADPRH) |
| MUO: | 115473919(ADPRH) 115474170 |
| GSH: | 117360968(ADPRH) 117361301 |
| PTET: | 122355059 122355417 |
| LROH: | 127173935 127173936(adprh) |
| MASI: | 127421955 127427134 |
| IPU: | 100528393(adprh) 108274007 |
| PHYP: | 113547472 113547477 |
| SMEO: | 124388883 124388884 |
| AMEX: | 103037544(adprh) 111192396 |
| CMAO: | 118809711 118809712 118809713 |
| CHAR: | 105894051(adprh) 105900953 |
| TNG: | GSTEN00035061G001 GSTEN00035062G001 |
| PGEO: | 117445003 117464680(adprh) |
| CSAI: | 133419079 133419803(adprh) |
| PRET: | 103481379 103481399 |
| PFOR: | 103152333 103152348 |
| PLAI: | 106934950 106956260 |
| PMEI: | 106904148(adprh) 106924693 |
| GAF: | 122823533(adprh) 122823567 |
| PPRL: | 129377840(adprh) 129377866 |
| CTUL: | 119777812(adprh) 119796759 |
| GMU: | 124874862(adprh) 124875567 |
| KMR: | 108249548 108249559(adprh) |
| ALIM: | 106521401 106535168 |
| AOCE: | 111568801 111574344 |
| BPEC: | 110170987 110171022 |
| SASA: | 100194575(adprh) 106579059 106586332(adprh) |
| STRU: | 115160839 115160840 115162372 |
| OTW: | 112223322(adprh) 112237465 112237501 |
| OMY: | 110492864(adprh) 110520181 110520182 |
| ONE: | 115109915 115109924(adprh) |
| SNH: | 120045812(adprh) 120058290 120058293 |
| CCLU: | 121536716 121536718 121572470(adprh) |
| SFM: | 108930637(adprh) 108933024 |
| PSPA: | 121307308(adprh) 121322949 |
| ARUT: | 117399057(adprh) 117402915 |
| PSEX: | 120531144 120531145 120536480(adprh) |
| LCM: | 102353586 102354521(ADPRH) |
| PMRN: | 116936989 116943767(ADPRH) |
| LRJ: | 133357247(ADPRH) 133362082 |
| BBEL: | 109462731 109482741 109485214 |
| LPIC: | 129273705 129273706 129276724 |
| APLC: | 110980273 110983402 |
| ARUN: | 117292219 117294786 |
| HRO: | HELRODRAFT_161549 HELRODRAFT_184901 HELRODRAFT_65081 HELRODRAFT_65129 |
| MCAF: | 127736034 127736036 |
| MMER: | 123530266 123561984 123563285 123564832 123564841 |
| RPHI: | 132712761 132712762 132727360 132732520 132735432 132735435 132740105 132755056 |
| DPOL: | 127866562 127866565 127866567 127866568 127872552 127873588 |
| MAEA: | 128203423 128207633 128211417 128221070 |
| LAK: | 106157901 106158834 106174255 |
| XEN: | 124440981 124447726 124448018 124448032 124448139 124448144 124448145 124448183 124448191 124448195 124448819 124448820 124448855 124456687 124456688 124457245 124457248 124457255 124457603 124457942 124459019 |
| ACAN: | ACA1_020140 ACA1_147520 |
| NGR: | NAEGRDRAFT_31389 NAEGRDRAFT_33467(AM35b) NAEGRDRAFT_54990(AM35a) NAEGRDRAFT_80552 |
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| Reference |
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| Authors |
Moss J, Jacobson MK, Stanley SJ. |
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| Title |
Reversibility of arginine-specific mono(ADP-ribosyl)ation: identification in erythrocytes of an ADP-ribose-L-arginine cleavage enzyme. |
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| Journal |
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| Reference |
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| Authors |
Moss J, Stanley SJ, Nightingale MS, Murtagh JJ Jr, Monaco L, Mishima K, Chen HC, Williamson KC, Tsai SC. |
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| Title |
Molecular and immunological characterization of ADP-ribosylarginine hydrolases. |
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| Journal |
J Biol Chem 267:10481-8 (1992) |
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| Sequence |
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| Reference |
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| Authors |
Konczalik P, Moss J. |
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| Title |
Identification of critical, conserved vicinal aspartate residues in mammalian and bacterial ADP-ribosylarginine hydrolases. |
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| Journal |
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| Reference |
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| Authors |
Takada T, Iida K, Moss J. |
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| Title |
Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase. |
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| Journal |
J Biol Chem 268:17837-43 (1993) |
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| Sequence |
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| Reference |
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| Authors |
Ohno T, Tsuchiya M, Osago H, Hara N, Jidoi J, Shimoyama M. |
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| Title |
Detection of arginine-ADP-ribosylated protein using recombinant ADP-ribosylarginine hydrolase. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.2.2.19 |
| ExPASy - ENZYME nomenclature database: | 3.2.2.19 |
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