KEGG ENZYME: 3.2.2.19

ENZYME: 3.2.2.19

Entry

EC 3.2.2.19                 Enzyme

Name

[protein ADP-ribosylarginine] hydrolase;
ADP-ribose-L-arginine cleavage enzyme;
ADP-ribosylarginine hydrolase;
Nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase;
protein-omega-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase

Class

Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds

Sysname

protein-Nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase

Reaction(IUBMB)

(1) protein-Nomega-(ADP-D-ribosyl)-L-arginine + H2O = ADP-D-ribose + protein-L-arginine [RN:R07626];
(2) Nomega-(ADP-D-ribosyl)-L-arginine + H2O = ADP-D-ribose + L-arginine [RN:R01886]

Reaction(KEGG)

R01886 R07626

Substrate

protein-Nomega-(ADP-D-ribosyl)-L-arginine [CPD:C16011];
H2O [CPD:C00001];
Nomega-(ADP-D-ribosyl)-L-arginine [CPD:C01201]

Product

ADP-D-ribose [CPD:C00301];
protein-L-arginine [CPD:C00613];
L-arginine [CPD:C00062]

Comment

The enzyme will remove ADP-D-ribose from arginine residues in ADP-ribosylated proteins.

History

EC 3.2.2.19 created 1989, modified 2004

Orthology

K01245

ADP-ribosylarginine hydrolase

Genes

HSA:	141(ADPRH)

PTR:	470893(ADPRH)

PPS:	100968536(ADPRH)

GGO:	101150307(ADPRH)

PON:	100440790(ADPRH)

NLE:	100602502(ADPRH)

HMH:	116466906(ADPRH)

MCC:	712562(ADPRH)

MCF:	102138957(ADPRH)

MTHB:

126947746

MNI:	105470337(ADPRH)

CSAB:

103228225(ADPRH)

CATY:

105589730(ADPRH)

PANU:

101022390(ADPRH)

TGE:	112619716(ADPRH)

MLEU:

105544622(ADPRH)

RRO:	104657619(ADPRH)

RBB:	108541872(ADPRH)

TFN:	117083467(ADPRH)

PTEH:

111543816(ADPRH)

CANG:

105510731(ADPRH)

CJC:	100391892(ADPRH)

SBQ:	101054411(ADPRH)

CIMI:

108296455(ADPRH)

CSYR:

103254572(ADPRH)

MMUR:

105879922(ADPRH)

LCAT:

123630512(ADPRH)

PCOQ:

105806300(ADPRH)

OGA:	100963855(ADPRH)

MMU:	11544(Adprh)

MCAL:

110311490(Adprh)

MPAH:

110329643(Adprh)

RNO:	25371(Adprh)

MCOC:

116085900(Adprh)

ANU:	117718235(Adprh)

MUN:	110555394(Adprh)

CGE:	100761196(Adprh)

MAUA:

101842244(Adprh)

PROB:

127227165(Adprh)

PLEU:

114701487(Adprh)

MORG:

121461960(Adprh)

MFOT:

126505595

AAMP:

119825642(Adprh)

NGI:	103741941(Adprh)

HGL:	101705433(Adprh)

CPOC:

100713280(Adprh)

CCAN:

109694540(Adprh)

DORD:

105987933(Adprh)

DSP:	122097939(Adprh)

NCAR:

124993324

OCU:

100354201

OPI:	101534352(ADPRH)

TUP:	102473277(ADPRH)

GVR:	103595385(ADPRH)

CFA:	100855709(ADPRH)

CLUD:

112677714(ADPRH)

VVP:	112913462(ADPRH)

VLG:	121484441(ADPRH)

AML:	100479971(ADPRH)

UMR:	103678790(ADPRH)

UAH:	113251889(ADPRH)

UAR:	123784030(ADPRH)

ELK:

111151469

LLV:

125097753

MPUF:

101672105(ADPRH)

NVS:	122908534(ADPRH)

ORO:	101363531(ADPRH)

EJU:	114214719(ADPRH)

ZCA:	113916213(ADPRH)

MLX:	118007065(ADPRH)

NSU:	110582030(ADPRH)

LWW:	102742050(ADPRH)

LRUF:

124526447

PUC:	125917706 125917711

HHV:	120225968(ADPRH)

BTA:	525738(ADPRH)

BOM:	102277051(ADPRH)

BIU:	109577238(ADPRH)

BBUB:

102404516(ADPRH)

BBIS:

104992478(ADPRH)

CHX:	102168665(ADPRH)

OAS:	101106222(ADPRH)

ODA:	120871264(ADPRH)

CCAD:

122445583(ADPRH)

SSC:	100153158(ADPRH)

CFR:	102524560(ADPRH)

CBAI:

105081594(ADPRH)

CDK:	105090325(ADPRH)

VPC:	102538613(ADPRH)

BACU:

103002571(ADPRH)

LVE:	103086426(ADPRH)

OOR:	101281103(ADPRH)

DLE:	111167283(ADPRH)

PSIU:

116753673(ADPRH)

ECB:	100070997(ADPRH)

EPZ:	103547420(ADPRH)

MYB:	102245153(ADPRH)

MYD:	102755321(ADPRH)

MMYO:

118676173(ADPRH)

MLF:	102426289(ADPRH)

MNA:	107527215(ADPRH)

PKL:	118724330(ADPRH)

HAI:	109388460(ADPRH)

DRO:	112320614(ADPRH)

SHON:

118986588(ADPRH)

AJM:	119059196(ADPRH)

PDIC:

114490559(ADPRH)

PHAS:

123826860(ADPRH)

MMF:	118617150(ADPRH)

RFQ:	117036413(ADPRH)

PALE:

102881506(ADPRH)

PGIG:

120586657(ADPRH)

PVP:	105301917(ADPRH)

RAY:	107508368(ADPRH)

MJV:	108392248(ADPRH)

TOD:	119257494(ADPRH)

SARA:

101539676(ADPRH)

LAV:	100660874(ADPRH)

TMU:

101350795

ETF:	101637935(ADPRH)

DNM:	101434760(ADPRH)

MDO:	100016348(ADPRH)

GAS:	123239476(ADPRH)

SHR:	100927416(ADPRH)

AFZ:

127554101

PCW:	110208068(ADPRH)

GGA:	426545(ADPRHL)

PCOC:

116238875 116242110(ADPRH)

MGP:	100540673(ADPRH) 104916026

CJO:	107322016(ADPRH) 107325783

NMEL:

110401341(ADPRH) 110402643

APLA:

101795135(ADPRH)

ACYG:

106039946(ADPRH)

AFUL:

116501476(ADPRH) 116501650

TGU:	100225609 100226233(ADPRH)

LSR:	110474901 110476539(ADPRH)

SCAN:

103818418(ADPRH) 103819895

PMOA:

120504029(ADPRH) 120505586

OTC:	121344704(ADPRH) 121348155

PRUF:

121349252 121360411(ADPRH)

GFR:	102040950(ADPRH)

FAB:	101806150(ADPRH) 101808754

PHI:	102101461(ADPRH) 102112496

PMAJ:

107209760(ADPRH) 107212272

CCAE:

111937223 111941677(ADPRH)

CCW:	104689397(ADPRH) 104695645

CBRC:

103613724(ADPRH) 103621695

ETL:	114059619(ADPRH) 114065648

ZAB:	102069290(ADPRH)

ACHL:

103801240

SVG:	106856988(ADPRH) 106858395

FPG:	101915329(ADPRH)

FCH:	102058856(ADPRH)

CLV:	102084426 102087478(ADPRH)

EGZ:	104123010(ADPRH)

NNI:	104014985(ADPRH) 104023367

PLET:

104619793(ADPRH)

PCRI:

104028846(ADPRH)

PCAO:

104045584(ADPRH)

ACUN:

113475984(ADPRH)

TALA:

104364187(ADPRH) 116962294

PADL:

103916851(ADPRH) 103925986

AFOR:

103894075 103894983(ADPRH)

ACHC:

115337800 115343780(ADPRH)

HALD:

104324771(ADPRH)

HLE:	104831586(ADPRH) 104835803

AGEN:

126034964 126048945

GCL:	127022565 127028525

CCRI:

104157627

CSTI:

104559003(ADPRH) 104560117

EHS:	104503408(ADPRH)

CMAC:

104478363(ADPRH)

MUI:	104533728(ADPRH)

FGA:	104074367(ADPRH)

GSTE:

104258494(ADPRH)

LDI:	104348492(ADPRH)

MNB:	103771505(ADPRH)

NNT:	104403752(ADPRH)

SHAB:

115601636(ADPRH)

DPUB:

104299529(ADPRH)

PGUU:

104461561(ADPRH)

ACAR:

104529867 104531015(ADPRH)

CPEA:

104395753(ADPRH)

AVIT:

104278212(ADPRH)

CVF:	104290908(ADPRH)

CUCA:

104054854 104055985(ADPRH)

TEO:	104384406(ADPRH)

BRHI:

104491034(ADPRH)

AAM:	106490658(ADPRH)

AROW:

112974426(ADPRH)

NPD:	112948423(ADPRH)

TGT:	104577451(ADPRH)

DNE:	112979286(ADPRH)

SCAM:

104149205(ADPRH)

ASN:	102386159(ADPRH)

AMJ:	102562154(ADPRH) 102567119

CPOO:

109305674(ADPRH)

GGN:	109303505(ADPRH)

PSS:	102452391(ADPRH)

CMY:	102934922(ADPRH) 119566298

CPIC:

101931729(ADPRH) 101936712

TST:	117888510(ADPRH)

CABI:

116839122(ADPRH)

MRV:	120394810(ADPRH) 120404512

ACS:	100563208(adprh) 100565391

PVT:	110078575 110088473(ADPRH)

SUND:

121926624(ADPRH) 121935601

PBI:	103049757(ADPRH) 103050993

PMUR:

107282553 107289021(ADPRH)

CTIG:

120303882(ADPRH) 120304568

TSR:	106557080 106557382(ADPRH)

PGUT:

117663793(ADPRH) 117669151

VKO:	123029470(ADPRH) 123032210

PMUA:

114582790 114595963(ADPRH)

ZVI:	118085653(ADPRH) 118095262

GJA:	107117555(ADPRH) 107122687

STOW:

125430542(ADPRH) 125445296

XLA:	108704185 432184(adprh.L) 447554(adprh.S) 495095(adprh)

XTR:	100135190(adprh) 493544(adprh)

NPR:	108784947 108784953 108789187

RTEM:

120943082 120943841(ADPRH)

BBUF:

121007570 121007979(ADPRH)

BGAR:

122944489 122945050(ADPRH)

DRE:	445059(adprh)

SRX:

107726130

SANH:

107704615(adprh)

SGH:

107571852

CCAR:

109110344

CAUA:

113112133

CGIB:

127969173

MAMB:

125260965(adprh)

CIDE:

127523546

MASI:

127421955 127427134

IPU:	100528393(adprh) 108274007

PHYP:

113547472 113547477

SMEO:

124388883 124388884

TFD:	113650622 113650623

AMEX:

103037544 111192396

EEE:

113576880

TRU:	101073656 101076629

TNG:	GSTEN00035061G001 GSTEN00035062G001

LCO:	109141701(adprh)

NCC:	104947179(adprh)

CGOB:

115024306(adprh)

ELY:	117247246(adprh)

EFO:	125880885(adprh)

PLEP:

121959068(adprh)

SLUC:

116060957(adprh)

ECRA:

117937315(adprh)

ESP:	116671313(adprh)

PFLV:

114548095

GAT:	120819115(adprh)

PPUG:

119212659(adprh)

MSAM:

119915760(adprh)

CUD:	121528113(adprh)

ALAT:

119009492(adprh)

MZE:	101482423(adprh)

ONL:	100711972(adprh)

OAU:	116327642(adprh)

OLA:	101172847(adprh)

OML:	112153970(adprh)

XMA:	102216979 102225753

XCO:	114133640 114136652

XHE:	116727404 116727496

PRET:

103481379 103481399

PFOR:

103152333 103152348

PLAI:

106934950 106956260

PMEI:

106904148(adprh) 106924693

GAF:	122823533(adprh) 122823567

CVG:	107094293 107094305

CTUL:

119777812(adprh) 119796759

GMU:	124874862(adprh) 124875567

NFU:	107387950 107387955

KMR:	108249548 108249559(adprh)

ALIM:

106521401 106535168

NWH:	119423604 119423619

AOCE:

111568801 111574344

CSEM:

103381590

POV:	109641266(adprh)

SSEN:

122759594(adprh)

HHIP:

117752751(adprh)

HSP:	118100484(adprh)

LCF:

108890419

SDU:	111219950(adprh)

SLAL:

111652249(adprh)

XGL:	120794853(adprh)

SSCV:

125991555

BPEC:

110170987 110171022

MALB:

109973617(adprh)

BSPL:

114846085(adprh)

SASA:

100194575(adprh) 106579059 106586332(adprh)

STRU:

115160839 115160840 115162372

OTW:	112223322(adprh) 112237465 112237501

OMY:	110492864(adprh) 110520181 110520182

OGO:	124043928 124043931

ONE:	115109915 115109924(adprh)

SALP:

111976284

SNH:	120045812(adprh) 120058290 120058293

CCLU:

121536716 121536718 121572470(adprh)

ELS:	105016254 105024377

SFM:	108930637(adprh) 108933024

PKI:	111833209(adprh)

AANG:

118220254(adprh)

LOC:	102692964(adprh)

PSPA:

121307308(adprh) 121322949

ARUT:

117399057(adprh) 117402915

PSEX:

120531144 120531145 120536480(adprh)

LCM:	102353586 102354521(ADPRH)

CMK:

103176834

RTP:	109926461(adprh)

BFO:	118404985 118425262

BBEL:

109462731 109482741 109485214

SPU:	577960 578587

APLC:

110980273 110983402

AJC:	117105666 117120575

SKO:	100373408 100373742

HRO:	HELRODRAFT_161549 HELRODRAFT_184901 HELRODRAFT_65081 HELRODRAFT_65129

LGI:	LOTGIDRAFT_170414

PCAN:

112556689

BGT:

106056268

GAE:

121378956

HRF:

124131820

MYI:

110453922

PMAX:

117337337

MCAF:

127736034 127736036

MMER:

123530266 123561984 123563268 123563285 123564832 123564841

DPOL:

127866562 127866565 127866567 127866568 127872552 127873588

LAK:	106157901 106158834 106174255

NVE:	5499174 5504669 5504679

EPA:

110239995

ATEN:

116298878

ADF:

107341614

AMIL:

114957647

SPIS:

111328293

DGT:

114539455

XEN:	124440981 124447726 124448018 124448032 124448139 124448144 124448145 124448183 124448191 124448195 124448819 124448820 124448855 124456687 124456688 124457245 124457248 124457255 124457603 124457942 124459019

AQU:

100637875

DDI:	DDB_G0289675(adprh)

DPP:	DICPUDRAFT_34975

DFA:	DFA_04483(adprh)

ACAN:

ACA1_020140 ACA1_147520

NGR:	NAEGRDRAFT_31389 NAEGRDRAFT_33467(AM35b) NAEGRDRAFT_54990(AM35a) NAEGRDRAFT_80552

» show all

Reference

1 [PMID:2994036]

Authors

Moss J, Jacobson MK, Stanley SJ.

Title

Reversibility of arginine-specific mono(ADP-ribosyl)ation: identification in erythrocytes of an ADP-ribose-L-arginine cleavage enzyme.

Journal

Proc Natl Acad Sci U S A 82:5603-7 (1985)
DOI:10.1073/pnas.82.17.5603

Reference

2 [PMID:1375222]

Authors

Moss J, Stanley SJ, Nightingale MS, Murtagh JJ Jr, Monaco L, Mishima K, Chen HC, Williamson KC, Tsai SC.

Title

Molecular and immunological characterization of ADP-ribosylarginine hydrolases.

Journal

J Biol Chem 267:10481-8 (1992)

Sequence

[rno:25371]

Reference

3 [PMID:10358013]

Authors

Konczalik P, Moss J.

Title

Identification of critical, conserved vicinal aspartate residues in mammalian and bacterial ADP-ribosylarginine hydrolases.

Journal

J Biol Chem 274:16736-40 (1999)
DOI:10.1074/jbc.274.24.16736

Reference

4 [PMID:8349667]

Authors

Takada T, Iida K, Moss J.

Title

Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase.

Journal

J Biol Chem 268:17837-43 (1993)

Sequence

[hsa:141] [mmu:11544]

Reference

5 [PMID:8678289]

Authors

Ohno T, Tsuchiya M, Osago H, Hara N, Jidoi J, Shimoyama M.

Title

Detection of arginine-ADP-ribosylated protein using recombinant ADP-ribosylarginine hydrolase.

Journal

Anal Biochem 231:115-22 (1995)
DOI:10.1006/abio.1995.1510

Other DBs

ExplorEnz - The Enzyme Database:

3.2.2.19

IUBMB Enzyme Nomenclature:

3.2.2.19

ExPASy - ENZYME nomenclature database:

3.2.2.19

BRENDA, the Enzyme Database:

3.2.2.19

CAS:	98668-52-1

DBGET integrated database retrieval system