KEGG   ENZYME: 3.2.2.22
Entry
EC 3.2.2.22                 Enzyme                                 
Name
rRNA N-glycosylase;
ribosomal ribonucleate N-glycosidase;
nigrin b;
RNA N-glycosidase;
rRNA N-glycosidase;
ricin;
momorcochin-S;
Mirabilis antiviral protein;
momorcochin-S;
gelonin;
saporins
Class
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
Sysname
rRNA N-glycohydrolase
Reaction(IUBMB)
Hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes
Comment
Ricin A-chain and related toxins show this activity. Naked rRNA is attacked more slowly than rRNA in intact ribosomes. Naked rRNA from Escherichia coli is cleaved at a corresponding position.
History
EC 3.2.2.22 created 1990, modified 2000
Reference
1  [PMID:3288622]
  Authors
Endo Y, Tsurugi K
  Title
The RNA N-glycosidase activity of ricin A-chain. The characteristics of the enzymatic activity of ricin A-chain with ribosomes and with rRNA.
  Journal
J Biol Chem 263:8735-9 (1988)
Other DBs
ExplorEnz - The Enzyme Database: 3.2.2.22
IUBMB Enzyme Nomenclature: 3.2.2.22
ExPASy - ENZYME nomenclature database: 3.2.2.22
BRENDA, the Enzyme Database: 3.2.2.22
CAS: 113756-12-0

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Protein sequence (2417)   
   UniProt (1790)   
   SWISS-PROT (88)   
   RefSeq(pep) (11)   
   PDBSTR (491)   
   PMD (37)   
DNA sequence (673)   
   RefSeq(nuc) (11)   
   GenBank (337)   
   EMBL (325)   
3D Structure (257)   
   PDB (257)   
Protein domain (18)   
   InterPro (18)   
All databases (3365)   

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