Entry |
|
Name |
rRNA N-glycosylase;
ribosomal ribonucleate N-glycosidase;
nigrin b;
RNA N-glycosidase;
rRNA N-glycosidase;
ricin;
momorcochin-S;
Mirabilis antiviral protein;
momorcochin-S;
gelonin;
saporins
|
Class |
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
|
Sysname |
rRNA N-glycohydrolase
|
Reaction(IUBMB) |
Hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes
|
Comment |
Ricin A-chain and related toxins show this activity. Naked rRNA is attacked more slowly than rRNA in intact ribosomes. Naked rRNA from Escherichia coli is cleaved at a corresponding position.
|
History |
EC 3.2.2.22 created 1990, modified 2000
|
Reference |
|
Authors |
Endo Y, Tsurugi K |
Title |
The RNA N-glycosidase activity of ricin A-chain. The characteristics of the enzymatic activity of ricin A-chain with ribosomes and with rRNA. |
Journal |
J Biol Chem 263:8735-9 (1988) |
Other DBs |
ExplorEnz - The Enzyme Database: | 3.2.2.22 |
ExPASy - ENZYME nomenclature database: | 3.2.2.22 |
|