| Entry |
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| Name |
rRNA N-glycosylase;
ribosomal ribonucleate N-glycosidase;
nigrin b;
RNA N-glycosidase;
rRNA N-glycosidase;
ricin;
momorcochin-S;
Mirabilis antiviral protein;
momorcochin-S;
gelonin;
saporins
|
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| Class |
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
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| Sysname |
rRNA N-glycohydrolase
|
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| Reaction(IUBMB) |
Hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes
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| Comment |
Ricin A-chain and related toxins show this activity. Naked rRNA is attacked more slowly than rRNA in intact ribosomes. Naked rRNA from Escherichia coli is cleaved at a corresponding position.
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| History |
EC 3.2.2.22 created 1990, modified 2000
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| Reference |
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| Authors |
Endo Y, Tsurugi K |
|---|
| Title |
The RNA N-glycosidase activity of ricin A-chain. The characteristics of the enzymatic activity of ricin A-chain with ribosomes and with rRNA. |
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| Journal |
J Biol Chem 263:8735-9 (1988) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.2.2.22 |
| ExPASy - ENZYME nomenclature database: | 3.2.2.22 |
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