Entry
Name
DNA-formamidopyrimidine glycosylase;
Fapy-DNA glycosylase;
deoxyribonucleate glycosidase;
2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase;
2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase;
formamidopyrimidine-DNA glycosylase;
DNA-formamidopyrimidine glycosidase;
Fpg protein
Class
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
BRITE hierarchy
Sysname
DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing]
Reaction(IUBMB)
Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine
Comment
May play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents. Also involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA.
History
EC 3.2.2.23 created 1990, modified 2000
Orthology
K10563 formamidopyrimidine-DNA glycosylase
Genes
CSAT : 104742751 104759983 104778169
BNA : 106406040 106445720 125597648
HSYR : 120125431 120185814
PSAT : 127087594 127103976 127136708
MESC : 110613783 110627208
SSPL : 121805948 121808654
HAN : 110910254 110910281 110910293
ECAD : 122606001 122608353
PSOM : 113282760 113355866
ATS : 109735369 109759070 109776489
TDC : 119331489 119338923 119352729 119361754
TAES : 123043137 123051038 123149551 123159386 123167134 123186976
TUA : 125521947 125530990 125535063
MFLO : 136519539 136529812 136530388 136531388
SITA : 101760696 101762550
PVIR : 120665663 120671278 120704035
PHAI : 112887992 112889703
ZOF : 121981123 122021510 122038056 122052739
SMO : SELMODRAFT_170576 SELMODRAFT_75016
PPP : 112275825 112276680 112285495
LBG : 92209435(LODBEIA_P42390)
CAL : CAALFM_C601820CA(FPG1)
CTEN : 18249694(PSN45_003303)
YLI : 2908403(YALI2_F00833g)
NTE : NEUTE1DRAFT104118(NEUTE1DRAFT_104118)
SMP : 10808186(SMAC4_07911)
TATV : 25776794(TrAtP1_008656)
TASP : 36615948(TrAFT101_002773)
MAW : 19247769(J3458_000676)
PLJ : 28884841(PLICBS_006045)
PTRR : 6339656(PtrM4_013110)
CDEP : 91086522(L203_102310)
KMG : 30164524(I203_106237)
KNE : 92179809(IAR55_002551)
CCAC : CcaHIS019_0102690(CcaverHIS019_0102690)
ABV : AGABI2DRAFT41042(AGABI2DRAFT_41042)
SCM : SCHCO_02662471(SCHCODRAFT_02662471)
EHX : EMIHUDRAFT_450608(Fpg1-1) EMIHUDRAFT_454338(Fpg1-2) EMIHUDRAFT_508419(Fpg2-1) EMIHUDRAFT_508420(Fpg2-2)
ECOO : ECRM13514_4624(mutM)
ECOH : ECRM13516_4422(mutM)
ECW : EcE24377A_4136(mutM)
EDJ : ECDH1ME8569_3520(mutM)
ECOI : ECOPMV1_03969(mutM)
REE : electrica_00113(mutM)
RTG : NCTC13098_00131(mutM_2)
SENM : TRABTM_A_00870(mutM)
CLAP : NCTC11466_04538(mutM)
KIE : NCTC12125_03928(mutM)
CMIK : PMARG_ME00211(mutM)
AHN : NCTC12129_04889(mutM)
METY : MRY16398_01180(mutM)
PTF : PROFFT_A_00650(mutM)
PSHI : SAMEA2665130_2896(mutM)
YPG : YpAngola_A0058(mutM)
YPI : YpsIP31758_0064(mutM)
SMW : SMWW4_v1c47710(mutM)
SFJ : SAMEA4384070_4772(mutM)
SOF : NCTC11214_01628(mutM)
SSAR : SSARUM_004700(mutM)
PAQU : DMB82_0019640(mutM)
PARL : PEC302110_00840(mutM)
DIC : Dpoa569_003771(mutM)
TPTY : NCTC11468_03733(mutM)
PHEI : NCTC12003_03909(mutM)
PRJ : NCTC6933_03927(mutM)
LRI : NCTC12151_00140(mutM)
HIZ : R2866_1436(mutM) R2866_1525(fpg2)
HIC : NTHIC486_00028(mutM)
HPIT : NCTC13334_00184(mutM)
HHZ : NCTC10839_01857(mutM)
HAEG : NCTC8502_00049(mutM)
PDAG : 4362423_00013(mutM)
ADP : NCTC12871_00589(mutM)
ALIG : NCTC10568_02386(mutM)
ASEG : NCTC10977_00726(mutM)
AVT : NCTC3438_00725(mutM)
RPNE : NCTC8284_03421(mutM_3)
PAET : NCTC13378_01650(mutM)
XFT : PD_0053(mutM) PD_0138(mutM)
XFM : Xfasm12_0055 Xfasm12_0143
XFN : XfasM23_0045 XfasM23_0126
XFF : XFLM_05505 XFLM_05965
XFL : P303_11215 P303_11670
XFS : D934_01215 D934_01680
XFH : XFHB_00290 XFHB_00695
XTW : AB672_00305 AB672_00765
XCA : xcc-b100_4366(mutM2)
XFU : XFF4834R_chr41530(mutM)
XPH : XppCFBP6546_12795(mutM)
XHD : LMG31886_43830(mutM_2)
SINC : DAIF1_00570(mutM_1)
LLZ : LYB30171_02516(mutM_2)
TAMN : N4264_02735(mutM) N4264_09775
VAU : VANGNB10_cI2544c(mutM)
VPL : SA104470976_02523(mutM)
VSA : VSAL_I0158(mutM) VSAL_I0188(mutM)
PAEB : NCGM1900_0360(mutM)
PVD : CFBP1590__4909(mutM)
PPRC : PFLCHA0_c58240(mutM)
PMUD : NCTC8068_05090(mutM)
PFW : PF1751_v1c52110(mutM)
PPUU : PputUW4_05148(mutM)
PTRT : HU722_0027960(mutM)
PTW : TUM18999_04980(mutM)
PTAE : NCTC10697_00266(mutM)
MSHE : MAALD49_37290(mutM)
MNK : RE428_15830 RE428_47100(mutM)
PSYC : DABAL43B_0438(mutM)
MCAT : MC25239_00178(mutM)
MCUN : NCTC10297_00616(mutM)
SCAA : TUM17387_00720(mutM_1)
SALH : HMF8227_00054(mutM)
LLG : 44548918_02427(mutM)
LJR : NCTC11533_02593(mutM)
LCJ : NCTC11976_00197(mutM)
LWA : SAMEA4504053_0879(mutM)
LSS : NCTC12082_01774(mutM)
LADL : NCTC12735_01916(mutM)
LANT : TUM19329_30830(mutM)
MISZ : MishRS11D_38000(mutM)
THIO : AYJ59_02555 AYJ59_03525
TIB : THMIRHAM_19860(mutM)
TSE : THMIRHAS_23020(mutM)
TZO : THMIRHAT_02760(mutM)
RHEI : ATY27_06070 ATY27_08630
TFRI : Thiofri_04487(mutM)
TNI : TVNIR_0101(mutM_[H])
GAI : IMCC3135_05280(mutM)
THIC : TspCOW1_27500(mutM)
HCH : HCH_00567(mutM1) HCH_02013(mutM2)
HAHE : ENC22_02385 ENC22_20795
HAHH : O5O45_16405 O5O45_22995(mutM)
HAAH : HALA3H3_210132(mutM)
ALCA : ASALC70_02158(mutM)
AEL : NCTC12917_00080(mutM)
CHJ : NCTC10426_01315(mutM)
SOK : D0B54_00550 D0B54_08230
CDIZ : CEDIAZO_00363(mutM)
NMM : NMBM01240149_0858(mutM)
NMS : NMBM01240355_1235(mutM)
NMQ : NMBM04240196_0907(mutM)
NMZ : NMBNZ0533_1284(mutM)
NWE : SAMEA3174300_0286(mutM)
NZO : SAMEA4504057_1397(mutM)
NCI : NCTC10296_00319(mutM)
NCZ : NCTC10294_00808(mutM)
NANI : NCTC12227_01422(mutM)
ECOR : SAMEA4412678_0461(mutM)
REH : H16_A0377(h16_A0377)
BMV : BMASAVP1_A0083(mutM)
BML : BMA10229_A1507(mutM)
BPM : BURPS1710b_0758(mutM)
BPL : BURPS1106A_0590(mutM)
BUE : BRPE67_ACDS02400(mutM)
PLG : NCTC10937_00383(mutM)
LMIR : NCTC12852_00655(mutM)
BUO : BRPE64_ACDS02460(mutM)
BTRM : SAMEA390648701824(fpg)
AXX : ERS451415_05369(mutM)
LIM : L103DPR2_00894(mutM)
LIH : L63ED372_02347(mutM)
SMIO : CATMQ487_10870(mutM)
URU : DSM104443_00371(mutM_1) DSM104443_02032(mutM_2)
UPL : DSM104440_00420(mutM)
THAG : CKCBHOJB_00572(mutM)
FPHO : SHINM1_000400(mutM)
BEBA : BWI17_03305 BWI17_16535
ERW : ERWE_CDS_04520(mutM)
ERG : ERGA_CDS_04450(mutM)
RBS : RHODOSMS8_03243(mutM)
SMEL : SM2011_c01154(mutM)
SFD : USDA257_c62200(mutM)
SAME : SAMCFNEI73_Ch0369(mutM)
AGR : AGROH133_03484(mutM)
ALF : CFBP5473_14345(mutM)
AVV : RvVAT039_19700(mutM)
AVF : RvVAR031_06880(mutM)
ASAL : CFBP5507_14670(mutM)
RPUS : CFBP5875_14155(mutM)
ALEG : CFBP4996_14525(mutM)
REC : RHECIAT_CH0000393(fpg)
REL : REMIM1_CH00361(mutM)
REP : IE4803_CH00383(mutM)
REI : IE4771_CH00392(mutM)
RTR : RTCIAT899_CH02200(mutM)
RGA : RGR602_CH00378(mutM)
RPHA : AMC79_CH00396(mutM)
RLW : RlegWSM1455_23910(mutM)
RBW : RLCC275e_23765(mutM)
NEN : NCHU2750_41120(mutM)
BSUI : BSSP1_I1982 BSSP1_I1983
BSUV : BSPT2_I1983 BSPT2_I1984
BSUC : BSSP2_I1987 BSSP2_I1988
BIO : BR141012304_10561(mutM)
BSEP : HAP48_0016175(mutM)
BCAN : BcanWSM471_00555(mutM)
VGO : GJW-30_1_04297(mutM)
BHS : BM1374165_00258(mutM)
BBK : BARBAKC583_1221(mutM)
BTX : BM1374166_00249(mutM)
BEZ : NCTC12898_00138(mutM)
MMES : MMSR116_21055(mutM)
MTUN : MTUNDRAET4_3346(mutM)
FIL : BN1229_v1_1288(mutM)
FIY : BN1229_v1_1286(mutM)
BVY : NCTC9239_03477(mutM)
TSV : DSM104635_03998(mutM)
RLI : RLO149_c044570(mutM)
PHP : PhaeoP97_03555(mutM)
PPIC : PhaeoP14_03458(mutM)
SUAM : BOO69_00020 BOO69_15425
SINL : DSM14862_03251(mutM)
SUAL : KDD17_00735 KDD17_15205(mutM)
SPSE : SULPSESMR1_03236(mutM)
RMM : ROSMUCSMR3_01692(mutM)
AHT : ANTHELSMS3_01079(mutM)
LALG : LentiSH36_03005(mutM)
PLCG : RVY76_11965 RVY76_14455(mutM)
MARU : FIU81_15265(mutM1) FIU81_16620(mutM2)
LVS : LOKVESSMR4R_03320(mutM)
AALK : LGT41_0003920(mutM)
SBIN : SBA_ch1_12890(mutM)
SPAG : sphantq_02617(mutM)
CIJ : WG74_03625 WG74_10470
SFLA : SPHFLASMR4Y_02754(mutM)
QSP : L1F33_12490 L1F33_14350(mutM)
ERYZ : F7D01_09925(mutM) F7D01_13915
AFR : AFE_0463 AFE_2758(mutM)
AFE : Lferr_0623 Lferr_2378
ACZ : Acaty_c0328 Acaty_c0494
AFI : Acife_0551 Acife_0853
AFJ : AFERRID_07100 AFERRID_16980
ATX : GCD22_00551(mutM) GCD22_03369(mutM)
AFP : K1Y48_02330 K1Y48_02920(mutM)
GEV : GSVR_21150(mutM_1) GSVR_43610(mutM_2)
GEC : GEO60473_18850(mutM)
GEO : Geob_0290(mutM-2) Geob_1575(mutM-1)
GBM : Gbem_0815(mutM-2) Gbem_2133(mutM-1)
GBN : GEOBRER4_19620(mutM_1) GEOBRER4_33150(mutM_2)
GER : KP004_09655(mutM) KP004_16190
GSUB : KP001_05535(mutM) KP001_20050
GNT : KP003_09065(mutM) KP003_16065
GPL : M1B72_03750 M1B72_11105(mutM)
DMS : E8L03_17140(mutM) E8L03_20270
ACP : A2cp1_0299 A2cp1_4070
AFW : Anae109_0299 Anae109_0505
ANK : AnaeK_0288 AnaeK_4038
AORY : AMOR_28580 AMOR_30940
APAU : AMPC_25730 AMPC_36230
MXA : MXAN_4980 MXAN_5932(mutM)
MYM : A176_000964 A176_001908
CCX : COCOR_02475(fpgX) COCOR_06479(mutM)
PPAK : JY651_01020(mutM) JY651_06800(mutM)
MBD : MEBOL_001629 MEBOL_001995
CFUS : CYFUS_008258 CYFUS_008751
SCU : SCE1572_41585 SCE1572_45500
MRM : A7982_05024 A7982_05358
SAMY : DB32_001046 DB32_007434
LLU : AKJ09_03556 AKJ09_10760
BBAT : Bdt_1723(fpg) Bdt_2139(fpg)
PSTI : SOO65_12640(mutM) SOO65_12880
BAZ : BAMTA208_14280(mutM)
BSON : S101395_01442(mutM)
BIF : N288_03265 N288_19560
BFD : NCTC4823_01378(mutM_1) NCTC4823_01660(mutM_2)
BACQ : DOE78_03205 DOE78_18410
BACA : FAY30_14330 FAY30_18245(mutM)
BCO : Bcell_0842 Bcell_3213
BCOH : BC6307_11360 BC6307_16775
BCIR : C2I06_06250 C2I06_11385
NTX : NQZ71_07070(mutM) NQZ71_12150
NIL : L8T27_009700 L8T27_014690(mutM)
BKW : BkAM31D_03115(mutM_1) BkAM31D_18615(mutM_2)
BCL : ABC0889 ABC2708(mutM)
BON : A361_05245 A361_22140
CGOT : J1899_03955 J1899_16740(mutM)
CSUA : IM538_14470(mutM) IM538_18625(mutM)
CFIR : NAF01_04925 NAF01_19890(mutM)
PARG : PspKH34_07460(mutM)
LYP : MTP04_26970 MTP04_33230
HNZ : P9989_03400(mutM) P9989_13865(mutM)
HSHI : MUO14_00245(mutM) MUO14_03825(mutM)
HAMY : MUO15_03325(mutM) MUO15_20795(mutM)
VIL : CFK37_12990(mutM) CFK37_15195
VNE : CFK40_08375(mutM) CFK40_11470
FPN : ABE65_012360 ABE65_015455
FAR : ABE41_011530 ABE41_014270
FEC : QNH15_14065(mutM) QNH15_17420(mutM)
PRD : F7984_06505 F7984_15120(mutM)
NMK : CHR53_17375 CHR53_21200(mutM)
NDT : L1999_18700(mutM) L1999_23000(mutM)
NCM : QNK12_19290(mutM) QNK12_24210(mutM)
MLIT : KDJ21_002820(mutM) KDJ21_011890(mutM)
MEBZ : LPC09_02055(mutM) LPC09_18770(mutM)
AIA : AWH56_014350(mutM) AWH56_023630
BLEN : NCTC4824_01405(mutM_1) NCTC4824_02120(mutM_2)
BOU : I5818_08285(mutM) I5818_12300
SFOR : QNH23_02875(mutM) QNH23_03995(mutM)
ALKL : MM271_07225(mutM) MM271_19805(mutM)
PUK : PU629_01340(mutM) PU629_05965(mutM)
SUQ : HMPREF0772_11462(mutM)
SDP : NCTC12225_01321(mutM)
SPIC : SAMEA4384060_1268(mutM)
SSH : NCTC13712_01679(mutM)
SSIM : SAMEA4384339_1572(mutM)
SSTE : SAMEA4384403_1063(mutM)
LMOC : LMOSLCC5850_1628(mutM)
LMW : LMOSLCC2755_1572(mutM)
LMX : LMOSLCC2372_1627(mutM)
LMZ : LMOSLCC2482_1621(mutM)
LMON : LMOSLCC2376_1520(mutM)
LMOS : LMOSLCC7179_1538(mutM)
LMOO : LMOSLCC2378_1582(mutM)
LMOY : LMOSLCC2479_1626(mutM)
LMOT : LMOSLCC2540_1644(mutM)
LMOA : LMOATCC19117_1575(mutM)
LGZ : NCTC10812_01554(mutM)
GMO : NCTC11323_00306(mutM)
GHA : NCTC10459_00340(mutM)
BBE : BBR47_14060(mutM) BBR47_55330
BLR : BRLA_c009250 BRLA_c044920
BFM : BP422_02170 BP422_23335
BAGR : BA6348_04615 BA6348_21910
BRW : GOP56_15030(mutM) GOP56_20600(mutM)
BCHS : JNE38_07485(mutM) JNE38_29185
BCOP : JD108_16725(mutM) JD108_21085(mutM)
BPAB : PSE45_06890(mutM) PSE45_26310
BHUI : LOK74_03110(mutM) LOK74_19735
BAYD : BSPP4475_15050(mutM)
BBOR : RFB14_01425(mutM) RFB14_19220(mutM)
BRUM : NDK47_20040(mutM) NDK47_25890
BREH : HP435_07010(mutM) HP435_26870
PJD : Pjdr2_1524 Pjdr2_2633
GYM : GYMC10_2375 GYMC10_4911
PPM : PPSC2_08355(mutM1) PPSC2_13685(mutM3)
PPO : PPM_1585(mutM1) PPM_2686(mutM3)
PPOL : X809_08690 X809_30085
PPQ : PPSQR21_016850(nei) PPSQR21_027210
PPOY : RE92_03825 RE92_23050
PMS : KNP414_01301(mutM) KNP414_02940
PMQ : PM3016_1621 PM3016_3180
PTA : HPL003_16290 HPL003_20140
PSAB : PSAB_08700 PSAB_14020
PDU : PDUR_09915 PDUR_15690
PBD : PBOR_11765 PBOR_20290
PGM : PGRAT_10910 PGRAT_17395
POD : PODO_09515 PODO_16910
PAEN : P40081_11530 P40081_20635
PAEF : R50345_09705 R50345_17005
PAEQ : R50912_11075 R50912_18915
PSTE : PSTEL_10135 PSTEL_15640
PAEE : R70331_10355 R70331_17155
PAEH : H70357_11320 H70357_20225
PAEJ : H70737_09265 H70737_16760
PBJ : VN24_01630 VN24_24090
PIH : UB51_07225 UB51_15110
PRI : PRIO_2363(mutM) PRIO_3832
PPEO : ABE82_08495 ABE82_14145
PNP : IJ22_05010 IJ22_21000
POW : IJ21_25460 IJ21_37670
PBV : AR543_09925 AR543_15240
PXL : BS614_13585 BS614_21330
PYG : AWM70_03530 AWM70_08605
PSWU : SY83_17925 SY83_21120
PDH : B9T62_05680(mutM) B9T62_14585
PIB : BBD41_03000 BBD41_21105
PCX : LPB68_02110 LPB68_17935
PKB : B4V02_11365 B4V02_16965
PAIH : ASL14_03030 ASL14_25705
PVO : PVOR_14459 PVOR_26378
PLW : D5F53_05355(mutM) D5F53_17765(mutM)
PLEN : EIM92_15455 EIM92_19495(mutM)
PPSC : EHS13_16490 EHS13_23155(mutM)
PLUT : EI981_11290 EI981_19865(mutM)
PALB : EJC50_21500 EJC50_24130(mutM)
PCHI : PC41400_09475 PC41400_13185
PBK : Back11_03120(mutM_1) Back11_12410(mutM_2)
PPRT : ET464_06200(mutM) ET464_09235(mutM)
PBAC : HUB98_03560 HUB98_26670(mutM)
PRZ : GZH47_26165(mutM) GZH47_29470
PLYC : GXP70_17960 GXP70_21440(mutM)
PSOP : KP014_12415(mutM) KP014_19080
PTRI : KDC22_10120(mutM) KDC22_18535
PALO : E6C60_2047 E6C60_2841
PCEL : HUB94_10010(mutM) HUB94_14770
PTJ : JRJ22_08980(mutM) JRJ22_15015
PALR : HGI30_07890(mutM) HGI30_10985
PTHI : NDS46_17135 NDS46_21255(mutM)
PKA : PQ456_07360(mutM) PQ456_12920
PUI : PUW25_08230(mutM) PUW25_16225
PMAH : PTQ21_14960(mutM) PTQ21_24295
PDY : QJQ58_00855(mutM) QJQ58_04895
PMAE : LMZ02_15240(mutM) LMZ02_20270
PWN : QNH46_08950(mutM) QNH46_13320
PSPN : L1F29_19625 L1F29_23950(mutM)
PPOG : QPK24_07740(mutM) QPK24_15575
PAUN : MJA45_15960 MJA45_19950(mutM)
PHK : SK066_10540 SK066_16025(mutM)
PNK : AASFL403_06110 AASFL403_11525(mutM)
PPAB : KET34_10575(mutM) KET34_21060
PKP : SK3146_00795(mutM_1) SK3146_02193(mutM_2)
PGLU : A3958_02255 A3958_20450
PHEX : L0M14_13295(mutM) L0M14_18175(mutM)
PLZH : C0638_19385 C0638_24755
TCO : Theco_1332 Theco_1737
COHN : KCTCHS21_30640 KCTCHS21_43210(mutM)
CCHL : FPL14_05475(mutM) FPL14_28020(mutM)
CHEB : HH215_04655(mutM) HH215_12530(mutM)
COHL : J4772_12195(mutM) J4772_19395(mutM)
SACA : FFV09_18070(mutM) FFV09_22670
PLIG : NAG76_19235 NAG76_22135(mutM)
KZO : NCTC404_02042(mutM_1) NCTC404_02833(mutM_2)
SPH : MGAS10270_Spy0409(fpg)
SPI : MGAS10750_Spy0421(fpg)
SPJ : MGAS2096_Spy0427(fpg)
SPK : MGAS9429_Spy0407(fpg)
STZ : SPYALAB49_000450(mutM)
SNV : SPNINV200_08910(fpg)
SNC : HMPREF0837_11518(mutM)
SPNG : HMPREF1038_00990(mutM)
SPNE : SPN034156_19140(fpg)
SPNU : SPN034183_08700(fpg)
SPNM : SPN994038_08590(fpg)
SPNO : SPN994039_08600(fpg)
SGG : SGGBAA2069_c16550(fpg)
SCP : HMPREF0833_10926(mutM)
SVB : NCTC12167_00654(mutM)
SMEN : SAMEA4412692_0082(mutM)
SFER : NCTC12278_01410(mutM)
SCAI : NCTC12191_00046(mutM)
SPSU : NCTC13786_01815(fpg)
SPOC : NCTC10925_01347(fpg)
SAUP : NCTC3168_01304(mutM)
SURN : NCTC13766_01629(mutM)
SVF : NCTC3166_01444(mutM)
SMIE : NCTC11169_00804(mutM)
LPW : LpgJCM5343_14180(nei)