KEGG   ENZYME: 3.2.2.29
Entry
EC 3.2.2.29                 Enzyme                                 
Name
thymine-DNA glycosylase;
mismatch-specific thymine-DNA glycosylase;
mismatch-specific thymine-DNA N-glycosylase;
hTDG;
hsTDG;
TDG;
thymine DNA glycosylase;
G/T glycosylase;
uracil/thymine DNA glycosylase;
T:G mismatch-specific thymidine-DNA glycosylase;
G:T mismatch-specific thymine DNA-glycosylase
Class
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
Sysname
thymine-DNA deoxyribohydrolase (thymine-releasing)
Reaction(IUBMB)
Hydrolyses mismatched double-stranded DNA and polynucleotides, releasing free thymine.
Comment
Thymine-DNA glycosylase is part of the DNA-repair machinery. Thymine removal is fastest when it is from a G/T mismatch with a 5'-flanking C/G pair. The glycosylase removes uracil from G/U, C/U, and T/U base pairs faster than it removes thymine from G/T [3].
History
EC 3.2.2.29 created 2009
Orthology
K20813  thymine-DNA glycosylase
Genes
HSA6996(TDG)
PTR452188(TDG)
PPS100980045(TDG) 100989432
GGO101130939(TDG)
PON100452129(TDG)
NLE100598008(TDG)
MCC700061(TDG)
MCF101866862(TDG)
CSAB103238979(TDG)
CATY105573292(TDG)
PANU101017410(TDG)
TGE112634371(TDG)
RRO104657468(TDG)
RBB108544252(TDG)
TFN117089512(TDG)
PTEH111524668(TDG)
CJC100398863(TDG)
SBQ101038544(TDG)
CSYR103266485(TDG)
MMUR105875583(TDG)
LCAT123639361(TDG)
OGA100949300(TDG)
MMU21665(Tdg) 545124(Tdg-ps)
MCAL110289134 110302718(Tdg)
MPAH110326545(Tdg)
RNO114521(Tdg)
MCOC116075717(Tdg)
MUN110563926(Tdg)
CGE100752484 100771878 100772748(Tdg)
MAUA101828697(Tdg) 101833826 121133556
PLEU114686948 114700613(Tdg)
MORG121456618(Tdg)
AAMP119803301(Tdg)
NGI103742144(Tdg)
HGL101703457(Tdg)
CPOC100724604(Tdg)
CCAN109675720(Tdg)
DORD105990442(Tdg)
DSP122119175(Tdg)
NCAR124983435
OCU100355930(TDG)
OPI101528416(TDG)
TUP102496464(TDG)
CFA475448(TDG)
VVP112930670(TDG)
VLG121481483(TDG)
AML100478809(TDG)
UMR103676486(TDG)
UAH113256064(TDG)
UAR123780559(TDG)
ELK111142095
LLV125107936
MPUF101689547(TDG)
ORO101384203(TDG)
EJU114222990(TDG)
ZCA113922058(TDG)
MLX117998803(TDG)
FCA101082502(TDG)
PYU121040511(TDG)
PBG122472617(TDG)
PTG102969722(TDG)
PPAD109265430(TDG)
AJU106971878(TDG)
HHV120245715(TDG)
BTA517825(TDG)
BOM102268073(TDG)
BIU109559456(TDG)
BBUB102399440(TDG)
CHX102189100(TDG)
OAS101123623(TDG)
ODA120858643(TDG)
CCAD122423314(TDG)
SSC100155184(TDG)
CFR102518004(TDG)
CDK105097477(TDG)
VPC102525287(TDG)
BACU103009535(TDG)
LVE103081678(TDG)
OOR101289555(TDG)
DLE111187909(TDG)
PCAD102989557(TDG)
PSIU116749477 116760048(TDG)
ECB100053458(TDG)
EPZ103562005(TDG)
EAI106846788(TDG)
MYB102253254(TDG)
MYD102751349(TDG)
MMYO118650277(TDG)
MLF102421436(TDG)
MNA107545149(TDG)
PKL118728358(TDG)
HAI109387776(TDG)
DRO112321711(TDG)
SHON119002145(TDG)
AJM119060237 119060459
PDIC114513279(TDG)
PHAS123810624(TDG)
MMF118624126(TDG)
RFQ117029039(TDG)
PALE102888665(TDG)
PGIG120614943(TDG)
PVP105310754(TDG)
RAY107501144(TDG)
MJV108395214(TDG)
TOD119247359(TDG) 119247368
SARA101542462(TDG)
LAV100671433(TDG)
TMU101341896
DNM101435767(TDG)
MDO100021839(TDG)
GAS123248922(TDG)
SHR100920398(TDG)
PCW110205665(TDG)
OAA100076258(TDG)
GGA395510(TDG)
PCOC116233250(TDG)
MGP100545972(TDG)
CJO107314745(TDG)
NMEL110393853(TDG)
APLA101802890(TDG)
ACYG106035893(TDG)
AFUL116490948(TDG)
TGU100222509(TDG)
LSR110473604(TDG)
SCAN103813586(TDG)
PMOA120508042(TDG)
OTC121347866(TDG)
PRUF121357739(TDG)
GFR102035597(TDG)
FAB101813146(TDG)
PHI102112018(TDG)
PMAJ107204445(TDG)
CCAE111935992(TDG)
CCW104696236(TDG)
ETL114060737(TDG)
ZAB106629860(TDG)
FPG101912560(TDG)
FCH102049571(TDG)
CLV102092705(TDG) 110358245
EGZ104132738(TDG)
NNI104013372(TDG)
PLET104623412(TDG)
ACUN113491437(TDG)
TALA104362512(TDG)
PADL103924530(TDG)
ACHC115352665(TDG)
AAM106488729(TDG)
AROW112961527(TDG)
NPD112958395(TDG)
DNE112993925(TDG)
ASN102368125(TDG)
AMJ102567507(TDG)
CPOO109316569(TDG)
GGN109296115(TDG)
PSS102452289(TDG)
CMY102941802(TDG)
CPIC101935707(TDG)
TST117881386(TDG)
CABI116825963(TDG)
MRV120384328(TDG)
ACS100567264(tdg)
PVT110084774(TDG)
SUND121931543(TDG)
PBI103058406(TDG)
PMUR107294621(TDG)
TSR106557042(TDG)
PGUT117655388(TDG)
VKO123028903(TDG)
PMUA114605962(TDG)
ZVI118090779(TDG)
GJA107119987(TDG)
STOW125434731(TDG)
XLA399413(tdg.S)
XTR448432(tdg)
NPR108789008(TDG)
RTEM120932110(TDG)
BBUF120979275(TDG)
BGAR122925939(TDG)
DRE553789(tdg.1) 558951(tdg.2)
SRX107716643 107716672 107753540 107753681
SANH107665730 107665733 107679582 107679604
SGH107574736 107574747 107590837 107590866
CCAR109065141 109065142 109074826 109112013 109112014
CAUA113043271(tdg) 113043272 113066764 113095310
PPRM120459009(tdg.2) 120459087(tdg.1)
MAMB125247087(tdg.2) 125247443(tdg.1)
IPU108269283(tdg.1) 108269360(tdg.2)
PHYP113546520 113546553
SMEO124386311(tdg.1) 124386322(tdg.2)
TFD113635573(tdg.2) 113636089(tdg.1)
AMEX103043944 103045467
EEE113586428 113586448
TRU101067104 101067326
TNGGSTEN00004540G001 GSTEN00004541G001
LCO104937569 104937575
NCC104948407 104948415
CGOB115010187 115010233
ELY117261585 117261625
PLEP121950720 121950771
SLUC116046808(tdg.2) 116046812
ECRA117948732(tdg.1) 117949310(tdg.2)
PFLV114560007 114560430
GAT120808931(tdg.2) 120809529 120812634
PPUG119196355(tdg.2) 119196410(tdg.1)
MSAM119893480 119894164(tdg.2)
CUD121514636 121514653(tdg.2)
ALAT119023960(tdg.2) 119023961
MZE101483821 101484631
ONL100698171(tdg) 100698435
OAU116313957(tdg.2) 116313959
OLA101155844(tdg) 101162834
OML112151959 112151960
XMA102223318 102226852(tdg)
XCO114133528 114156867(tdg)
XHE116730895 116730915
PRET103465701 103465703(tdg)
PFOR103156558 103156561
PLAI106939000 106939003
PMEI106933967 106933969
GAF122835147(tdg.2) 122835757(tdg.1)
CVG107081070 107092187 107092203
CTUL119798191(tdg.1) 119798193(tdg.2)
GMU124855721(tdg.1) 124877621(tdg.2)
NFU107388368(tdg) 107388370
KMR108245713 108245718
ALIM106522812 106522814
NWH119415418(tdg.2) 119415420(tdg.1)
AOCE111567879 111567882
CSEM103379812 103379813
POV109624640 109624666
SSEN122776349(tdg.2) 122776371(tdg.1)
HHIP117763667(tdg.1) 117763672(tdg.2)
HSP118110123(tdg.1) 118110124(tdg.2)
LCF108889295 108889296
SDU111229630 111229702
SLAL111650459(tdg) 111650466
XGL120792658(tdg.2) 120793792(tdg.1)
HCQ109530839 109530840
BPEC110160314 110160346
MALB109973201 109975014
BSPL114857768(tdg.1) 114857842(tdg.2)
SASA106561084 106561087 106584662 106584663
OTW112218271 112218273(tdg.2) 112221315 112222201
OMY110492132 110492152 110521257 110521258
OGO124037006 124037008 124039580(tdg.1) 124039602
ONE115134518 115134519 115144706 115144708
SALP111962111 111962113 111972058 111972059
SNH120052301 120052302 120066620 120066621
ELS105009540(tdg) 105009541
SFM108920955 108920957
PKI111844304 111844308 111847043
AANG118218770 118218771 118231363 118231687
LOC102682644(tdg)
PSPA121318478 121319620
ARUT117415830 117420017
LCM102350121(TDG)
CMK103179828
BFO118403306
BBEL109462309
CIN104266612
SCLV120338754
SPU586471
APLC110982095
DMEDmel_CG1981(Thd1)
DER6555861
DSIDsimw501_GD24378(Dsim_GD24378)
DYADyak_GE14511
DSR110185485
DPODpse_GA15170
DPE6602004
DMN108164486
DWI6651298
DMODmoj_GI14092
DAZ108617810
DNV108655366
DHE111593706
LCQ111683328
AME408649 725801
ACER107992495 107999117
ALAB122718843 122720041
BIM100741428 100745769
BBIF117204817 117208381
BVK117231193 117237707
BVAN117158113 117163389
BTER100648503 100649696
BPYO122570892 122577836
CCAL108626054 108626232 108627180
OBB114872787 114876182
MGEN117224639 117225009
NMEA116425224 116427667
CGIG122397983
SOC105199434 105205270
MPHA105833412 105838336
AEC105153872 105154007 105154122
ACEP105618145 105622736
PBAR105424915 105427395 105427396
VEM105566649
HST105182606 105188391
DQU106746477 106752272
CFO105248080 105259395
FEX115236526 115245063
LHU105674984 105679748
PGC109855243 109858127
OBO105278771 105285578
PCF106785249 106792647
PFUC122520013 122525916
VPS122631464 122633068
NVI100116130 100120200
CSOL105364184 105365644
TPRE106657129 111694519
MDL103568547 103580461
CGLO123259989 123272512
FAS105266105 105273696
DAM107037909 107048238
CCIN107269758
TCA658765
DPA109541058
SOY115887130
ATD109601644
CSET123322189
AGB108906831
LDC111513469 111514412
NVL108565870
APLN108737596
PPYR116167470
OTU111419488
BMOR101735453
BMAN114248693
DPLKGM_200103
BANY112047020
PMAC106707729
PXU106118483
PRAP110991611
ZCE119837551
HAW110382226
TNL113495872
PXY105387432 105390882 105396146
API100164619
DNX107168052
AGS114132970
RMD113555908
BTAB109044134
DCI103507244 103507245
CLEC106667760 106669980
HHAL106682041 106689665
NLU111048183
PHUPhum_PHUM302160
FOC113202449
TPAL117651747
ZNE110831912
CSEC111871104
FCD110859143
DPXDAPPUDRAFT_43853
DMK116920206
PVM113800830 113821442
PJA122247745 122255942
PCHN125042755
HAME121857233 121864623
PCLA123746559
PTRU123499975
HAZT108677341
EAF111697897 111712809
PPOI119101900
ISCIscW_ISCW008783
DSV119431365
RSAN119406250
RMP119163320
TUT107360226
CSCU111632264
PTEP107437527
SDM118187549
TSPTsp_05734
HROHELRODRAFT_124128 HELRODRAFT_71611
LGILOTGIDRAFT_132396
PCAN112571781
BGT106070853
GAE121369243
HRF124116998
HRJ124266004
CRG105344766
MYI110448845
PMAX117331708
OBI106876312
OSN115227526
LAK106166915 106178371
SMMSmp_149220
SHXMS3_0014538
OVIT265_11500
NVE5514443
EPA110237087 110251124
ADF107349925 107358636
AMIL114953672
PDAM113685282
SPIS111325133
DGT114530645
HMG100203258 100206585
TADTRIADDRAFT_6342
AQU100639845
QSU111990107 112019157
CRECHLRE_03g180100v5
CVRCHLNCDRAFT_134530
DHADEHA2F17270g
PICPICST_55251
PGUPGUG_04234
SPAASPAPADRAFT_51743
LELLELG_02693
CALCAALFM_C306530WA(CaO19.7442)
CTPCTRG_05704 CTRG_05712
COTCORT_0A05590
CDUCD36_86500
CTENCANTEDRAFT_100862
YLIYALI0F04796g
CLUCLUG_04196
CLUSA9F13_04g03289
CAURCJI97_001930
SLBAWJ20_1623
NCRNCU02098
SMPSMAC_04996
PANPODANSg09472
TTTTHITE_2121304
MTMMYCTH_2019108
CTHRCTHT_0058600
MGRMGG_11518
PPEIPpBr36_08461
TMNUCRPA7_1261
SSCKSPSK_00047
FGRFGSG_00873
FPUFPSE_11649
FVRFVEG_00629 FVEG_08412
FOXFOXG_00833
NHENECHADRAFT_75270
TRETRIREDRAFT_64832
TRRM419DRAFT_43526
MAWMAC_06227
MAJMAA_00707
CMTCCM_05432
PLJVFPFJ_09108
VALVDBG_07391
VDAVDAG_06102
CFJCFIO01_11617
CHIGCH63R_05823
ELAUCREL1_6459
PFYPFICI_06964
SSLSS1G_05672
BFUBCIN_05g00430
MBEMBM_03404
PSCOLY89DRAFT_565894
GLZGLAREA_08425
ANIAN5479.2
AFMAFUA_6G13340
ACTACLA_086590
NFINFIA_059260
AORAO090003000458
ANGANI_1_2406074(An08g10020)
AFVAFLA_001231
ALUCAKAW2_51782S
ACHEACHE_10146S
APUUAPUU_40809S
PCSPc22g01220
PDPPDIP_45790
TMFPMAA_063500
TRGTRUGW13939_06628
CIMCIMG_10236
CPWCPC735_013310
UREUREG_03494
PBLPAAG_04642
PBNPADG_04800
ABEARB_07552
TVETRV_07036
BGHBDBG_05233
PNOSNOG_14120
PTEPTT_08555
BZECOCCADRAFT_6753
BSCCOCSADRAFT_40835
BORCOCMIDRAFT_104028
AALTCC77DRAFT_1030286
ZTRMYCGRDRAFT_24066
PFJMYCFIDRAFT_110830
FFUCLAFUR5_04044
BCOMBAUCODRAFT_64646
NPAUCRNP2_1118
TMLGSTUM_00001121001 GSTUM_00005557001
SPOSPCC965.05c(thp1)
CNECNF00820
CNBCNBF3900
CNGCNAG_05891
CGICGB_F5460C
TMSTREMEDRAFT_65863
TASAA1Q1_07383
PPLPOSPLDRAFT_101350
TVSTRAVEDRAFT_137083
DSQDICSQDRAFT_67668
PCOPHACADRAFT_203182 PHACADRAFT_203552 PHACADRAFT_259229 PHACADRAFT_266509
SHSSTEHIDRAFT_103259
HIRHETIRDRAFT_241775
ADLAURDEDRAFT_156468
FMEFOMMEDRAFT_152913
GTRGLOTRDRAFT_139869
LBCLACBIDRAFT_298866 LACBIDRAFT_303372 LACBIDRAFT_312282 LACBIDRAFT_316334 LACBIDRAFT_316355 LACBIDRAFT_316369 LACBIDRAFT_316377
MRRMoror_1803 Moror_7098
MOREE1B28_004957
CCICC1G_09247
SCMSCHCODRAFT_67576
ABPAGABI1DRAFT69564(AGABI1DRAFT_69564)
ABVAGABI2DRAFT200628(AGABI2DRAFT_200628)
CPUTCONPUDRAFT_113454
SLASERLADRAFT_456783
WSEWALSEDRAFT_47705
WICJ056_001084
UMAUMAG_10845
PFPPFL1_04534
MGLMGL_2765
PGRPGTG_07986
MBRMONBRDRAFT_29131
SREPTSG_02460
SPARSPRG_01482
 » show all
Reference
1  [PMID:10767625]
  Authors
Waters TR, Swann PF
  Title
Thymine-DNA glycosylase and G to A transition mutations at CpG sites.
  Journal
Mutat Res 462:137-47 (2000)
DOI:10.1016/S1383-5742(00)00031-4
Reference
2  [PMID:8407958]
  Authors
Neddermann P, Jiricny J
  Title
The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells.
  Journal
J Biol Chem 268:21218-24 (1993)
  Sequence
[hsa:6996]
Reference
3  [PMID:9685338]
  Authors
Waters TR, Swann PF
  Title
Kinetics of the action of thymine DNA glycosylase.
  Journal
J Biol Chem 273:20007-14 (1998)
DOI:10.1074/jbc.273.32.20007
Other DBs
ExplorEnz - The Enzyme Database: 3.2.2.29
IUBMB Enzyme Nomenclature: 3.2.2.29
ExPASy - ENZYME nomenclature database: 3.2.2.29
BRENDA, the Enzyme Database: 3.2.2.29

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