Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
BRITE hierarchy

S-adenosyl-L-homocysteine homocysteinylribohydrolase

(1) S-adenosyl-L-homocysteine + H2O = S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine [RN:R00194];
(2) 5'-deoxyadenosine + H2O = 5-deoxy-D-ribose + adenine [RN:R12621];
(3) S-methyl-5'-thioadenosine + H2O = 5-(methylsulfanyl)-D-ribose + adenine [RN:R01401]

R00194 R01401 R12621
Reaction

S-adenosyl-L-homocysteine [CPD:C00021];
H2O [CPD:C00001];
5'-deoxyadenosine [CPD:C05198];
S-methyl-5'-thioadenosine [CPD:C00170]

This enzyme, found in bacteria and plants, acts on three different substrates. It is involved in the S-adenosyl-L-methionine (SAM, AdoMet) cycle, which recycles S-adenosyl-L-homocysteine back to SAM, and in salvage pathways for 5'-deoxyadenosine and S-methyl-5'-thioadenosine, which are produced from SAM during the action of many enzymes. cf. the plant enzyme EC 3.2.2.16, methylthioadenosine nucleosidase.

EC 3.2.2.9 created 1972, modified 2004, modified 2020