Entry |
|
Name |
S-adenosyl-L-methionine hydrolase (L-homoserine-forming);
S-adenosylmethionine cleaving enzyme;
methylmethionine-sulfonium-salt hydrolase;
adenosylmethionine lyase;
adenosylmethionine hydrolase;
S-adenosylmethionine hydrolase;
S-adenosyl-L-methionine hydrolase
|
Class |
Hydrolases;
Acting on ether bonds;
Thioether and trialkylsulfonium hydrolases
 |
Sysname |
S-adenosyl-L-methionine hydrolase (L-homoserine-forming)
|
Reaction(IUBMB) |
S-adenosyl-L-methionine + H2O = L-homoserine + S-methyl-5'-thioadenosine [RN: R00175]
|
Reaction(KEGG) |
|
Substrate |
|
Product |
L-homoserine [CPD: C00263];
S-methyl-5'-thioadenosine [CPD: C00170]
|
Comment |
Also hydrolyses S-methyl-L-methionine to dimethyl sulfide and homoserine. cf. EC 3.13.1.8, S-adenosyl-L-methionine hydrolase (adenosine-forming).
|
History |
EC 3.3.1.2 created 1972, modified 1976, modified 2018
|
Orthology |
K21534 | S-adenosyl-L-methionine hydrolase (L-homoserine-forming) |
|
Reference |
|
Authors |
Mazelis M, Levin B, Mallinson N. |
Title |
Decomposition of methyl methionine sulfonium salts by a bacterial enzyme. |
Journal |
Biochim Biophys Acta 105:106-14 (1965) |
Other DBs |
ExplorEnz - The Enzyme Database: | 3.3.1.2 |
ExPASy - ENZYME nomenclature database: | 3.3.1.2 |
BRENDA, the Enzyme Database: | 3.3.1.2 |
|