KEGG   ENZYME: 3.3.2.13
Entry
EC 3.3.2.13                 Enzyme                                 
Name
chorismatase;
chorismate/3,4-dihydroxycyclohexa-1,5-dienoate synthase;
fkbO (gene name);
rapK (gene name)
Class
Hydrolases;
Acting on ether bonds;
Ether hydrolases
Sysname
chorismate pyruvate-hydrolase
Reaction(IUBMB)
chorismate + H2O = (4R,5R)-4,5-dihydroxycyclohexa-1(6),2-diene-1-carboxylate + pyruvate [RN:R10583]
Reaction(KEGG)
R10583
Substrate
chorismate [CPD:C00251];
H2O [CPD:C00001]
Product
(4R,5R)-4,5-dihydroxycyclohexa-1(6),2-diene-1-carboxylate [CPD:C20710];
pyruvate [CPD:C00022]
Comment
The enzyme found in several bacterial species is involved in the biosynthesis of macrocyclic polyketides.
History
EC 3.3.2.13 created 2013
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
Orthology
K18239  chorismatase
Genes
PARZDTQ13_05210
SRCM271_40655
SMALSMALA_8314
SSOII1A49_45310
SQZFQU76_32190
SKACP970_02280
STSUB7R87_01750
SROIIAG44_38935
SDDD9753_34425
ACTNL083_2967(rapK)
ACTRAsp14428_14190(rapK)
 » show all
Reference
1  [PMID:21383123]
  Authors
Andexer JN, Kendrew SG, Nur-e-Alam M, Lazos O, Foster TA, Zimmermann AS, Warneck TD, Suthar D, Coates NJ, Koehn FE, Skotnicki JS, Carter GT, Gregory MA, Martin CJ, Moss SJ, Leadlay PF, Wilkinson B
  Title
Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.
  Journal
Proc Natl Acad Sci U S A 108:4776-81 (2011)
DOI:10.1073/pnas.1015773108
  Sequence
Reference
2  [PMID:24036425]
  Authors
Juneja P, Hubrich F, Diederichs K, Welte W, Andexer JN
  Title
Mechanistic implications for the chorismatase FkbO based on the crystal structure.
  Journal
J Mol Biol 426:105-15 (2014)
DOI:10.1016/j.jmb.2013.09.006
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.3.2.13
IUBMB Enzyme Nomenclature: 3.3.2.13
ExPASy - ENZYME nomenclature database: 3.3.2.13
BRENDA, the Enzyme Database: 3.3.2.13

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