KEGG   ENZYME: 3.3.2.13Help
Entry
EC 3.3.2.13                 Enzyme                                 

Name
chorismatase;
chorismate/3,4-dihydroxycyclohexa-1,5-dienoate synthase;
fkbO (gene name);
rapK (gene name)
Class
Hydrolases;
Acting on ether bonds;
Ether hydrolases
BRITE hierarchy
Sysname
chorismate pyruvate-hydrolase
Reaction(IUBMB)
chorismate + H2O = (4R,5R)-4,5-dihydroxycyclohexa-1(6),2-diene-1-carboxylate + pyruvate [RN:R10583]
Reaction(KEGG)
Substrate
chorismate [CPD:C00251];
H2O [CPD:C00001]
Product
(4R,5R)-4,5-dihydroxycyclohexa-1(6),2-diene-1-carboxylate [CPD:C20710];
pyruvate [CPD:C00022]
Comment
The enzyme found in several bacterial species is involved in the biosynthesis of macrocyclic polyketides.
History
EC 3.3.2.13 created 2013
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
Orthology
K18239  chorismatase
Genes
SRC: M271_40655
SMAL: SMALA_8314
ACTN: L083_2967(rapK)
Taxonomy
Reference
1  [PMID:21383123]
  Authors
Andexer JN, Kendrew SG, Nur-e-Alam M, Lazos O, Foster TA, Zimmermann AS, Warneck TD, Suthar D, Coates NJ, Koehn FE, Skotnicki JS, Carter GT, Gregory MA, Martin CJ, Moss SJ, Leadlay PF, Wilkinson B
  Title
Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.
  Journal
Proc Natl Acad Sci U S A 108:4776-81 (2011)
DOI:10.1073/pnas.1015773108
  Sequence
Reference
2  [PMID:24036425]
  Authors
Juneja P, Hubrich F, Diederichs K, Welte W, Andexer JN
  Title
Mechanistic Implications for the Chorismatase FkbO Based on the Crystal Structure.
  Journal
J Mol Biol 426:105-15 (2014)
DOI:10.1016/j.jmb.2013.09.006
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.3.2.13
IUBMB Enzyme Nomenclature: 3.3.2.13
ExPASy - ENZYME nomenclature database: 3.3.2.13
BRENDA, the Enzyme Database: 3.3.2.13

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