KEGG   ENZYME: 3.3.2.7Help
Entry
EC 3.3.2.7                  Enzyme                                 

Name
hepoxilin-epoxide hydrolase;
hepoxilin epoxide hydrolase;
hepoxylin hydrolase;
hepoxilin A3 hydrolase
Class
Hydrolases;
Acting on ether bonds;
Ether hydrolases
BRITE hierarchy
Sysname
(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate hydrolase
Reaction(IUBMB)
hepoxilin A3 + H2O = trioxilin A3 [RN:R04609]
Reaction(KEGG)
R04609;
(other) R07036
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Substrate
hepoxilin A3 [CPD:C04849];
H2O [CPD:C00001]
Product
trioxilin A3 [CPD:C04843]
Comment
Converts hepoxilin A3 into trioxilin A3. Highly specific for the substrate, having only slight activity with other epoxides such as leukotriene A4 and styrene oxide [2]. Hepoxilin A3 is an hydroxy-epoxide derivative of arachidonic acid that is formed via the 12-lipoxygenase pathway [2]. It is probable that this enzyme plays a modulatory role in inflammation, vascular physiology, systemic glucose metabolism and neurological function [4]. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol 5,6-oxide hydrolase) [3].
History
EC 3.3.2.7 created 1992, modified 2006
Pathway
ec00590  Arachidonic acid metabolism
Reference
1  [PMID:3348791]
  Authors
Pace-Asciak CR.
  Title
Formation and metabolism of hepoxilin A3 by the rat brain.
  Journal
Biochem Biophys Res Commun 151:493-8 (1988)
DOI:10.1016/0006-291X(88)90620-1
Reference
2  [PMID:2722835]
  Authors
Pace-Asciak CR, Lee WS.
  Title
Purification of hepoxilin epoxide hydrolase from rat liver.
  Journal
J Biol Chem 264:9310-3 (1989)
Reference
3  [PMID:11154734]
  Authors
Fretland AJ, Omiecinski CJ.
  Title
Epoxide hydrolases: biochemistry and molecular biology.
  Journal
Chem Biol Interact 129:41-59 (2000)
DOI:10.1016/S0009-2797(00)00197-6
Reference
4  [PMID:15748653]
  Authors
Newman JW, Morisseau C, Hammock BD.
  Title
Epoxide hydrolases: their roles and interactions with lipid metabolism.
  Journal
Prog Lipid Res 44:1-51 (2005)
DOI:10.1016/j.plipres.2004.10.001
Other DBs
ExplorEnz - The Enzyme Database: 3.3.2.7
IUBMB Enzyme Nomenclature: 3.3.2.7
ExPASy - ENZYME nomenclature database: 3.3.2.7
BRENDA, the Enzyme Database: 3.3.2.7
CAS: 122096-98-4

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