KEGG ENZYME: 3.3.2.9

ENZYME: 3.3.2.9

Entry

EC 3.3.2.9                  Enzyme

Name

microsomal epoxide hydrolase;
microsomal oxirane/oxetane hydrolase;
epoxide hydratase (ambiguous);
microsomal epoxide hydratase (ambiguous);
epoxide hydrase;
microsomal epoxide hydrase;
arene-oxide hydratase (ambiguous);
benzo[a]pyrene-4,5-oxide hydratase;
benzo(a)pyrene-4,5-epoxide hydratase;
aryl epoxide hydrase (ambiguous);
cis-epoxide hydrolase;
mEH;
EPHX1 (gene name)

Class

Hydrolases;
Acting on ether bonds;
Ether hydrolases

Sysname

cis-stilbene-oxide hydrolase

Reaction(IUBMB)

(1) cis-stilbene oxide + H2O = (1R,2R)-1,2-diphenylethane-1,2-diol [RN:R07627];
(2) 1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-({[(4-methoxyphenyl)methyl](methyl)amino}methyl)-2-methylpropane-1,3-diol [RN:R11930]

Reaction(KEGG)

R07627 R11930;
(other) R07013 R07014 R07027 R07071 R07072 R07082 R09410 R09417 R09443

Substrate

cis-stilbene oxide [CPD:C16014];
H2O [CPD:C00001];
1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine [CPD:C21775]

Product

(1R,2R)-1,2-diphenylethane-1,2-diol;
2-({[(4-methoxyphenyl)methyl](methyl)amino}methyl)-2-methylpropane-1,3-diol [CPD:C21776]

Comment

This is a key hepatic enzyme that catalyses the hydrolytic ring opening of oxiranes (epoxides) and oxetanes to give the corresponding diols. The enzyme is involved in the metabolism of numerous substrates including the stereoselective hydrolytic ring opening of 7-oxabicyclo[4.1.0]hepta-2,4-dienes (arene oxides) to the corresponding trans-dihydrodiols. The reaction proceeds via a triad mechanism and involves the formation of an hydroxyalkyl-enzyme intermediate. Five epoxide-hydrolase enzymes have been identified in vertebrates to date: EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol-5,6-oxide hydrolase).

History

EC 3.3.2.9 created 2006 (EC 3.3.2.3 created 1978, modified 1999, part incorporated 2006), modified 2017

Pathway

ec00980

Metabolism of xenobiotics by cytochrome P450

Orthology

K01253

microsomal epoxide hydrolase

Genes

HSA:	2052(EPHX1)

PTR:	457777(EPHX1)

PPS:	100995858(EPHX1)

GGO:	101130068(EPHX1)

PON:	100173792(EPHX1) 100437687 129050146

PPYG:

129044266(EPHX1) 129044281

NLE:	100592261(EPHX1)

HMH:	116457775(EPHX1)

SSYN:

129458456(EPHX1)

MCC:	700180(EPHX1)

MCF:	101866419(EPHX1)

MTHB:

126937150

MNI:	105478502(EPHX1)

CSAB:

103230002(EPHX1)

CATY:

105576938(EPHX1)

PANU:

101012773(EPHX1)

TGE:	112623225(EPHX1)

MLEU:

105552348(EPHX1)

RRO:	104660094(EPHX1)

RBB:	108538734(EPHX1)

TFN:	117074936(EPHX1)

PTEH:

111537082(EPHX1)

CANG:

105516681(EPHX1)

CJC:	100409580(EPHX1)

SBQ:	101029266(EPHX1)

CIMI:

108302734(EPHX1)

ANAN:

105722319(EPHX1)

CSYR:

103269955(EPHX1)

MMUR:

105863794(EPHX1)

LCAT:

123627522(EPHX1)

PCOQ:

105810378(EPHX1)

OGA:	100943654(EPHX1)

MMU:	13849(Ephx1)

MCAL:

110290857

MPAH:

110321688(Ephx1)

RNO:	25315(Ephx1)

MCOC:

116096986(Ephx1)

ANU:	117722048 117722080(Ephx1)

ASYL:

127697521 127697606 127697608 127697609 127697610

MUN:	110559921(Ephx1)

CGE:	100750792(Ephx1) 100758590

MAUA:

101835523 121137159

PROB:

127223704(Ephx1)

PLEU:

114686406

MORG:

121435840 121435939

MFOT:

126502146 126502147

AAMP:

119827559 119828107

NGI:	103725112 103725113

HGL:	101725522(Ephx1)

CPOC:

100721931(Ephx1)

CCAN:

109691482 109691483

DORD:

106001117

DSP:	122102745(Ephx1)

DMER:

138827600(Ephx1)

PLOP:

125359706(Ephx1)

NCAR:

124961084

MMMA:

107140500(Ephx1)

ITI:	101960577(Ephx1)

OCU:	100009104(EPHX1)

OPI:	101530165(EPHX1)

TUP:	102495357(EPHX1)

GVR:	103600115(EPHX1)

CFA:	480113(EPHX1)

CLUD:

112648822(EPHX1)

VVP:	112923564(EPHX1)

VLG:	121486260(EPHX1)

NPO:	129508629(EPHX1)

AML:	100477671(EPHX1)

UMR:	103669061(EPHX1)

UAH:	113262914(EPHX1)

UAR:	123791844(EPHX1)

ELK:

111150921

LLV:

125085943

MPUF:

106003316(EPHX1)

MNP:	132025517(EPHX1)

MLK:	131814562(EPHX1)

NVS:	122918688(EPHX1)

ORO:	101368385(EPHX1)

EJU:	114215601(EPHX1)

ZCA:	113933305(EPHX1)

MLX:	118013009(EPHX1)

NSU:	110571396(EPHX1) 123323815

LWW:	102745377(EPHX1)

FCA:	101085519(EPHX1)

PYU:	121015164(EPHX1)

PCOO:

112863168(EPHX1)

PBG:	122476210(EPHX1)

PVIV:

125159627(EPHX1)

LRUF:

124510305

LGF:	123585286(EPHX1)

AJU:

106968617

PTG:	102949568(EPHX1)

PPAD:

109250808(EPHX1)

PUC:	125917789 125917793

PLEZ:

122211984(EPHX1)

HHV:	120234147(EPHX1)

BTA:	535293(EPHX1)

BOM:	102267623(EPHX1)

BIU:	109570425(EPHX1)

BBUB:

102409402(EPHX1)

BBIS:

104997889(EPHX1)

CHX:	100860945(EPHX1)

OAS:	101111038(EPHX1)

BTAX:

128061886(EPHX1)

CSUM:

138090496(EPHX1)

ODA:	120880347(EPHX1)

CCAD:

122451836(EPHX1)

MREE:

136168284(EPHX1)

OVR:	110128647(EPHX1)

MBEZ:

129551639(EPHX1)

SSC:	397639(EPHX1)

CFR:	102519415(EPHX1)

CBAI:

105083879(EPHX1)

CDK:	105099693(EPHX1)

VPC:	102527697(EPHX1)

BACU:

103003233(EPHX1)

BMUS:

118892445(EPHX1)

LVE:	103074317(EPHX1)

OOR:	101288139(EPHX1)

LALB:

132508078(EPHX1)

GMF:	115859455(EPHX1)

DDP:	132414731(EPHX1)

DLE:	111177519(EPHX1)

PCAD:

102984566(EPHX1)

PSIU:

116748723(EPHX1)

PPHC:

136120688(EPHX1)

NASI:

112404976(EPHX1)

ECB:	100054269(EPHX1)

EPZ:	103543505(EPHX1)

EAI:	106844729(EPHX1)

MYB:	102263401(EPHX1)

MYD:	102767193(EPHX1)

MMYO:

118678977(EPHX1)

MDT:	132222379(EPHX1)

MYUM:

138999231(EPHX1)

PKL:	118727632(EPHX1)

EFUS:

103293524(EPHX1)

MNA:	107543604(EPHX1)

DRO:	112318922(EPHX1)

SHON:

119003202(EPHX1)

AJM:	119044442(EPHX1)

PDIC:

114512342(EPHX1)

PHAS:

123832837(EPHX1)

MMF:	118640564(EPHX1)

PPAM:

129073004(EPHX1)

HAI:	109391461(EPHX1)

RFQ:	117018666(EPHX1)

PALE:

102883919(EPHX1)

PGIG:

120619125(EPHX1)

PVP:	105292584(EPHX1)

RAY:	107517097(EPHX1)

MJV:	108408993(EPHX1)

TOD:	119244568(EPHX1)

SARA:

101537100(EPHX1)

SFUM:

130045366(EPHX1)

SETR:

126013425(EPHX1)

LAV:	100673770(EPHX1)

TMU:

101360751

ETF:	101652159(EPHX1)

DNM:	101418215(EPHX1)

MDO:	100025778(EPHX1)

GAS:	123245662(EPHX1)

SHR:	100925093(EPHX1)

AFZ:

127559537

PCW:	110205523(EPHX1)

TVP:	118845616 118845679 118846549 118848514

PBRV:

138141744(EPHX1)

MLAO:

141513201(EPHX1)

OAA:	100081956(EPHX1)

TACU:

119940827(EPHX1)

GGA:	421321(EPHX1) 421447(EPHX1L)

PCOC:

116229249 116231009(EPHX1)

MGP:	100539493 100545721(EPHX1)

CJO:	107311037(EPHX1) 107311272

TPAI:

128086988(EPHX1) 128088795

LMUT:

125688586 125690026(EPHX1)

NMEL:

110395399(EPHX1) 110396838

APLA:

101790722 101801005(EPHX1)

ACYG:

106029739 106031535(EPHX1)

CATA:

118253352(EPHX1) 118254315

AFUL:

116487216(EPHX1) 116487912

TGU:	100222959(EPHX1) 100227392

LSR:	110477509(EPHX1) 110477916

SCAN:

103817382 103819288(EPHX1)

PMOA:

120505979(EPHX1) 120506812

OTC:	121335741 121346931(EPHX1)

PRUF:

121357056(EPHX1) 121358526

ATRC:

139587473(EPHX1) 139591550

GFR:	102041759(EPHX1) 102042334

FAB:	101806940(EPHX1) 101814529

OMA:	130250644 130251392(EPHX1)

PHI:	102100615 102109472(EPHX1)

PMAJ:

107201686 107201817(EPHX1)

CCAE:

111926266(EPHX1) 111926954

CCW:	104684354 104685565(EPHX1)

CBRC:

103612689(EPHX1) 103624121

ACOE:

138107711(EPHX1) 138108031

ETL:	114059335 114073697(EPHX1)

ZAB:	102060438 102070896(EPHX1)

ZLE:	135445732 135446061(EPHX1)

ACHL:

103799966(EPHX1)

SVG:	106853010 106853915(EPHX1)

MMEA:

130575999 130578661(EPHX1)

HRT:	120750675 120750700(EPHX1)

SATI:

136359328 136359558(EPHX1)

CCIC:

134042084 134042714(EPHX1)

FPG:	101912868 101914944(EPHX1)

FCH:	102050687 102059804(EPHX1)

CCRI:

104161930(EPHX1) 104164844

NNT:	104405042(EPHX1) 104406829

SHAB:

115613418 115613509(EPHX1)

ACUN:

113478105(EPHX1) 113478705

TALA:

104363663 104368663(EPHX1)

ACHC:

115349892(EPHX1) 115350316

HALD:

104314305 104325460(EPHX1)

HLE:	104838144(EPHX1) 104840322

AGEN:

126051650 126052582

HHAR:

128149818 128150574(EPHX1)

GCL:	127014846 127015250

CSTI:

104553225(EPHX1) 104557585

LDI:	104348936(EPHX1) 104350292

MNB:	103775848 103777511(EPHX1)

DPUB:

104299949 104300896(EPHX1)

PPUS:

135183601 135186668(EPHX1)

AVIT:

104267999(EPHX1) 104268224

BRHI:

104491536(EPHX1)

EGZ:	104124117 104134609(EPHX1)

NNI:	104018666 104019274(EPHX1)

PCRI:

104024981 104031194(EPHX1)

PCAO:

104043305(EPHX1) 104050640

PADL:

103922855 103925015(EPHX1)

AFOR:

103898883(EPHX1) 103902677

FGA:	104070751 104073957(EPHX1)

GSTE:

104259295(EPHX1)

CBOY:

140649437 140649601(EPHX1)

CLV:	102085632(EPHX1) 102092641

CNIC:

135986594 135987075(EPHX1)

MUI:

104547407

PGUU:

104458493(EPHX1) 104459025

PLET:

104618973(EPHX1) 104619723

EHS:	104512259 104514942

CMAC:

104481879(EPHX1) 104486566

CUCA:

104056265 104067037(EPHX1)

TEO:	104370184(EPHX1) 104373427

BREG:

104637062 104637550(EPHX1)

OHA:	104329296 104331963(EPHX1)

ACAR:

104518807 104527715

CPEA:

104386207(EPHX1) 104396428

CVF:	104282324 104294655(EPHX1)

RTD:	128906503(EPHX1) 128907507

CRID:

134512647(EPHX1) 134512899

LMIC:

141740382(EPHX1) 141740700

AAM:	106482713(EPHX1) 106485556

AROW:

112963396(EPHX1) 112973398

NPD:	112942790(EPHX1) 112957521

TGT:	104578955(EPHX1)

DNE:	112980038(EPHX1) 112997146

SCAM:

104151569(EPHX1) 104151692

ASN:	102368835(EPHX1) 102386213

AMJ:	102571832 102577262(EPHX1)

CPOO:

109319775(EPHX1) 109319862

GGN:	109296897(EPHX1)

PSS:	102456152 102457257(EPHX1)

CMY:	102934448(EPHX1) 102942209

CCAY:

125633687(EPHX1) 125633785

DCC:	119852686(EPHX1) 119853587

CPIC:

101936865(EPHX1) 101949762

TST:	117874510(EPHX1) 117874592

CABI:

116819064 116823869(EPHX1)

MRV:	120400560(EPHX1) 120400786

ACS:	100554472 100555586(ephx1)

ASAO:

132761291 132761373(EPHX1)

PVT:	110075401(EPHX1)

SUND:

121915364(EPHX1) 121934079

PBI:	103058096(EPHX1)

PMUR:

107289275(EPHX1)

CTIG:

120307226(EPHX1) 120307716

TSR:	106541570 106542798(EPHX1)

PGUT:

117671761(EPHX1) 117671857

PCAE:

139320939(EPHX1) 139321372

APRI:

131188013(EPHX1)

PTEX:

113433034(EPHX1) 113433158

NSS:	113420395(EPHX1) 113420917

VKO:	123025614(EPHX1) 123032030

PMUA:

114594523 114594618(EPHX1)

PRAF:

128410969 128411072(EPHX1)

ZVI:	118081778 118083220(EPHX1)

HCG:	128348556 128350086(EPHX1)

GJA:	107119060(EPHX1)

STOW:

125425855 125437417(EPHX1)

EMC:

129328324

XLA:	108716563 432100(ephx1.L)

XTR:	100158543(ephx1) 105946059

NPR:	108787057(EPHX1) 108802126

RTEM:

120937855(EPHX1) 120938076 120938077

ACAT:

141140814(EPHX1) 141141036 141141037 141141039 141141307

BBUF:

120999601(EPHX1) 120999807 120999808 120999809

BGAR:

122931001 122931002 122931003 122934641(EPHX1)

DTC:	141060003 141060004 141060127(EPHX1)

PWL:	138296769(EPHX1) 138296799

MUO:	115465310(EPHX1) 115465422

GSH:	117357613(EPHX1) 117358061

DRE:	394043(ephx1)

SRX:

107732537

SANH:

107690044(ephx1)

SGH:	107553477 107601524

CCAR:

109044833 109080243

CAUA:

113062837 113063108 113120712

CGIB:

127938440 127983838

PTET:

122324509 122324778(ephx1)

LROH:

127182777(ephx1)

GRF:	141283472(ephx1) 141340922

OMC:	131527413(ephx1)

PPRM:

120493268(ephx1)

RKG:	130103079(ephx1)

MAMB:

125278271(ephx1)

CIDE:

127501785

CERY:

137018484(ephx1)

MASI:

127410303 127415710

TROS:

130565846(ephx1)

TDW:	130434266(ephx1)

MANU:

129429137 129429138(ephx1)

PDAB:

135737846 135738195(ephx1)

IPU:	108263372(ephx5)

PHYP:

113542048(ephx1)

SMEO:

124376972(ephx1)

TFD:	113647581(ephx1)

TVC:	132843536(ephx1)

TRN:	134320569(ephx1)

AMEX:

103040834(ephx1)

CMAO:

118815250(ephx1)

EEE:	113587098(ephx1)

CHAR:

105900083(ephx1) 105909349 122131879(ephx5)

SPIL:

134063550 134063551 134064511 134064516 134076521 134098571(ephx1)

ASAD:

121685788 121685789 121685790 121711424(ephx1)

TRU:	101066103(ephx1)

TFS:	130534365(ephx5)

TNG:	GSTEN00030811G001

LCO:	104918259 104918311(ephx1)

NCC:	104963447(ephx1)

TBEN:

117489081(ephx1) 117499680(ephx5)

CGOB:

115003531(ephx1) 115020096

PGEO:

117439870(ephx1) 117459885(ephx5)

GACU:

117536607(ephx1) 117553133(ephx5)

EMAC:

134859195(ephx5) 134876952(ephx1)

ELY:	117248410(ephx5) 117271285(ephx1)

EFO:	125897156(ephx1) 125903794(ephx5)

PLEP:

121954425(ephx5) 121955668(ephx1) 121964048

SLUC:

116051469(ephx5) 116065557(ephx1)

ECRA:

117960017(ephx5) 117961646(ephx1)

ESP:	116705706 116705884(ephx1)

PFLV:

114571843 114573297(ephx1)

GAT:	120807746(ephx1) 120820603(ephx5)

PPUG:

119194870(ephx1) 119214299(ephx5)

AFB:	129092092(ephx5) 129107120(ephx1)

CLUM:

117727545(ephx1) 117743845(ephx5)

PSWI:

130202368 130203056 130207069(ephx5)

CANA:

137779690(ephx5) 137785945(ephx1)

CVE:	137871140(ephx1) 137883177(ephx5)

MSAM:

119909018(ephx1) 119916924(ephx5) 119918272

SCHU:

122863157(ephx1) 122884001(ephx5)

CUD:	121506648(ephx1) 121510636 121510637 121510638

SPUL:

138585360(ephx1) 138588468(ephx5)

LMIX:

132975118(ephx5) 132984500(ephx1)

ALAT:

119012274(ephx1) 119033157 119033158

ASTR:

137603608(ephx5) 137613282(ephx1)

MZE:	101463752 101487605(ephx1)

ONL:	100693015(ephx1) 100711364 100711636

OAU:	116314224(ephx1) 116318528

OLA:	101166982 101172051(ephx1)

OML:	112141000(ephx1) 112161741(ephx5)

CSAI:

133418422(ephx1) 133463478(ephx5)

XMA:	102229129 102230310(ephx1)

XCO:	114138263 114158698(ephx1)

XHE:	116713645 116734282(ephx1)

PRET:

103477226

PFOR:

103134161(ephx1)

PLAI:

106961696(ephx1)

PMEI:

106930043(ephx1)

GAF:	122824815(ephx1) 122842946(ephx5)

PPRL:

129359987(ephx5) 129369188(ephx1)

CVG:	107093270(ephx1)

CTUL:

119797626(ephx5) 119797636(ephx1)

GMU:	124859323(ephx5) 124881512(ephx1)

NFU:

107375461

KMR:	108233942(ephx5) 108246518(ephx1)

ALIM:

106515907 106532950(ephx1)

NWH:	119417756(ephx5) 119417998(ephx1)

AOCE:

111583489(ephx1) 111585235(ephx5)

EJA:	138195516(ephx5) 138205601(ephx1)

BFRE:

138616083(ephx5) 138626711(ephx1)

MCEP:

124999376(ephx1) 125019156(ephx5)

CSEM:

103380678(ephx1)

POV:	109632306(ephx1)

SSEN:

122784166(ephx1)

SSOE:

131444106(ephx1)

HHIP:

117758195(ephx1)

HSP:	118099717(ephx1)

PPLT:

128459892(ephx1)

SMAU:

118290106(ephx1)

LCF:	108877099(ephx5) 108901766

SDU:	111220582 111239530(ephx1)

SLAL:

111661516(ephx1)

XGL:	120788741(ephx1) 120796290(ephx5)

HCQ:	109516170 109524815

SSCV:

125978755(ephx5) 125990183(ephx1)

SBIA:

133496267(ephx1) 133509465(ephx5)

PEE:	133409921(ephx5) 133416960(ephx1)

PTAO:

133468425(ephx1) 133485561(ephx5)

BPEC:

110154206(ephx1) 110156779

ENY:	140351254 140359315(ephx1)

MALB:

109958771(ephx1)

BSPL:

114870553(ephx5)

SJO:	128372653(ephx5) 128377137(ephx1)

SSCO:

133991709(ephx5) 133997416(ephx1)

SASA:

106571450 106607860

STRU:

115174737 115192170 115201724

OTW:	112224705(ephx5) 112250359(ephx1) 112261919

OMY:	110499486(ephx5) 110499548 110522278 110529658

OGO:	123990800 123995128 124040433(ephx5)

ONE:	115107806 115118720 115139362 115144473

OKI:	109866501 109870261 109870264 109900267

OKE:	118357678 118386954 118397798 118402703(ephx5)

OMM:	135505924(ephx1) 135523371 135523372 135557642

OCLA:

139376990 139376992 139407169 139415173

SALP:

111954385 111973113 112069884 112071241

SNH:	120019006 120024146 120029362 120029363 120029925 120029926

SFON:

129817416 129825166 129828593 129828594

CCLU:

121547755(ephx5) 121548868 121552613

ELS:	105009996 105017773(ephx1)

OEP:	134022645(ephx5) 134024944(ephx1)

SFM:	108925178(ephx1)

PKI:	111854029(ephx1)

AANG:

118217958(ephx5) 118230719(ephx1)

AROT:

135244422(ephx5) 135257488(ephx1)

CCOG:

133129808(ephx1)

LOC:	102682886(ephx1) 102687913

PSPA:

121315717 121315718

ARUT:

117402351(ephx5) 117402598

PSEX:

120516512(ephx5)

LCM:	102353239(EPHX1)

CMK:

103181611

RTP:

109925374

CPLA:

122548566

HOC:

132836231

HAKA:

140733202

PMRN:

116947939(EPHX1)

LRJ:	133341224(EPHX1)

BFO:	118403733 118403746 118404497 118404498 118404531 118418327

BBEL:

109476326 109476397

CIN:

100176449

SCLV:

120335264

SPU:	105437391 588166

LPIC:

129268187

AJJ:	139954750 139984448

APLC:

110978249

ARUN:

117300781 117300797 117300816 117307114

AAMU:

139949912 139949933

AFIL:

140144777 140145245 140145251 140145570 140145571 140161721 140161724 140162422 140162631 140162632 140162633

AJC:	117103745 117114357 117116249

SKO:

100371948

PFLL:

139115568 139115570

RZE:

108357011

VPS:

122631147

HHAL:

106691877

SGRE:

126293680

PVM:

113814676

PJA:

122245740

PCHN:

125032423 125032492

PMOO:

119596527

HAME:

121867766

MNZ:

135195063

MRJ:

136831311

PORN:

139748216

EAF:	111705076 111705077

TCF:

131883078

DSV:

119461825

VDE:

111248235

VJA:

111259854

GOE:	100900077 100903336

TUT:

107364002

DPTE:

113797953 113798526

DFR:	124490217 124493950

CSCU:

111622807

CVS:

136988276

PTEP:

107446491

ABRU:

129961830 129972631

UDV:

129216968

SDM:

118180616

LPOL:

106458781 106473233 106477280

PMEO:

129585230 129589033 129591709 129591716

CEL:	CELE_W01A11.1(W01A11.1)

CBR:

CBG_18950

CRQ:	GCK72_017934

NAI:	NECAME_00373

LOA:	LOAG_01695

TSP:

Tsp_04403

LAK:

106154062

NVE:

5500949

EPA:

110242247

ADF:

107344265

AMIL:

114972824 114974329 114974331 122947169

MCAZ:

138033822 138033823

MFOO:

138003317 138003318 138004578

PDAM:

113677512

SPIS:

111325313

XEN:

124459167

RES:	135691373 135691374

TAD:	TRIADDRAFT_63297

NCR:

NCU08783

NTE:	NEUTE1DRAFT122640(NEUTE1DRAFT_122640)

SMP:	10802655(SMAC4_04550)

PAN:	PODANSg1577 PODANSg2534

PBEL:

QC761_700510

PPSD:

QC762_001380 QC762_700510

PPSP:

QC763_001380 QC763_700510

PPSA:

QC764_001380 QC764_700510

MTM:	MYCTH_2120346

MGR:

MGG_14882

PPEI:

PpBr36_06535

PGRI:

PgNI_00652

SSCK:

SPSK_07616

FGR:	FGSG_01765

FPU:	FPSE_11393

FPOA:

FPOAC1_001873 FPOAC1_006228 FPOAC1_013440

FVN:	FVRRES_02107 FVRRES_06832

FVR:	FVEG_12319

FOX:	FOXG_13212

NHE:	NECHADRAFT_45915 NECHADRAFT_53192

FFC:	NCS54_00980200 NCS54_01394900

FKR:	NCS57_00503200 NCS57_01376900

FMU:	J7337_007667 J7337_013713

TRE:	TRIREDRAFT_64469

TRR:	M419DRAFT_36708

TATV:

25775213(TrAtP1_008766) 25784646(TrAtP1_010175) 25784909(TrAtP1_000276)

TASP:

36609288(TrAFT101_011057) 36610727(TrAFT101_002074) 36611755(TrAFT101_002671)

MAJ:

MAA_09463

MBRN:

26246650(G6M90_00g067860)

PCHM:

VFPPC_14740

CMT:

CCM_05222

AMUS:

LMH87_011228

CFJ:	CFIO01_01286

CLUP:

CLUP02_04735 CLUP02_07353

CHIG:

CH63R_03746 CH63R_06191 CH63R_09604

CDET:

87938675(CDEST_02172) 87940776(CDEST_04273) 87946027(CDEST_09524) 87949185(CDEST_12685)

ELA:	UCREL1_8323

PFY:	PFICI_13875

BFU:	BCIN_14g05560

MBE:

MBM_02500

PSCO:

LY89DRAFT_710694

GLZ:	GLAREA_08702 GLAREA_12516

ANI:	ANIA_03017

AFM:	AFUA_2G14860 AFUA_3G08960

ACT:	ACLA_036930

NFI:	NFIA_068170

AOR:	AO090005001384

ANG:	An12g08930 An16g02170(hyl1)

AFV:	AFLA_004204

ALUC:

AKAW2_61223A AKAW2_70182A

ACHE:

ACHE_40396A

APUU:

APUU_30512A APUU_60886A

PCS:	N7525_008829

PDP:	PDIP_08560

TMF:	EYB26_001367 EYB26_001374

TRG:	TRUGW13939_03191 TRUGW13939_06026

PBN:	PADG_00494

BGH:	BDBG_05030

PNO:	SNOG_02284

PTE:

PTT_15786

PTRR:

6342899(PtrM4_115840) 6348645(PtrM4_076820)

BZE:	COCCADRAFT_33094

BSC:	COCSADRAFT_185751

BOR:	COCMIDRAFT_107314

AALT:

CC77DRAFT_1022077 CC77DRAFT_801013

ADAC:

96081677(ACET3X_001355) 96087156(ACET3X_006834)

ARAB:

EKO05_0003744 EKO05_0007025

ZTR:	MYCGRDRAFT_71676

PFJ:	MYCFIDRAFT_52339

FFU:	CLAFUR5_02648 CLAFUR5_03954 CLAFUR5_04468 CLAFUR5_14183

CBET:

CB0940_02999 CB0940_03071 CB0940_11798 CB0940_12212

BCOM:

BAUCODRAFT_490072

NPA:	UCRNP2_8786

CNE:

CNN02220

CNB:

CNBN2260

CNG:	CNAG_06497

CGI:	CGB_N3310C

CDEC:

89992731(IAS62_005962)

CTEG:

91993137(I308_106282)

CBAS:

91985939(I312_105895)

KMG:	30160928(I203_105297)

KDJ:	28972205(I303_106853)

KBI:	30208865(I302_101090)

KPIN:

30173546(I206_107278)

KSH:	87957953(IL334_005823)

KER:	91103453(V865_004652)

TMS:	TREMEDRAFT_45464

TASA:

A1Q1_01368

CCAC:

CcaHIS019_0301030(CcaverHIS019_0301030)

SGRA:

EX895_004028 EX895_004254

» show all

Reference

1 [PMID:4998715]

Authors

Oesch F, Daly J.

Title

Solubilization, purification, and properties of a hepatic epoxide hydrase.

Journal

Biochim Biophys Acta 227:692-7 (1971)
DOI:10.1016/0005-2744(71)90018-0

Reference

Authors

Jakoby WB, Fjellstedt TA.

Title

Epoxidases.

Journal

In: Boyer PD (ed). The Enzymes. 3rd ed. Vol. 7. New York: Academic Press; 1972. p. 199-212.

Reference

3 [PMID:4584115]

Authors

Oesch F.

Title

Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds.

Journal

Xenobiotica 3:305-40 (1973)
DOI:10.3109/00498257309151525

Reference

4 [PMID:4463951]

Authors

Oesch F.

Title

Purification and specificity of a human microsomal epoxide hydratase.

Journal

Biochem J 139:77-88 (1974)
DOI:10.1042/bj1390077

Reference

5 [PMID:240858]

Authors

Lu AY, Ryan D, Jerina DM, Daly JW, Levin W.

Title

Liver microsomal expoxide hydrase. Solubilization, purification, and characterization.

Journal

J Biol Chem 250:8283-8 (1975)

Reference

6 [PMID:7986671]

Authors

Bellucci G, Chiappe C, Ingrosso G.

Title

Kinetics and stereochemistry of the microsomal epoxide hydrolase-catalyzed hydrolysis of cis-stilbene oxides.

Journal

Chirality 6:577-82 (1994)
DOI:10.1002/chir.530060711

Reference

7 [PMID:11154734]

Authors

Fretland AJ, Omiecinski CJ.

Title

Epoxide hydrolases: biochemistry and molecular biology.

Journal

Chem Biol Interact 129:41-59 (2000)
DOI:10.1016/S0009-2797(00)00197-6

Reference

8 [PMID:15822179]

Authors

Morisseau C, Hammock BD.

Title

Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles.

Journal

Annu Rev Pharmacol Toxicol 45:311-33 (2005)
DOI:10.1146/annurev.pharmtox.45.120403.095920

Reference

9 [PMID:15748653]

Authors

Newman JW, Morisseau C, Hammock BD.

Title

Epoxide hydrolases: their roles and interactions with lipid metabolism.

Journal

Prog Lipid Res 44:1-51 (2005)
DOI:10.1016/j.plipres.2004.10.001

Reference

10 [PMID:28600384]

Authors

Toselli F, Fredenwall M, Svensson P, Li XQ, Johansson A, Weidolf L, Hayes MA

Title

Oxetane Substrates of Human Microsomal Epoxide Hydrolase.

Journal

Drug Metab Dispos 45:966-973 (2017)
DOI:10.1124/dmd.117.076489

Other DBs

ExplorEnz - The Enzyme Database:

3.3.2.9

IUBMB Enzyme Nomenclature:

3.3.2.9

ExPASy - ENZYME nomenclature database:

3.3.2.9

BRENDA, the Enzyme Database:

3.3.2.9

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