KEGG   ENZYME: 3.4.11.14
Entry
EC 3.4.11.14                Enzyme                                 
Name
cytosol alanyl aminopeptidase;
arylamidase;
aminopolypeptidase;
thiol-activated aminopeptidase;
human liver aminopeptidase;
puromycin-sensitive aminopeptidase;
soluble alanyl aminopeptidase;
cytosol aminopeptidase III;
alanine aminopeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases
Reaction(IUBMB)
Release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides
Comment
A puromycin-sensitive, Co2+-activated zinc-sialoglycoprotein that is generally cytosolic. Multiple forms are widely distributed in mammalian tissues and body fluids. In peptidase family M1 (membrane alanyl aminopeptidase family)
History
EC 3.4.11.14 created 1978
Orthology
K08776  puromycin-sensitive aminopeptidase
Genes
HSA9520(NPEPPS)
PTR745883 749281(NPEPPS)
PPS100975499(NPEPPS) 117976498
GGO101131451(NPEPPS)
PON100439609(NPEPPS)
NLE100584360 100588275
MCC693995(NPEPPS)
MCF102138685(NPEPPS)
MTHB126938422
CSAB103243576(NPEPPS)
CATY105579514
PANU101018545(NPEPPS)
TGE112608878(NPEPPS)
RRO104674885(NPEPPS)
RBB108533943(NPEPPS)
TFN117067130(NPEPPS)
PTEH111537501(NPEPPS)
CJC100409612(NPEPPS)
SBQ101027874(NPEPPS)
CSYR103252898(NPEPPS)
MMUR105872145(NPEPPS)
LCAT123620796(NPEPPS)
OGA100962852(NPEPPS)
MMU19155(Npepps)
MCAL110304961(Npepps)
MPAH110331520(Npepps)
RNO50558(Npepps)
MCOC116079224(Npepps)
MUN110551434(Npepps)
CGE100763186(Npepps)
MAUA101836292(Npepps)
PLEU114692951(Npepps)
MORG121456281(Npepps)
MFOT126510225
AAMP119811751(Npepps)
NGI103743834(Npepps)
HGL101726089(Npepps)
CPOC100723805(Npepps)
CCAN109683393
DORD106001928(Npepps)
DSP122101750(Npepps)
NCAR124980192
OCU100350778(NPEPPS)
OPI101527158(NPEPPS)
TUP102501950(NPEPPS)
CFA480538(NPEPPS)
CLUD112655016(NPEPPS)
VVP112917811(NPEPPS)
VLG121473283(NPEPPS)
AML100479817(NPEPPS)
UMR103660811(NPEPPS)
UAH113265551(NPEPPS)
UAR123802820(NPEPPS)
ELK111151354
LLV125087500
MPUF101684280(NPEPPS)
ORO101375036(NPEPPS)
EJU114198414(NPEPPS)
ZCA113939455(NPEPPS)
MLX118024822(NPEPPS)
NSU110593291(NPEPPS)
FCA101098097(NPEPPS)
PYU121044873(NPEPPS)
PBG122485444(NPEPPS)
LRUF124513298
PTG102958269(NPEPPS)
PPAD109247377(NPEPPS)
AJU106980476(NPEPPS)
HHV120229160(NPEPPS)
BTA534122(NPEPPS)
BOM102283776(NPEPPS)
BIU109573967(NPEPPS)
BBUB102407502(NPEPPS)
CHX102173501(NPEPPS)
OAS101122874(NPEPPS)
ODA120867255(NPEPPS)
CCAD122442313(NPEPPS)
SSC414413(NPEPPS)
CFR102505480(NPEPPS)
CBAI105073292(NPEPPS)
CDK105106945(NPEPPS)
VPC102531816(NPEPPS)
BACU103013058(NPEPPS)
LVE103089473(NPEPPS)
OOR101274479(NPEPPS)
DLE111166238(NPEPPS)
PCAD102993314
PSIU116745302(NPEPPS)
ECB100069104(NPEPPS)
EPZ103559701
EAI106826382(NPEPPS)
MYB102253060(NPEPPS)
MYD102755319(NPEPPS)
MMYO118671243(NPEPPS)
MLF102426318(NPEPPS)
MNA107529028(NPEPPS)
PKL118702054(NPEPPS)
HAI109380821(NPEPPS)
DRO112316223(NPEPPS)
SHON118978017(NPEPPS)
AJM119052605(NPEPPS)
PDIC114502260(NPEPPS)
PHAS123817273(NPEPPS)
MMF118633866(NPEPPS)
RFQ117013271(NPEPPS)
PALE102894538(NPEPPS)
PGIG120611227(NPEPPS)
PVP105308380
RAY107520647(NPEPPS)
MJV108396422(NPEPPS)
TOD119232857(NPEPPS)
SARA101557971(NPEPPS)
LAV100677368(NPEPPS)
TMU101347169
DNM101420638
MDO100019211(NPEPPS)
GAS123247577(NPEPPS)
SHR100932447(NPEPPS)
PCW110215708(NPEPPS)
OAA100087737(NPEPPS)
GGA426231(NPEPPS)
PCOC116233636(NPEPPS)
MGP100550875(NPEPPS)
CJO107325198(NPEPPS)
NMEL110388406(NPEPPS)
ACYG106048489(NPEPPS)
AFUL116498402(NPEPPS)
TGU105758921(NPEPPS)
LSR110478680(NPEPPS)
SCAN103821811
PMOA120500170(NPEPPS)
OTC121334835(NPEPPS)
PRUF121356964(NPEPPS)
GFR102032640(NPEPPS)
FAB101812143(NPEPPS)
PHI102106156(NPEPPS)
PMAJ107215068(NPEPPS)
CCAE111940019
CBRC103619955(NPEPPS)
ETL114070654
ZAB102075094
ACHL103805369
FPG101918907(NPEPPS)
FCH102059698
CLV102089128(NPEPPS)
EGZ104122120
NNI104012216(NPEPPS)
PLET104627471(NPEPPS)
PCRI104024480(NPEPPS)
ACUN113490797(NPEPPS)
TALA104365642(NPEPPS)
PADL103915533
AFOR103895304
ACHC115344700(NPEPPS)
HALD104311226(NPEPPS)
CCRI104160632(NPEPPS)
CSTI104557894(NPEPPS)
EHS104516342(NPEPPS)
CMAC104477002(NPEPPS)
MUI104544371
FGA104069788(NPEPPS)
GSTE104255409(NPEPPS)
LDI104348256
MNB103768162(NPEPPS)
OHA104334676
NNT104405208(NPEPPS)
DPUB104310174(NPEPPS)
PGUU104462517(NPEPPS)
AVIT104273346
CVF104286510
AAM106497297
AROW112969517
NPD112960168
TGT104574149
DNE112992129(NPEPPS)
SCAM104150785
ASN102368663(NPEPPS)
AMJ102560510(NPEPPS)
CPOO109320238
GGN109290955
PSS102463159(NPEPPS)
CMY102943125(NPEPPS)
CPIC101952968(NPEPPS)
TST117869125(NPEPPS)
CABI116831416(NPEPPS)
MRV120392174(NPEPPS)
ACS100567726(npepps)
PVT110074890(NPEPPS)
SUND121932625(NPEPPS)
PBI103051094(NPEPPS)
PMUR107282639(NPEPPS) 107294509
CTIG120303514(NPEPPS)
TSR106547200
PGUT117664579(NPEPPS)
VKO123030563(NPEPPS)
PMUA114582573(NPEPPS)
ZVI118094165(NPEPPS)
GJA107111497(NPEPPS)
STOW125445267(NPEPPS)
XLA108702505(npepps.S) 733291(npepps.L)
XTR780147(npepps)
NPR108794542(NPEPPS)
RTEM120918283(NPEPPS)
BBUF121003251(NPEPPS)
BGAR122940282(NPEPPS)
DRE407726(npepps)
SRX107718863 107753845
SANH107674532 107680533
SGH107562071(npepps)
CCAR109072054 109072057
CAUA113055053 113110619 113110775
PPRM120468916(npepps)
MAMB125256244(npepps)
IPU108270751(npepps)
PHYP113527099(npepps)
SMEO124390890(npepps)
TFD113657782(npepps)
AMEX103022633
EEE113575408(npepps)
TRU101073265
TNGGSTEN00011946G001
LCO104933025
CGOB115006228(npepps)
ELY117255074(npepps)
EFO125885465(npepps)
PLEP121942075(npepps)
SLUC116049857(npepps)
ECRA117951968(npepps)
PFLV114548324
GAT120824584(npepps)
PPUG119217881(npepps)
MSAM119897874(npepps)
CUD121508171(npepps)
ALAT119016804(npepps)
MZE101475000(npepps)
ONL100711411(npepps)
OAU116321470(npepps)
OLA101158915
OML112138115(npepps)
XMA102234560(npepps)
XCO114144481(npepps)
XHE116720226(npepps)
PRET103470327(npepps)
PFOR103153646(npepps)
PLAI106958123(npepps)
PMEI106930245(npepps)
GAF122829182(npepps)
CVG107098842
CTUL119796347(npepps)
GMU124868088(npepps)
NFU107382387(npepps)
KMR108244358(npepps)
ALIM106519027(npepps)
NWH119422621(npepps)
AOCE111572437(npepps)
MCEP125003689(npepps)
CSEM103383154
POV109641588(npepps)
SSEN122771286(npepps)
HHIP117763688(npepps)
HSP118098388(npepps)
LCF108883870
SDU111238247(npepps)
SLAL111658785(npepps)
XGL120800261(npepps)
HCQ109512617
BPEC110155941(npepps)
MALB109952896(npepps)
BSPL114861097(npepps)
SASA106564746 106587691
STRU115178368 115208697
OTW112245656 112265222
OMY110485887 110493605
OGO124002640 124015723
ONE115103749 115142528
SALP111982481 112067983
SNH120032506 120066283
CCLU121533969 121534030(npepps)
ELS105021481(npepps)
SFM108918777(npepps)
PKI111850757
AANG118218395(npepps)
LOC102697964(npepps)
PSPA121302027 121324177(npepps)
ARUT117433447 117435083
LCM102349250(NPEPPS)
CMK103185706(npepps)
RTP109915008
BFO118405580
BBEL109462181
CIN100183092
SPU583749
APLC110986655
SKO100373801(Npepps)
DMEDmel_CG1009(Psa)
DER6545669
DSE6610336
DSIDsimw501_GD13621(Dsim_GD13621)
DYADyak_GE21157
DAN6507399
DSR110178727
DPO4814127
DPE6599595
DMN108151320
DWI6638905
DGR6557671
DMODmoj_GI16669
DAZ108613320
DNV108652232
DHE111592452
DVI6622927
CCAT101449431
BOD106618526
RZE108365476 108374314 108374315
MDE101893750
SCAC106088627
LCQ111679422
LSQ119604924
HIS119647828 119649544
AGAAgaP_AGAP005728
ACOZ120948360
AARA120897371
ASTE118513135
AAG5576957
AALB109430897 115263179 115263344
CQUCpipJ_CPIJ008439
CPII120417614
CNS116345678
BCOO119077950 119078235 119079928
AME410769
ACER107992786
ALAB122716517
BIM100741395
BBIF117209756
BVK117235017
BVAN117158730
BTER100651719
BPYO122568992
CCAL108629431
OBB114877932
MGEN117221570
NMEA116424417
CGIG122396715
SOC105199614
MPHA105829325
AEC105143429 105151239
ACEP105617451
PBAR105425942
VEM105559291
HST105184381
DQU106746295
CFO105248763
FEX115233217 115234014 115240313
LHU105671775
PGC109855869
OBO105286580
PCF106786848
PFUC122518806
VPS122627074
NVI100115075 100116757
CSOL105360712
TPRE106653910
MDL103579499
CGLO123264777
FAS105267276
DAM107040821
AGIF122849523 122849524
LHT122507128 122512091
CCIN107275127
TCA656477
DPA109537682
SOY115885143
ATD109599931 109599941
CSET123322639 123322640
AGB108914205
LDC111505170
NVL108562938
APLN108734075
PPYR116173199
OTU111414843
BMOR101743240
BMAN114251647
MSEX115440059
DPLKGM_213611
BANY112043153
NIQ126774167
PMAC106719202
PPOT106109754
PXU106115164 106121308 106122244 106122719 106127970 106128030
PRAP111003727
ZCE119840752
HAW110379613
HZE124635057
TNL113501529
SLIU111359055
OFU114361612
PXY105386434
CFEL113386518 113386521 113387607 113388545
API100162520
DNX107171705 107173520
AGS114122911
RMD113553686
BTAB109039204 109039215
DCI113470132
CLEC106663042 106666024
HHAL106683501
NLU111046243 111056058
PHUPhum_PHUM390660
FOC113202215 113205249 113205250
TPAL117640273 117643417
ZNE110833944
CSEC111872423
FCD110842395 110844739 110849652 110852645
DPXDAPPUDRAFT_300392
DMK116918542
PVM113808335
PJA122256351
PCHN125037401
HAME121853214
PCLA123768261
PTRU123498097
HAZT108668146
EAF111695728 111698679
LSM121121076 121122113 121123516
PPOI119097997 119098607 119099111
ISCIscW_ISCW008629
DSV119461967
RSAN119378988
RMP119176030
VDE111245225 111247374 111247702 111247900
VJA111262660 111268301 111269886 111272680
TUT107366781
DPTE113791744 113792572
DFR124495840 124496867
CELCELE_F49E8.3(pam-1)
CBRCBG_05905(Cbr-pam-1)
BMYBM_BM4229(Bma-pam-1)
LOALOAG_08229
NAINECAME_11562
TSPTsp_08066
HROHELRODRAFT_175168
LGILOTGIDRAFT_202512 LOTGIDRAFT_204438
PCAN112562400 112562481
BGT106055534 106070834
GAE121387431
HRF124135903 124151563
HRJ124254753 124289158
CRG105348440
MYI110441409
PMAX117339115
MMER123539487
OBI106877238 106878308
OSN115223377 115223635 115231593
LAK106171262 106182016
SMMSmp_091470
OVIT265_09672
EGLEGR_07486 EGR_07978 EGR_10634 EGR_10706
NVE5516782
EPA110235391
ATEN116307796
AMIL114970510
PDAM113669668 113670052
SPIS111328198 111328200
DGT114517443
XEN124452581
HMG100205272 100207973
TADTRIADDRAFT_22803 TRIADDRAFT_26823
AQU100633278 100641491
ATHAT4G33090(APM1)
ALY9303275
CRB17878826
CSAT104716854 104721507 104729951
EUSEUTSA_v10024371mg
BRP103834499 103850079
BNA106361112 106361113 106363803 106368761 106404833 106404871 106452059 106452062
BOE106309192 106332415
RSZ108821056 108840456 108843162
THJ104803719
CPAP110822080
CIT102614871 102628994
CICCICLE_v10007414mg CICLE_v10024930mg
PVY116109861 116142476
MINC123195347 123211335
TCC18588103 18588104 18596186
GRA105767355 105782159 105802563
GHI107893393 107893713 107906079 107929927 107953894
GAB108452195 108453136 108463275
DZI111274664 111286643 111286645 111299245
EGR104423004 104437866 104437868
GMX100798014 100811437
GSJ114408838 114414833
PVUPHAVU_009G079500g
VRA106761873
VAR108330555
VUN114162919
CCAJ109789352 109802346
APRC113864459
MTR11418915 11423248
CAM101493693(NPEPPS) 101506534
LJALj0g3v0306299.1(Lj0g3v0306299.1) Lj0g3v0306299.2(Lj0g3v0306299.2) Lj1g3v1787580.1(Lj1g3v1787580.1) Lj3g3v0420560.1(Lj3g3v0420560.1)
ADU107461018
AIP107606297
AHF112706346 112766402
LANG109334078 109343813
FVE101304606 101306444 101307603
RCN112174016 112174018 112186455 112186456
PPER18782354 18791712 18792614 18793193
PMUM103320116 103320590 103320593 103327661
PAVI110761230 110761289 110765092 110765102
PDUL117627408 117627415 117633915
MDM103415389 103440784 103453592 103454499 114826473 114826474
PXB103927509 103927510 103927512 103932778 103948738 103952459 103955429 103961541
ZJU107420117 107435523 107435783
MNT21386557 21403302
CSV101211362 101215753
CMO103490040 103493679 107990275
BHJ120084370 120086990
MCHA111024975
CMAX111479875 111481198
CMOS111446596 111457505
CPEP111788106 111789757
RCU8258548
JCU105638111
HBR110635760 110659417
MESC110603445 110611332 110611333
POP18106996 7462240
PEU105122157
PALZ118030755 118054980
JRE109003063 109003064 109003066 109005302 109008886
QSU111985176 111985177 111985193 111985222 111985224 111993435 111995618 111995622 112003476 112007170 112007431 112010584 112010590 112019908 112025441
QLO115951422 115954273 115954274 115955075 115968958 115969146 115969160 115969186 115969204 115989572 115991934
TWL119996571 120002831
VVI100244572 100264544
VRI117912558 117922174
SLY101250430
SPEN107028337
SOT102600594
SSTN125841206
CANN107838982
NTA107806287 107820013
NSY104247919
NTO104087993
NAU109211551
INI109185019
ITR116022713
SIND105164645
OEU111384240 111398246
EGT105977086
SSPL121752047 121768394 121769899 121779590 121785107
HAN110865669 110880240
ECAD122586860 122591245
LSV111881790 111908607
CCAV112505842 112510518
DCR108204326 108208966
CSIN114316671 114318743 114322499
BVG104886599
SOE110795863
CQI110705402 110728402
NNU104588260 104590405
MING122068672 122083326
TSS122656281 122666600
PSOM113347676 113350420
NCOL116255728
OSA4328737 4345501 4346854 4346856
DOSAOs02t0218200-01(Os02g0218200) Os08t0398700-01(Os08g0398700) Os09t0362500-01(Os09g0362500)
OBR102705102 102705375 102705410 102709866
BDI100827486 100831967 100835157
ATS109747276 109766709 109766976 109767809 109770108 109770110 109775281
TDC119287108 119294599 119301382 119301384 119307628 119308994 119308995 119309522 119316634 119326314
TAES123082602 123087320 123090622 123095652 123103574 123103575 123110584 123111781 123111782 123121345 123121346 123127293 123136986 123141002 123144386 123161448
TUA125509123 125509124 125509133 125512265 125531238
SBI110437022 8054615 8082957
ZMA103627107 103634048 103643317
SITA101760579 101778842 101783031
SVS117844990 117852428 117860940
PVIR120655105 120660466 120677541 120678752 120692396 120712257
PHAI112880745 112892827 112897408 112898246
PDA103696266 103720809
EGU105040383 105054374 105056651
MUS103969965 103990013
DCT110105162 110105172
PEQ110027819
AOF109827863 109851370
ATR18435092
SMOSELMODRAFT_138421 SELMODRAFT_423961 SELMODRAFT_438332 SELMODRAFT_446442 SELMODRAFT_447892 SELMODRAFT_73707 SELMODRAFT_86614
PPP112296078
CRECHLRE_02g076200v5
MPPMICPUCDRAFT_34050
CMECYME_CMS341C
GSLGasu_15870 Gasu_26180
SREPTSG_02947
DDIDDB_G0270670(psaB) DDB_G0270994(psaA)
DPPDICPUDRAFT_45518 DICPUDRAFT_46283 DICPUDRAFT_47371 DICPUDRAFT_49420
DFADFA_00878 DFA_02449 DFA_06599(psaB)
EHIEHI_008380(114.t00005)
EDIEDI_061590
EIVEIN_079080 EIN_226640
ACANACA1_061810 ACA1_132890 ACA1_220200
SMINv1.2.001356.t1(symbB.v1.2.001356.t1) v1.2.007673.t1(symbB.v1.2.007673.t1) v1.2.020603.t1(symbB.v1.2.020603.t1) v1.2.020603.t2(symbB.v1.2.020603.t2) v1.2.028585.t1(symbB.v1.2.028585.t1)
PTIPHATRDRAFT_29758
FCYFRACYDRAFT_182429
TPSTHAPS_269937
AAFAURANDRAFT_27603(APN1)
PIFPITG_02917 PITG_08804
PSOJPHYSODRAFT_347580 PHYSODRAFT_537824
SPARSPRG_03881 SPRG_08367
GTTGUITHDRAFT_93634
TBRTb11.02.1070 Tb927.3.4750 Tb927.3.4790
TBGTbgDal_III5310 TbgDal_III5350 TbgDal_XI4060
TCR508153.60 511051.70
LMALMJF_26_0300 LMJF_29_2240
LIFLINJ_26_0290 LINJ_29_2350
LDOLDBPK_260290 LDBPK_292350
LMILMXM_08_29_2240 LMXM_26_0300
LBZLBRM_26_0330 LBRM_29_2220
LPANLPMP_260300 LPMP_292270
NGRNAEGRDRAFT_35172 NAEGRDRAFT_57020 NAEGRDRAFT_83248
TVATVAG_2v0313720 TVAG_2v0324800
ADEAdeh_1419
ACPA2cp1_2528
AFWAnae109_2417
ANKAnaeK_2441
MXAMXAN_6822
MSDMYSTI_07420
MYMA176_000001 A176_007738
MFBMFUL124B02_39380
CCXCOCOR_07401(pepN2)
MFULILAB_12350
MMASMYMAC_006516
SURSTAUR_1076
AGEAA314_09539
AVMJQX13_08545
MBDMEBOL_002556
CFUSCYFUS_009398
VINAKJ08_0421
SAYTPY_3721
SAPSulac_3417
STHRBXT84_13950
AFOAfer_0493
AYMYM304_11100
ATQGH723_13785
AQZKSP35_10935
ABAAcid345_1050
ACAACP_2284
GMAAciX8_4814
GRWFTO74_18175
TSAAciPR4_0518
TRSTerro_1002
NDENIDE0352
NMVNITMOv2_0271
NJANSJP_1397
 » show all
Reference
1  [PMID:4841062]
  Authors
Starnes WL, Behal FJ.
  Title
A human liver aminopeptidase. The amino acid and carbohydrate content, and some physical properties of a sialic acid containing glycoprotein.
  Journal
Biochemistry 13:3221-7 (1974)
DOI:10.1021/bi00713a004
Reference
2  [PMID:698181]
  Authors
Kao YJ, Starnes WL, Behal FJ.
  Title
Human kidney alanine aminopeptidase: physical and kinetic properties of a sialic acid containing glycoprotein.
  Journal
Biochemistry 17:2990-4 (1978)
DOI:10.1021/bi00608a008
Reference
3  [PMID:6108169]
  Authors
Sidorowicz W, Hsia WC, Maslej-Zownir O, Behal FJ.
  Title
Multiple molecular forms of human alanine aminopeptidase: immunochemical properties.
  Journal
Clin Chim Acta 107:245-56 (1980)
DOI:10.1016/0009-8981(80)90452-0
Other DBs
ExplorEnz - The Enzyme Database: 3.4.11.14
IUBMB Enzyme Nomenclature: 3.4.11.14
ExPASy - ENZYME nomenclature database: 3.4.11.14
BRENDA, the Enzyme Database: 3.4.11.14
CAS: 243859-94-1

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