KEGG   ENZYME: 3.4.11.15
Entry
EC 3.4.11.15                Enzyme                                 
Name
aminopeptidase Y;
aminopeptidase Co;
aminopeptidase (cobalt-activated);
lysyl aminopeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases
Reaction(IUBMB)
Preferentially, release of N-terminal lysine
Comment
Requires Co2+; inhibited by Zn2+ and Mn2+. An enzyme best known from Saccharomyces cerevisiae that hydrolyses Lys-NHPhNO2 and, more slowly, Arg-NHPhNO2. Type example of peptidase family M28
History
EC 3.4.11.15 created 1989, modified 1997
Orthology
K01264  aminopeptidase Y
Genes
SCEYBR286W(APE3)
SEUBDI49_1309
SPAOSPAR_B03810
AGOAGOS_ADR123W
ERCEcym_6317
KLAKLLA0_D06424g
KMXKLMA_20821(APE3)
LTHKLTH0H10054g
VPOKpol_1027p12
ZROZYRO0G21208g
CGRCAGL0G07623g
NCSNCAS_0B07580(NCAS0B07580)
NDINDAI_0B04920(NDAI0B04920)
TPFTPHA_0I01120(TPHA0I01120)
TBLTBLA_0C02710(TBLA0C02710)
TDLTDEL_0D01650(TDEL0D01650)
TGBHG536_0F01790
KAFKAFR_0A03620(KAFR0A03620)
KNGKNAG_0C01650(KNAG0C01650)
ZMKHG535_0H01310
PPAPAS_chr1-4_0611
DHADEHA2C09702g
PICPICST_89245(APE3.1)
PGUPGUG_03742
SPAASPAPADRAFT_60220
LELLELG_02607
CALCAALFM_C208800CA(APE3)
CTPCTRG_01938
COTCORT_0C03660
CDUCD36_22970
CTENCANTEDRAFT_116304
YLIYALI0B21186g
CLUCLUG_02528
CLUSA9F13_07g03443
CAURCJI97_005268
SLBAWJ20_3460(APE3)
PKZC5L36_0A10230
BNNFOA43_001459
BBRXBRETT_002624
OPAHPODL_04270
SLUDSCDLUD_003585
PANPODANSg1533 PODANSg1579
MTMMYCTH_54466
CTHRCTHT_0037000 CTHT_0050060
MGRMGG_09692
TMNUCRPA7_2183 UCRPA7_292 UCRPA7_8511
SSCKSPSK_07399
FGRFGSG_06527 FGSG_06545
FPUFPSE_01712 FPSE_01730
FVRFVEG_05601 FVEG_05619
FOXFOXG_02417 FOXG_02433
NHENECHADRAFT_60585 NECHADRAFT_93056
TRETRIREDRAFT_81070 TRIREDRAFT_81087
TRRM419DRAFT_111063 M419DRAFT_111088
MAWMAC_03330 MAC_09822
MAJMAA_06797 MAA_07115
CMTCCM_05888 CCM_07880
PLJVFPFJ_10537 VFPFJ_11514
VALVDBG_01281 VDBG_09096
VDAVDAG_07246
CFJCFIO01_00127 CFIO01_05349 CFIO01_11238
CHIGCH63R_05524
SAPOSAPIO_CDS2153 SAPIO_CDS5260
ELAUCREL1_1439 UCREL1_4559
PFYPFICI_05842
SSLSS1G_07901
BFUBCIN_15g01050(Bcape3)
MBEMBM_02398
PSCOLY89DRAFT_736041
GLZGLAREA_00751
ANIAN3918.2
AFMAFUA_2G00220
ACTACLA_094720
NFINFIA_032410
AORAO090012000110
ANGANI_1_196034(An03g01660)
AFVAFLA_001826
ALUCAKAW2_10116S
ACHEACHE_41346A
APUUAPUU_40441S
TRGTRUGW13939_10289
PNOSNOG_13567(SNOG_13566)
PTEPTT_11069
BZECOCCADRAFT_106836
BSCCOCSADRAFT_115584
BORCOCMIDRAFT_107450
AALTCC77DRAFT_955703
ZTRMYCGRDRAFT_77799
PFJMYCFIDRAFT_57906
PSQPUNSTDRAFT_92380
 » show all
Reference
1  [PMID:6758786]
  Authors
Achstetter T, Ehmann C, Wolf DH.
  Title
Aminopeptidase Co, a new yeast peptidase.
  Journal
Biochem Biophys Res Commun 109:341-7 (1982)
DOI:10.1016/0006-291X(82)91726-0
Reference
2  [PMID:8175799]
  Authors
Yasuhara T, Nakai T, Ohashi A
  Title
Aminopeptidase Y, a new aminopeptidase from Saccharomyces cerevisiae. Purification, properties, localization, and processing by protease B.
  Journal
J Biol Chem 269:13644-50 (1994)
  Sequence
[sce:YBR286W]
Reference
3  [PMID:8175800]
  Authors
Nishizawa M, Yasuhara T, Nakai T, Fujiki Y, Ohashi A
  Title
Molecular cloning of the aminopeptidase Y gene of Saccharomyces cerevisiae. Sequence analysis and gene disruption of a new aminopeptidase.
  Journal
J Biol Chem 269:13651-5 (1994)
  Sequence
[sce:YBR286W]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.11.15
IUBMB Enzyme Nomenclature: 3.4.11.15
ExPASy - ENZYME nomenclature database: 3.4.11.15
BRENDA, the Enzyme Database: 3.4.11.15
CAS: 114796-97-3

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