| Entry |
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| Name |
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases
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| Reaction(IUBMB) |
Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate
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| Comment |
Aminoacyl-arylamides are poor substrates. This is an abundant cytosolic enzyme in mammalian cells, in peptidase family M18 of aminopeptidase I
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| History |
EC 3.4.11.21 created 2000
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| Orthology |
| K01267 | aspartyl aminopeptidase |
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| Genes |
| ORO: | 101377864 101381373(DNPEP) |
| XLA: | 443951(dnpep.L) 495491(dnpep.S) |
| SRX: | 107705617 107748542(dnpep) |
| SANH: | 107660142 107688842 |
| CAUA: | 113050772 113093833(dnpep) |
| SASA: | 100194946(dnpep) 106573845 106575848 106597606 |
| STRU: | 115180875 115182105 |
| CCLU: | 121558980 123489014 |
| CEL: | CELE_F01F1.9(dnpp-1) |
| CBR: | CBG_09068(Cbr-dnpp-1) |
| BMY: | BM_BM3133(Bma-dnpp-1) |
| ADF: | 107329665 107350220 107350221 |
| AMIL: | 114949180 114968905 114968906 |
| CSAT: | 104708650 104726613 104734478 104737556 104762129 104768665 |
| EUS: | EUTSA_v10013255mg EUTSA_v10015798mg |
| BNA: | 106388426 106388471 106433116 111197966 |
| CPAP: | 110807128 110820360 |
| CIC: | CICLE_v10019750mg CICLE_v10031166mg |
| MINC: | 123192289 123204605 123205986 123210509 |
| GHI: | 107886259 107887600 107918286 107932892 107933248 107940210 |
| DZI: | 111284871 111289291 111296045 111313779 |
| GMX: | 100776903 100781379 100790595 |
| GSJ: | 114403863 114409930 114416248 114419679 |
| PVU: | PHAVU_007G103100g PHAVU_009G167900g |
| CCAJ: | 109794673 109810635 |
| APRC: | 113848356 113849795 113870988 |
| LJA: | Lj0g3v0302719.1(Lj0g3v0302719.1) Lj5g3v1774930.1(Lj5g3v1774930.1) |
| AIP: | 107618571 107631486 110266944 |
| AHF: | 112712724 112722219 112777446 112804910 |
| LANG: | 109336320 109343373 109362372 |
| RCN: | 112172054 112180506 112199489 |
| PMUM: | 103331182 103338038 |
| PAVI: | 110746844 110762985 |
| PDUL: | 117618747 117627770 |
| MDM: | 103410047 103412875 103426947 103437558 103455017 |
| PXB: | 103928660 103928661 103929143 103938229 103947015 103950035 |
| ZJU: | 107404057 107413029 107418158 |
| CSV: | 101209810 101216468 101216946 116404099 |
| BHJ: | 120070984 120070985 120080765 |
| MCHA: | 111007193 111007194 111018753 |
| CMAX: | 111466015 111466023 111477309 |
| CMOS: | 111441256 111441257 111458303 |
| CPEP: | 111788587 111793087 111793088 |
| HBR: | 110634582 110665277 110671911 |
| MESC: | 110617239 110624845 |
| POP: | 7454541 7454697 7490903 |
| PEU: | 105125354 105131532 105139449 |
| PALZ: | 118044722 118045133 118057593 |
| JRE: | 108986585 108999798 109004214 109013972 109016152 109016298 |
| QSU: | 112002743 112009418 112010089 112010090 112011567 112022838 |
| SPEN: | 107005013 107014450 |
| SSTN: | 125844714 125859350 |
| CANN: | 107850599 107862692 |
| NTA: | 107800412 107803166 107803199 107817226 107831767 |
| SIND: | 105161051 105166273 |
| OEU: | 111399459 111405317 111405371 |
| SSPL: | 121752449 121788525 |
| ECAD: | 122605645 122607867 |
| CCAV: | 112511214 112511660 |
| CSIN: | 114261345 114315575 114316155 |
| SOE: | 110779794 110787309 110798378 |
| CQI: | 110722434 110723257 110724279 110739760 |
| MING: | 122064681 122078820 122094016 |
| TSS: | 122639405 122656692 122670949 |
| PSOM: | 113298134 113302798 113309742 113322636 |
| NCOL: | 116245616 116254476 116264041 |
| DOSA: | Os01t0967900-01(Os01g0967900) Os12t0236500-01(Os12g0236500) |
| TDC: | 119270679 119301554 119309395 119347745 |
| TAES: | 123063625 123072760 123080935 123103730 123111946 123121505 |
| SITA: | 101755168 101784674 |
| PVIR: | 120663812 120672747 120697006 120709356 |
| PHAI: | 112885847 112891386 |
| MUS: | 103968438 103976519 103987637 |
| SMO: | SELMODRAFT_101663 SELMODRAFT_164111 SELMODRAFT_176342 SELMODRAFT_442726 SELMODRAFT_80579 SELMODRAFT_86972 |
| PPP: | 112272625 112275315 112284941 112286821 |
| VCN: | VOLCADRAFT_104511 VOLCADRAFT_104613 |
| OLU: | OSTLU_13136 OSTLU_27563 |
| OTA: | OT_ostta12g02290 OT_ostta15g01820 |
| BPG: | Bathy02g01120 Bathy06g00320 |
| MIS: | MICPUN_55052 MICPUN_62784 |
| MPP: | MICPUCDRAFT_1995 MICPUCDRAFT_43781 |
| NCS: | NCAS_0H02030(NCAS0H02030) |
| NDI: | NDAI_0C01630(NDAI0C01630) |
| TPF: | TPHA_0H01750(TPHA0H01750) |
| TBL: | TBLA_0A03690(TBLA0A03690) |
| TDL: | TDEL_0E02010(TDEL0E02010) |
| KAF: | KAFR_0D05010(KAFR0D05010) |
| KNG: | KNAG_0B04250(KNAG0B04250) |
| CAL: | CAALFM_C110820CA(CaO19.2335) |
| CTP: | CTRG_04069 CTRG_04076 |
| NTE: | NEUTE1DRAFT81751(NEUTE1DRAFT_81751) |
| BFU: | BCIN_10g02290(Bcape4) |
| ANG: | ANI_1_1652024(An02g11940) |
| ADL: | AURDEDRAFT_110468 AURDEDRAFT_156374 |
| LBC: | LACBIDRAFT_188577(LbPR_M2) |
| ABP: | AGABI1DRAFT113568(AGABI1DRAFT_113568) |
| ABV: | AGABI2DRAFT116970(AGABI2DRAFT_116970) |
| SCM: | SCHCO_02499312(SCHCODRAFT_02499312) |
| EHI: | EHI_021340(10.t00011) EHI_106690(217.t00007) |
| EDI: | EDI_150800 EDI_155340 |
| EIV: | EIN_390410 EIN_424340 |
| BBO: | BBOV_IV011550(23.m06108) |
| TET: | TTHERM_00011120 TTHERM_00355370 |
| PTM: | GSPATT00013990001 GSPATT00027930001 |
| SMIN: | v1.2.004511.t1(symbB.v1.2.004511.t1) v1.2.011340.t1(symbB.v1.2.011340.t1) v1.2.020548.t1(symbB.v1.2.020548.t1) |
| PTI: | PHATRDRAFT_20708 PHATRDRAFT_27719 |
| FCY: | FRACYDRAFT_182384 FRACYDRAFT_195912 |
| TPS: | THAPSDRAFT_32859 THAPSDRAFT_34170 |
| AAF: | AURANDRAFT_20254 AURANDRAFT_34091 |
| EHX: | EMIHUDRAFT_426835 EMIHUDRAFT_430284 |
| NGR: | NAEGRDRAFT_66747 NAEGRDRAFT_76854 |
| TVA: | TVAG_2v0255700 TVAG_2v0355130 TVAG_2v0494480 TVAG_2v0839460 TVAG_2v0867840 TVAG_2v0921540 TVAG_2v1048090 |
| PPUD: | DW66_1300 DW66_1660 |
| PVD: | CFBP1590__3872(apeB) |
| PPRC: | PFLCHA0_c44540(apeB) |
| PTW: | TUM18999_44440(apeB) |
| PTAE: | NCTC10697_01455(apeB) |
| HAXI: | HAALTHF_46450n(apeB) |
| PLG: | NCTC10937_01632(apeB) |
| CCOH: | SAMEA4530647_2163(apeB) |
| PFAA: | MM59RIKEN_24790(apeB) |
| BPRO: | PMF13cell1_01779(apeB) |
| CSCI: | HDCHBGLK_01943(apeB) |
| ACEL: | acsn021_00230(apeB) |
| ACHT: | bsdcttw_00300(apeB) |
| PHX: | KGNDJEFE_02207(apeB) |
| CBAR: | PATL70BA_1463(apeB) |
| ETM: | CE91St48_36180(apeB) |
| PHAR: | NCTC13077_01594(apeB) |
| PIV: | NCTC13079_00245(apeB) |
| VRM: | 44547418_00760(apeB) |
| VDN: | NCTC11831_01197(apeB) |
| DHO: | Dia5BBH33_04460 Dia5BBH33_16670 |
| MMAE: | MMARE11_47000(pepC) |
| MBAI: | MB901379_04284(apeB) |
| MHEK: | JMUB5695_00635(apeB) |
| MPHL: | MPHLCCUG_00691(apeB) |
| MTHN: | 4412656_03950(apeB) |
| MAUU: | NCTC10437_04881(apeB) |
| MFLV: | NCTC10271_00641(apeB) |
| MSAL: | DSM43276_00619(apeB) |
| MTER: | 4434518_03543(pepC) |
| CDIP: | ERS451417_01250(apeB) |
| CPP: | CpP54B96_1057(pepC2) |
| CUN: | Cul210932_1154(pepC2) |
| CUS: | CulFRC11_1122(pepC2) |
| CUQ: | Cul210931_1104(pepC2) |
| CUZ: | Cul05146_1178(pepC2) |
| CUJ: | CUL131002_1136c(pepC2) |
| CMIN: | NCTC10288_01265(pepC) |
| CRL: | NCTC7448_01915(apeB) |
| CCYS: | SAMEA4530656_1094(apeB) |
| NFR: | ERS450000_03652(apeB) |
| NAD: | NCTC11293_01342(apeB) |
| NWL: | NWFMUON74_05810(apeB) |
| RCR: | NCTC10994_01958(apeB) |
| SAMB: | SAM23877_3854(apeB) |
| SCZ: | ABE83_12230 ABE83_18660 |
| SLE: | sle_35070(sle_35070) |
| SGM: | GCM10017557_42880(apeB) |
| SVU: | B1H20_16355 B1H20_23570 |
| SDX: | C4B68_10180 C4B68_19495 |
| SFY: | GFH48_20075 GFH48_25440 |
| SCAV: | CVT27_15895 CVT27_22355 |
| STUI: | GCM10017668_36050(apeB) |
| SATA: | C5746_20330 C5746_26795 |
| SCAL: | I6J39_16305 I6J39_23315 |
| SLF: | JEQ17_23870 JEQ17_25820 |
| KAB: | B7C62_16485 B7C62_23930 |
| AMAU: | DSM26151_20990(apeB) |
| PSEV: | USB125703_01760(apeB) |
| AAGI: | NCTC2676_1_02998(apeB) |
| DCO: | SAMEA4475696_0121(apeB) |
| CGRN: | 4412665_00882(apeB) |
| PAUS: | NCTC13651_00600(apeB) |
| TBW: | NCTC13354_00656(apeB) |
| AHW: | NCTC11636_02243(apeB) |
| AIR: | NCTC12972_00095(apeB) |
| ASLA: | NCTC11923_00031(apeB) |
| AVC: | NCTC10951_01692(apeB) |
| BAFH: | BafHLJ01_0692(pepX) |
| BTHO: | Btheta7330_03426(apeB) |
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| Reference |
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| Authors |
Kelly JA, Neidle EL, Neidle A. |
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| Title |
An aminopeptidase from mouse brain cytosol that cleaves N-terminal acidic amino acid residues. |
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| Journal |
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| Reference |
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| Authors |
Wilk S, Wilk E, Magnusson RP |
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| Title |
Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.4.11.21 |
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